KEGG   ORTHOLOGY: K04361
Entry
K04361                      KO                                     

Name
EGFR, ERBB1
Definition
epidermal growth factor receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04214  Apoptosis - fly
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H00016  Oral cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00055  Laryngeal cancer
H01508  Salivary gland cancer
H01559  Oropharyngeal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04013 MAPK signaling pathway - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04012 ErbB signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04014 Ras signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04015 Rap1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04630 JAK-STAT signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04066 HIF-1 signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04068 FoxO signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04020 Calcium signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04072 Phospholipase D signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04151 PI3K-Akt signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04520 Adherens junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04540 Gap junction
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04915 Estrogen signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04921 Oxytocin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04926 Relaxin signaling pathway
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   04928 Parathyroid hormone synthesis, secretion and action
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05206 MicroRNAs in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05205 Proteoglycans in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05230 Central carbon metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05231 Choline metabolism in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05212 Pancreatic cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05225 Hepatocellular carcinoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05226 Gastric cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05214 Glioma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05218 Melanoma
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05219 Bladder cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05215 Prostate cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05213 Endometrial cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05224 Breast cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05223 Non-small cell lung cancer
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05131 Shigellosis
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05171 Coronavirus disease - COVID-19
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05163 Human cytomegalovirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   05165 Human papillomavirus infection
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
   01522 Endocrine resistance
    K04361  EGFR, ERBB1; epidermal growth factor receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04361  EGFR, ERBB1; epidermal growth factor receptor
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04361  EGFR, ERBB1; epidermal growth factor receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04361  EGFR, ERBB1; epidermal growth factor receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of pancreatic cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
  Exosomal proteins of bladder cancer cells
   K04361  EGFR, ERBB1; epidermal growth factor receptor
Other DBs
GO: 0005006
Genes
HSA: 1956(EGFR)
PTR: 463415(EGFR)
PPS: 100974885(EGFR)
GGO: 101126190(EGFR)
PON: 100459280(EGFR)
NLE: 100597255(EGFR)
MCC: 613027(EGFR)
MCF: 102138724(EGFR)
CSAB: 103226055(EGFR)
RRO: 104675886(EGFR)
RBB: 108522039(EGFR)
CJC: 100412158(EGFR)
SBQ: 101047461(EGFR)
MMU: 13649(Egfr)
MCAL: 110304228(Egfr)
MPAH: 110330480(Egfr)
RNO: 24329(Egfr)
