KEGG   ORTHOLOGY: K04359
Entry
K04359                      KO                                     

Name
PDGFA
Definition
platelet-derived growth factor subunit A
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 JAK-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04020 Calcium signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09162 Cancer: specific types
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A
Other DBs
GO: 0005161
Genes
HSA: 5154(PDGFA)
PTR: 740202(PDGFA)
PPS: 100991389(PDGFA)
GGO: 101132059(PDGFA)
PON: 100440212(PDGFA)
NLE: 100583683(PDGFA)
MCC: 707725(PDGFA)
MCF: 102126620(PDGFA)
CSAB: 103246906(PDGFA)
RRO: 104664975(PDGFA)
RBB: 108542315(PDGFA)
CJC: 100412906(PDGFA)
SBQ: 101034511(PDGFA)
MMU: 18590(Pdgfa)
MCAL: 110294651(Pdgfa)
MPAH: 110312881(Pdgfa)
RNO: 25266(Pdgfa)
MUN: 110550699(Pdgfa)
CGE: 100771503(Pdgfa)
NGI: 103748699(Pdgfa)
HGL: 101725739(Pdgfa)
CCAN: 109684500(Pdgfa)
OCU: 100352388(PDGFA)
TUP: 102499235(PDGFA)
CFA: 491597(PDGFA)
VVP: 112929281(PDGFA)
AML: 100473486(PDGFA)
UMR: 103670054(PDGFA)
ORO: 101386160(PDGFA)
ELK: 111145884
FCA: 101087287(PDGFA)
PPAD: 109251089(PDGFA)
AJU: 106966514(PDGFA)
BTA: 505908(PDGFA)
BOM: 102271219(PDGFA)
BIU: 109578611(PDGFA)
BBUB: 102394875(PDGFA)
CHX: 102174268(PDGFA)
OAS: 114110564(PDGFA)
SSC: 100519764(PDGFA)
CFR: 102520052(PDGFA)
CDK: 105102061(PDGFA)
BACU: 103005337(PDGFA)
LVE: 103089216(PDGFA)
OOR: 101287211(PDGFA)
DLE: 111169371(PDGFA)
PCAD: 102989848(PDGFA)
ECB: 100055086(PDGFA)
EPZ: 103555992(PDGFA)
EAI: 106834748(PDGFA)
MYB: 102253551(PDGFA)
MYD: 102762551(PDGFA)
MNA: 107543141(PDGFA)
HAI: 109380137(PDGFA)
DRO: 112319719(PDGFA)
PALE: 102893670(PDGFA)
RAY: 107497394(PDGFA)
TMU: 101344666
MDO: 100020951(PDGFA)
SHR: 100924985(PDGFA) 116422035
PCW: 110201572(PDGFA)
OAA: 100081033(PDGFA)
GGA: 374196(PDGFA)
MGP: 100545955(PDGFA)
CJO: 107320713(PDGFA)
NMEL: 110405632(PDGFA)
APLA: 101803502(PDGFA)
ACYG: 106033384(PDGFA)
TGU: 100222155(PDGFA)
LSR: 110475507(PDGFA)
SCAN: 103817870(PDGFA)
GFR: 102032936(PDGFA)
FAB: 101810376(PDGFA)
PHI: 102099148(PDGFA)
PMAJ: 107211209(PDGFA)
CCAE: 111936274(PDGFA)
CCW: 104685042(PDGFA)
ETL: 114054750(PDGFA)
FPG: 101922505(PDGFA)
FCH: 102059520(PDGFA)
CLV: 102085857(PDGFA)
EGZ: 104128975(PDGFA)
NNI: 104015206(PDGFA)
ACUN: 113485656(PDGFA)
PADL: 103913559(PDGFA)
ASN: 102386051(PDGFA)
AMJ: 102568490(PDGFA)
PSS: 102453111(PDGFA)
CMY: 102936738(PDGFA)
CPIC: 101940087(PDGFA)
ACS: 100560004(pdgfa)
PVT: 110090337(PDGFA)
PBI: 103066198(PDGFA)
PMUR: 107291891(PDGFA)
PMUA: 114584301(PDGFA)
GJA: 107115509(PDGFA)
XLA: 108701573(pdgfa.L) 397765(pdgfa.S)
XTR: 100038202(pdgfa)
NPR: 108800714(PDGFA)
DRE: 103909601 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)
IPU: 108259440
EEE: 113576794(pdgfa) 113581484
TRU: 101063539 101077475(pdgfa)
LCO: 104925707(pdgfa) 104938193
NCC: 104945697(pdgfa)
ONL: 100690958 100702821(pdgfa)
OLA: 101156252(pdgfa) 101171139
XMA: 102226782(pdgfa) 102233791
XCO: 114145269 114160156(pdgfa)
PRET: 103469195(pdgfa) 103476211
CVG: 107090056 107095213(pdgfa)
NFU: 107373888 107376493(pdgfa)
KMR: 108237947 108247650(pdgfa)
ALIM: 106518714(pdgfa) 106522509
