KEGG   ORTHOLOGY: K04357
Entry
K04357                      KO                                     

Name
EGF
Definition
epidermal growth factor
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05226  Gastric cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00020  Colorectal cancer
H01210  Hypomagnesemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04357  EGF; epidermal growth factor
   04012 ErbB signaling pathway
    K04357  EGF; epidermal growth factor
   04014 Ras signaling pathway
    K04357  EGF; epidermal growth factor
   04015 Rap1 signaling pathway
    K04357  EGF; epidermal growth factor
   04630 JAK-STAT signaling pathway
    K04357  EGF; epidermal growth factor
   04066 HIF-1 signaling pathway
    K04357  EGF; epidermal growth factor
   04068 FoxO signaling pathway
    K04357  EGF; epidermal growth factor
   04020 Calcium signaling pathway
    K04357  EGF; epidermal growth factor
   04072 Phospholipase D signaling pathway
    K04357  EGF; epidermal growth factor
   04151 PI3K-Akt signaling pathway
    K04357  EGF; epidermal growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04357  EGF; epidermal growth factor
   04540 Gap junction
    K04357  EGF; epidermal growth factor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04357  EGF; epidermal growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04357  EGF; epidermal growth factor
   05231 Choline metabolism in cancer
    K04357  EGF; epidermal growth factor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04357  EGF; epidermal growth factor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04357  EGF; epidermal growth factor
   05212 Pancreatic cancer
    K04357  EGF; epidermal growth factor
   05226 Gastric cancer
    K04357  EGF; epidermal growth factor
   05214 Glioma
    K04357  EGF; epidermal growth factor
   05218 Melanoma
    K04357  EGF; epidermal growth factor
   05219 Bladder cancer
    K04357  EGF; epidermal growth factor
   05215 Prostate cancer
    K04357  EGF; epidermal growth factor
   05213 Endometrial cancer
    K04357  EGF; epidermal growth factor
   05224 Breast cancer
    K04357  EGF; epidermal growth factor
   05223 Non-small cell lung cancer
    K04357  EGF; epidermal growth factor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04357  EGF; epidermal growth factor
   05165 Human papillomavirus infection
    K04357  EGF; epidermal growth factor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04357  EGF; epidermal growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04357  EGF; epidermal growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04357  EGF; epidermal growth factor
Other DBs
GO: 0005155
Genes
HSA: 1950(EGF)
PTR: 461435(EGF)
PPS: 100975632(EGF)
GGO: 101153700(EGF)
PON: 100455021(EGF)
NLE: 100588963(EGF)
MCC: 698619(EGF)
MCF: 102123415(EGF)
CSAB: 103236114(EGF)
RRO: 104682421(EGF)
RBB: 108541026(EGF)
CJC: 100388651(EGF)
SBQ: 101052478(EGF)
MMU: 13645(Egf)
MCAL: 110291005(Egf)
MPAH: 110320006(Egf)
RNO: 25313(Egf)
MUN: 110553196(Egf)
CGE: 100763146(Egf)
NGI: 103742642(Egf)
HGL: 106007527(Egf)
CCAN: 109700925(Egf)
OCU: 100008808(EGF)
TUP: 102490423(EGF)
CFA: 403657(EGF)
VVP: 112934223(EGF)
AML: 100467733
UMR: 103661742(EGF)
UAH: 113255562(EGF)
ORO: 101377629(EGF)
ELK: 111156359
FCA: 493978(EGF)
PTG: 102959656(EGF)
PPAD: 109248153(EGF)
AJU: 106983657(EGF)
BTA: 530315(EGF)
BOM: 102285914(EGF)
BIU: 109559983(EGF)
BBUB: 102416325(EGF)
CHX: 106502173(EGF)
SSC: 397083(EGF)
CFR: 102523769(EGF)
CDK: 105089905(EGF)
BACU: 103004366(EGF)
LVE: 103073883(EGF)
OOR: 101283152(EGF)
DLE: 111186135(EGF)
PCAD: 102977431(EGF)
ECB: 106782874(EGF)
EPZ: 103543333
EAI: 106829795(EGF)
MYB: 102264252(EGF)
MYD: 102758044(EGF)
MNA: 107534373(EGF)
HAI: 109379436(EGF)
DRO: 112296254(EGF)
PALE: 102891552(EGF)
RAY: 107508819(EGF)
MJV: 108408073(EGF)
LAV: 100670137(EGF)
TMU: 101355971
MDO: 100619143(EGF)
SHR: 100933169(EGF)
PCW: 110218605(EGF)
OAA: 100074960(EGF)
GGA: 408035(EGF)
MGP: 100543460(EGF)
CJO: 107313609(EGF)
NMEL: 110399042(EGF)
APLA: 101795002(EGF)
ACYG: 106038683(EGF)
TGU: 100218747(EGF)
LSR: 110467994(EGF)
SCAN: 103826255(EGF)
GFR: 102034269(EGF)
FAB: 101819290(EGF)
PHI: 102112980(EGF)
PMAJ: 107203603(EGF)
CCAE: 111927782(EGF)
CCW: 104697130(EGF)
ETL: 114062174(EGF)
FPG: 101916879(EGF)
FCH: 102049265(EGF)
CLV: 102083886(EGF)
EGZ: 104135535(EGF)
NNI: 104021157(EGF)
ACUN: 113479739(EGF)
PADL: 103926035(EGF)
AAM: 106491937(EGF)
ASN: 102388605(EGF)
AMJ: 102560233(EGF)
PSS: 102453328(EGF)
CMY: 102933086(EGF)
CPIC: 101934754(EGF)
ACS: 100562822(egf)
PVT: 110087292(EGF)
PBI: 103061516(EGF)
PMUR: 107290128(EGF)
PMUA: 114604055(EGF)
GJA: 107122699(EGF)
XLA: 108704401 108710179(egf.L)
XTR: 100127663(egf)
NPR: 108798307(EGF)
DRE: 403045(egf)
IPU: 108268549(egf)
PHYP: 113547167
AMEX: 103045727(egf)
EEE: 113579942(egf)
TRU: 101061284(egf)
LCO: 104917921(egf)
NCC: 104953729(egf)
MZE: 101487082(egf)
ONL: 100706539(egf)
OLA: 101167023(egf)
XMA: 102219388(egf)
XCO: 114138665(egf)
PRET: 103471828(egf)
CVG: 107095811(egf)
NFU: 107374766(egf)
KMR: 108236662(egf)
ALIM: 106513245
AOCE: 111588376(egf)
CSEM: 103390644(egf)
POV: 109625474(egf)
LCF: 108885177(egf)
SDU: 111232468(egf)
SLAL: 111648180(egf)
HCQ: 109524192(egf)
BPEC: 110153711(egf)
MALB: 109964289
SASA: 106611584(egf)
OTW: 112256330(egf)
SALP: 111968192(egf)
ELS: 105027559(egf)
SFM: 108938717(egf)
PKI: 111849374(egf)
LCM: 102348800 102356822(EGF)
CMK: 103180890(egf)
RTP: 109929559(egf)
SKO: 102807105
ADF: 107331023
 » show all
Reference
PMID:3491360
  Authors
Bell GI, Fong NM, Stempien MM, Wormsted MA, Caput D, Ku LL, Urdea MS, Rall LB, Sanchez-Pescador R
  Title
Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization.
  Journal
Nucleic Acids Res 14:8427-46 (1986)
DOI:10.1093/nar/14.21.8427
  Sequence
[hsa:1950]
Reference
  Authors
Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT
  Title
Neurotrophic actions of a novel molluscan epidermal growth factor.
  Journal
J Neurosci 20:6355-64 (2000)
DOI:10.1523/JNEUROSCI.20-17-06355.2000
  Sequence
[mmu:13645]
LinkDB

KEGG   ORTHOLOGY: K18496
Entry
K18496                      KO                                     

Name
FGF1
Definition
fibroblast growth factor 1
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04390  Hippo signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04014 Ras signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04015 Rap1 signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04390 Hippo signaling pathway
    K18496  FGF1; fibroblast growth factor 1
   04151 PI3K-Akt signaling pathway
    K18496  FGF1; fibroblast growth factor 1
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K18496  FGF1; fibroblast growth factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K18496  FGF1; fibroblast growth factor 1
  09162 Cancer: specific types
   05226 Gastric cancer
    K18496  FGF1; fibroblast growth factor 1
   05218 Melanoma
    K18496  FGF1; fibroblast growth factor 1
   05224 Breast cancer
    K18496  FGF1; fibroblast growth factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K18496  FGF1; fibroblast growth factor 1
   00536 Glycosaminoglycan binding proteins
    K18496  FGF1; fibroblast growth factor 1
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K18496  FGF1; fibroblast growth factor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K18496  FGF1; fibroblast growth factor 1
Other DBs
GO: 0005104
Genes
HSA: 2246(FGF1)
PTR: 462158(FGF1)
PPS: 100972676(FGF1)
GGO: 101151075(FGF1)
PON: 100174103(FGF1)
NLE: 100603200(FGF1)
MCC: 705970(FGF1)
MCF: 102134593(FGF1)
CSAB: 103244714(FGF1)
RRO: 104681837(FGF1)
RBB: 108530219(FGF1)
CJC: 100392014(FGF1)
SBQ: 101040924(FGF1)
MMU: 14164(Fgf1)
MCAL: 110284837(Fgf1)
MPAH: 110333309(Fgf1)
RNO: 25317(Fgf1)
MUN: 110559286(Fgf1)
CGE: 100764257(Fgf1)
NGI: 103736084(Fgf1)
HGL: 101717777(Fgf1)
CCAN: 109684968(Fgf1) 109684969
OCU: 100328898(FGF1)
TUP: 102472932(FGF1)
CFA: 607724(FGF1)
VVP: 112934748(FGF1)
AML: 100463878(FGF1)
UMR: 103663709(FGF1)
UAH: 113255360(FGF1)
ORO: 101363195(FGF1)
ELK: 111156955
FCA: 101082206(FGF1)
PTG: 102967663(FGF1)
PPAD: 109252228(FGF1)
AJU: 106967134(FGF1)
BTA: 281160(FGF1)
BOM: 102287352(FGF1)
BIU: 109562156(FGF1)
BBUB: 102393179(FGF1)
CHX: 102188850(FGF1)
OAS: 101109353(FGF1)
SSC: 397497(FGF1)
CFR: 102513829(FGF1)
CDK: 105090819(FGF1)
BACU: 103018997(FGF1)
LVE: 103090095(FGF1)
OOR: 101277714(FGF1)
DLE: 111183039(FGF1)
PCAD: 102979009(FGF1)
ECB: 100033960(FGF1)
EPZ: 103550265(FGF1)
EAI: 106836975(FGF1)
MYB: 102256157(FGF1)
MYD: 102766495(FGF1)
MNA: 107531500(FGF1)
HAI: 109393705(FGF1)
DRO: 112318067(FGF1)
PALE: 102894192(FGF1)
RAY: 107500865(FGF1)
MJV: 108391030(FGF1)
LAV: 100663763(FGF1)
TMU: 101359380
MDO: 100023197(FGF1)
SHR: 100929695(FGF1)
PCW: 110220894(FGF1)
OAA: 100078822(FGF1)
GGA: 396094(FGF1)
CJO: 107320055(FGF1)
NMEL: 110405391(FGF1)
APLA: 101794210(FGF1)
ACYG: 106032819(FGF1)
TGU: 105759362(FGF1)
LSR: 110476395(FGF1)
SCAN: 103817397(FGF1)
GFR: 102031991(FGF1)
FAB: 101817673(FGF1)
PHI: 102103492(FGF1)
PMAJ: 107210662(FGF1)
CCAE: 111935800(FGF1)
CCW: 104689475(FGF1)
ETL: 114066997(FGF1)
FPG: 101922474(FGF1)
FCH: 102051939(FGF1)
CLV: 102091153(FGF1)
EGZ: 104133414(FGF1)
NNI: 104012024(FGF1)
ACUN: 113485315(FGF1)
PADL: 103923131(FGF1)
AAM: 106487164(FGF1)
ASN: 102367772(FGF1)
AMJ: 102570160(FGF1)
PSS: 102452758(FGF1)
CMY: 102931997(FGF1)
CPIC: 101933626(FGF1)
ACS: 100564309(fgf1)
PVT: 110086304(FGF1)
PBI: 103048921(FGF1)
PMUR: 107301319(FGF1)
PMUA: 114591226(FGF1)
GJA: 107113068(FGF1)
XLA: 108712499(fgf1.S) 444686(fgf1.L)
XTR: 100217324(fgf1)
NPR: 108794559(FGF1)
DRE: 100005049(fgf1b) 393733(fgf1a)
IPU: 100528431(fgf1) 108278801(fgf1)
PHYP: 113530070 113541732(fgf1)
EEE: 113585519(fgf1)
TRU: 101069995
LCO: 104917779(fgf1) 104938805
MZE: 101468745 101481636(fgf1)
ONL: 100693787 100705330(fgf1)
OLA: 101161650 101168387(fgf1)
XMA: 102217141 102220806(fgf1)
XCO: 114139185 114152626(fgf1)
PRET: 103471210 103475366(fgf1)
NFU: 107375089 107386707(fgf1)
KMR: 108238930(fgf1) 108240579
ALIM: 106523408 106534413(fgf1)
POV: 109635763(fgf1) 109645500
LCF: 108882928 108893486(fgf1)
MALB: 109959975(fgf1) 109971167
SASA: 100196882(fgf1) 106603858(FGF1)
SFM: 108936823(fgf1)
PKI: 111833360
LCM: 102355138(FGF1)
CMK: 103184127(fgf1)
RTP: 109916803
AME: 551529
BIM: 100745674
BTER: 100651312
CCAL: 108622110
OBB: 114877029
SOC: 105196647
MPHA: 105831911
AEC: 105154970
PBAR: 105422421
HST: 105191877
CFO: 105249468
LHU: 105667913
OBO: 105277247
PCF: 106790970
NVI: 100123442
CSOL: 105359465
MDL: 103576174
TCA: 100142029(FGF-2) 103314033(FGF-1)
ATD: 109598033
API: 100167265
DNX: 107168505
AGS: 114131083
RMD: 113553764
CLEC: 106669526
ZNE: 110832544
OBI: 106871146
 » show all
Reference
PMID:2393407
  Authors
Crumley G, Dionne CA, Jaye M
  Title
The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon.
  Journal
Biochem Biophys Res Commun 171:7-13 (1990)
DOI:10.1016/0006-291X(90)91348-V
  Sequence
[hsa:2246]
LinkDB

KEGG   ORTHOLOGY: K18497
Entry
K18497                      KO                                     

Name
FGF2
Definition
fibroblast growth factor 2
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04810  Regulation of actin cytoskeleton
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04014 Ras signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04015 Rap1 signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04151 PI3K-Akt signaling pathway
    K18497  FGF2; fibroblast growth factor 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K18497  FGF2; fibroblast growth factor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K18497  FGF2; fibroblast growth factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K18497  FGF2; fibroblast growth factor 2
   05205 Proteoglycans in cancer
    K18497  FGF2; fibroblast growth factor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K18497  FGF2; fibroblast growth factor 2
   05218 Melanoma
    K18497  FGF2; fibroblast growth factor 2
   05224 Breast cancer
    K18497  FGF2; fibroblast growth factor 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K18497  FGF2; fibroblast growth factor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K18497  FGF2; fibroblast growth factor 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K18497  FGF2; fibroblast growth factor 2
   00536 Glycosaminoglycan binding proteins
    K18497  FGF2; fibroblast growth factor 2
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K18497  FGF2; fibroblast growth factor 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K18497  FGF2; fibroblast growth factor 2
Other DBs
GO: 0005104
Genes
HSA: 2247(FGF2)
PTR: 641462(FGF2)
PPS: 100968351(FGF2)
GGO: 101137337(FGF2)
PON: 100459751(FGF2)
NLE: 100593123(FGF2)
MCC: 574136(FGF2)
MCF: 102133679(FGF2)
CSAB: 103236710(FGF2)
RRO: 104661758(FGF2)
RBB: 108515579(FGF2)
SBQ: 101030554(FGF2)
MMU: 14173(Fgf2)
MCAL: 110291557(Fgf2)
MPAH: 110320512(Fgf2)
RNO: 54250(Fgf2)
MUN: 110545886(Fgf2)
CGE: 100757429(Fgf2)
NGI: 103746947(Fgf2)
HGL: 101720583(Fgf2)
OCU: 100009068(FGF2)
TUP: 102498637(FGF2)
CFA: 403857(FGF2)
VVP: 112933647(FGF2)
AML: 100479986(FGF2)
UMR: 103661850(FGF2)
UAH: 113255677(FGF2)
ORO: 101369428(FGF2)
ELK: 111156005
FCA: 100135772(FGF2)
PTG: 102969772(FGF2)
PPAD: 109246691(FGF2)
AJU: 106977090(FGF2)
BTA: 281161(FGF2)
BOM: 102284897(FGF2)
BIU: 109570879(FGF2)
BBUB: 102393273(FGF2)
CHX: 102186892(FGF2)
OAS: 443306(FGF2)
SSC: 397643(FGF2)
CDK: 105093669(FGF2)
BACU: 103015722(FGF2)
LVE: 103090898(FGF2)
OOR: 101280803(FGF2)
DLE: 111186075(FGF2)
PCAD: 102989017(FGF2)
ECB: 100033955(FGF2)
MYB: 102246008(FGF2)
MYD: 102762815(FGF2)
MNA: 107529795(FGF2)
HAI: 109374154(FGF2)
DRO: 112312217(FGF2)
PALE: 107196088(FGF2)
RAY: 107518501(FGF2)
LAV: 100657533(FGF2)
TMU: 101342442
MDO: 619384(FGF2)
SHR: 100934542(FGF2)
PCW: 110222958(FGF2)
OAA: 114815531(FGF2)
GGA: 396413(FGF2)
MGP: 100550388(FGF2)
CJO: 107313543(FGF2)
NMEL: 110398111(FGF2)
APLA: 101798064(FGF2)
ACYG: 106042430(FGF2)
TGU: 100227798(FGF2)
LSR: 110484373(FGF2)
SCAN: 103821418(FGF2)
GFR: 102035880(FGF2)
FAB: 101807010(FGF2)
PHI: 102104728(FGF2)
PMAJ: 107202986(FGF2)
ETL: 114061094(FGF2)
FPG: 101918253(FGF2)
FCH: 102054561(FGF2)
CLV: 110364865(FGF2)
ACUN: 113479640(FGF2)
PADL: 103926140(FGF2)
AAM: 106491847(FGF2)
ASN: 102385563(FGF2)
AMJ: 102567370(FGF2)
PSS: 102444616(FGF2)
CMY: 102931444(FGF2)
CPIC: 101938814(FGF2)
ACS: 100559071(fgf2)
PVT: 110072861(FGF2)
PBI: 103053614(FGF2)
PMUR: 107283368(FGF2)
TSR: 106542651(FGF2)
PMUA: 114604525(FGF2)
GJA: 107109560(FGF2)
XLA: 100101279(fgf2) 108706695(fgf2.S)
XTR: 550087(fgf2)
NPR: 108790780(FGF2)
DRE: 404231(fgf2)
SANH: 107694403(fgf2) 107700884
SGH: 107559624(fgf1) 107568661
CCAR: 109065695
IPU: 108258196(fgf2)
PHYP: 113528646
AMEX: 103037892(fgf2)
EEE: 113589363(fgf2)
TRU: 115252306
LCO: 104931006(fgf2)
NCC: 104957748(fgf2)
MZE: 101483487(fgf2)
ONL: 100696875(fgf2)
XMA: 102225642(fgf2)
XCO: 114139089(fgf2)
PRET: 103471877(fgf2)
CVG: 107099215(fgf2)
NFU: 107380334(fgf2)
KMR: 108236605(fgf2)
AOCE: 111570066(fgf2)
CSEM: 103390695(fgf2)
POV: 109641290(fgf2)
LCF: 108901525(fgf2)
SDU: 111232376(fgf2)
SLAL: 111644654(fgf2)
HCQ: 109529054(fgf2)
BPEC: 110153728(fgf2)
MALB: 109956730(fgf2)
SASA: 106604591 106611625(fgf2)
SALP: 111965796 111967553(fgf2)
ELS: 105028130(fgf2)
SFM: 108938772(fgf2)
PKI: 111832812 111835519(fgf2)
LCM: 102351407(FGF2)
CMK: 103188323(fgf2)
RTP: 109916889
BFO: 118419131
APLC: 110983759
EPA: 110237525
ADF: 107340900
PDAM: 113683295
SPIS: 111338817
HMG: 101235368(FGF)
 » show all
Reference
PMID:3780670
  Authors
Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC
  Title
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
  Journal
EMBO J 5:2523-8 (1986)
DOI:10.1002/j.1460-2075.1986.tb04530.x
  Sequence
[hsa:2247]
Reference
  Authors
Okada-Ban M, Thiery JP, Jouanneau J
  Title
Fibroblast growth factor-2.
  Journal
Int J Biochem Cell Biol 32:263-7 (2000)
DOI:10.1016/S1357-2725(99)00133-8
  Sequence
[hsa:2247]
LinkDB

