KEGG   ORTHOLOGY: K04361
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04068  FoxO signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04214  Apoptosis - fly
map04320  Dorso-ventral axis formation
map04510  Focal adhesion
map04520  Adherens junction
map04540  Gap junction
map04630  JAK-STAT signaling pathway
map04810  Regulation of actin cytoskeleton
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05131  Shigellosis
map05160  Hepatitis C
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
H02467  Neonatal inflammatory skin and bowel disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 JAK-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05207 Chemical carcinogenesis - receptor activation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05208 Chemical carcinogenesis - reactive oxygen species
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05171 Coronavirus disease - COVID-19
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05131 Shigellosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
CATY: 105588269(EGFR)
PANU: 101003588(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
TFN: 117073506(EGFR)
PTEH: 111555709(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
MMUR: 105877217(EGFR)
MMU: 13649(Egfr)
MCAL: 110304228(Egfr)
MPAH: 110330480(Egfr)
RNO: 24329(Egfr)
MCOC: 116071392(Egfr)
CGE: 100774580(Egfr)
PLEU: 114705532(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CCAN: 109693753(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
VVP: 112925820(EGFR)
VLG: 121471236(EGFR)
UMR: 103674660(EGFR)
UAH: 113257444(EGFR)
ORO: 101386858(EGFR)
ELK: 111157042
MPUF: 101685824(EGFR)
EJU: 114213645(EGFR)
MLX: 118024535(EGFR)
FCA: 100510799(EGFR)
PTG: 102967370(EGFR)
PPAD: 109267979(EGFR)
AJU: 106976977(EGFR)
HHV: 120238884(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
BBUB: 102398103(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
ODA: 120867903(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CDK: 105105749(EGFR)
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
DLE: 111184548(EGFR)
PCAD: 102975467(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
MMYO: 118665909(EGFR)
MNA: 107525996(EGFR)
HAI: 109388365(EGFR)
DRO: 112306912(EGFR)
SHON: 118983507(EGFR)
AJM: 119057339(EGFR)
MMF: 118620077(EGFR)
PALE: 102893495(EGFR)
RAY: 107498193(EGFR)
MJV: 108406292
TOD: 119231744(EGFR)
LAV: 100659125(EGFR)
TMU: 101356822
MDO: 100029625(EGFR)
SHR: 100914017(EGFR)
PCW: 110204990(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
PCOC: 116232773(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
NMEL: 110393050(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
TGU: 100221035(EGFR)
LSR: 110471171(EGFR)
SCAN: 103819418(EGFR)
PMOA: 120505010(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCAE: 111923657(EGFR)
CCW: 104689262(EGFR)
ETL: 114057239(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
NNI: 104012443(EGFR)
ACUN: 113477535(EGFR)
PADL: 103914859(EGFR)
AAM: 106495273(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
CPOO: 109312928(EGFR)
GGN: 109291886(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
TST: 117872619(EGFR)
CABI: 116832636(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
PBI: 103050691(EGFR)
PMUR: 107284695(EGFR)
TSR: 106539158(EGFR)
PGUT: 117664986(EGFR)
PMUA: 114607096(EGFR)
ZVI: 118077665(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
DRE: 378478(egfra) 571431
IPU: 108280575(egfr)
PHYP: 113546391(egfr)
EEE: 113587946 113590490(egfr)
TRU: 101069322(egfr) 101073748
ELY: 117264749 117272055(egfra)
PLEP: 121951033(egfra)
SLUC: 116046206(egfra) 116056499
ECRA: 117954310(egfra)
PFLV: 114548913 114564973(egfr)
GAT: 120811612 120816150(egfra)
MSAM: 119901961(egfra) 119913984
CUD: 121519822(egfra)
OLA: 101159776(egfr) 101169984
OML: 112147305(egfra) 112151354
XCO: 114136421 114146596(egfr)
XHE: 116712093 116721778(egfr)
PRET: 103456976 103479868(egfr)
CVG: 107081719(egfr) 107098892
CTUL: 119787990 119794178(egfra)
NFU: 107383161 107383833(egfr)
KMR: 108241698(egfra) 108250946
ALIM: 106531647 106533007(egfr)
AOCE: 111573600(egfr) 111586710
CSEM: 103377298 103396351(egfr)
LCF: 108883329(egfr) 108894667
SDU: 111231258(egfr) 111237405
SLAL: 111647380 111652941(egfr)
XGL: 120789875 120798813(egfra)
HCQ: 109521299(egfr) 109530291
BPEC: 110170351(egfr)
SFM: 108937670(egfr)
LOC: 102688253(egfr)
ARUT: 117400452(egfra)
CMK: 103181270(egfr)
RTP: 109927384
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DER: 6548211
DSE: 6615396
DSI: Dsimw501_GD11601(Dsim_GD11601)
DAN: 6495667
DSR: 110189726
DPE: 6592980
DWI: 6637989
DAZ: 108615522
DNV: 108653770
DHE: 111592533
DVI: 6627038
MDE: 101887261
LCQ: 111687210
AGA: AgaP_AGAP008819(EGFR)
ACOZ: 120959256
AARA: 120900188
AAG: 5564544
CPII: 120426263
AME: 100577393
ACER: 107993429
BIM: 100740344
BTER: 100645521
CCAL: 108632582
OBB: 114874001
MGEN: 117222212
NMEA: 116429624
CGIG: 122399503
MPHA: 105828088
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
VEM: 105567241
HST: 105191569
DQU: 106742590
CFO: 105257833
FEX: 115245656
LHU: 105676042
PGC: 109852274
OBO: 105287957
PCF: 106793740
NVI: 100118970
CSOL: 105367460
MDL: 103576901
TCA: 660037(DER)
DPA: 109536124
ATD: 109595878
AGB: 108907320
NVL: 108556379
PPYR: 116173497
OTU: 111421879
BMOR: 101741679
BMAN: 114245679
MSEX: 115455774
BANY: 112045731
PMAC: 106717252
PPOT: 106104475
PXU: 106126270
PRAP: 110998172
ZCE: 119835646
HAW: 110375773
TNL: 113507132
PXY: 105385471
API: 100168353
DNX: 107162454
AGS: 114127776
RMD: 113550916
BTAB: 109031082
DCI: 103506274
CLEC: 106668239
NLU: 111048742
ZNE: 110832144
FCD: 110842323
HAME: 121865936
EAF: 111709702
DSV: 119442537
RSAN: 119387318
RMP: 119159406
VDE: 111252123
VJA: 111269280
TUT: 107359081
DPTE: 113792070
CSCU: 111623507
CEL: CELE_ZK1067.1(let-23)
CBR: CBG00911(Cbr-let-23)
BMY: BM_BM7615(Bma-let-23)
PCAN: 112561120
BGT: 106066507
GAE: 121387807
CRG: 105330118(Egfr)
MYI: 110442986
PMAX: 117318155
LAK: 106153603
AQU: 100637905
 » show all
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
DOI:10.1038/309418a0
  Sequence
[hsa:1956]
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