AOCE: 111562600(pdgfa) 111588207
POV: 109638650(pdgfa) 109639258
LCF: 108886167(pdgfa) 108887178
SDU: 111216525 111227111(pdgfa)
SLAL: 111667551(pdgfa) 111673426
BPEC: 110169079(pdgfa)
MALB: 109952877 109972908(pdgfa)
SFM: 108930223(pdgfa)
LCM: 102352946(PDGFA)
CMK: 103175503 103178687(pdgfa)
RTP: 109916423(pdgfa) 109936774
CCAL: 108622908
AEC: 105146079
VEM: 105561417
BMOR: 101735793
ZNE: 110830060
 » show all
Reference
PMID:3422746
  Authors
Bonthron DT, Morton CC, Orkin SH, Collins T
  Title
Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.
  Journal
Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492
  Sequence
[hsa:5154]
LinkDB

KEGG   ORTHOLOGY: K17386
Entry
K17386                      KO                                     

Name
PDGFB
Definition
platelet-derived growth factor subunit B
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00015  Malignant pleural mesothelioma
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04014 Ras signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04015 Rap1 signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04630 JAK-STAT signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04020 Calcium signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04072 Phospholipase D signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
   04151 PI3K-Akt signaling pathway
    K17386  PDGFB; platelet-derived growth factor subunit B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17386  PDGFB; platelet-derived growth factor subunit B
   04540 Gap junction
    K17386  PDGFB; platelet-derived growth factor subunit B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17386  PDGFB; platelet-derived growth factor subunit B
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
   05206 MicroRNAs in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
   05231 Choline metabolism in cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
  09162 Cancer: specific types
   05214 Glioma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05218 Melanoma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05211 Renal cell carcinoma
    K17386  PDGFB; platelet-derived growth factor subunit B
   05215 Prostate cancer
    K17386  PDGFB; platelet-derived growth factor subunit B
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K17386  PDGFB; platelet-derived growth factor subunit B
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K17386  PDGFB; platelet-derived growth factor subunit B
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17386  PDGFB; platelet-derived growth factor subunit B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K17386  PDGFB; platelet-derived growth factor subunit B
   00536 Glycosaminoglycan binding proteins
    K17386  PDGFB; platelet-derived growth factor subunit B
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K17386  PDGFB; platelet-derived growth factor subunit B
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K17386  PDGFB; platelet-derived growth factor subunit B
Other DBs
GO: 0005161
Genes
HSA: 5155(PDGFB)
PTR: 458844(PDGFB)
PPS: 100984583(PDGFB)