KEGG   ORTHOLOGY: K04358
Entry
K04358                      KO                                     

Name
FGF
Definition
fibroblast growth factor
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Disease
H00041  Kaposi sarcoma
H00255  Hypogonadotropic hypogonadism
H00484  Multiple synostosis syndrome
H00642  Lacrimo-auriculo-dento-digital syndrome
H00677  Aplasia of lacrimal and salivary glands
H00822  Renal hypodysplasia and aplasia
H01728  Potter syndrome
H01854  Metacarpal 4-5 fusion
H01905  Trichomegaly
H02286  Congenital deafness with inner ear agenesis, microtia, and microdontia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04358  FGF; fibroblast growth factor
   04014 Ras signaling pathway
    K04358  FGF; fibroblast growth factor
   04015 Rap1 signaling pathway
    K04358  FGF; fibroblast growth factor
   04151 PI3K-Akt signaling pathway
    K04358  FGF; fibroblast growth factor
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04358  FGF; fibroblast growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04358  FGF; fibroblast growth factor
  09162 Cancer: specific types
   05226 Gastric cancer
    K04358  FGF; fibroblast growth factor
   05218 Melanoma
    K04358  FGF; fibroblast growth factor
   05224 Breast cancer
    K04358  FGF; fibroblast growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04358  FGF; fibroblast growth factor
   00536 Glycosaminoglycan binding proteins
    K04358  FGF; fibroblast growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04358  FGF; fibroblast growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04358  FGF; fibroblast growth factor
Genes
HSA: 2248(FGF3) 2249(FGF4) 2250(FGF5) 2251(FGF6) 2252(FGF7) 2253(FGF8) 2254(FGF9) 2255(FGF10) 26281(FGF20) 27006(FGF22) 8817(FGF18) 8822(FGF17) 8823(FGF16)
PTR: 101056934(FGF8) 466693(FGF3) 468631(FGF22) 471553(FGF10) 472708(FGF17) 473676(FGF16) 739611(FGF18) 739665(FGF20) 744731(FGF9) 744975(FGF7) 747181(FGF6) 747727(FGF4)
PPS: 100967638(FGF4) 100967980(FGF3) 100968963(FGF22) 100969230(FGF8) 100970008(FGF20) 100979704(FGF9) 100980043(FGF5) 100982572(FGF17) 100985264(FGF16) 100989491(FGF6) 100992612(FGF10) 100992953(FGF18) 100995394(FGF7)
GGO: 101126805(FGF8) 101128423(FGF9) 101129138(FGF7) 101131137(FGF17) 101132851(FGF4) 101133590(FGF3) 101135528(FGF10) 101135749(FGF5) 101137223(FGF22) 101140831(FGF6) 101142002(FGF18) 101143620(FGF20) 101146312(FGF16)
PON: 100172539(FGF7) 100431992(FGF10) 100432789(FGF8) 100437858(FGF5) 100440363(FGF3) 100440732(FGF4) 100448388(FGF22) 100450364(FGF17) 100454475(FGF9) 100454905(FGF16) 100459069(FGF6) 100460498(FGF18) 100460891(FGF20)
NLE: 100580620(FGF7) 100583276(FGF5) 100585623(FGF16) 100587475(FGF4) 100587808(FGF3) 100588427(FGF18) 100590822(FGF10) 100591900(FGF17) 100598059(FGF22) 100598611(FGF8) 100601992(FGF9) 100603249(FGF20) 100605698
MCC: 574345(FGF7) 695896(FGF5) 701584(FGF10) 701847(FGF20) 702072(FGF18) 702727(FGF22) 705612(FGF16) 706659(FGF17) 708918(FGF3) 709016(FGF4) 710739(FGF6) 721324(FGF9) 722394(FGF8)
MCF: 102120710(FGF6) 102121261(FGF16) 102127718(FGF22) 102131922(FGF7) 102134212(FGF3) 102134588(FGF4) 102137925(FGF17) 102138682(FGF20) 102140602(FGF8) 102140725(FGF9) 102141473(FGF18) 102143550(FGF10) 102146180(FGF5)
CSAB: 103215226(FGF10) 103215381(FGF20) 103215436(FGF17) 103216414(FGF8) 103218416(FGF6) 103232230(FGF16) 103233582(FGF22) 103235869(FGF5) 103244968(FGF18) 103245650(FGF7) 103246179(FGF3) 103246230(FGF4) 103248989(FGF9)
RRO: 104654819(FGF5) 104656314(FGF9) 104656317(FGF10) 104656501(FGF8) 104656917(FGF7) 104658202(FGF20) 104658983(FGF6) 104663951(FGF17) 104670122(FGF18) 104671441(FGF22) 104674686(FGF16) 104677136(FGF3) 104677137(FGF4)
RBB: 108513599(FGF18) 108515073(FGF8) 108517319(FGF7) 108521318(FGF17) 108526452(FGF20) 108532456(FGF5) 108535339(FGF10) 108536494(FGF6) 108537873(FGF22) 108538230(FGF4) 108538240(FGF3) 108538283(FGF9) 108544577(FGF16)
CJC: 100385862(FGF20) 100386978(FGF5) 100387695(FGF10) 100388550(FGF16) 100390531(FGF6) 100392792(FGF9) 100398595 100401797(FGF17) 100402660(FGF18) 100405886(FGF7) 100409540(FGF4) 100410253(FGF3) 100414371(FGF22)
SBQ: 101031255(FGF7) 101031426(FGF5) 101040388(FGF20) 101040926(FGF17) 101042449(FGF3) 101046606(FGF10) 101046667(FGF18) 101047221(FGF4) 101048161(FGF8) 101048187(FGF6) 101050264(FGF16) 101052821(FGF9)
MMU: 14165(Fgf10) 14171(Fgf17) 14172(Fgf18) 14174(Fgf3) 14175(Fgf4) 14176(Fgf5) 14177(Fgf6) 14178(Fgf7) 14179(Fgf8) 14180(Fgf9) 67112(Fgf22) 80857(Fgf20) 80903(Fgf16)
MCAL: 110285629(Fgf8) 110287226(Fgf16) 110289950(Fgf7) 110295342(Fgf5) 110296943(Fgf6) 110299316(Fgf4) 110299386(Fgf3) 110300580(Fgf20) 110303818(Fgf22) 110305760(Fgf18) 110308330(Fgf10) 110308847(Fgf17) 110309422(Fgf9)
MPAH: 110314005(Fgf16) 110317154(Fgf6) 110318603(Fgf7) 110325518(Fgf9) 110325648(Fgf17) 110326486(Fgf8) 110327081(Fgf22) 110329060(Fgf10) 110330786(Fgf5) 110332000(Fgf18) 110336606(Fgf4) 110336807(Fgf20) 110337766(Fgf3)
RNO: 116499(Fgf4) 170579(Fgf22) 170633(Fgf3) 170700(Fgf6) 25443(Fgf10) 25444(Fgf9) 29348(Fgf7) 29349(Fgf8) 29368(Fgf17) 29369(Fgf18) 60464(Fgf16) 60662(Fgf5) 66017(Fgf20)
MUN: 110539533 110546441(Fgf3) 110546548(Fgf4) 110547817(Fgf18) 110548616(Fgf6) 110549737(Fgf9) 110550451(Fgf10) 110550525(Fgf5) 110551350(Fgf22) 110551663(Fgf17) 110556776(Fgf8) 110560157(Fgf7) 110564316(Fgf20)
CGE: 100750999(Fgf8) 100751051(Fgf10) 100757734(Fgf3) 100758023(Fgf4) 100759509(Fgf9) 100761504 100761599(Fgf7) 100763237(Fgf5) 100764611(Fgf17) 100767099(Fgf16) 100772115(Fgf6) 100773578(Fgf20) 103160353(Fgf22)
NGI: 103727190(Fgf9) 103727544(Fgf6) 103733041(Fgf7) 103734036(Fgf10) 103737403(Fgf22) 103737833(Fgf16) 103742625(Fgf5) 103743281(Fgf20) 103744005(Fgf8) 103747727(Fgf17) 103748184(Fgf18) 103751500(Fgf4) 103751508(Fgf3)
HGL: 101699438(Fgf8) 101700281(Fgf5) 101701530(Fgf9) 101701734(Fgf20) 101707578(Fgf10) 101707706(Fgf17) 101710458(Fgf3) 101711919(Fgf4) 101714076(Fgf7) 101716030(Fgf16) 101718946(Fgf18) 101720536(Fgf22) 101722884(Fgf6)
CCAN: 109675784(Fgf16) 109675851(Fgf9) 109676636(Fgf7) 109680643(Fgf10) 109691333(Fgf8) 109693681(Fgf22) 109695172(Fgf17) 109696354(Fgf4) 109696355(Fgf3) 109696982(Fgf18) 109698751(Fgf20) 109702196(Fgf6) 109702471(Fgf5)
OCU: 100008681(FGF7) 100008834(FGF8) 100316906(FGF5) 100340478(FGF18) 100342742(FGF16) 100342802(FGF10) 100342943(FGF4) 100346367(FGF6) 100355861(FGF9) 103345488(FGF17)
TUP: 102470048(FGF3) 102470471(FGF4) 102470973(FGF20) 102476072(FGF7) 102477924(FGF17) 102478652(FGF6) 102489294(FGF9) 102492980(FGF5) 102494532(FGF22) 102496545(FGF8) 102496950(FGF18) 102500031(FGF10) 102500824(FGF16)
CFA: 100855820(FGF20) 403868(FGF8) 403915(FGF7) 477340(FGF9) 483680(FGF4) 486735(FGF6) 491974(FGF16) 607952(FGF17) 608459(FGF5) 611641(FGF18) 611707(FGF3) 612404(FGF22) 612454(FGF10)
VVP: 112908925(FGF20) 112909183(FGF16) 112913369(FGF8) 112917377(FGF6) 112918609(FGF9) 112919573(FGF5) 112920051(FGF7) 112924012(FGF3) 112924013(FGF4) 112926828(FGF17) 112928529(FGF18) 112933766(FGF10)
AML: 100464088(FGF18) 100466947(FGF16) 100467527(FGF20) 100468641(FGF5) 100470803 100471023(FGF6) 100473739(FGF9) 100474108(FGF17) 100475745(FGF10) 100479573(FGF7) 100481939(FGF22) 100482817(FGF8)
UMR: 103658995(FGF8) 103664292(FGF9) 103664645(FGF10) 103664781(FGF18) 103665349(FGF5) 103671137(FGF3) 103673325(FGF17) 103675746(FGF6) 103675826(FGF16) 103676724(FGF7) 103681372(FGF20)
UAH: 113242141(FGF16) 113242699(FGF22) 113243917(FGF4) 113243934(FGF3) 113251181(FGF9) 113251656(FGF8) 113257435(FGF6) 113260960(FGF10) 113262031(FGF20) 113263042(FGF5) 113264085(FGF18) 113269603(FGF7) 113270070(FGF17)
ORO: 101364070(FGF6) 101366655(FGF16) 101366748(FGF10) 101370946(FGF4) 101373546(FGF8) 101377940(FGF7) 101379430(FGF17) 101379461(FGF18) 101379943(FGF20) 101381072(FGF9) 101382205(FGF22) 101382345(FGF5) 101385349(FGF3)
FCA: 100136904(FGF5) 101083745(FGF22) 101083766(FGF20) 101084335(FGF9) 101084652(FGF8) 101084778(FGF16) 101090489(FGF10) 101090606(FGF17) 101091459(FGF6) 101097982(FGF7) 101098518(FGF18) 111556546(FGF4) 111556666(FGF3)
PTG: 102949835(FGF5) 102956185(FGF7) 102957299(FGF20) 102959014(FGF8) 102964398(FGF18) 102969970(FGF6) 102970087(FGF17) 102970275(FGF9) 102970576(FGF10) 102971941(FGF22)
PPAD: 109247037(FGF4) 109247038(FGF3) 109257669(FGF22) 109258958(FGF16) 109263014(FGF7) 109266172(FGF9) 109267492(FGF18) 109273012(FGF8) 109275883(FGF10) 109276373(FGF6) 109277040(FGF5) 109277365(FGF17) 109277393(FGF20)
AJU: 106965488(FGF6) 106966945(FGF8) 106967112(FGF10) 106967225(FGF7) 106972632(FGF20) 106973440(FGF18) 106976900(FGF5) 106979814(FGF9) 106981101(FGF17) 106988440(FGF16) 113595410(FGF3) 113595513(FGF4) 113596382(FGF22)
BTA: 100300257(FGF17) 326284(FGF8) 326285(FGF10) 519657(FGF22) 533929(FGF18) 536771(FGF5) 539083(FGF20) 540317(FGF6) 540758(FGF16) 613731(FGF9) 616885(FGF7) 618474(FGF4) 618481(FGF3)
BOM: 102265554(FGF8) 102271394(FGF3) 102271993(FGF10) 102272008(FGF6) 102273668(FGF9) 102274702(FGF20) 102275883(FGF22) 102279034(FGF16) 102281308(FGF5) 102282456(FGF17) 102286083(FGF7) 102287270(FGF18)
BIU: 109553379(FGF20) 109554256 109555562(FGF16) 109559742(FGF6) 109561058(FGF22) 109565142(FGF7) 109567047(FGF9) 109575026(FGF18) 109575038(FGF10) 109579084(FGF8)
BBUB: 102391983(FGF10) 102392089(FGF20) 102395809(FGF9) 102400272(FGF16) 102400377(FGF3) 102400689(FGF4) 102401446(FGF5) 102403867(FGF7) 102407728(FGF22) 102409021(FGF6) 102409475(FGF18) 102416639(FGF8) 112577628(FGF17)
CHX: 102169384(FGF17) 102169602(FGF9) 102170206(FGF4) 102171226(FGF5) 102171403(FGF20) 102171599(FGF22) 102174339(FGF10) 102178396(FGF18) 102178454(FGF7) 102179261(FGF8) 102179273(FGF16) 102180381(FGF6) 108634211(FGF3)
OAS: 100642180(FGF5) 101104968(FGF16) 101113716(FGF8) 101114608(FGF22) 101116004(FGF4) 101116269(FGF3) 101116719(FGF6) 101116844(FGF9) 101118502(FGF17) 101121489(FGF20) 443074(FGF10) 443095(FGF7) 780460(FGF18)
SSC: 100152116(FGF6) 100152223(FGF16) 100155720(FGF17) 100156242(FGF8) 100513672(FGF5) 100516301(FGF20) 100518595(FGF4) 100519127(FGF3) 100525013(FGF18) 100525086(FGF10) 110259378(FGF22) 396717(FGF9) 397281(FGF7)
CFR: 102504464(FGF20) 102506593(FGF6) 102506716(FGF16) 102506811(FGF8) 102513465(FGF10) 102519120(FGF7) 102520066(FGF5) 102522544(FGF17) 102523201(FGF22) 102523878(FGF9) 102524081(FGF18) 116666646(FGF4) 116666647(FGF3)
CDK: 105084385(FGF8) 105089379(FGF18) 105091325(FGF6) 105091789(FGF5) 105093420(FGF22) 105095567(FGF16) 105096404(FGF9) 105102396(FGF20) 105102821(FGF17) 105104468(FGF4) 105104761(FGF7) 105107148(FGF10) 116157091
BACU: 103001602(FGF8) 103002427(FGF6) 103004048(FGF9) 103009981 103012368 103012419(FGF5) 103013036(FGF20) 103017891(FGF18) 103018238(FGF17) 103018926 103020278(FGF7) 103020625(FGF16)
LVE: 103069069(FGF8) 103069327(FGF5) 103071879(FGF18) 103072981(FGF16) 103077422(FGF6) 103080890(FGF3) 103083967(FGF10) 103086359(FGF7) 103087751(FGF22) 103088257(FGF17) 103090085(FGF4) 103091027(FGF20) 103091045(FGF9)
OOR: 101273136(FGF20) 101273794(FGF4) 101274052(FGF3) 101274700(FGF16) 101275198(FGF6) 101276595(FGF18) 101279631(FGF22) 101281106(FGF5) 101281389(FGF10) 101284280(FGF9) 101287893(FGF17) 101287969(FGF8) 101288260(FGF7)
DLE: 111163180(FGF10) 111169009(FGF17) 111170514(FGF22) 111172624(FGF8) 111173604(FGF20) 111175159(FGF9) 111176641(FGF6) 111178181(FGF16) 111181612(FGF7) 111183603(FGF3) 111184119(FGF4) 111185506(FGF18) 111187587(FGF5)
PCAD: 102974068(FGF3) 102974802(FGF8) 102976992(FGF10) 102981134(FGF6) 102982984(FGF5) 102985937(FGF16) 102990012(FGF9) 102992556(FGF17) 102992726(FGF20) 102993417(FGF18) 102994154(FGF7) 112067418(FGF4)
ECB: 100033961(FGF7) 100050037(FGF20) 100050353(FGF9) 100051221(FGF6) 100052655(FGF10) 100056444(FGF17) 100060219(FGF5) 100060309(FGF8) 100060525(FGF4) 100071790(FGF16) 100072461(FGF22) 100146649(FGF3) 100629648(FGF18)
EPZ: 103542556 103542783(FGF18) 103543606 103544063(FGF3) 103544754(FGF22) 103549913(FGF5) 103551394(FGF8) 103551851(FGF7) 103556855(FGF20) 103557835(FGF6) 103558900(FGF9) 103559741(FGF10) 103568034(FGF17)
EAI: 106824930(FGF10) 106828064(FGF5) 106828264(FGF20) 106828556(FGF9) 106828887(FGF8) 106831535(FGF6) 106834247(FGF22) 106837360(FGF18) 106838575(FGF7) 106844246(FGF4) 106844254(FGF3) 106846929(FGF16) 106847700(FGF17)