CGE: 100774580(Egfr)
NGI: 103748852
HGL: 101723771(Egfr)
CCAN: 109693753(Egfr)
OCU: 100008806(EGFR)
TUP: 102485304(EGFR)
CFA: 404306(EGFR)
VVP: 112925820(EGFR)
UMR: 103674660(EGFR)
UAH: 113257444(EGFR)
ORO: 101386858(EGFR)
ELK: 111157042
FCA: 100510799(EGFR)
PTG: 102967370(EGFR)
PPAD: 109267979(EGFR)
AJU: 106976977(EGFR)
BTA: 407217(EGFR)
BOM: 102269868
BIU: 109576048(EGFR)
BBUB: 102398103(EGFR)
CHX: 102172767(EGFR)
OAS: 780479(EGFR)
SSC: 397070(EGFR)
CFR: 102504272(EGFR)
CDK: 105105749(EGFR)
BACU: 103017029(EGFR)
LVE: 103071962(EGFR)
OOR: 101275398(EGFR)
DLE: 111184548(EGFR)
PCAD: 102975467(EGFR)
ECB: 100067755(EGFR)
EPZ: 103560128(EGFR)
EAI: 106824133(EGFR)
MYB: 102257758(EGFR)
MYD: 102775204(EGFR)
MNA: 107525996(EGFR)
HAI: 109388365(EGFR)
DRO: 112306912(EGFR)
PALE: 102893495(EGFR)
RAY: 107498193(EGFR)
MJV: 108406292
LAV: 100659125(EGFR)
TMU: 101356822
MDO: 100029625(EGFR)
SHR: 100914017(EGFR)
PCW: 110204990(EGFR)
OAA: 100075894(EGFR)
GGA: 396494(EGFR)
MGP: 100543252(EGFR)
CJO: 107309802(EGFR)
NMEL: 110393050(EGFR)
APLA: 101797830(EGFR)
ACYG: 106046417(EGFR)
TGU: 100221035(EGFR)
LSR: 110471171(EGFR)
SCAN: 103819418(EGFR)
GFR: 102045482(EGFR)
FAB: 101818290(EGFR)
PHI: 102101445(EGFR)
PMAJ: 107200328(EGFR)
CCAE: 111923657(EGFR)
CCW: 104689262(EGFR)
ETL: 114057239(EGFR)
FPG: 101910521(EGFR)
FCH: 102058683(EGFR)
CLV: 102097879(EGFR)
EGZ: 104131586(EGFR)
NNI: 104012443(EGFR)
ACUN: 113477535(EGFR)
PADL: 103914859(EGFR)
AAM: 106495273(EGFR)
ASN: 102378285(EGFR)
AMJ: 102565209(EGFR)
PSS: 102443405(EGFR)
CMY: 102933326(EGFR)
CPIC: 101952725(EGFR)
ACS: 100562231(egfr)
PVT: 110081594(EGFR)
PBI: 103050691(EGFR)
PMUR: 107284695(EGFR)
TSR: 106539158(EGFR)
PMUA: 114607096(EGFR)
GJA: 107119225(EGFR)
XLA: 108719997(egfr.S) 724072(egfr.L)
XTR: 100492965(egfr)
DRE: 378478(egfra) 571431
IPU: 108280575(egfr)
PHYP: 113546391(egfr)
EEE: 113587946 113590490(egfr)
TRU: 101069322(egfr) 101073748
OLA: 101159776(egfr) 101169984
XCO: 114136421 114146596(egfr)
PRET: 103456976 103479868(egfr)
CVG: 107081719(egfr) 107098892
NFU: 107383161 107383833(egfr)
KMR: 108241698(egfr) 108250946
ALIM: 106531647 106533007(egfr)
AOCE: 111573600(egfr) 111586710
CSEM: 103377298 103396351(egfr)
LCF: 108883329(egfr) 108894667
SDU: 111231258(egfr) 111237405
SLAL: 111647380 111652941(egfr)
HCQ: 109521299(egfr) 109530291
BPEC: 110170351(egfr)
SFM: 108937670(egfr)
CMK: 103181270(egfr)
RTP: 109927384
SPU: 586488
SKO: 100372961
DME: Dmel_CG10079(Egfr)
DER: 6548211
DSE: 6615396
DSI: Dsimw501_GD11601(Dsim_GD11601)
DAN: 6495667
DSR: 110189726
DPE: 6592980
DWI: 6637989
DAZ: 108615522
DNV: 108653770
DHE: 111592533
DVI: 6627038
MDE: 101887261
LCQ: 111687210
AGA: AgaP_AGAP008819(EGFR)
AAG: 5564544
AME: 100577393
BIM: 100740344
BTER: 100645521
CCAL: 108632582
OBB: 114874001
MPHA: 105828088
AEC: 105144059
ACEP: 105627284
PBAR: 105427056
VEM: 105567241
HST: 105191569
DQU: 106742590
CFO: 105257833
LHU: 105676042
PGC: 109852274
OBO: 105287957
PCF: 106793740
NVI: 100118970
CSOL: 105367460
MDL: 103576901
TCA: 660037(DER)
DPA: 109536124
ATD: 109595878
NVL: 108556379
BMOR: 101741679
BMAN: 114245679
PMAC: 106717252
PRAP: 110998172
HAW: 110375773
TNL: 113507132
PXY: 105385471
API: 100168353
DNX: 107162454
AGS: 114127776
RMD: 113550916
BTAB: 109031082
CLEC: 106668239
ZNE: 110832144
FCD: 110842323
TUT: 107359081
DPTE: 113792070
CSCU: 111623507
CEL: CELE_ZK1067.1(let-23)
CBR: CBG00911(Cbr-let-23)
BMY: Bm1_48745
PCAN: 112561120
CRG: 105330118(Egfr)
MYI: 110442986
LAK: 106153603
AQU: 100637905
 » show all
Reference
  Authors
Shao H, Cheng HY, Cook RG, Tweardy DJ
  Title
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
  Journal
Cancer Res 63:3923-30 (2003)
  Sequence
[hsa:1956]
Reference
  Authors
Habib AA, Chatterjee S, Park SK, Ratan RR, Lefebvre S, Vartanian T
  Title
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
  Journal
J Biol Chem 276:8865-74 (2001)
DOI:10.1074/jbc.M008458200
  Sequence
[hsa:1956]
Reference
PMID:6328312
  Authors
Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al.