GGO: 101138492(PDGFB)
PON: 100460243(PDGFB)
NLE: 100586714(PDGFB)
MCC: 703173(PDGFB)
MCF: 102125183(PDGFB)
CSAB: 103223339(PDGFB)
RRO: 104682558(PDGFB)
RBB: 108520474(PDGFB)
CJC: 100388628(PDGFB)
SBQ: 101043776(PDGFB)
MMU: 18591(Pdgfb)
MCAL: 110310626(Pdgfb)
MPAH: 110334927(Pdgfb)
RNO: 24628(Pdgfb)
MUN: 110557819(Pdgfb)
CGE: 100774990(Pdgfb)
NGI: 103748570(Pdgfb)
HGL: 101698830(Pdgfb)
CCAN: 109692977(Pdgfb)
OCU: 100358772(PDGFB)
TUP: 102482500(PDGFB)
CFA: 442986(PDGFB)
VVP: 112933988(PDGFB)
AML: 100475543(PDGFB)
UMR: 103676520(PDGFB)
UAH: 113241764(PDGFB)
ORO: 101370194(PDGFB)
ELK: 111157534
FCA: 100135774(PDGFB)
PTG: 102971867(PDGFB)
PPAD: 109265580(PDGFB)
AJU: 106981002(PDGFB)
BTA: 540106(PDGFB)
BOM: 102266290(PDGFB)
BBUB: 102396940(PDGFB)
CHX: 102184232(PDGFB)
OAS: 443545(PDGFB)
CFR: 102509299(PDGFB)
CDK: 105091934(PDGFB)
BACU: 103014878(PDGFB)
LVE: 103085145(PDGFB)
OOR: 101281603(PDGFB)
DLE: 111186344(PDGFB)
PCAD: 102982885(PDGFB)
ECB: 100070283(PDGFB)
EPZ: 103565679(PDGFB)
EAI: 106836855(PDGFB)
MYB: 102239511(PDGFB)
MYD: 102752730(PDGFB)
MNA: 107531241(PDGFB)
HAI: 109392273(PDGFB)
DRO: 112321825(PDGFB)
PALE: 102897699(PDGFB)
RAY: 107502078(PDGFB)
MJV: 108397360(PDGFB)
LAV: 100663544(PDGFB)
TMU: 101344115
MDO: 100012899(PDGFB)
SHR: 100917875(PDGFB)
PCW: 110205795(PDGFB)
OAA: 100085757(PDGFB)
GGA: 374128(PDGFB)
MGP: 100542930(PDGFB)
CJO: 107312675(PDGFB)
NMEL: 110392622(PDGFB)
APLA: 101794895(PDGFB)
ACYG: 106035929(PDGFB)
TGU: 100228287(PDGFB)
LSR: 110483837(PDGFB)
SCAN: 103813271(PDGFB)
GFR: 102036985(PDGFB)
FAB: 101815450(PDGFB)
PHI: 102099229(PDGFB)
PMAJ: 107205105(PDGFB)
CCAE: 111934907(PDGFB)
CCW: 104696330(PDGFB)
ETL: 114055364(PDGFB)
FPG: 101920861(PDGFB)
FCH: 102055848(PDGFB)
CLV: 102096932(PDGFB)
EGZ: 104134236(PDGFB)
NNI: 104021619(PDGFB)
ACUN: 113488033(PDGFB)
PADL: 103915655(PDGFB)
AAM: 106488469(PDGFB) 106488478
ASN: 102371668(PDGFB)
AMJ: 102562234(PDGFB)
PSS: 102451145(PDGFB)
CMY: 102929576(PDGFB)
CPIC: 101949242(PDGFB)
ACS: 100554817(pdgfb)
PVT: 110075932(PDGFB)
PBI: 103054969(PDGFB)
PMUR: 107288137(PDGFB)
TSR: 106544589(PDGFB)
PMUA: 114605091(PDGFB)
GJA: 107117132(PDGFB)
XLA: 108714525(pdgfb.L) 493575(pdgfb.S)
XTR: 100492827(pdgfb)
NPR: 108798502(PDGFB)
DRE: 798657(si:ch211-79m20.1)
IPU: 108259423(PDGFB)
PHYP: 113547643
AMEX: 103037777
EEE: 113585737
TRU: 101072289(pdgfb)
LCO: 104925464
MZE: 101487929
ONL: 100712331
OLA: 101162100(pdgfb)
XMA: 102235349
XCO: 114145108
PRET: 103477155
CVG: 107090045
NFU: 107375167(pdgfb)
KMR: 108232032
ALIM: 106522503
AOCE: 111582470
CSEM: 103383236
POV: 109639241
LCF: 108887165
SDU: 111216519
SLAL: 111673435
HCQ: 109511462
MALB: 109951610(pdgfb)
ELS: 105012081
LCM: 102355435(PDGFB)
CMK: 103173461
RTP: 109928695
API: 100568518(ACYPI24120)
HMG: 100201588
VG: 5176147(WMSV_gp3) 9538324(WMSV_gp4)
 » show all
Reference
PMID:3517869
  Authors
Rao CD, Igarashi H, Chiu IM, Robbins KC, Aaronson SA
  Title
Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
  Journal
Proc Natl Acad Sci U S A 83:2392-6 (1986)
DOI:10.1073/pnas.83.8.2392
  Sequence
[hsa:5155]
LinkDB

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