MYB: 102250238(FGF10) 102250520(FGF3) 102251158(FGF16) 102254187(FGF22) 102255119(FGF6) 102259056(FGF8) 102259580(FGF20) 102260092(FGF17) 102260244(FGF5) 102261041(FGF9) 102261751(FGF7) 102262222(FGF18)
MYD: 102751896(FGF18) 102753348(FGF9) 102754068(FGF22) 102754856(FGF6) 102755169(FGF17) 102757267(FGF3) 102760407(FGF7) 102764131(FGF8) 102766184(FGF10) 102769456(FGF16) 102769868(FGF5)
MNA: 107526261(FGF10) 107532758(FGF16) 107534042(FGF20) 107534875(FGF7) 107536980(FGF9) 107537102(FGF5) 107538572(FGF22) 107538886(FGF6) 107540349(FGF18) 107542168 107542543(FGF8) 107543550(FGF17)
HAI: 109373530(FGF5) 109377773(FGF9) 109379381(FGF18) 109379623(FGF8) 109382437(FGF17) 109385680(FGF16) 109389289(FGF3) 109389290(FGF4) 109390582(FGF22) 109392478(FGF6) 109392844(FGF10) 109394542(FGF7) 109394578(FGF20)
DRO: 112300468 112302323(FGF6) 112305225(FGF17) 112306790(FGF20) 112311746(FGF7) 112312291(FGF22) 112315295(FGF10) 112317419(FGF4) 112317420(FGF3) 112317958(FGF16) 112319696(FGF18) 112319711(FGF5) 112323185(FGF9)
PALE: 102887777(FGF7) 102887882(FGF9) 102888098(FGF20) 102890153(FGF16) 102892141(FGF6) 102893226(FGF8) 102893244(FGF4) 102894115(FGF18) 102894279(FGF17) 102895642(FGF5) 102895922(FGF10) 102896895(FGF22)
RAY: 107497786(FGF8) 107500922(FGF22) 107501960(FGF7) 107502706(FGF20) 107503931(FGF3) 107503977(FGF4) 107507115(FGF16) 107509200(FGF17) 107511020(FGF18) 107513447(FGF6) 107514447(FGF9) 107516440(FGF5) 107518965(FGF10)
MJV: 108383974(FGF18) 108391342(FGF6) 108393043(FGF9) 108393279(FGF20) 108396343(FGF5) 108397295(FGF17) 108397792(FGF10) 108402439(FGF16) 108405921(FGF8)
LAV: 100656129(FGF5) 100656791(FGF20) 100656834(FGF18) 100658495(FGF16) 100662939(FGF8) 100663120(FGF10) 100668860(FGF4) 100668915(FGF6) 100669156(FGF22) 100671479(FGF9) 100672847(FGF7) 100675766(FGF17)
MDO: 100012499(FGF16) 100012692(FGF10) 100014690(FGF5) 100019563(FGF6) 100021631(FGF4) 100021692(FGF3) 100021885(FGF20) 100023400(FGF8) 100023928(FGF9) 100024639(FGF22) 100025923(FGF7) 100030474(FGF17) 100031074(FGF18)
SHR: 100915656(FGF22) 100920456(FGF9) 100921812(FGF4) 100922075(FGF3) 100923118(FGF18) 100925286(FGF20) 100925381(FGF8) 100925383(FGF7) 100928224(FGF5) 100932059(FGF17) 100934722(FGF6) 100934743(FGF16) 116423189(FGF10)
PCW: 110192126(FGF8) 110193058(FGF16) 110195834(FGF9) 110197115(FGF4) 110197149(FGF3) 110200415(FGF17) 110201241(FGF20) 110202312(FGF7) 110209854(FGF5) 110212412(FGF18) 110215327(FGF10) 110218646(FGF6) 110223533(FGF22)
OAA: 100073730(FGF5) 100075228(FGF4) 100075300(FGF3) 100075757(FGF10) 100080372(FGF8) 100084373(FGF16) 100088500(FGF17) 100089135(FGF20) 100089319(FGF9) 100089414(FGF22) 100093377(FGF18) 103165700(FGF6) 114813732(FGF7)
GGA: 100858338(FGF22) 378917(FGF9) 395432(FGF10) 395453(FGF18) 396267(FGF3) 396313(FGF8) 415439(FGF7) 422330(FGF16) 428779(FGF20) 428857(FGF4) 768907(FGF6) 770457(FGF5)
MGP: 100538626(FGF20) 100539058(FGF18) 100540381(FGF3) 100540464(FGF22) 100548838(FGF6) 100550193(FGF16) 100550759(FGF7) 104910684(FGF5) 104911992(FGF8)
CJO: 107305970(FGF10) 107308312(FGF9) 107312883(FGF16) 107313516(FGF5) 107313688(FGF20) 107314467(FGF4) 107314469(FGF3) 107315948(FGF8) 107318735(FGF7) 107320505(FGF18) 107325468(FGF22)
NMEL: 110389087(FGF22) 110389317(FGF9) 110390665(FGF6) 110398266(FGF20) 110398386(FGF5) 110399995(FGF8) 110401571(FGF4) 110402192(FGF3) 110402985(FGF16) 110404057(FGF7) 110405399(FGF18)
APLA: 101790873(FGF3) 101793257(FGF9) 101795837(FGF7) 101795878(FGF17) 101797915(FGF8) 101798153(FGF18) 101800554(FGF16) 101801536(FGF20) 101803036(FGF6) 106014914(FGF5) 113840147(FGF10) 113843807(FGF4) 113845652(FGF22)
ACYG: 106030986(FGF8) 106033638(FGF7) 106034308(FGF18) 106036399(FGF10) 106038600(FGF16) 106040408(FGF9) 106041868(FGF5) 106044753(FGF3) 106046284(FGF6)
TGU: 100217634(FGF9) 100217790(FGF7) 100221251(FGF20) 100225191(FGF10) 100225823(FGF3) 100227412(FGF18) 100228127(FGF5) 100228553(FGF8) 100228700(FGF4) 100229784(FGF6) 100232335(FGF16) 105758940(FGF22)
LSR: 110467903(FGF16) 110469618(FGF3) 110469637(FGF4) 110470160(FGF5) 110470749(FGF9) 110472960(FGF20) 110473589(FGF8) 110474175(FGF7) 110475704(FGF18) 110475777(FGF22) 110479026(FGF6) 110483756(FGF10)
SCAN: 103813872(FGF8) 103816025(FGF7) 103816506(FGF16) 103819601(FGF6) 103822218(FGF4) 103822219(FGF3) 103823450(FGF5) 103823777(FGF18) 103826197(FGF20) 103827318(FGF9) 115484358(FGF22)
GFR: 102032503(FGF10) 102033173(FGF3) 102033341(FGF4) 102034856(FGF6) 102036865(FGF7) 102039340(FGF8) 102039574(FGF5) 102039970(FGF9) 102044043(FGF20) 102045202(FGF18)
FAB: 101805762(FGF22) 101806288(FGF16) 101807018(FGF4) 101807377(FGF20) 101807954(FGF3) 101811386(FGF8) 101813182(FGF18) 101814778(FGF9) 101816411(FGF10) 101816520(FGF7) 101817706(FGF6)
PHI: 102099294(FGF4) 102099537(FGF22) 102100899(FGF8) 102102399(FGF3) 102103462(FGF18) 102103712(FGF9) 102104207(FGF7) 102105200(FGF16) 102107459(FGF10) 102110749(FGF20) 102112031(FGF5) 102113891(FGF17) 102114147(FGF6)
PMAJ: 107198543(FGF18) 107202807(FGF20) 107203620(FGF5) 107203899(FGF16) 107204934(FGF6) 107205342(FGF3) 107205474(FGF4) 107206622(FGF8) 107207567(FGF9) 107209251(FGF7) 107213981(FGF17) 107215372(FGF22) 107215713(FGF10)
CCAE: 111923652(FGF9) 111928437(FGF20) 111929223(FGF16) 111929453(FGF5) 111929899(FGF6) 111930412(FGF3) 111930413(FGF4) 111931248(FGF8) 111934105(FGF7) 111935684(FGF18) 111944138(FGF10) 111946013
CCW: 104683986(FGF7) 104686647(FGF10) 104690018(FGF9) 104691724(FGF16) 104696042(FGF18) 104696174(FGF6) 104697633(FGF3) 104697890(FGF8) 104698257(FGF5)
ETL: 114056046(FGF10) 114057693(FGF9) 114059950(FGF7) 114063992(FGF16) 114065451(FGF20) 114066378(FGF22) 114067083(FGF6) 114067986(FGF3) 114067993(FGF4) 114068193 114070490(FGF17) 114071700(FGF8)
FPG: 101914322(FGF18) 101915107(FGF3) 101916006(FGF17) 101916268(FGF20) 101918748(FGF16) 101919998(FGF6) 101920129(FGF22) 101920320(FGF5) 101921871(FGF10) 101922378(FGF7) 101922782(FGF8) 101923673(FGF9)
FCH: 102046877(FGF20) 102050449(FGF17) 102052861(FGF3) 102053161(FGF7) 102053900(FGF6) 102055419(FGF8) 102055682(FGF9) 102056167(FGF10) 102057421(FGF18) 102057449(FGF16) 102058475(FGF5) 106631501(FGF22)
CLV: 102083432(FGF8) 102085878(FGF3) 102087779(FGF7) 102090612(FGF16) 102092640(FGF6) 102093546(FGF5) 102093657(FGF20) 102095791(FGF4) 102096506(FGF17) 102096791(FGF18) 102098285(FGF9) 110357664(FGF10)
EGZ: 104121820(FGF10) 104124208(FGF6) 104124707(FGF3) 104124708(FGF4) 104125614(FGF8) 104127847(FGF17) 104129448(FGF20) 104130923(FGF7) 104131686(FGF9) 104135705(FGF16) 104135937(FGF18)
NNI: 104009490(FGF3) 104009491(FGF4) 104013554(FGF8) 104015868(FGF5) 104016039(FGF17) 104016313(FGF22) 104016558(FGF18) 104017125(FGF7) 104020832(FGF20) 104021856(FGF6) 104023035(FGF9) 104023557(FGF16)
ACUN: 113477989(FGF9) 113479601(FGF5) 113480233(FGF16) 113481251(FGF3) 113481677(FGF8) 113484022(FGF7) 113485186(FGF18) 113491459(FGF6)
PADL: 103916315(FGF8) 103917220(FGF6) 103917416(FGF10) 103917705(FGF5) 103920109(FGF9) 103920226(FGF16) 103921961(FGF18) 103922745(FGF7) 103923487(FGF22) 103925822(FGF3) 103926336(FGF20)
AAM: 106488061(FGF18) 106489310(FGF16) 106489560(FGF6) 106490079(FGF20) 106494282(FGF5) 106495321(FGF17) 106496545(FGF7) 106496881(FGF8) 106498135(FGF3) 106499515(FGF10) 106500410(FGF9)
ASN: 102367831(FGF20) 102367960(FGF6) 102368255(FGF22) 102369492(FGF16) 102371387(FGF17) 102371490(FGF5) 102374611(FGF18) 102377921(FGF8) 102378092(FGF4) 102382611(FGF9) 102384145(FGF3) 102385765(FGF10)
AMJ: 102563000(FGF4) 102563948(FGF3) 102564109(FGF6) 102564190(FGF18) 102568685(FGF10) 102570596(FGF17) 102571915(FGF20) 102572183(FGF5) 102572653(FGF22) 102573090(FGF16) 102577004(FGF9) 106737014(FGF8) 109280173(FGF7)
PSS: 102446503(FGF9) 102448824(FGF20) 102450143(FGF10) 102450997(FGF16) 102451693(FGF5) 102452666(FGF8) 102454096(FGF7) 102456820(FGF3) 102457231(FGF4) 102459766(FGF18) 102462016(FGF6) 102462557(FGF17)
CMY: 102929419(FGF8) 102929495 102929722(FGF3) 102932179(FGF22) 102932399(FGF5) 102932554(FGF18) 102933711(FGF9) 102934890(FGF10) 102935697(FGF7) 102936451(FGF17) 102937481(FGF6) 102945353(FGF20) 102947001(FGF16)
CPIC: 101934624 101934872(FGF8) 101935771(FGF18) 101940244(FGF6) 101940956(FGF9) 101943839(FGF16) 101944151(FGF17) 101944394(FGF4) 101944401(FGF7) 101946516(FGF3) 101947974(FGF22) 101949872(FGF20) 101951015(FGF10) 103305916(FGF5)
ACS: 100552550(fgf5) 100555902(fgf18) 100558885(fgf8) 100558897(fgf7) 100559789(fgf6) 100561559(fgf9) 100562107(fgf16) 100564627(fgf3) 100564828(fgf4) 100565291(fgf10) 100567137(fgf20)
PVT: 110072606(FGF22) 110073508(FGF3) 110073880(FGF10) 110074324(FGF16) 110077017(FGF20) 110077238(FGF7) 110077610(FGF8) 110078969(FGF18) 110083555(FGF9) 110084110(FGF5) 110087491(FGF6)
PBI: 103049719(FGF5) 103053671(FGF7) 103053799 103055593(FGF10) 103058497(FGF9) 103062808 103062929(FGF8) 103063584 103067221(FGF4) 103067683(FGF3) 112541431(FGF18)
PMUR: 107282293(FGF22) 107284612(FGF16) 107285258(FGF8) 107285824(FGF4) 107286506(FGF9) 107287457(FGF18) 107287685(FGF7) 107291018(FGF10) 107301330(FGF3) 107301832(FGF20) 107303155(FGF5)
TSR: 106538537(FGF20) 106543519(FGF10) 106544293(FGF9) 106545598 106549061(FGF8) 106549292(FGF3) 106549294(FGF4) 106549816(FGF18) 106551644(FGF16) 106552933(FGF7)
PMUA: 114584997(FGF7) 114588594(FGF22) 114589344(FGF16) 114593638(FGF18) 114595727(FGF9) 114596867(FGF3) 114596868(FGF4) 114596925(FGF6) 114597563(FGF8) 114603754(FGF5) 114604225(FGF20) 114606419(FGF10)
GJA: 107107945(FGF5) 107110406(FGF6) 107112547(FGF18) 107114445(FGF8) 107115357(FGF9) 107116759(FGF20) 107120325(FGF17) 107121500(FGF3) 107121520(FGF4) 107121547(FGF10) 107123230(FGF16) 107124462(FGF7) 107126231(FGF22)
XLA: 101027307(fgf5.S) 108697431(fgf8.S) 108698341(FGF16) 108700069 108706603 108708721 108710781(fgf6.L) 108712225(fgf5.L) 108712445(fgf6.S) 108712902(fgf7.S) 108713205(fgf22.L) 108715251 108718395(fgf10.L) 373569(fgf10.S) 373669(fgf3.S) 378562(fgf9.S) 378586(fgf4.L) 378587(fgf4.S) 399105(fgf20.L) 399183(fgf8.L) 734697(fgf7.L)
XTR: 100217325(fgf4) 100217326(fgf6) 100217327(fgf9) 100233215(fgf22) 100233218(fgf20) 100486176(fgf5) 100492309(fgf16) 493516(fgf3) 493525(fgf8) 496833(fgf7) 548923(fgf10)
NPR: 108785453(FGF3) 108785455(FGF4) 108788271(FGF6) 108789072(FGF5) 108792194(FGF7) 108792831(FGF18) 108793985(FGF9) 108794060(FGF8) 108794128(FGF20) 108796567(FGF10)
DRE: 100005852(fgf22) 101883614(fgf9) 30538(fgf8a) 30549(fgf3) 30560(fgf6a) 359829(fgf18a) 359830(fgf10a) 359831(fgf24) 407737(fgf17) 493181(fgf7) 494454(fgf5) 494455(fgf6b) 497639(fgf18b) 559630(fgf20a) 564770(fgf20b) 570435(fgf4) 65089(fgf8b) 692065(fgf16) 751792(fgf10b)
OLA: 100049318(fgf20a) 100049319(fgf20b) 100125457(fgf8) 101159024(fgf5) 101161850 101162992 101167802(fgf16) 101169181(fgf4) 101171313(fgf7) 101173793(fgf18) 101174269(fgf10) 101174326 101174421(fgf6) 101174814(fgf3)
LCM: 102345389(FGF17) 102346042(FGF16) 102346137(FGF8) 102349922(FGF18) 102351067(FGF7) 102352226(FGF20) 102352812(FGF6) 102353488(FGF10) 102356182 102357981(FGF5) 102359750(FGF22) 102360221(FGF4) 102362535(FGF9) 102364799(FGF3)
CMK: 103175016(fgf4) 103175102(fgf3) 103177314(fgf18) 103177849(fgf10) 103178186(fgf20) 103178838(fgf16) 103180906(fgf5) 103182076(fgf22) 103182483 103183275(fgf9) 103185197 103185575(fgf6) 103186971(fgf7) 103187266
CIN: 445650(fgf8/17/18) 445651(fgf9/16/20) 445776(fgf4/5/6) 445789(fgf3/7/10/22)
SPU: 100894102 582058(FGF)
AME: 113219412
BIM: 100745016
BTER: 100644953
CCAL: 108623144
OBB: 114876777
SOC: 105194738
MPHA: 105839408
AEC: 105154875
ACEP: 105618270
PBAR: 105432505
VEM: 105568015
HST: 105185732
DQU: 106748616
CFO: 105250422
LHU: 105672274
PGC: 109857030
OBO: 105281715
PCF: 106791662
NVI: 100678771
CSOL: 105363672
MDL: 103572717
DPA: 109541096
NVL: 108557033
PXY: 105388826
API: 100569010
AGS: 114124492
RMD: 113557100
CLEC: 106661928
ZNE: 110839652
PVM: 113829301
CEL: CELE_C05D11.4(let-756)
CBR: CBG19663(Cbr-let-756)
CRG: 105346677
LAK: 106158471
 » show all
Reference
PMID:2475908
  Authors
Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA
  Title
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.
  Journal
Science 245:752-5 (1989)
DOI:10.1126/science.2475908
  Sequence
[hsa:2252]
Reference
  Authors
Beenken A, Mohammadi M
  Title
The FGF family: biology, pathophysiology and therapy.
  Journal
Nat Rev Drug Discov 8:235-53 (2009)
DOI:10.1038/nrd2792
LinkDB