  Title
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
  Journal
Nature 309:418-25 (1984)
DOI:10.1038/309418a0
  Sequence
[hsa:1956]
LinkDB

KEGG   ORTHOLOGY: K04362
Entry
K04362                      KO                                     

Name
FGFR1, CD331
Definition
fibroblast growth factor receptor 1 [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04714  Thermogenesis
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05230  Central carbon metabolism in cancer
Disease
H00031  Breast cancer
H00255  Hypogonadotropic hypogonadism
H00443  Osteoglophonic dysplasia
H00458  Syndromic craniosynostoses
H01207  Trigonocephaly
H01756  Pfeiffer syndrome
H01850  Hartsfield syndrome
H01988  Jackson-Weiss syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04014 Ras signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04015 Rap1 signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04151 PI3K-Akt signaling pathway
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05205 Proteoglycans in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05230 Central carbon metabolism in cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09162 Cancer: specific types
   05218 Melanoma
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05215 Prostate cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   05224 Breast cancer
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
   00536 Glycosaminoglycan binding proteins
    K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
CD molecules [BR:ko04090]
 Proteins
  K04362  CD331, FGFR1; fibroblast growth factor receptor 1
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K04362  FGFR1, CD331; fibroblast growth factor receptor 1
Other DBs
GO: 0005007
Genes
HSA: 2260(FGFR1)
PTR: 464122(FGFR1)
PPS: 100988115(FGFR1)
GGO: 101152179(FGFR1)
PON: 100174545(FGFR1)
NLE: 100602423(FGFR1)
MCC: 700126(FGFR1)
MCF: 102144714(FGFR1)
CSAB: 103215648(FGFR1)
RRO: 104679640(FGFR1)
RBB: 108512401(FGFR1)
CJC: 100390192(FGFR1)
SBQ: 101033213(FGFR1)
MMU: 14182(Fgfr1)
MCAL: 110299550(Fgfr1)
MPAH: 110336809(Fgfr1)
RNO: 79114(Fgfr1)
MUN: 110563307(Fgfr1)
CGE: 100773586(Fgfr1)
NGI: 103745770(Fgfr1)
HGL: 101700324(Fgfr1)
CCAN: 109688936(Fgfr1)
OCU: 100351861(FGFR1)
TUP: 102484087(FGFR1)
CFA: 100856477(FGFR1)
VVP: 112916136(FGFR1)
AML: 100472630(FGFR1)
UMR: 103659146(FGFR1)
UAH: 113262086(FGFR1)
ORO: 101364849(FGFR1)
ELK: 111144420
FCA: 101086055(FGFR1)
PTG: 102972346(FGFR1)
PPAD: 109262303(FGFR1)
AJU: 106978376(FGFR1)
BTA: 281768(FGFR1)
BOM: 102267776(FGFR1)
BIU: 109553304(FGFR1)
BBUB: 102407288(FGFR1)
CHX: 102180282(FGFR1)
OAS: 780507(FGFR1)
SSC: 100153248(FGFR1)
CFR: 102515264(FGFR1)
CDK: 105105270(FGFR1)
BACU: 103017733(FGFR1)
LVE: 103069902(FGFR1)
OOR: 101279623(FGFR1)
DLE: 111173523(FGFR1)
PCAD: 102989551(FGFR1)
ECB: 100057614(FGFR1)
EPZ: 103560266(FGFR1)
EAI: 106824659(FGFR1)
MYB: 102253832(FGFR1)
MYD: 102759202(FGFR1)
MNA: 107535065(FGFR1)
HAI: 109373149(FGFR1)
DRO: 112306733(FGFR1)
PALE: 102898943(FGFR1)
RAY: 107515961(FGFR1)
MJV: 108403050(FGFR1)
LAV: 100662289(FGFR1)
TMU: 101342270
MDO: 100029852(FGFR1)
SHR: 100914347(FGFR1)
PCW: 110207578(FGFR1)
OAA: 100074240(FGFR1)
GGA: 396516(FGFR1)
MGP: 100547498(FGFR1)
CJO: 107323773(FGFR1)
NMEL: 110387131(FGFR1)
ACYG: 106044374(FGFR1)
TGU: 100221243(FGFR1)