KEGG   ORTHOLOGY: K22603
Entry
K22603                      KO                                     

Name
FGF19
Definition
fibroblast growth factor 19
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K22603  FGF19; fibroblast growth factor 19
   04014 Ras signaling pathway
    K22603  FGF19; fibroblast growth factor 19
   04015 Rap1 signaling pathway
    K22603  FGF19; fibroblast growth factor 19
   04151 PI3K-Akt signaling pathway
    K22603  FGF19; fibroblast growth factor 19
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K22603  FGF19; fibroblast growth factor 19
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K22603  FGF19; fibroblast growth factor 19
  09162 Cancer: specific types
   05226 Gastric cancer
    K22603  FGF19; fibroblast growth factor 19
   05218 Melanoma
    K22603  FGF19; fibroblast growth factor 19
   05224 Breast cancer
    K22603  FGF19; fibroblast growth factor 19
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K22603  FGF19; fibroblast growth factor 19
   00536 Glycosaminoglycan binding proteins
    K22603  FGF19; fibroblast growth factor 19
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K22603  FGF19; fibroblast growth factor 19
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K22603  FGF19; fibroblast growth factor 19
Other DBs
GO: 0005104
Genes
HSA: 9965(FGF19)
PTR: 747710(FGF19)
PPS: 100967291(FGF19)
PON: 100441475(FGF19)
NLE: 100606867(FGF19)
MCC: 709109(FGF19)
MCF: 102134957(FGF19)
CSAB: 103246343(FGF19)
RRO: 104677138(FGF19)
RBB: 108538219(FGF19)
SBQ: 101047544(FGF19)
MMU: 14170(Fgf15)
MCAL: 110299450(Fgf19)
MPAH: 110334904(Fgf19)
RNO: 170582(Fgf19)
MUN: 110546517(Fgf19)
CGE: 100758307(Fgf19)
NGI: 103751507(Fgf19)
HGL: 101710827(Fgf19)
OCU: 100358328(FGF19)
TUP: 102470889(FGF19) 102480823
CFA: 483681(FGF19)
VVP: 112924014(FGF19)
AML: 100470300(FGF19)
UMR: 103671138(FGF19)
UAH: 113243935(FGF19)
ORO: 101385649(FGF19)
ELK: 111149408
FCA: 101087099(FGF19)
PTG: 102966317(FGF19)
PPAD: 109246904(FGF19)
BTA: 521475(FGF19)
BOM: 102270828(FGF19)
BIU: 109554150(FGF19)
BBUB: 102414862(FGF19)
CHX: 102169942(FGF19)
OAS: 101115744(FGF19)
SSC: 100518950(FGF19)
CDK: 105104469(FGF19)
BACU: 103012083(FGF19)
LVE: 103081170
OOR: 101272704(FGF19)
DLE: 111184034(FGF19)
PCAD: 102974372(FGF19)
ECB: 100060488(FGF19)
EPZ: 103542877(FGF19)
EAI: 106844255(FGF19)
MYB: 102249614(FGF19)
MNA: 107542172(FGF19)
HAI: 109389288(FGF19)
DRO: 112317418(FGF19)
PALE: 102885081(FGF19)
TMU: 101354028
MDO: 100021575(FGF19)
SHR: 100916676(FGF19)
PCW: 110197122(FGF19)
OAA: 100075189(FGF19)
GGA: 395394(FGF19)
MGP: 100540226(FGF4)
CJO: 107314429(FGF19)
NMEL: 110400908(FGF19)
APLA: 101790481(FGF19)
ACYG: 106040879(FGF19)
TGU: 100219091(FGF19)
LSR: 110469617(FGF19)
SCAN: 115485473(FGF19)
GFR: 102033508(FGF19)
FAB: 101808144(FGF19)
PHI: 102102589(FGF19)
PMAJ: 107205427(FGF19)
CCAE: 111930414(FGF19)
ETL: 114067983(FGF19)
FCH: 102055464(FGF19)
CLV: 102095975(FGF19)
EGZ: 104124709(FGF19)
NNI: 104009492(FGF19)
ACUN: 113481250(FGF19)
AAM: 106498136(FGF19)
ASN: 102378328(FGF19)
AMJ: 102563235(FGF19)
PSS: 102457483(FGF19)
CMY: 102948383(FGF19)
CPIC: 101946231(FGF19)
ACS: 100565023(fgf19)
PVT: 110073517(FGF19)
PBI: 103067449(FGF19)
PMUR: 107285823(FGF19)
TSR: 106546689(FGF19)
PMUA: 114596871(FGF19)
GJA: 107121501(FGF19)
XLA: 101027274(fgf19.L) 108715066(fgf19.S)
XTR: 100217329(fgf19)
NPR: 108785439(FGF19)
DRE: 368245(fgf19)
CCAR: 109049194(fgf19) 109079029
IPU: 108270598(fgf19)
PHYP: 113536687(fgf19)
AMEX: 103031426(fgf19)
EEE: 113578786(fgf19)
TRU: 105418250
LCO: 104933822(fgf19)
NCC: 104963918
MZE: 101484510(fgf19)
ONL: 100706425(fgf19)
OLA: 101168929(fgf19)
XMA: 102237949(fgf19)
XCO: 114143132(fgf19)
PRET: 103462294(fgf19)
CVG: 107101770
NFU: 107372661
KMR: 108237895(fgf19)
ALIM: 106526567(fgf19)
AOCE: 111576242(fgf19)
CSEM: 103378962(fgf19)
POV: 109645710
LCF: 108877861(fgf19)
SDU: 111221755(fgf19)
SLAL: 111669309(fgf19)
HCQ: 109508004
BPEC: 110174537
MALB: 109967844(fgf19)
SASA: 106586997
OTW: 112249036(fgf19)
SALP: 111974797(fgf19)
ELS: 105017556(fgf19)
SFM: 108939257 108940897(fgf19)
PKI: 111841255 111851964(fgf19)
LCM: 102360486(FGF19)
CMK: 103175015(fgf19)
RTP: 109917921
 » show all
Reference
PMID:9931477
  Authors
Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N
  Title
Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.
  Journal
Biochim Biophys Acta 1444:148-51 (1999)
DOI:10.1016/S0167-4781(98)00255-3
  Sequence
[hsa:9965]
LinkDB

KEGG   ORTHOLOGY: K22429
Entry
K22429                      KO                                     

Name
FGF21
Definition
fibroblast growth factor 21
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04714  Thermogenesis
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K22429  FGF21; fibroblast growth factor 21
   04014 Ras signaling pathway
    K22429  FGF21; fibroblast growth factor 21
   04015 Rap1 signaling pathway
    K22429  FGF21; fibroblast growth factor 21
   04151 PI3K-Akt signaling pathway
    K22429  FGF21; fibroblast growth factor 21
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K22429  FGF21; fibroblast growth factor 21
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    K22429  FGF21; fibroblast growth factor 21
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K22429  FGF21; fibroblast growth factor 21
  09162 Cancer: specific types
   05226 Gastric cancer
    K22429  FGF21; fibroblast growth factor 21
   05218 Melanoma
    K22429  FGF21; fibroblast growth factor 21
   05224 Breast cancer
    K22429  FGF21; fibroblast growth factor 21
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K22429  FGF21; fibroblast growth factor 21
   00536 Glycosaminoglycan binding proteins
    K22429  FGF21; fibroblast growth factor 21
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K22429  FGF21; fibroblast growth factor 21
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K22429  FGF21; fibroblast growth factor 21
Other DBs
GO: 0005104
Genes
HSA: 26291(FGF21)
PTR: 468948(FGF21)
PPS: 100975521(FGF21)
GGO: 101149990(FGF21)
PON: 100447289(FGF21)
NLE: 100590773(FGF21)
MCC: 718288(FGF21)
MCF: 102126624(FGF21)
CSAB: 103234997(FGF21)
RRO: 104666549(FGF21)
CJC: 100389889(FGF21)
SBQ: 101048392(FGF21)
MMU: 56636(Fgf21)
MCAL: 110299358(Fgf21)
MPAH: 110338839(Fgf21)
RNO: 170580(Fgf21)
MUN: 110550501(Fgf21)
CGE: 100757339(Fgf21)
NGI: 103743629(Fgf21)
HGL: 101717974(Fgf21)
CCAN: 109682677(Fgf21)
OCU: 100356340(FGF21)
TUP: 102474175(FGF21)
CFA: 484395(FGF21)
VVP: 112931222(FGF21)
AML: 100478145(FGF21)
UMR: 103657101(FGF21)
UAH: 113243199(FGF21)
ORO: 101373782(FGF21)
ELK: 111160539
FCA: 101080595(FGF21)
PTG: 102963142(FGF21)
PPAD: 109253108(FGF21)
AJU: 106988712(FGF21)
BTA: 785576(FGF21)
BOM: 102282265(FGF21)
BIU: 109572074(FGF21)
BBUB: 102394633(FGF21)
CHX: 102185860(FGF21)
OAS: 101108510(FGF21)
SSC: 100302504(FGF21)
CFR: 102514176(FGF21)
CDK: 105102899(FGF21)
BACU: 103016083(FGF21)
LVE: 103081969(FGF21)
OOR: 101287388(FGF21)
DLE: 111180649(FGF21)
PCAD: 102973747(FGF21)
ECB: 100054542(FGF21)
EPZ: 103553325(FGF21)
EAI: 106838258(FGF21)
MYB: 102260667(FGF21)
MYD: 102768942(FGF21)
MNA: 107531851(FGF21)
HAI: 109391024(FGF21)
DRO: 112310055(FGF21)
PALE: 102886540(FGF21)
RAY: 107498854(FGF21)
MJV: 108400332(FGF21)
LAV: 100661893(FGF21)
TMU: 101356236
SHR: 100931317(FGF21)
PCW: 110219692(FGF21)
NMEL: 110391341
ASN: 102386963(FGF21)
AMJ: 102565552(FGF21)
CMY: 102941236
CPIC: 101934102(FGF21)
ACS: 100564275(fgf21)
PVT: 110078593(FGF21)
PBI: 103064082(FGF21)
PMUR: 107282458(FGF21)
TSR: 106538689(FGF21)
PMUA: 114582678(FGF21)
GJA: 107106394
XTR: 105947943
DRE: 724048(fgf21)
IPU: 108263130
PHYP: 113546510
EEE: 113589172
TRU: 101073344(fgf21)
LCO: 104920702(fgf21)
NCC: 104964186
MZE: 101485258(fgf21)
ONL: 100703128
OLA: 111946374
XMA: 102232669
XCO: 114153231
PRET: 103481230
CVG: 107101219
NFU: 107387534(fgf21)
KMR: 108237167
ALIM: 106517425
AOCE: 111584608
CSEM: 103381999(fgf21)
POV: 109626716(fgf21)
LCF: 108884404
SDU: 111219763(fgf21)
SLAL: 111658620(fgf21)
HCQ: 109524005
BPEC: 110159733
MALB: 109963646
SASA: 106579352
OTW: 112223261
SALP: 111977638
ELS: 109615792(fgf21)
 » show all
Reference
  Authors
Nishimura T, Nakatake Y, Konishi M, Itoh N
  Title
Identification of a novel FGF, FGF-21, preferentially expressed in the liver.
  Journal
Biochim Biophys Acta 1492:203-6 (2000)
DOI:10.1016/S0167-4781(00)00067-1
  Sequence
[hsa:26291]
LinkDB

KEGG   ORTHOLOGY: K22428
Entry
K22428                      KO                                     

Name
FGF23
Definition
fibroblast growth factor 23
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05226  Gastric cancer
Disease
H00214  Hypophosphatemic rickets
H01193  Familial tumoral calcinosis
H02141  Autosomal dominant hypophosphatemic rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K22428  FGF23; fibroblast growth factor 23
   04014 Ras signaling pathway
    K22428  FGF23; fibroblast growth factor 23
   04015 Rap1 signaling pathway
    K22428  FGF23; fibroblast growth factor 23
   04151 PI3K-Akt signaling pathway
    K22428  FGF23; fibroblast growth factor 23
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K22428  FGF23; fibroblast growth factor 23
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K22428  FGF23; fibroblast growth factor 23
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K22428  FGF23; fibroblast growth factor 23
  09162 Cancer: specific types
   05226 Gastric cancer
    K22428  FGF23; fibroblast growth factor 23
   05218 Melanoma
    K22428  FGF23; fibroblast growth factor 23
   05224 Breast cancer
    K22428  FGF23; fibroblast growth factor 23
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K22428  FGF23; fibroblast growth factor 23
   00536 Glycosaminoglycan binding proteins
    K22428  FGF23; fibroblast growth factor 23
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K22428  FGF23; fibroblast growth factor 23
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K22428  FGF23; fibroblast growth factor 23
Other DBs
GO: 0005104
Genes
HSA: 8074(FGF23)
PTR: 747164(FGF23)
PPS: 100989835(FGF23)
GGO: 101140441(FGF23)
PON: 100439010(FGF23)
NLE: 100605361(FGF23)
MCC: 710643(FGF23)
MCF: 102120346(FGF23)
CSAB: 103218414(FGF23)
RRO: 104658982(FGF23)
RBB: 108536498(FGF23)
CJC: 100392707(FGF23)
SBQ: 101048503(FGF23)
MMU: 64654(Fgf23)
MCAL: 110297028(Fgf23)
MPAH: 110317286(Fgf23)
RNO: 170583(Fgf23)
MUN: 110548635(Fgf23)
CGE: 100763837(Fgf23)
NGI: 103727545(Fgf23)
HGL: 101713698(Fgf23)
CCAN: 109702197(Fgf23)
OCU: 100343050(FGF23)
TUP: 102479073(FGF23)
CFA: 611773(FGF23)
VVP: 112917521(FGF23)
AML: 100472512(FGF23)
UMR: 103675745(FGF23)
UAH: 113258001(FGF23)
ORO: 101363779(FGF23)
ELK: 111159771
FCA: 101100063(FGF23)
PTG: 102958480(FGF23)
PPAD: 109276197(FGF23)
AJU: 106965456(FGF23)
BTA: 530239(FGF23)
BOM: 102274299(FGF23)
BIU: 109559743(FGF23)
BBUB: 102394505(FGF23)
CHX: 102168896(FGF23)
OAS: 101112475(FGF23)
SSC: 100155339(FGF23)
CFR: 102510802(FGF23)
CDK: 105091333(FGF23)
BACU: 103017322(FGF23)
LVE: 103074388(FGF23)
OOR: 101281525(FGF23)
DLE: 111176642(FGF23)
PCAD: 102991966(FGF23)
ECB: 100058460(FGF23)
EPZ: 103567716(FGF23)
EAI: 106831440(FGF23)
MYB: 102240867(FGF23)
MNA: 107538868(FGF23)
HAI: 109392469(FGF23)
DRO: 112306914(FGF23)
PALE: 102883346(FGF23)
RAY: 107513448(FGF23)
MJV: 108391341(FGF23)
LAV: 100668635(FGF23)
TMU: 101351251
MDO: 100019656(FGF23)
SHR: 100914586(FGF23)
PCW: 110218759(FGF23)
OAA: 114807786(FGF23)
GGA: 428104(FGF23)
MGP: 100549914(FGF23)
CJO: 107317989(FGF23)
NMEL: 110390661(FGF23)
APLA: 101802843(FGF23)
ACYG: 106046288(FGF23)
TGU: 100219174(FGF23)
LSR: 110479033(FGF23)
SCAN: 103819695(FGF23)
GFR: 102038755(FGF23)
FAB: 101818832(FGF23)
PHI: 102100267(FGF23)
PMAJ: 107204156(FGF23)
CCAE: 111930076(FGF23)
CCW: 104696480(FGF23)
ETL: 114067080(FGF23)
FPG: 101920171(FGF23)
FCH: 102053727(FGF23)
CLV: 102093014(FGF23)
EGZ: 104124209(FGF23)
NNI: 104021846(FGF23)
ACUN: 113491200(FGF23)
PADL: 103917221(FGF23)
AAM: 106489568(FGF23)
ASN: 102370401(FGF23)
AMJ: 102564803(FGF23)
PSS: 102443661(FGF23)
CMY: 102931217(FGF23)
CPIC: 101939980(FGF23)
ACS: 100559987(fgf23)
PVT: 110087506(FGF23)
PBI: 103051058(FGF23)
PMUR: 107298802(FGF23) 107298803
PMUA: 114596926(FGF23)
GJA: 107110402(FGF23)
XLA: 108710189(fgf23.2.L) 108710561(fgf23.1.L) 108712265(fgf23.2.S) 108712444(fgf23.1.S)
XTR: 100233219(fgf23.1) 100496800(fgf23.2)
NPR: 108787990(FGF23)
DRE: 494456(fgf23)
CCAR: 109059470
IPU: 108279611(fgf23)
PHYP: 113532387(fgf23)
EEE: 113578091(fgf23)
TRU: 101061209
LCO: 104926720(fgf23)
NCC: 104950093(fgf23)
MZE: 101479227(fgf23)
ONL: 100708188(fgf23)
OLA: 101158272 101175208(fgf23)
XCO: 114160874(fgf23)
PRET: 103459172(fgf23)
CVG: 107085771(fgf23)
NFU: 107386263(fgf23) 107389325
KMR: 108233282(fgf23) 108237499
ALIM: 106514814(fgf23)
AOCE: 111584045
CSEM: 103382742(fgf23)
POV: 109632765(fgf23)
LCF: 108886221
SDU: 111225015(fgf23)
SLAL: 111660016(fgf23)
HCQ: 109526794 109530114(fgf23)
BPEC: 110161810(fgf23)
MALB: 109969719
ELS: 105020243
SFM: 108918740(fgf23) 108931425
PKI: 111857581(fgf23)
LCM: 102351727(FGF23)
CMK: 103185576(fgf23)
RTP: 109920357
 » show all
Reference
  Authors
Yamashita T, Yoshioka M, Itoh N
  Title
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.
  Journal
Biochem Biophys Res Commun 277:494-8 (2000)
DOI:10.1006/bbrc.2000.3696
  Sequence
[hsa:8074]
LinkDB

KEGG   ORTHOLOGY: K05451
Entry
K05451            Tight     KO                                     

Name
NGFA
Definition
nerve growth factor, alpha
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05451  NGFA; nerve growth factor, alpha
   04014 Ras signaling pathway
    K05451  NGFA; nerve growth factor, alpha
   04015 Rap1 signaling pathway
    K05451  NGFA; nerve growth factor, alpha
   04151 PI3K-Akt signaling pathway
    K05451  NGFA; nerve growth factor, alpha
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05451  NGFA; nerve growth factor, alpha
 09150 Organismal Systems
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05451  NGFA; nerve growth factor, alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05451  NGFA; nerve growth factor, alpha
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05451  NGFA; nerve growth factor, alpha
Genes
MMU: 18048(Klk1b4)
Reference
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
LinkDB

KEGG   ORTHOLOGY: K02582
Entry
K02582                      KO                                     

Name
NGFB
Definition
nerve growth factor, beta
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
Disease
H00265  Hereditary sensory and autonomic neuropathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K02582  NGFB; nerve growth factor, beta
   04014 Ras signaling pathway
    K02582  NGFB; nerve growth factor, beta
   04015 Rap1 signaling pathway
    K02582  NGFB; nerve growth factor, beta
   04151 PI3K-Akt signaling pathway
    K02582  NGFB; nerve growth factor, beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K02582  NGFB; nerve growth factor, beta
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02582  NGFB; nerve growth factor, beta
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02582  NGFB; nerve growth factor, beta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K02582  NGFB; nerve growth factor, beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K02582  NGFB; nerve growth factor, beta
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K02582  NGFB; nerve growth factor, beta
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Others
   K02582  NGFB; nerve growth factor, beta
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K02582  NGFB; nerve growth factor, beta
Genes
HSA: 4803(NGF)
PTR: 469423(NGF)
PPS: 100995667(NGF)
GGO: 101149785(NGF)
PON: 100441497(NGF)
NLE: 100593913(NGF)
MCC: 711681(NGF)
MCF: 102132327(NGF)
CSAB: 103224160(NGF)
RRO: 104669070(NGF)
RBB: 108528126(NGF)
CJC: 100391837(NGF)
SBQ: 101038561(NGF)
MMU: 18049(Ngf)
MCAL: 110291584(Ngf)
MPAH: 110320585(Ngf)
RNO: 310738(Ngf)
MUN: 110564378(Ngf)
CGE: 100750778(Ngf)
NGI: 103734944(Ngf)
HGL: 101722226(Ngf)
CCAN: 109676961(Ngf)
OCU: 103350089(NGF)
TUP: 102501945(NGF)
CFA: 403402(NGF)
VVP: 112916832(NGF)
AML: 100469695(NGF)
UMR: 103669449(NGF)
UAH: 113244387(NGF)
ORO: 101384791(NGF)
FCA: 100144611(NGF)
PTG: 102961057(NGF)
PPAD: 109272115(NGF)
AJU: 106969645(NGF)
BTA: 281350(NGF)
BOM: 102287477(NGF)
BIU: 109555882(NGF)
BBUB: 102400650(NGF)
CHX: 100862660(NGF)
OAS: 101104540(NGF)
SSC: 100738968(NGF)
CFR: 102511686(NGF)
CDK: 105089623(NGF)
BACU: 103002155(NGF)
LVE: 103084220(NGF)
OOR: 101277874(NGF)
DLE: 111179989(NGF)
PCAD: 102988669(NGF)
ECB: 100065669(NGF)
EPZ: 103547744(NGF)
EAI: 106835685(NGF)
MYB: 102245962(NGF)
MYD: 102769020(NGF)
MNA: 107545260(NGF)
HAI: 109392809(NGF)
DRO: 112313781(NGF)
PALE: 102885454(NGF)
RAY: 107499858(NGF)
MJV: 108386081(NGF)
LAV: 100654499(NGF)
TMU: 101341922
MDO: 100010246(NGF)
SHR: 100930279(NGF)
PCW: 110219284(NGF)
OAA: 100074403(NGF)
GGA: 396466(NGF)
MGP: 100543801(NGF)
CJO: 107324926(NGF)
NMEL: 110388196(NGF)
APLA: 101792805(NGF)
ACYG: 106041304(NGF)
TGU: 751997(NGF)
LSR: 110473072(NGF)
SCAN: 103822331(NGF)
GFR: 102040631(NGF)
FAB: 101812533(NGF)
PHI: 102111404(NGF)
PMAJ: 107214905(NGF)
CCAE: 111939656(NGF)
CCW: 104692415(NGF)
ETL: 114064413(NGF)
FPG: 101920218(NGF)
FCH: 102055637(NGF)
CLV: 102097714(NGF)
EGZ: 104126776(NGF)
NNI: 104010337(NGF)
ACUN: 113488901(NGF)
PADL: 103923574(NGF)
AAM: 106485254(NGF)
ASN: 102380366(NGF)
AMJ: 102568830(NGF)
PSS: 102451252(NGF)
CMY: 102944320(NGF)
CPIC: 101952420(NGF)
ACS: 100553574(ngf)
PVT: 110072378(NGF)
PBI: 103057660(NGF)
PMUR: 107284057(NGF)
TSR: 106539191(NGF)
PMUA: 114599408(NGF)
GJA: 107107944(NGF)
XLA: 108708058(ngf.L) 108709389(ngf.S)
XTR: 100170161(ngf)
NPR: 108795094(NGF)
DRE: 30270(ngfa) 58133(ngfb)
IPU: 108271566(ngf) 108276493
PHYP: 113533487(ngf) 113545633
AMEX: 103030601 103031633(ngf)
NCC: 104941543(ngf) 104950112
POV: 109635098 109635456(ngf)
SFM: 108918378(ngf) 108939188
LCM: 102364322(NGF)
CMK: 103190249
RTP: 109934101
APLC: 110985730
SKO: 100313666
 » show all
Reference
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:3670305
  Authors
Selby MJ, Edwards R, Sharp F, Rutter WJ
  Title
Mouse nerve growth factor gene: structure and expression.
  Journal
Mol Cell Biol 7:3057-64 (1987)
DOI:10.1128/MCB.7.9.3057
  Sequence
[mmu:18049]
LinkDB

KEGG   ORTHOLOGY: K04526
Entry
K04526                      KO                                     

Name
INS
Definition
insulin
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04911  Insulin secretion
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04917  Prolactin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04940  Type I diabetes mellitus
ko04950  Maturity onset diabetes of the young
ko04960  Aldosterone-regulated sodium reabsorption
ko05010  Alzheimer disease
ko05215  Prostate cancer
Disease
H00408  Type 1 diabetes mellitus
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04526  INS; insulin
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP-PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04526  INS; insulin
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocytes
    K04526  INS; insulin
   04913 Ovarian steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  09149 Aging
   04211 Longevity regulating pathway
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
 09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K04526  INS; insulin
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04526  INS; insulin
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin
Genes
HSA: 3630(INS)
PTR: 449570(INS)
PPS: 100969387(INS)
GGO: 101132604(INS)
PON: 100453978(INS)
NLE: 100586809(INS)
MCC: 704534(INS)
MCF: 102133184(INS)
CSAB: 103239029(INS)
RRO: 104677102(INS)
RBB: 108539226(INS)
CJC: 100393089(INS)
SBQ: 101038116(INS)
MMU: 16333(Ins1) 16334(Ins2)
RNO: 24505(Ins1) 24506(Ins2)
MUN: 110547298
CGE: 100760716(Ins)
NGI: 103738986(Ins)
HGL: 101719971(Ins)
CCAN: 109689794
OCU: 100009181(INS)
TUP: 102481191(INS)
CFA: 483665(INS)
VVP: 112924140(INS)
AML: 100483432(INS)
UMR: 103671056
UAH: 113243960
ORO: 101383590(INS)
ELK: 111150279
FCA: 493804(INS)
PPAD: 109259395(INS)
AJU: 113595531(INS)
BTA: 280829(INS)
BOM: 102274400(INS)
BIU: 109554336(INS)
BBUB: 102396436(INS)
CHX: 108634241(INS)
OAS: 114110121(INS)
SSC: 397415(INS)
CFR: 116666555(INS)
CDK: 116152037(INS)
BACU: 103021022(INS)
LVE: 103085742(INS)
OOR: 101278494(INS)
DLE: 111183606(INS)
PCAD: 112062628(INS)
ECB: 111776000(INS)
EPZ: 103567614(INS)
EAI: 106824100(INS)
MYB: 102254396
MYD: 102753598(INS)
HAI: 109395936(INS)
DRO: 112317432
PALE: 102881117
RAY: 107513269(INS)
MJV: 108402614(INS)
LAV: 100661112(INS)
TMU: 101346705
PCW: 110197190(INS)
OAA: 114810063(INS)
GGA: 396145(INS-IGF2)
MGP: 100540225(INS)
CJO: 107314531(INS)
NMEL: 110400779(INS)
APLA: 101794427(INS)
ACYG: 106042601(INS)
TGU: 100231606(INS)
LSR: 110468670(INS)
SCAN: 103826754(INS)
GFR: 102044590(INS)
FAB: 101812165(INS)
PHI: 102111203(INS)
PMAJ: 107205419(INS)
CCAE: 111930707(INS)
CCW: 104687554(INS)
ETL: 114059852(INS)
FPG: 101915745(INS)
FCH: 102054961(INS)
CLV: 102092033(INS)
EGZ: 104124907
NNI: 104010412
ACUN: 113481160
PADL: 103920695(INS)
AAM: 106497062(INS)
ASN: 102378642(INS)
AMJ: 102565762(INS)
PSS: 102445198(INS)
CMY: 102935680(INS)
CPIC: 101937524(INS)
ACS: 100565615(ins)
PVT: 110076559(INS)
PBI: 103061255(INS)
PMUR: 107294042(INS)
TSR: 106547000(INS)
PMUA: 114585088
GJA: 107123376(INS)
XLA: 108696734 378695(ins.L) 378696(ins.S)
XTR: 100101718(ins)
NPR: 108792002(INS)
DRE: 100534937 30262(ins) 566735(insb)
PHYP: 113525002 113531241(ins)
EEE: 113591428(ins)
TRU: 101065226
NCC: 104961913(ins)
MZE: 101468103(ins) 101469513
ONL: 100692120(ins) 100704156
XMA: 102225241(ins) 102229304
XCO: 114139621 114153755(ins)
CVG: 107086316 107090300(ins)
CSEM: 103395680(ins)
SASA: 106567474(INS) 106603941(INS) 106612054
SFM: 108934283(ins)
PKI: 111850821(ins)
LCM: 102348278(INS)
CMK: 103186003(ins)
RTP: 109921259(ins)
DME: Dmel_CG14167(Ilp3) Dmel_CG14173(Ilp1) Dmel_CG33273(Ilp5) Dmel_CG6736(Ilp4) Dmel_CG8167(Ilp2)
DSI: Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)
BIM: 112211977
BTER: 100646077
CCAL: 108629740
OBB: 114873438
SOC: 105200753
MPHA: 105832901
AEC: 105147653
ACEP: 105625577
PBAR: 105432563
VEM: 105559845
HST: 105188195
DQU: 106750697
LHU: 105670049
PGC: 109860861
OBO: 105278524
PCF: 106791661
NVI: 100117514
CSOL: 105364979
MDL: 103569964
TCA: 100142381
BMOR: 100146109(Bbx-e1) 100146110(Bbx-f1) 100169657(Bbx-a4) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169716(Bbx-b7) 100169719(Bbx-b1) 100169720(Bbx-b4) 100169723(Bbx-b6) 100169726(Bbx-g1) 100653512(BmILP) 101736783 101741759
RMD: 113558495
CLEC: 112127432
FCD: 110851216
TSP: Tsp_10902
OBI: 106870869
LAK: 106180359
EGL: EGR_08330
AMIL: 114960007
SPIS: 111326395
 » show all
Reference
  Authors
Lizcano JM, Alessi DR
  Title
The insulin signalling pathway.
  Journal
Curr Biol 12:R236-8 (2002)
DOI:10.1016/S0960-9822(02)00777-7
Reference
PMID:2397023
  Authors
Sawa T, Ohgaku S, Morioka H, Yano S
  Title
Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.
  Journal
J Mol Endocrinol 5:61-7 (1990)
DOI:10.1677/jme.0.0050061
  Sequence
[mmu:16333 16334]
LinkDB

KEGG   ORTHOLOGY: K05459
Entry
K05459                      KO                                     

Name
IGF1
Definition
insulin-like growth factor 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05410  Hypertrophic cardiomyopathy
ko05414  Dilated cardiomyopathy
Disease
H00015  Malignant pleural mesothelioma
H02040  Insulin-like growth factor I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
   04935 Growth hormone synthesis, secretion and action
    K05459  IGF1; insulin-like growth factor 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  09156 Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  09149 Aging
   04211 Longevity regulating pathway
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancer
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
  09162 Cancer: specific types
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05459  IGF1; insulin-like growth factor 1
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05459  IGF1; insulin-like growth factor 1
Other DBs
GO: 0005159
Genes
HSA: 3479(IGF1)
PTR: 741055(IGF1)
PPS: 100982978(IGF1)
GGO: 101154397(IGF1)
PON: 100444645(IGF1)
NLE: 100595306(IGF1)
MCC: 698444(IGF1)
MCF: 102128018(IGF1)
CSAB: 103238957(IGF1)
RRO: 104657459(IGF1)
RBB: 108543134(IGF1)
CJC: 100394985(IGF1)
SBQ: 101036963(IGF1)
MMU: 16000(Igf1)
MCAL: 110304009(Igf1)
MPAH: 110326668(Igf1)
RNO: 24482(Igf1)
MUN: 110561622(Igf1)
CGE: 100751642(Igf1)
NGI: 103733723(Igf1)
HGL: 101707684(Igf1)
CCAN: 109677734 109697466(Igf1)
OCU: 100008668(IGF1)
TUP: 102490248(IGF1)
CFA: 610255(IGF1)
VVP: 112930717(IGF1)
AML: 100473254(IGF1)
UMR: 103676495(IGF1)
UAH: 113256079(IGF1)
ORO: 101386334(IGF1)
FCA: 101101237(IGF1)
PTG: 102962543(IGF1)
PPAD: 109265419(IGF1)
AJU: 106971906(IGF1)
BTA: 281239(IGF1)
BOM: 102272009(IGF1)
BIU: 109559448(IGF1)
BBUB: 102392528(IGF1)
CHX: 100860838(IGF1)
OAS: 443318(IGF1)
SSC: 397491(IGF1)
CFR: 102506236(IGF1)
CDK: 105097468(IGF1)
BACU: 103014780(IGF1)
LVE: 103078928(IGF1)
OOR: 101269950(IGF1)
DLE: 111187819(IGF1)
PCAD: 102990550(IGF1)
ECB: 100034198(IGF1)
EPZ: 103549360(IGF1)
EAI: 106827264(IGF1)
MYB: 102252071(IGF1)
MYD: 102752580(IGF1)
MNA: 107545147(IGF1)
HAI: 109387785(IGF1)
DRO: 112321846(IGF1)
PALE: 102890331(IGF1)
RAY: 107501166(IGF1)
MJV: 108410340(IGF1)
LAV: 100664710(IGF1)
TMU: 101361934
MDO: 100021295(IGF1)
SHR: 100918816(IGF1)
PCW: 110205653(IGF1)
OAA: 100075905(IGF1)
GGA: 418090(IGF1)
CJO: 107316281(IGF1)
NMEL: 110393921(IGF1)
APLA: 101793597(IGF1)
ACYG: 106035916(IGF1)
TGU: 100226283(IGF1)
LSR: 110473651(IGF1)
SCAN: 103819655(IGF1)
GFR: 102032215(IGF1)
FAB: 101808710(IGF1)
PHI: 102112946(IGF1)
PMAJ: 107204610(IGF1)
CCAE: 111936136(IGF1)
CCW: 104696228(IGF1)
ETL: 114056148(IGF1)
FPG: 101922655(IGF1)
FCH: 102060062(IGF1)
CLV: 102092089(IGF1)
EGZ: 104135582(IGF1)
NNI: 104013358(IGF1)
ACUN: 113491340(IGF1)
PADL: 103924427(IGF1)
AAM: 106488383(IGF1)
ASN: 102372626(IGF1)
AMJ: 102559209(IGF1)
PSS: 102454948(IGF1)
CMY: 102932263(IGF1)
CPIC: 101939474(IGF1)
ACS: 100566682(igf1)
PVT: 110084792(IGF1)
PBI: 103062109(IGF1)
PMUR: 107289460(IGF1)
PMUA: 114605733(IGF1)
GJA: 107119991(IGF1)
XLA: 108711020(igf1.L) 108712492 378699(igf1.S)
XTR: 100486334(igf1)
NPR: 108789614(IGF1)
DRE: 114433(igf1)
IPU: 100305062(igf1)
PHYP: 113532358(igf1) 113535157
AMEX: 103036238(igf1)
EEE: 113584584(igf1)
TRU: 100462939(igf1)
LCO: 104926290(igf1) 104935275
NCC: 104956990
MZE: 101464291 101476517(igf1)
ONL: 100534428 100534565(igf1)
OLA: 101168167(igf1) 105354483
XMA: 102221578 102222602(igf1)
XCO: 114142519 114160998(igf1)
PRET: 103459389(igf1) 103466958
CVG: 107085823(igf1) 107097451
NFU: 107386743(igf1) 107391385
KMR: 108228312 108233311(igf1)
ALIM: 106529338 106530265(igf1)
AOCE: 111568767(igf1) 111587489
CSEM: 103382578(igf1) 103384875
POV: 109639654 109640767(igf1)
LCF: 108897582(igf1) 108900498
SDU: 111225018(igf1) 111233786
SLAL: 111658878 111664700(igf1)
HCQ: 109528351 109530129(igf1)
MALB: 109967822(igf1) 109971005
ELS: 105013816 105030158(igf1)
SFM: 108931632(igf1) 114909159
PKI: 111834375 111846569(igf1)
LCM: 102361051(IGF1) 102365620
CMK: 103179868(igf1)
RTP: 109914145(igf1)
BFO: 118407319
CIN: 100170003(ins-l1)
DME: Dmel_CG14049(Ilp6)
DER: 6555537
DSE: 6616142
DSI: Dsimw501_GD28130(Dsim_GD28130)
DSR: 110183267
DPE: 6600159
DMN: 108164895
DWI: 6638043
DAZ: 108619735
DNV: 108658570
DHE: 111596753
MDE: 101896013
LCQ: 111675152
BIM: 105680848
BTER: 100648980
CCAL: 108632922
OBB: 114879882
SOC: 105197201
MPHA: 105840254
AEC: 105154102
ACEP: 105617935
VEM: 105562165
HST: 105186969
DQU: 106741669
CFO: 105257619
PGC: 109855579
OBO: 105283606
NVI: 100679703
CSOL: 105365464
TCA: 103315192
BMOR: 100147697(Bbx-c2) 100169656(Bbx-b11) 100169707(Bbx-a10) 100169715(Bbx-b10) 100169718(Bbx-b8) 100169722(Bbx-b3) 100169724(Bbx-b5) 100270769(Igflp) 101740144
PRAP: 110996560
TNL: 113497883
API: 100169635
CLEC: 106672819
ZNE: 110826827
CSCU: 111624540
CRG: 105319754
NVE: 5512419
EPA: 110241415
SPIS: 111342911
 » show all
Reference
PMID:3002851
  Authors
de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  Title
Organization of the human genes for insulin-like growth factors I and II.
  Journal
FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9
  Sequence
[hsa:3479]
Reference
  Authors
Zoidis E, Ghirlanda-Keller C, Schmid C
  Title
Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
  Journal
Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z
  Sequence
[hsa:3479]
LinkDB