LSR: 110473397(FGFR1)
SCAN: 103822693(FGFR1)
GFR: 102033908(FGFR1)
FAB: 101822220(FGFR1)
PHI: 102103637(FGFR1)
PMAJ: 107213845(FGFR1)
CCAE: 111938850(FGFR1)
CCW: 104694904(FGFR1)
ETL: 114066493(FGFR1)
FPG: 101914093(FGFR1)
FCH: 102055369(FGFR1)
CLV: 102085235(FGFR1)
EGZ: 104135322(FGFR1)
NNI: 104016019(FGFR1)
PADL: 103912362(FGFR1)
AAM: 106492992(FGFR1)
ASN: 102386174(FGFR1)
AMJ: 102574117(FGFR1)
PSS: 102461506(FGFR1)
CMY: 102942878
CPIC: 101941076(FGFR1)
ACS: 100559018(fgfr1)
PVT: 110072166(FGFR1)
PBI: 103066603(FGFR1)
PMUR: 107289991(FGFR1)
TSR: 106545617(FGFR1)
PMUA: 114585343(FGFR1)
GJA: 107113006(FGFR1)
XLA: 394418(fgfr1.L) 397782(xfgfra2) 399444(fgfr1.S)
XTR: 548648(fgfr1)
NPR: 108791453(FGFR1)
DRE: 30705(fgfr1a) 567905(fgfr1b) 569566
EEE: 113588173
TRU: 101073964 101078564(fgfr1)
OLA: 100125448(fgfr1) 101155126
XCO: 114149547 114154182(fgfr1)
CVG: 107081801
AOCE: 111571065
MALB: 109954836
LCM: 102361014(FGFR1)
CMK: 103190693
CIN: 101242971 445706(fgfr)
SPU: 373310(FGFR)
DME: Dmel_CG10244(Cad96Ca)
DER: 6555476
DSE: 6619674
DSI: Dsimw501_GD18227(Dsim_GD18227)
DAN: 6499881
DSR: 110189031
DPE: 6591372
DMN: 108156267
DWI: 6651312
DAZ: 108621257
DNV: 108650218
DHE: 111601307
DVI: 6629492
MDE: 101899591
LCQ: 111681381
AAG: 5566872
AME: 409061
BIM: 100741569
BTER: 100645261
CCAL: 108630549
OBB: 114878584
SOC: 105196016
MPHA: 105830817
AEC: 105151199
ACEP: 105624990
DQU: 106748875
LHU: 105675703
PGC: 109853575
OBO: 105287184
PCF: 106787566
CSOL: 105368181
MDL: 103574949
TCA: 659961(Cad96Ca)
DPA: 109536590
ATD: 109595758
NVL: 108565944
BMOR: 101745512
BMAN: 114253316
PMAC: 106720097
PRAP: 111004172
HAW: 110379194
TNL: 113500453
PXY: 105387388
DNX: 107166442
AGS: 114124499
RMD: 113556718
BTAB: 109043826
CLEC: 106674164
ZNE: 110836649
PVM: 113825602
TUT: 107365937
DPTE: 113790798
CSCU: 111629419
PTEP: 107441235
CBR: CBG04906
TSP: Tsp_00617
CRG: 105321229
MYI: 110459294
EGL: EGR_04208
AQU: 100632318
 » show all
Reference
PMID:1697263
  Authors
Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J
  Title
Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
  Journal
EMBO J 9:2685-92 (1990)
DOI:10.1002/j.1460-2075.1990.tb07454.x
  Sequence
[hsa:2260]
LinkDB

KEGG   ORTHOLOGY: K04363
Entry
K04363                      KO                                     

Name
PDGFRA, CD140A
Definition
platelet-derived growth factor receptor alpha [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01590  Chronic eosinophilic leukemia
H01591  Gastrotintestinal stromal tumor
H01599  Hypereosinophilic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04014 Ras signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04015 Rap1 signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04630 JAK-STAT signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04020 Calcium signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04072 Phospholipase D signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04151 PI3K-Akt signaling pathway
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   04540 Gap junction
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05206 MicroRNAs in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05230 Central carbon metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05231 Choline metabolism in cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09162 Cancer: specific types