KEGG   ORTHOLOGY: K04359
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 JAK-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04020 Calcium signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09162 Cancer: specific types
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
Other DBs
GO: 0005161
Genes
HSA: 5154(PDGFA)
PTR: 740202(PDGFA)
PPS: 100991389(PDGFA)
GGO: 101132059(PDGFA)
PON: 100440212(PDGFA)
NLE: 100583683(PDGFA)
MCC: 707725(PDGFA)
MCF: 102126620(PDGFA)
CSAB: 103246906(PDGFA)
RRO: 104664975(PDGFA)
RBB: 108542315(PDGFA)
CJC: 100412906(PDGFA)
SBQ: 101034511(PDGFA)
MMU: 18590(Pdgfa)
MCAL: 110294651(Pdgfa)
MPAH: 110312881(Pdgfa)
RNO: 25266(Pdgfa)
MUN: 110550699(Pdgfa)
CGE: 100771503(Pdgfa)
NGI: 103748699(Pdgfa)
HGL: 101725739(Pdgfa)
CCAN: 109684500(Pdgfa)
OCU: 100352388(PDGFA)
TUP: 102499235(PDGFA)
CFA: 491597(PDGFA)
VVP: 112929281(PDGFA)
AML: 100473486(PDGFA)
UMR: 103670054(PDGFA)
ORO: 101386160(PDGFA)
ELK: 111145884
FCA: 101087287(PDGFA)
PPAD: 109251089(PDGFA)
AJU: 106966514(PDGFA)
BTA: 505908(PDGFA)
BOM: 102271219(PDGFA)
BIU: 109578611(PDGFA)
BBUB: 102394875(PDGFA)
CHX: 102174268(PDGFA)
OAS: 114110564(PDGFA)
SSC: 100519764(PDGFA)
CFR: 102520052(PDGFA)
CDK: 105102061(PDGFA)
BACU: 103005337(PDGFA)
LVE: 103089216(PDGFA)
OOR: 101287211(PDGFA)
DLE: 111169371(PDGFA)
PCAD: 102989848(PDGFA)
ECB: 100055086(PDGFA)
EPZ: 103555992(PDGFA)
EAI: 106834748(PDGFA)
MYB: 102253551(PDGFA)
MYD: 102762551(PDGFA)
MNA: 107543141(PDGFA)
HAI: 109380137(PDGFA)
DRO: 112319719(PDGFA)
PALE: 102893670(PDGFA)
RAY: 107497394(PDGFA)
TMU: 101344666
MDO: 100020951(PDGFA)
SHR: 100924985(PDGFA) 116422035
PCW: 110201572(PDGFA)
OAA: 100081033(PDGFA)
GGA: 374196(PDGFA)
MGP: 100545955(PDGFA)
CJO: 107320713(PDGFA)
NMEL: 110405632(PDGFA)
APLA: 101803502(PDGFA)
ACYG: 106033384(PDGFA)
TGU: 100222155(PDGFA)
LSR: 110475507(PDGFA)
SCAN: 103817870(PDGFA)
GFR: 102032936(PDGFA)
FAB: 101810376(PDGFA)
PHI: 102099148(PDGFA)
PMAJ: 107211209(PDGFA)
CCAE: 111936274(PDGFA)
CCW: 104685042(PDGFA)
ETL: 114054750(PDGFA)
FPG: 101922505(PDGFA)
FCH: 102059520(PDGFA)
CLV: 102085857(PDGFA)
EGZ: 104128975(PDGFA)
NNI: 104015206(PDGFA)
ACUN: 113485656(PDGFA)
PADL: 103913559(PDGFA)
ASN: 102386051(PDGFA)
AMJ: 102568490(PDGFA)
PSS: 102453111(PDGFA)
CMY: 102936738(PDGFA)
CPIC: 101940087(PDGFA)
ACS: 100560004(pdgfa)
PVT: 110090337(PDGFA)
PBI: 103066198(PDGFA)
PMUR: 107291891(PDGFA)
PMUA: 114584301(PDGFA)
GJA: 107115509(PDGFA)
XLA: 108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 100038202(pdgfa)
NPR: 108800714(PDGFA)
DRE: 103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
IPU: 108259440
EEE: 113576794(pdgfa) 113581484
TRU: 101063539 101077475(pdgfa)
LCO: 104925707(pdgfa) 104938193
NCC: 104945697(pdgfa)
ONL: 100690958 100702821(pdgfa)
OLA: 101156252(pdgfa) 101171139
XMA: 102226782(pdgfa) 102233791
XCO: 114145269 114160156(pdgfa)
PRET: 103469195(pdgfa) 103476211
CVG: 107090056 107095213(pdgfa)
NFU: 107373888 107376493(pdgfa)
KMR: 108237947 108247650(pdgfa)
ALIM: 106518714(pdgfa) 106522509
AOCE: 111562600(pdgfa) 111588207
POV: 109638650(pdgfa) 109639258
LCF: 108886167(pdgfa) 108887178
SDU: 111216525 111227111(pdgfa)
SLAL: 111667551(pdgfa) 111673426
BPEC: 110169079(pdgfa)
MALB: 109952877 109972908(pdgfa)
SFM: 108930223(pdgfa)
LCM: 102352946(PDGFA)
CMK: 103175503 103178687(pdgfa)
RTP: 109916423(pdgfa) 109936774
CCAL: 108622908
AEC: 105146079
VEM: 105561417
BMOR: 101735793
ZNE: 110830060
 » show all
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
LinkDB

KEGG   ORTHOLOGY: K17386
Entry
K17386                      KO                                     

Name
PDGFB
Definition
platelet-derived growth factor subunit B
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04014 Ras signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04015 Rap1 signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04630 JAK-STAT signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04020 Calcium signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04072 Phospholipase D signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04151 PI3K-Akt signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17386  PDGFB; platelet-derived growth factor subunit B
   04540 Gap junction
    K17386  PDGFB; platelet-derived growth factor subunit B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17386  PDGFB; platelet-derived growth factor subunit B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
   05206 MicroRNAs in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
   05231 Choline metabolism in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
  09162 Cancer: specific types
   05214 Glioma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05218 Melanoma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05211 Renal cell carcinoma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05215 Prostate cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K17386  PDGFB; platelet-derived growth factor subunit B
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K17386  PDGFB; platelet-derived growth factor subunit B
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17386  PDGFB; platelet-derived growth factor subunit B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K17386  PDGFB; platelet-derived growth factor subunit B
   00536 Glycosaminoglycan binding proteins
    K17386  PDGFB; platelet-derived growth factor subunit B
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K17386  PDGFB; platelet-derived growth factor subunit B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K17386  PDGFB; platelet-derived growth factor subunit B
Other DBs
GO: 0005161
Genes
HSA: 5155(PDGFB)
PTR: 458844(PDGFB)
PPS: 100984583(PDGFB)
GGO: 101138492(PDGFB)
PON: 100460243(PDGFB)
NLE: 100586714(PDGFB)
MCC: 703173(PDGFB)
MCF: 102125183(PDGFB)
CSAB: 103223339(PDGFB)
RRO: 104682558(PDGFB)
RBB: 108520474(PDGFB)
CJC: 100388628(PDGFB)
SBQ: 101043776(PDGFB)
MMU: 18591(Pdgfb)
MCAL: 110310626(Pdgfb)
MPAH: 110334927(Pdgfb)
RNO: 24628(Pdgfb)
MUN: 110557819(Pdgfb)
CGE: 100774990(Pdgfb)
NGI: 103748570(Pdgfb)
HGL: 101698830(Pdgfb)
CCAN: 109692977(Pdgfb)
OCU: 100358772(PDGFB)
TUP: 102482500(PDGFB)
CFA: 442986(PDGFB)
VVP: 112933988(PDGFB)
AML: 100475543(PDGFB)
UMR: 103676520(PDGFB)
UAH: 113241764(PDGFB)
ORO: 101370194(PDGFB)
ELK: 111157534
FCA: 100135774(PDGFB)
PTG: 102971867(PDGFB)
PPAD: 109265580(PDGFB)
AJU: 106981002(PDGFB)
BTA: 540106(PDGFB)
BOM: 102266290(PDGFB)
BBUB: 102396940(PDGFB)
CHX: 102184232(PDGFB)
OAS: 443545(PDGFB)
CFR: 102509299(PDGFB)
CDK: 105091934(PDGFB)
BACU: 103014878(PDGFB)
LVE: 103085145(PDGFB)
OOR: 101281603(PDGFB)
DLE: 111186344(PDGFB)
PCAD: 102982885(PDGFB)
ECB: 100070283(PDGFB)
EPZ: 103565679(PDGFB)
EAI: 106836855(PDGFB)
MYB: 102239511(PDGFB)
MYD: 102752730(PDGFB)
MNA: 107531241(PDGFB)
HAI: 109392273(PDGFB)
DRO: 112321825(PDGFB)
PALE: 102897699(PDGFB)
RAY: 107502078(PDGFB)
MJV: 108397360(PDGFB)
LAV: 100663544(PDGFB)
TMU: 101344115
MDO: 100012899(PDGFB)
SHR: 100917875(PDGFB)
PCW: 110205795(PDGFB)
OAA: 100085757(PDGFB)
GGA: 374128(PDGFB)
MGP: 100542930(PDGFB)
CJO: 107312675(PDGFB)
NMEL: 110392622(PDGFB)
APLA: 101794895(PDGFB)
ACYG: 106035929(PDGFB)
TGU: 100228287(PDGFB)
LSR: 110483837(PDGFB)
SCAN: 103813271(PDGFB)
GFR: 102036985(PDGFB)
FAB: 101815450(PDGFB)
PHI: 102099229(PDGFB)
PMAJ: 107205105(PDGFB)
CCAE: 111934907(PDGFB)
CCW: 104696330(PDGFB)
ETL: 114055364(PDGFB)
FPG: 101920861(PDGFB)
FCH: 102055848(PDGFB)
CLV: 102096932(PDGFB)
EGZ: 104134236(PDGFB)
NNI: 104021619(PDGFB)
ACUN: 113488033(PDGFB)
PADL: 103915655(PDGFB)
AAM: 106488469(PDGFB) 106488478
ASN: 102371668(PDGFB)
AMJ: 102562234(PDGFB)
PSS: 102451145(PDGFB)
CMY: 102929576(PDGFB)
CPIC: 101949242(PDGFB)
ACS: 100554817(pdgfb)
PVT: 110075932(PDGFB)
PBI: 103054969(PDGFB)
PMUR: 107288137(PDGFB)
TSR: 106544589(PDGFB)
PMUA: 114605091(PDGFB)
GJA: 107117132(PDGFB)
XLA: 108714525(pdgfb.L) 493575(pdgfb.S)
XTR: 100492827(pdgfb)
NPR: 108798502(PDGFB)
DRE: 798657(si:ch211-79m20.1)
IPU: 108259423(PDGFB)
PHYP: 113547643
AMEX: 103037777
EEE: 113585737
TRU: 101072289(pdgfb)
LCO: 104925464
MZE: 101487929
ONL: 100712331
OLA: 101162100(pdgfb)
XMA: 102235349
XCO: 114145108
PRET: 103477155
CVG: 107090045
NFU: 107375167(pdgfb)
KMR: 108232032
ALIM: 106522503
AOCE: 111582470
CSEM: 103383236
POV: 109639241
LCF: 108887165
SDU: 111216519
SLAL: 111673435
HCQ: 109511462
MALB: 109951610(pdgfb)
ELS: 105012081
LCM: 102355435(PDGFB)
CMK: 103173461
RTP: 109928695
API: 100568518(ACYPI24120)
HMG: 100201588
VG: 5176147(WMSV_gp3) 9538324(WMSV_gp4)
 » show all
Reference
PMID:3517869
  Authors
Rao CD, Igarashi H, Chiu IM, Robbins KC, Aaronson SA
  Title
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
  Journal
Proc Natl Acad Sci U S A 83:2392-6 (1986)
DOI:10.1073/pnas.83.8.2392
  Sequence
[hsa:5155]
LinkDB

KEGG   ORTHOLOGY: K05450
Entry
K05450                      KO                                     

Name
PDGFC_D
Definition
platelet derived growth factor C/D
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04810  Regulation of actin cytoskeleton
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04014 Ras signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04015 Rap1 signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04020 Calcium signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04072 Phospholipase D signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05450  PDGFC_D; platelet derived growth factor C/D
   04540 Gap junction
    K05450  PDGFC_D; platelet derived growth factor C/D
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05450  PDGFC_D; platelet derived growth factor C/D
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  09162 Cancer: specific types
   05218 Melanoma
    K05450  PDGFC_D; platelet derived growth factor C/D
   05215 Prostate cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05450  PDGFC_D; platelet derived growth factor C/D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05450  PDGFC_D; platelet derived growth factor C/D
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05450  PDGFC_D; platelet derived growth factor C/D
Other DBs
GO: 0005161
Genes
HSA: 56034(PDGFC) 80310(PDGFD)
PTR: 466765(PDGFD) 736477(PDGFC)
PPS: 100982459(PDGFC) 100992738(PDGFD)
GGO: 101134877(PDGFD) 101144807(PDGFC)
PON: 100172718(PDGFD) 100437861(PDGFC)
NLE: 100585549(PDGFC) 100586178(PDGFD)
MCC: 700236(PDGFC) 704310(PDGFD)
MCF: 101925936(PDGFD) 102132043(PDGFC)
CSAB: 103236438(PDGFC) 103248362(PDGFD)
RRO: 104655283(PDGFD) 104658109(PDGFC)
RBB: 108529019(PDGFC) 108534757(PDGFD)
CJC: 100393010(PDGFC) 100398033(PDGFD)
SBQ: 101038849(PDGFC) 101049234(PDGFD)
MMU: 54635(Pdgfc) 71785(Pdgfd)
MCAL: 110290924(Pdgfc) 110301590(Pdgfd)
MPAH: 110319957(Pdgfc) 110327924(Pdgfd)
RNO: 66018(Pdgfd) 79429(Pdgfc)
MUN: 110540260(Pdgfd) 110542507(Pdgfc)
CGE: 100756952(Pdgfd) 100765334(Pdgfc)
NGI: 103731702(Pdgfd) 103751038(Pdgfc)
HGL: 101696768(Pdgfd) 101710927(Pdgfc)
CCAN: 109701575(Pdgfc) 109702404(Pdgfd)
OCU: 100008912(PDGFD) 100350272(PDGFC)
TUP: 102485007(PDGFD) 102487522(PDGFC)
CFA: 479460(PDGFD) 482666(PDGFC)
VVP: 112912529 112925942(PDGFD)
AML: 100479872(PDGFD) 100481171(PDGFC)
UMR: 103658054(PDGFC) 103662543(PDGFD)
UAH: 113255787(PDGFC) 113260127(PDGFD)
ORO: 101363701(PDGFD) 101378889(PDGFC)
FCA: 101084984(PDGFD) 101088742(PDGFC)
PTG: 102949957(PDGFD) 102970530(PDGFC)
PPAD: 109257520(PDGFD) 109262483(PDGFC)
AJU: 106974876(PDGFC) 106976474(PDGFD)
BTA: 525931(PDGFD) 613787(PDGFC)
BOM: 102273267(PDGFD) 102274384(PDGFC)
BIU: 109569805(PDGFD) 109571395(PDGFC)
BBUB: 102392849(PDGFC) 102411002(PDGFD)
CHX: 102168651(PDGFD) 102168934(PDGFC)
OAS: 101112600(PDGFC) 101117784(PDGFD)
SSC: 100515267(PDGFC) 100524161(PDGFD)
CFR: 102508964(PDGFC) 102515439(PDGFD)
CDK: 105101177(PDGFC) 116155424(PDGFD)
BACU: 103015925(PDGFD) 103019677(PDGFC)
LVE: 103076387(PDGFC) 103085046(PDGFD)
OOR: 101278539(PDGFC) 101290342(PDGFD)
DLE: 111167562(PDGFD) 111179012(PDGFC)
PCAD: 102985889(PDGFD) 102995661(PDGFC)
ECB: 100061488(PDGFD) 100062015(PDGFC)
EPZ: 103547315(PDGFC) 103558709(PDGFD)
EAI: 106833032(PDGFC) 106843123(PDGFD)
MYB: 102240259(PDGFD) 102248385(PDGFC)
MYD: 102766117(PDGFC) 102772727(PDGFD)
MNA: 107527538(PDGFC) 107532411(PDGFD)
HAI: 109372936(PDGFC) 109394938(PDGFD)
DRO: 112312671(PDGFC) 112314347(PDGFD)
PALE: 102890668(PDGFC) 102894123(PDGFD)
RAY: 107507553(PDGFC) 107520204(PDGFD)
MJV: 108390154(PDGFD) 108393368(PDGFC)
LAV: 100661451(PDGFD) 100672750(PDGFC)
MDO: 100011261(PDGFD) 100023701(PDGFC)
SHR: 100916102(PDGFD) 100928148(PDGFC)
PCW: 110213688(PDGFC) 110214961(PDGFD)
OAA: 100078558(PDGFD) 100079757(PDGFC)
GGA: 395469(PDGFC) 418978(PDGFD)
MGP: 100543088(PDGFD) 100547981(PDGFC)
CJO: 107308377(PDGFD) 107313060(PDGFC)
NMEL: 110389823(PDGFD) 110397304(PDGFC)
APLA: 101789650(PDGFC) 101798843(PDGFD)
ACYG: 106032364(PDGFC) 106034125(PDGFD)
TGU: 100217775(PDGFC) 100221512(PDGFD)
LSR: 110470019(PDGFD) 110475433(PDGFC)
SCAN: 103812525(PDGFD) 103826223(PDGFC)
GFR: 102035549(PDGFC) 102044886(PDGFD)
FAB: 101806397(PDGFD) 101808607(PDGFC)
PHI: 102106969(PDGFC) 102112153(PDGFD)
PMAJ: 107203600(PDGFC) 107209392(PDGFD)
CCAE: 111923382(PDGFD) 111927858(PDGFC)
CCW: 104690110(PDGFD) 104697317(PDGFC)
ETL: 114057056(PDGFC) 114065863(PDGFD)
FPG: 101910328(PDGFD) 101915028(PDGFC)
FCH: 102048020(PDGFC) 102052290(PDGFD)
CLV: 102087107(PDGFC) 102088608(PDGFD)
EGZ: 104124151(PDGFC) 104133608(PDGFD)
NNI: 104021357(PDGFC) 104023065(PDGFD)
ACUN: 113479700(PDGFC) 113484247(PDGFD)
PADL: 103915458(PDGFD) 103918093(PDGFC)
AAM: 106491877(PDGFC) 106495523(PDGFD)
ASN: 102378690(PDGFC) 102380973(PDGFD)
AMJ: 102569106(PDGFC) 102572032(PDGFD)
PSS: 102445898(PDGFD) 102452310(PDGFC)
CMY: 102930493(PDGFD) 102939099(PDGFC)
CPIC: 101938348(PDGFD) 101944573(PDGFC)
ACS: 100551866(pdgfd) 100568114(pdgfc)
PVT: 110072781(PDGFC) 110091114(PDGFD)
PBI: 103051428(PDGFC) 103065334(PDGFD)
PMUR: 107290460(PDGFC) 107294823(PDGFD)
TSR: 106541330 106551812(PDGFD)
PMUA: 114595668(PDGFD) 114603981(PDGFC)
GJA: 107126145(PDGFD) 107126248(PDGFC)
XLA: 108699243(pdgfc.L) 108706647(pdgfc.S) 108707572 108709984(pdgfd.S)
XTR: 100492060(pdgfd) 100494492(pdgfc)
NPR: 108789641(PDGFC)
DRE: 100535718(pdgfd) 560564(pdgfc)
IPU: 108269254(pdgfc) 108277755(pdgfd)
PHYP: 113544462(pdgfd) 113547158(pdgfc)
AMEX: 103040737(pdgfc) 103045444(pdgfd)
EEE: 113578705(pdgfd) 113582430(pdgfc)
TRU: 101062634(pdgfc) 101063213(pdgfd)
LCO: 104928604(pdgfc) 104929855(pdgfd)
NCC: 104952384(pdgfc) 104961516(pdgfd)
MZE: 101466155(pdgfc) 101473381(pdgfd)
ONL: 100700544(pdgfd) 100707883(pdgfc)
OLA: 101159654(pdgfc) 101163754(pdgfd)
XMA: 102217846(pdgfc) 102220475(pdgfd)
XCO: 114139572(pdgfc) 114162009(pdgfd)
PRET: 103471839(pdgfc) 103474493(pdgfd)
CVG: 107091713(pdgfc) 107100525(pdgfd)
NFU: 107379856(pdgfc) 107380445(pdgfd)
KMR: 108236624(pdgfc) 108244637(pdgfd)
ALIM: 106513253(pdgfc) 106521430(pdgfd)
AOCE: 111572666(pdgfd) 111574994(pdgfc)
CSEM: 103378536(pdgfd) 103390671(pdgfc)
POV: 109634384(pdgfd) 109640033(pdgfc)
LCF: 108885187(pdgfc) 108886631(pdgfd)
SDU: 111224145(pdgfd) 111232625(pdgfc)
SLAL: 111648147(pdgfc) 111655272(pdgfd)
HCQ: 109525495(pdgfd) 109526276(pdgfc)
BPEC: 110153706(pdgfc) 110174393(pdgfd)
MALB: 109964277(pdgfc) 109971615(pdgfd)
SASA: 106581363 106604525(pdgfc) 106611576 106613208(pdgfd)
ELS: 105024074(pdgfd) 105027646(pdgfc)
SFM: 108924448(pdgfc) 108930808 108932118(pdgfd)
LCM: 102351685(PDGFD) 102356509(PDGFC)
CMK: 103182267(pdgfc) 103185765(pdgfd)
RTP: 109915080(pdgfd) 109938372(pdgfc)
 » show all
Reference
  Authors
Tsai YJ, Lee RK, Lin SP, Chen YH
  Title
Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.
  Journal
Biochim Biophys Acta 1492:196-202 (2000)
DOI:10.1016/S0167-4781(00)00066-X
  Sequence
[hsa:56034]
Reference
  Authors
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA
  Title
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
  Journal
Arterioscler Thromb Vasc Biol 24:787-92 (2004)
DOI:10.1161/01.ATV.0000120785.82268.8b
  Sequence
[mmu:54635]
LinkDB

KEGG   ORTHOLOGY: K05453
Entry
K05453                      KO                                     

Name
CSF1, MCSF
Definition
macrophage colony-stimulating factor 1
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04151  PI3K-Akt signaling pathway
ko04380  Osteoclast differentiation
ko04640  Hematopoietic cell lineage
ko04668  TNF signaling pathway
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   04014 Ras signaling pathway
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   04015 Rap1 signaling pathway
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   04668 TNF signaling pathway
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   04151 PI3K-Akt signaling pathway
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
   05022 Pathways of neurodegeneration - multiple diseases
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
Cytokines and growth factors [BR:ko04052]
 Cytokines
  CSF and other factors
   K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
Genes
HSA: 1435(CSF1)
PTR: 457127(CSF1)
PPS: 100994576(CSF1)
GGO: 101131872(CSF1)
PON: 100452144(CSF1)
NLE: 100590081(CSF1)
MCC: 702532(CSF1)
MCF: 102141631(CSF1)
CSAB: 103224269(CSF1)
RRO: 104680325(CSF1)
RBB: 108528053(CSF1)
CJC: 100386071(CSF1)
SBQ: 101036115(CSF1)
MMU: 12977(Csf1)
MCAL: 110291496(Csf1)
MPAH: 110320052(Csf1)
RNO: 78965(Csf1)
MUN: 110545505(Csf1)
CGE: 100767142(Csf1)
NGI: 103747824(Csf1)
HGL: 101709756(Csf1)
CCAN: 109694805(Csf1)
OCU: 100338577(CSF1)
TUP: 102492960(CSF1)
CFA: 611795(CSF1)
VVP: 112918277(CSF1)
AML: 100467411(CSF1)
UMR: 103675205(CSF1)
UAH: 113244914(CSF1)
ORO: 101365427(CSF1)
ELK: 111143313
FCA: 101091467(CSF1)
PTG: 102972710(CSF1)
PPAD: 109272007(CSF1)
AJU: 106977865(CSF1)
BTA: 281094(CSF1)
BOM: 102269710(CSF1)
BIU: 109555962(CSF1)
BBUB: 102395229(CSF1)
CHX: 102185051(CSF1)
OAS: 101104200(CSF1)
SSC: 100513084(CSF1)
CFR: 102518652(CSF1)
CDK: 105085658(CSF1)
BACU: 103005966(CSF1)
LVE: 103077876(CSF1)
OOR: 101278934(CSF1)
DLE: 111180064(CSF1)
PCAD: 102974293(CSF1)
ECB: 100146493(CSF1)
EPZ: 103557529(CSF1)
EAI: 106827389(CSF1)
MYB: 102263365(CSF1)
MYD: 102766818(CSF1)
MNA: 107545236(CSF1)
HAI: 109371584(CSF1)
DRO: 112313968(CSF1)
PALE: 102894339(CSF1)
RAY: 107516132(CSF1)
MJV: 108400987(CSF1)
LAV: 100670704(CSF1)
TMU: 101357438
MDO: 100033077(CSF1)
SHR: 100930278(CSF1)
PCW: 110218309(CSF1)
OAA: 100073393(CSF1)
GGA: 100499189(CSF1)
MGP: 100549089(CSF1)
CJO: 107324667(CSF1)
NMEL: 110388070(CSF1)
APLA: 101804317(CSF1)
ACYG: 106048436(CSF1)
TGU: 100499187(CSF1)
LSR: 110469193(CSF1)
SCAN: 103822422(CSF1)
GFR: 102039316(CSF1)
FAB: 101815683(CSF1)
PHI: 102099590(CSF1)
PMAJ: 107214717(CSF1)
CCAE: 111939755(CSF1)
CCW: 104692438(CSF1)
ETL: 114071378(CSF1)
FPG: 101918873(CSF1)
FCH: 102056981(CSF1)
CLV: 102096751(CSF1)
EGZ: 104127764(CSF1)
NNI: 104018429(CSF1)
ACUN: 113489043(CSF1)
PADL: 103925944(CSF1)
ASN: 102376334(CSF1)
AMJ: 102560814(CSF1)
PSS: 102451139(CSF1)
CMY: 102929703(CSF1)
CPIC: 101951664(CSF1)
ACS: 103278674(csf1)
PVT: 110087976(CSF1)
PBI: 103049576(CSF1)
PMUR: 107286268(CSF1)
TSR: 106551233(CSF1)
PMUA: 114599167(CSF1)
GJA: 107106414(CSF1)
XLA: 101243553
DRE: 100004617(csf1a)
SANH: 107656002
SGH: 107556909
IPU: 108280990
PHYP: 113539503
AMEX: 103045744
EEE: 113589084
SASA: 106565101 106583500(csf1)
OTW: 112244887 112255312(csf1)
SALP: 111963545 111970343(csf1)
ELS: 105016804
SFM: 108938164(csf1)
PKI: 111841531(csf1)
 » show all
Reference
PMID:3493529
  Authors
Wong GG, Temple PA, Leary AC, Witek-Giannotti JS, Yang YC, Ciarletta AB, Chung M, Murtha P, Kriz R, Kaufman RJ, et al.
  Title
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
  Journal
Science 235:1504-8 (1987)
DOI:10.1126/science.3493529
  Sequence
[hsa:1435]
LinkDB

KEGG   ORTHOLOGY: K05461
Entry
K05461                      KO                                     

Name
KITLG
Definition
KIT ligand
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04640  Hematopoietic cell lineage
ko04916  Melanogenesis
ko05200  Pathways in cancer
Disease
H00604  Deafness, autosomal dominant
H00884  Familial progressive hyperpigmentation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05461  KITLG; KIT ligand
   04014 Ras signaling pathway
    K05461  KITLG; KIT ligand
   04015 Rap1 signaling pathway
    K05461  KITLG; KIT ligand
   04072 Phospholipase D signaling pathway
    K05461  KITLG; KIT ligand
   04151 PI3K-Akt signaling pathway
    K05461  KITLG; KIT ligand
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05461  KITLG; KIT ligand
  09152 Endocrine system
   04916 Melanogenesis
    K05461  KITLG; KIT ligand
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05461  KITLG; KIT ligand
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05461  KITLG; KIT ligand
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05461  KITLG; KIT ligand
Genes
HSA: 4254(KITLG)
PTR: 452114(KITLG)
PPS: 100973372(KITLG)
GGO: 101125404(KITLG)
PON: 100459690(KITLG)
NLE: 100587810(KITLG)
MCC: 574254(KITLG)
MCF: 102136326(KITLG)
CSAB: 103238826(KITLG)
RRO: 104662215(KITLG)
RBB: 108528921(KITLG)
CJC: 100410844(KITLG)
SBQ: 101047247(KITLG)
MMU: 17311(Kitl)
MCAL: 110302981(Kitlg)
MPAH: 110326225(Kitlg)
RNO: 60427(Kitlg)
MUN: 110559281(Kitlg)
CGE: 100752139(Kitlg)
NGI: 103726473(Kitlg)
HGL: 101697092(Kitlg)
CCAN: 109685488(Kitlg)
OCU: 100009028(KITLG)
TUP: 102501429(KITLG)
CFA: 403507(KITLG)
VVP: 112914895(KITLG)
AML: 100469856(KITLG)
UMR: 103660144(KITLG)
UAH: 113256194(KITLG)
ORO: 101378811(KITLG)
ELK: 111142191
FCA: 493937(KITLG)
PTG: 102951678(KITLG)
PPAD: 109265299(KITLG)
AJU: 106976559(KITLG)
BTA: 281885(KITLG)
BOM: 102284187(KITLG)
BIU: 109558333(KITLG)
BBUB: 102401528(KITLG)
CHX: 100860807(KITLG)
OAS: 443371(KITLG)
SSC: 397509(KITLG)
CFR: 102506677(KITLG)
CDK: 105094866(KITLG)
BACU: 103001593(KITLG)
LVE: 103080643(KITLG)
OOR: 101277409(KITLG) 101277587
DLE: 111163585(KITLG)
PCAD: 102973751(KITLG)
ECB: 100034127(KITLG)
EPZ: 103555517(KITLG)
EAI: 106836514(KITLG)
MYB: 102250743(KITLG)
MYD: 102756911(KITLG)
MNA: 107526843(KITLG)
HAI: 109376220(KITLG)
DRO: 112315389(KITLG)
PALE: 102884034(KITLG)
RAY: 107508690(KITLG)
MJV: 108396268(KITLG)
LAV: 100654759(KITLG)
TMU: 101350740
MDO: 100021399(KITLG)
SHR: 100934452(KITLG)
PCW: 110213181(KITLG)
OAA: 100080577(KITLG)
GGA: 396028(KITLG)
MGP: 100543963(KITLG)
CJO: 107311375(KITLG)
NMEL: 110392930(KITLG)
APLA: 101804576(KITLG)
ACYG: 106036954(KITLG)
TGU: 100225713(KITLG)
LSR: 110469367(KITLG)
SCAN: 103813653(KITLG)
GFR: 102045131(KITLG)
FAB: 101814650(KITLG)
PHI: 102111137(KITLG)
PMAJ: 107205063(KITLG)
CCAE: 111937682(KITLG)
CCW: 104698430(KITLG)
ETL: 114066680(KITLG)
FPG: 101914651(KITLG)
FCH: 102046056(KITLG)
CLV: 102094371(KITLG)
EGZ: 104134499(KITLG)
NNI: 104011693(KITLG)
ACUN: 113491550(KITLG)
PADL: 103914682(KITLG)
AAM: 106488178(KITLG)
ASN: 102375492(KITLG)
AMJ: 102568076(KITLG)
PSS: 102444025(KITLG)
CMY: 102936491(KITLG)
CPIC: 101952779(KITLG)
ACS: 100561046(kitlg)
PVT: 110069931(KITLG)
PBI: 103063279(KITLG)
PMUR: 107283118(KITLG)
TSR: 106551302(KITLG)
PMUA: 114605166(KITLG)
GJA: 107121241(KITLG)
XLA: 373760(kitlg.S) 379817(kitlg.L)
XTR: 733847(kitlg)
NPR: 108787228(KITLG)
DRE: 553179(kitlga) 553181(kitlgb)
IPU: 108269259(kitlg) 108280131
PHYP: 113532417 113546649(kitlg)
AMEX: 103034617(kitlg) 103037950
EEE: 113583341(kitlg) 113584395
TRU: 100294698(scf) 101068411
LCO: 104931879(kitlg) 104932598
NCC: 104966456
ONL: 100695935(kitlg) 102080356
OLA: 101175300(kitlg) 105357082
PRET: 103459420 103465622(kitlg)
CVG: 107083205(kitlg) 107088334
KMR: 108235061 108250238(kitlg)
ALIM: 106521770 106524000(kitlg)
AOCE: 111572796(kitlg) 111581874
CSEM: 103379524(kitlg) 103382827
POV: 109632701 109643127(kitlg)
LCF: 108890542 108894073(kitlg)
SDU: 111222528(kitlg)
SLAL: 111655571(kitlg) 111663653
HCQ: 109520052 109530888(kitlg)
BPEC: 110155116(kitlg)
MALB: 109956329(kitlg) 109959875
SALP: 111952941(kitlg) 111962725
ELS: 105018304(kitlg) 105020288
SFM: 108918641 108931332(kitlg)
PKI: 111835194(kitlg) 111860952
LCM: 102364515
CMK: 103179846(kitlg)
RTP: 109921130
 » show all
Reference
  Authors
Ronnstrand L
  Title
Signal transduction via the stem cell factor receptor/c-Kit.
  Journal
Cell Mol Life Sci 61:2535-48 (2004)
DOI:10.1007/s00018-004-4189-6
  Sequence
[hsa:4254]
LinkDB

KEGG   ORTHOLOGY: K05448
Entry
K05448                      KO                                     

Name
VEGFA
Definition
vascular endothelial growth factor A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04370  VEGF signaling pathway
ko04510  Focal adhesion
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05219  Bladder cancer
ko05323  Rheumatoid arthritis
ko05418  Fluid shear stress and atherosclerosis
Disease
H01456  Diabetic nephropathy
H01457  Diabetic retinopathy
H01459  Diabetic neuropathy
H01529  Avascular necrosis of femoral head
H01709  Glucocorticoid-induced osteonecrosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04014 Ras signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04015 Rap1 signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04370 VEGF signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04066 HIF-1 signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
   04151 PI3K-Akt signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05448  VEGFA; vascular endothelial growth factor A
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K05448  VEGFA; vascular endothelial growth factor A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05206 MicroRNAs in cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05205 Proteoglycans in cancer
    K05448  VEGFA; vascular endothelial growth factor A
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K05448  VEGFA; vascular endothelial growth factor A
   05211 Renal cell carcinoma
    K05448  VEGFA; vascular endothelial growth factor A
   05219 Bladder cancer
    K05448  VEGFA; vascular endothelial growth factor A
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05448  VEGFA; vascular endothelial growth factor A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05448  VEGFA; vascular endothelial growth factor A
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05448  VEGFA; vascular endothelial growth factor A
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K05448  VEGFA; vascular endothelial growth factor A
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05448  VEGFA; vascular endothelial growth factor A
   05165 Human papillomavirus infection
    K05448  VEGFA; vascular endothelial growth factor A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05448  VEGFA; vascular endothelial growth factor A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05448  VEGFA; vascular endothelial growth factor A
   00536 Glycosaminoglycan binding proteins
    K05448  VEGFA; vascular endothelial growth factor A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05448  VEGFA; vascular endothelial growth factor A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K05448  VEGFA; vascular endothelial growth factor A
Other DBs
GO: 0005172
Genes
HSA: 7422(VEGFA)
PTR: 736875(VEGFA)
PPS: 100970217(VEGFA)
GGO: 101131949(VEGFA)
PON: 100448769(VEGFA)
NLE: 100601396(VEGFA)
MCC: 574209(VEGFA)
MCF: 102140241(VEGFA)
CSAB: 103221446(VEGFA)
RRO: 104667362(VEGFA)
RBB: 108533452(VEGFA)
CJC: 100389629(VEGFA)
SBQ: 101032691(VEGFA)
MMU: 22339(Vegfa)
MCAL: 110284402(Vegfa)
MPAH: 110335444(Vegfa)
RNO: 83785(Vegfa)
MUN: 110550366(Vegfa)
CGE: 100755957(Vegfa)
NGI: 103730772(Vegfa)
HGL: 101702403(Vegfa)
CCAN: 109682127(Vegfa)
OCU: 100008899(VEGFA)
TUP: 102499303(VEGFA)
CFA: 403802(VEGFA)
VVP: 112914029(VEGFA)
AML: 100482983(VEGFA)
UMR: 103664148(VEGFA)
UAH: 113261040(VEGFA)
ORO: 101363442(VEGFA)
ELK: 111147726
FCA: 493845(VEGFA)
PTG: 102954556(VEGFA)
PPAD: 109271390(VEGFA)
AJU: 106974016(VEGFA)
BTA: 281572(VEGFA)
BOM: 102270607(VEGFA)
BIU: 109576576(VEGFA)
BBUB: 102396324(VEGFA)
CHX: 100860957(VEGFA)
OAS: 443103(VEGFA)
SSC: 397157(VEGFA)
CFR: 102514843(VEGFA)
CDK: 105088633(VEGFA)
BACU: 103008131(VEGFA)
LVE: 103089095(VEGFA)
OOR: 101279969(VEGFA)
DLE: 111178866(VEGFA)
PCAD: 102981739(VEGFA)
ECB: 100033839(VEGFA)
EPZ: 103548136(VEGFA)
EAI: 106828747(VEGFA)
MYB: 102254357(VEGFA)
MYD: 102771975(VEGFA)
MNA: 107536886(VEGFA)
HAI: 109382864(VEGFA)
DRO: 112302143(VEGFA)
PALE: 102890394(VEGFA)
RAY: 107502007(VEGFA)
MJV: 108407135(VEGFA)
LAV: 100661392(VEGFA)
TMU: 101341920
MDO: 100012132(VEGFA)
SHR: 100913423(VEGFA)
PCW: 110201281(VEGFA)
OAA: 100077009(VEGFA)
GGA: 395909(VEGFA)
MGP: 100539186(VEGFA)
CJO: 107311307(VEGFA)
NMEL: 110395890(VEGFA)
APLA: 101805258(VEGFA)
ACYG: 106048193(VEGFA)
TGU: 100230266(VEGFA)
LSR: 110481675(VEGFA)
SCAN: 103817849(VEGFA)
GFR: 102038819(VEGFA)
FAB: 101806742(VEGFA)
PHI: 102114381(VEGFA)
PMAJ: 107201252(VEGFA)
CCAE: 111927585(VEGFA)
CCW: 104684484(VEGFA)
ETL: 114059331(VEGFA)
FPG: 101913384(VEGFA)
FCH: 102053577(VEGFA)
CLV: 102087578(VEGFA)
EGZ: 104132722(VEGFA)
NNI: 104018695(VEGFA)
ACUN: 113477922(VEGFA)
PADL: 103922897(VEGFA)
AAM: 106485436(VEGFA)
ASN: 102372950(VEGFA)
AMJ: 102576555(VEGFA)
PSS: 102448827(VEGFB) 102456411(VEGFA)
CMY: 102932696 102942789(VEGFA)
CPIC: 101942497(VEGFB) 101951073(VEGFA)
ACS: 100568086(vegfa)
PVT: 110074690(VEGFA)
PBI: 103060055(VEGFA) 103062159(VEGFB)
PMUR: 107289233(VEGFA) 107291631
TSR: 106549397(VEGFA)
PMUA: 114586844(VEGFB) 114594528(VEGFA)
GJA: 107125774(VEGFA)
XLA: 100037058(vegfa.S) 373589(vegfa.L)
XTR: 100038089(vegfa)
NPR: 108794236(VEGFB) 108800210(VEGFA)
DRE: 30682(vegfaa) 558154(vegfab)
EEE: 113578092(vegfa) 113578974
NCC: 104944845(vegfa) 104948932 104960665(vegfb)
MZE: 101467969(vegfb) 101472090(vegfa)
ONL: 100706193(vegfa) 102078498(vegfb)
OLA: 100125510(vegfa) 105354863(vegfb)
XMA: 102234868(vegfa)
XCO: 114158479(vegfa)
PRET: 103457700(vegfa)
CVG: 107087971(vegfb) 107090862 107094489(vegfa)
NFU: 107377612(vegfb) 107378043(vegfa) 107378093
KMR: 108231395(vegfb) 108231808 108247685(vegfa)
ALIM: 106515731(vegfb) 106520044(vegfa)
CSEM: 103380788(vegfa) 103388751 103390839(vegfb)
POV: 109632474(vegfa)
SDU: 111227814 111238405(vegfa)
SLAL: 111664160 111672585(vegfa)
HCQ: 109511963(vegfb) 109521925 109523530(vegfa)
BPEC: 110154009(vegfa) 110158996(vegfb) 110161092
SFM: 108925295(vegfb) 108929118(vegfa) 108937353
LCM: 102347582(VEGFB) 102367264(VEGFA)
CMK: 103179198(vegfa)
RTP: 109912926(vegfa)
 » show all
Reference
PMID:2479986
  Authors
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N
  Title
Vascular endothelial growth factor is a secreted angiogenic mitogen.
  Journal
Science 246:1306-9 (1989)
DOI:10.1126/science.2479986
  Sequence
[hsa:7422]
LinkDB