   05214 Glioma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05218 Melanoma
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
   05215 Prostate cancer
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K04363  PDGFRA, CD140A; platelet-derived growth factor receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K04363  CD140a, PDGFRA; platelet-derived growth factor receptor, alpha polypeptide
Other DBs
GO: 0005018
Genes
HSA: 5156(PDGFRA)
PTR: 461318(PDGFRA)
PPS: 100982337(PDGFRA)
GGO: 101124928(PDGFRA)
PON: 100431735(PDGFRA)
NLE: 100603207(PDGFRA)
MCC: 697002(PDGFRA)
MCF: 102138392(PDGFRA)
CSAB: 103235675(PDGFRA)
RRO: 104658857(PDGFRA)
RBB: 108533750(PDGFRA)
CJC: 100412331(PDGFRA)
SBQ: 101040156(PDGFRA)
MMU: 18595(Pdgfra)
MCAL: 110295292(Pdgfra)
MPAH: 110331028(Pdgfra)
RNO: 25267(Pdgfra)
MUN: 110558105(Pdgfra)
CGE: 100760258(Pdgfra)
NGI: 103734393(Pdgfra)
HGL: 101697360(Pdgfra)
CCAN: 109685094(Pdgfra) 109702274
OCU: 100343006(PDGFRA)
TUP: 102488187(PDGFRA)
CFA: 442860(PDGFRA)
VVP: 112933353(PDGFRA)
AML: 100464991(PDGFRA)
UMR: 103672737(PDGFRA)
UAH: 113262493(PDGFRA)
ORO: 101372359(PDGFRA)
ELK: 111148924
FCA: 101090765(PDGFRA)
PTG: 102955481(PDGFRA)
PPAD: 109278988(PDGFRA)
AJU: 106983998(PDGFRA)
BTA: 282301(PDGFRA)
BOM: 102282598(PDGFRA)
BIU: 109560475(PDGFRA)
BBUB: 102409620(PDGFRA)
CHX: 102174007(PDGFRA)
OAS: 101106012(PDGFRA)
SSC: 100627123(PDGFRA)
CFR: 102512589(PDGFRA)
CDK: 105103397(PDGFRA)
BACU: 102998016(PDGFRA)
LVE: 103071473(PDGFRA)
OOR: 101269459(PDGFRA)
DLE: 111169692(PDGFRA)
PCAD: 102994349(PDGFRA)
ECB: 100059815(PDGFRA)
EPZ: 103552305(PDGFRA)
EAI: 106839051(PDGFRA)
MYB: 102255326(PDGFRA)
MYD: 102761943(PDGFRA)
MNA: 107532710(PDGFRA)
HAI: 109381815(PDGFRA)
DRO: 112316918(PDGFRA)
PALE: 102895362(PDGFRA)
RAY: 107499793(PDGFRA)
MJV: 108385741(PDGFRA)
LAV: 100670735(PDGFRA)
TMU: 101348884
MDO: 100013088(PDGFRA)
SHR: 100925116(PDGFRA)
PCW: 110200158(PDGFRA)
OAA: 100084432(PDGFRA)
GGA: 395509(PDGFRA)
MGP: 100542010(PDGFRA)
CJO: 107313741(PDGFRA)
NMEL: 110397725(PDGFRA)
APLA: 101797285(PDGFRA)
ACYG: 106030788(PDGFRA)
TGU: 100218386(PDGFRA)
LSR: 110469831(PDGFRA)
SCAN: 103825217(PDGFRA)
GFR: 102044274(PDGFRA)
FAB: 101820996(PDGFRA)
PHI: 102113476(PDGFRA)
PMAJ: 107203533(PDGFRA)
CCAE: 111928019(PDGFRA)
CCW: 104690630(PDGFRA)
ETL: 114058301(PDGFRA)
FPG: 101913531(PDGFRA)
FCH: 102054310(PDGFRA)
CLV: 102087625(PDGFRA)
EGZ: 104129386(PDGFRA)
NNI: 104020776(PDGFRA)
ACUN: 113479434(PDGFRA)
PADL: 103926287(PDGFRA)
AAM: 106490172(PDGFRA)
ASN: 102378120(PDGFRA)
AMJ: 102575338(PDGFRA)
PSS: 102443708(PDGFRA)
CMY: 102935642(PDGFRA)
CPIC: 101935558(PDGFRA)
ACS: 100565834(pdgfra)
PVT: 110078407(PDGFRA)
PBI: 103067713(PDGFRA)
PMUR: 107298631(PDGFRA)
PMUA: 114604335(PDGFRA)
GJA: 107106036(PDGFRA)
XLA: 108706592(pdgfra.S) 380245(pdgfra.L)
XTR: 100124862(pdgfra)
NPR: 108804111(PDGFRA)
DRE: 386856(pdgfra)
CCAR: 109112741
IPU: 108258040(pdgfra)
PHYP: 113546841(pdgfra)
AMEX: 103044267(pdgfra)
EEE: 113586382(pdgfra)
TRU: 101073543(pdgfra)
LCO: 104919088(pdgfra)
NCC: 104947073(pdgfra)
MZE: 101471693(pdgfra)
ONL: 100692594(pdgfra)
OLA: 100049280(pdgfra)
XMA: 102219876(pdgfra)
XCO: 114151105(pdgfra)
PRET: 103463840(pdgfra)
CVG: 107091563(pdgfra)
NFU: 107393382(pdgfra)
KMR: 108243392(pdgfra)
ALIM: 106524096(pdgfra)