KEGG   ORTHOLOGY: K16858
Entry
K16858                      KO                                     

Name
VEGFB
Definition
vascular endothelial growth factor B
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K16858  VEGFB; vascular endothelial growth factor B
   04014 Ras signaling pathway
    K16858  VEGFB; vascular endothelial growth factor B
   04015 Rap1 signaling pathway
    K16858  VEGFB; vascular endothelial growth factor B
   04151 PI3K-Akt signaling pathway
    K16858  VEGFB; vascular endothelial growth factor B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16858  VEGFB; vascular endothelial growth factor B
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K16858  VEGFB; vascular endothelial growth factor B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K16858  VEGFB; vascular endothelial growth factor B
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K16858  VEGFB; vascular endothelial growth factor B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K16858  VEGFB; vascular endothelial growth factor B
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K16858  VEGFB; vascular endothelial growth factor B
Other DBs
GO: 0005172
Genes
HSA: 7423(VEGFB)
PTR: 741897(VEGFB)
GGO: 101128291(VEGFB)
PON: 100456050(VEGFB)
NLE: 100599288(VEGFB)
MCC: 722115(VEGFB)
MCF: 102127655(VEGFB)
CSAB: 103233363(VEGFB)
RRO: 104673082(VEGFB)
RBB: 108542677(VEGFB)
CJC: 100400081(VEGFB)
SBQ: 101028762(VEGFB)
MMU: 22340(Vegfb)
MCAL: 110285510(Vegfb)
MPAH: 110327962(Vegfb)
RNO: 89811(Vegfb)
MUN: 110551598(Vegfb)
CGE: 100759545(Vegfb)
NGI: 103738800(Vegfb)
HGL: 101700074(Vegfb)
CCAN: 109683276(Vegfb)
TUP: 102494761(VEGFB)
CFA: 476036(VEGFB)
VVP: 112924316(VEGFB)
AML: 100465735(VEGFB)
UMR: 103679547(VEGFB)
UAH: 113244181(VEGFB)
ORO: 101377548(VEGFB)
ELK: 111149705
FCA: 101092465(VEGFB)
PTG: 102961989(VEGFB)
PPAD: 109246982(VEGFB)
AJU: 113597217(VEGFB)
BTA: 282121(VEGFB)
BOM: 102283195(VEGFB)
BIU: 109554117(VEGFB)
BBUB: 102411458(VEGFB)
CHX: 102189099(VEGFB)
OAS: 101115840(VEGFB)
SSC: 100521837(VEGFB)
CDK: 105101542(VEGFB)
BACU: 103008905(VEGFB)
LVE: 103085446(VEGFB)
OOR: 101272980(VEGFB)
DLE: 111171309 111183816(VEGFB)
PCAD: 102978151(VEGFB)
ECB: 100055238(VEGFB)
EPZ: 103542197(VEGFB)
EAI: 106833635(VEGFB)
MYB: 102257492(VEGFB)
MYD: 102755405(VEGFB)
MNA: 107539800(VEGFB)
HAI: 109384216(VEGFB)
DRO: 112317384(VEGFB)
PALE: 102882963(VEGFB) 102883443
RAY: 107497088(VEGFB)
MJV: 108407564(VEGFB)
LAV: 100668949(VEGFB)
TMU: 101352912
MDO: 100028411(VEGFB)
SHR: 100922413(VEGFB)
PCW: 110195533(VEGFB)
ACS: 100563755(vegfb)
PVT: 110083368(VEGFB)
GJA: 107115192(VEGFB)
XMA: 102227796(vegfb)
XCO: 114139399(vegfb)
MPHA: 105833695
ACEP: 105627016
PBAR: 105422466
VEM: 105562115
LHU: 105669099
PGC: 109856750
PMAC: 106709585
PRAP: 110998333
HAW: 110375215
TNL: 113507309
PXY: 105382749
ZNE: 110839891
PVM: 113817695
SPIS: 111322288
 » show all
Reference
PMID:8919691
  Authors
Grimmond S, Lagercrantz J, Drinkwater C, Silins G, Townson S, Pollock P, Gotley D, Carson E, Rakar S, Nordenskjold M, Ward L, Hayward N, Weber G
  Title
Cloning and characterization of a novel human gene related to vascular endothelial growth factor.
  Journal
Genome Res 6:124-31 (1996)
DOI:10.1101/gr.6.2.124
  Sequence
[hsa:7423]
Reference
  Authors
Iyer S, Scotney PD, Nash AD, Ravi Acharya K
  Title
Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.
  Journal
J Mol Biol 359:76-85 (2006)
DOI:10.1016/j.jmb.2006.03.002
  Sequence
[hsa:7423]
LinkDB

KEGG   ORTHOLOGY: K16859
Entry
K16859                      KO                                     

Name
PGF
Definition
placenta growth factor
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K16859  PGF; placenta growth factor
   04014 Ras signaling pathway
    K16859  PGF; placenta growth factor
   04015 Rap1 signaling pathway
    K16859  PGF; placenta growth factor
   04151 PI3K-Akt signaling pathway
    K16859  PGF; placenta growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16859  PGF; placenta growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K16859  PGF; placenta growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K16859  PGF; placenta growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K16859  PGF; placenta growth factor
Genes
HSA: 5228(PGF)
PTR: 741830(PGF)
PPS: 100984147(PGF)
GGO: 101125053(PGF)
PON: 100440872(PGF)
NLE: 100600228(PGF)
MCC: 701219(PGF)
MCF: 102134620(PGF)
CSAB: 103229341(PGF)
RRO: 104677582(PGF)
RBB: 108534920(PGF)
CJC: 100386568(PGF)
SBQ: 101042551(PGF)
MMU: 18654(Pgf)
MCAL: 110307029(Pgf)
MPAH: 110324731(Pgf)
RNO: 94203(Pgf)
MUN: 110546968(Pgf)
CGE: 100754799(Pgf)
NGI: 103747350(Pgf)
HGL: 101725085(Pgf)
CCAN: 109694002(Pgf)
OCU: 100339515(PGF)
TUP: 102480300(PGF)
CFA: 100855780(PGF)
VVP: 112927283(PGF)
AML: 100480980(PGF)
UMR: 103671076(PGF)
UAH: 113270324(PGF)
ORO: 101369724(PGF)
ELK: 111148570
FCA: 101095904(PGF)
PTG: 102960599(PGF)
PPAD: 109253846(PGF)
AJU: 106974417(PGF)
BTA: 280894(PGF)
BOM: 102273440(PGF)
BIU: 109565356(PGF)
BBUB: 102389960(PGF)
CHX: 102169297(PGF)
OAS: 443245(PGF)
SSC: 100156404(PGF)
CFR: 102520919(PGF)
CDK: 105086095(PGF)
BACU: 103017555(PGF)
LVE: 103082053(PGF)
OOR: 101284353(PGF)
DLE: 111176246(PGF)
PCAD: 102979244(PGF)
ECB: 100051349(PGF)
EAI: 106827733(PGF)
MYB: 102243042(PGF)
MYD: 102761298(PGF)
MNA: 107533829(PGF)
HAI: 109381519(PGF)
DRO: 112311551(PGF)
PALE: 102889783(PGF)
RAY: 107504821(PGF)
MJV: 108399226(PGF)
LAV: 100674895(PGF)
TMU: 101355158
MDO: 100023623(PGF)
SHR: 100925473(PGF)
PCW: 110208321(PGF)
OAA: 100093060(PGF)
GGA: 771832(PGF)
MGP: 100542999(PGF)
NMEL: 110401232(PGF)
APLA: 101800933(PGF)
ACYG: 106038790(PGF)
TGU: 100221017(PGF)
LSR: 110477279(PGF)
SCAN: 103826914(PGF)
GFR: 102038207(PGF)
PHI: 102099617(PGF)
PMAJ: 107206015(PGF)
CCAE: 111929568(PGF)
CCW: 104688590(PGF)
ETL: 114056008(PGF)
FPG: 101920675(PGF)
FCH: 102059983(PGF)
CLV: 102097929(PGF)
EGZ: 104133226(PGF)
NNI: 104021035(PGF)
PADL: 103913044(PGF)
ASN: 102386060(PGF)
AMJ: 102567693(PGF)
PSS: 102451883(PGF)
CMY: 102935251(PGF)
CPIC: 101934809(PGF) 101941746
ACS: 100552896(pgf)
PVT: 110075606 110079090(PGF)
PBI: 103050803 103067148(PGF)
PMUR: 107293072(PGF)
TSR: 106541647(PGF) 106551621
PMUA: 114591899(PGF) 114603133
GJA: 107118328(PGF) 107125835
DRE: 101883508(pgfa) 557468(pgfb)
IPU: 108258015 108270479(pgf)
PHYP: 113538606(pgf)
AMEX: 107197829
EEE: 113587029
LCO: 104919815
MZE: 101474897(pgf) 101480538
ONL: 100695462 100703833(pgf)
OLA: 101161449
PRET: 103457897 103461058(pgf)
CVG: 107085608(pgf)
NFU: 107392368
KMR: 108236961(pgf)
ALIM: 106520837(pgf) 106535210
CSEM: 103381019 103396668(pgf)
SDU: 111225931(pgf) 111240400
SLAL: 111663130(pgf) 111672600
HCQ: 109513204
BPEC: 110155603
ELS: 105017540 105026447(pgf)
SFM: 108941445(pgf)
PKI: 111852514(pgf)
LCM: 102359260(PGF) 102361405
CMK: 103190808
RTP: 109922076
MPHA: 105840098
ACEP: 105621844
PBAR: 105425447
HST: 105192042
 » show all
Reference
PMID:1924389
  Authors
Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG
  Title
Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.
  Journal
Proc Natl Acad Sci U S A 88:9267-71 (1991)
DOI:10.1073/pnas.88.20.9267
  Sequence
[hsa:5228]
Reference
  Authors
De Falco S
  Title
The discovery of placenta growth factor and its biological activity.
  Journal
Exp Mol Med 44:1-9 (2012)
DOI:10.3858/emm.2012.44.1.025
Reference
  Authors
Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Akerud P, De Mol M, Salomaki H, Phillipson M, Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L, Carmeliet P
  Title
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
  Journal
Cancer Cell 19:31-44 (2011)
DOI:10.1016/j.ccr.2010.11.009
  Sequence
[hsa:5228]
LinkDB

KEGG   ORTHOLOGY: K05449
Entry
K05449                      KO                                     

Name
VEGFC_D
Definition
vascular endothelial growth factor C/D
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04668  TNF signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05200  Pathways in cancer
Disease
H00535  Hereditary lymphedema
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04014 Ras signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04015 Rap1 signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04668 TNF signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05449  VEGFC_D; vascular endothelial growth factor C/D
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05449  VEGFC_D; vascular endothelial growth factor C/D
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05449  VEGFC_D; vascular endothelial growth factor C/D
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05449  VEGFC_D; vascular endothelial growth factor C/D
Other DBs
GO: 0005172
Genes
HSA: 2277(VEGFD) 7424(VEGFC)
PTR: 465508(VEGFD) 471358(VEGFC)
PPS: 100969999(VEGFD) 100990660(VEGFC)
GGO: 101140168(VEGFD) 101140874(VEGFC)
PON: 100433743(VEGFD) 100453191(VEGFC)
NLE: 100595914(VEGFC) 100601827(VEGFD)
MCC: 699502(VEGFC) 712654(VEGFD)
MCF: 102117741(VEGFC) 107126428(VEGFD)
CSAB: 103231636(VEGFD) 103236566(VEGFC)
RRO: 104664532(VEGFD) 104678733(VEGFC)
RBB: 108534048(VEGFC) 108539697(VEGFD)
CJC: 100395294(VEGFC) 100407908(VEGFD)
SBQ: 101044650(FIGF) 101048128(VEGFC)
MMU: 14205(Vegfd) 22341(Vegfc)
MCAL: 110287326(Vegfd) 110300171(Vegfc)
MPAH: 110313900(Vegfd) 110336732(Vegfc)
RNO: 114111(Vegfc) 360457(Vegfd)
MUN: 110539385(Vegfd) 110542126(Vegfc)
CGE: 100753419(Vegfc) 100773421(Vegfd)
NGI: 103740292(Vegfd) 103745233(Vegfc)
HGL: 101719504(Vegfc) 101726005(Vegfd)
CCAN: 109676954(Vegfc)
OCU: 100338090(VEGFD) 100338211(VEGFC)
TUP: 102486007(VEGFD) 102498502(VEGFC)
CFA: 482932(VEGFC) 491749(VEGFD)
VVP: 112910539(VEGFD) 112932844(VEGFC)
AML: 100482213(VEGFD) 100483046(VEGFC)
UMR: 103668144(VEGFD) 103679375(VEGFC)
UAH: 113240706(VEGFD) 113262230(VEGFC)
ORO: 101372364(FIGF) 101375487(VEGFC)
FCA: 101085368(VEGFC) 493703(VEGFD)
PTG: 102952237(VEGFC) 102965995(VEGFD)
PPAD: 109248315(VEGFD) 109257848(VEGFC)
AJU: 106974232(VEGFD) 106976756(VEGFC)
BTA: 282122(VEGFC) 286799(VEGFD)
BOM: 102276010(VEGFD) 102280941(VEGFC)
BIU: 109553526(VEGFC) 109555471(VEGFD)
BBUB: 102408631(VEGFC)
CHX: 102185645(VEGFD) 102189826(VEGFC)
OAS: 101102873(VEGFD) 101105629(VEGFC)
SSC: 100155670(VEGFD) 100525960(VEGFC)
CFR: 102514127(VEGFC) 102522536(VEGFD)
CDK: 105084416(VEGFC) 105100399(VEGFD)
BACU: 103007348(VEGFD) 103014140(VEGFC)
LVE: 103074827(VEGFC) 103087133(VEGFD)
OOR: 101284490(FIGF) 101286312(VEGFC)
DLE: 111168922(VEGFD) 111173342(VEGFC)
PCAD: 102980523(VEGFD) 102989984(VEGFC)
ECB: 100050877(VEGFD) 100060890(VEGFC)
EPZ: 103551779(VEGFC) 103564509(VEGFD)
EAI: 106841578(VEGFD) 106843564(VEGFC)
MYB: 102252136(VEGFC) 102260639(VEGFD)
MYD: 102764314(VEGFD) 102770606(VEGFC)
MNA: 107529497(FIGF) 107541939(VEGFC)
HAI: 109387670(VEGFC) 109395927(VEGFD)
DRO: 112306665(VEGFC) 112313412(VEGFD)
PALE: 102884251(VEGFC) 102889143(VEGFD)
RAY: 107497293(FIGF) 107521392(VEGFC)
MJV: 108384371(FIGF) 108391501(VEGFC)
LAV: 100657845(VEGFC) 100665819(VEGFD)
MDO: 100013301(VEGFC) 100031803(VEGFD)
SHR: 100918372(VEGFD) 100928742(VEGFC)
PCW: 110215985(VEGFC) 110222446(VEGFD)
OAA: 100082290(VEGFD) 100084886(VEGFC)
GGA: 395255(VEGFD) 422573(VEGFC)
CJO: 107313491(VEGFC) 107325582(VEGFD)
NMEL: 110398494(VEGFC) 110404988(VEGFD)
APLA: 101791715(VEGFD) 101794827(VEGFC)
ACYG: 106037783(FIGF) 106041769(VEGFC)
TGU: 100221203(VEGFC) 100227068(VEGFD)
LSR: 110471620(VEGFD) 110480973(VEGFC)
SCAN: 103815820(VEGFD) 103825795(VEGFC)
GFR: 102036850(VEGFC) 102037618(VEGFD)
FAB: 101814975(VEGFD) 101821523(VEGFC)
PHI: 102101573(VEGFC) 102108122(VEGFD)
PMAJ: 107203121(VEGFC) 107212276(VEGFD)
CCW: 104686165(VEGFD) 104690559(VEGFC)
ETL: 114064933(VEGFC) 114066572(VEGFD)
FPG: 101912084(VEGFD) 101912626(VEGFC)
FCH: 102046374(VEGFC) 102060261(VEGFD)
CLV: 102091004(VEGFC) 102094006(VEGFD)
EGZ: 104127304(FIGF) 104129420(VEGFC)
NNI: 104021276(VEGFC) 104022532(FIGF)
ACUN: 113479244(VEGFC) 113485862(VEGFD)
PADL: 103918203(FIGF) 103922574(VEGFC)
AAM: 106484003(VEGFC) 106491870(VEGFD)
ASN: 102379047(VEGFC)
AMJ: 102569065(VEGFD) 102571219(VEGFC)
PSS: 102452480(VEGFD) 102457900(VEGFC)
CMY: 102937370(VEGFC) 102939169(VEGFD)
CPIC: 101937490(VEGFC) 101951395(VEGFD)
ACS: 100564908(vegfd) 1005