AOCE: 111569607(pdgfra)
CSEM: 103376707(pdgfra)
POV: 109625664(pdgfra)
LCF: 108879100(pdgfra)
SDU: 111226338(pdgfra)
SLAL: 111644345(pdgfra)
HCQ: 109532287(pdgfra)
BPEC: 110154688(pdgfra)
MALB: 109962087(pdgfra)
SASA: 106560269 106584117(pdgfra)
SALP: 111972315(pdgfra) 111976174
ELS: 105011836(pdgfra)
SFM: 108922803(pdgfra)
PKI: 111850064
LCM: 102353753(PDGFRA)
CMK: 103178167(pdgfra)
RTP: 109927411(pdgfra)
NVE: 5507990
PDAM: 113683455
 » show all
Reference
PMID:2544881
  Authors
Claesson-Welsh L, Eriksson A, Westermark B, Heldin CH
  Title
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.
  Journal
Proc Natl Acad Sci U S A 86:4917-21 (1989)
DOI:10.1073/pnas.86.13.4917
  Sequence
[hsa:5156]
Reference
PMID:8188664
  Authors
Vassbotn FS, Havnen OK, Heldin CH, Holmsen H
  Title
Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.
  Journal
J Biol Chem 269:13874-9 (1994)
  Sequence
[hsa:5156]
LinkDB

KEGG   ORTHOLOGY: K05087
Entry
K05087                      KO                                     

Name
IGF1R, CD221
Definition
insulin-like growth factor 1 receptor [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04144  Endocytosis
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00015  Malignant pleural mesothelioma
H00048  Hepatocellular carcinoma
H00050  Synovial sarcoma
H01274  Growth delay due to insulin-like growth factor I resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04014 Ras signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04015 Rap1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04066 HIF-1 signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04068 FoxO signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04152 AMPK signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04150 mTOR signaling pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04140 Autophagy - animal
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04520 Adherens junction
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04550 Signaling pathways regulating pluripotency of stem cells
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04914 Progesterone-mediated oocyte maturation
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09156 Nervous system
   04730 Long-term depression
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09149 Aging
   04211 Longevity regulating pathway
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   04213 Longevity regulating pathway - multiple species
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05205 Proteoglycans in cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05214 Glioma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05218 Melanoma
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05215 Prostate cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   05224 Breast cancer
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
   01522 Endocrine resistance
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   K05087  IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05087  CD221, IGF1R; insulin-like growth factor 1 receptor
Other DBs
GO: 0005010 0031994
Genes
HSA: 3480(IGF1R)
PTR: 453676(IGF1R)
PPS: 100981083(IGF1R)
GGO: 101154546(IGF1R)
PON: 100172156(IGF1R)
NLE: 100593288(IGF1R)
MCC: 708227(IGF1R)
MCF: 102130142(IGF1R)
CSAB: 103231259(IGF1R)
RRO: 104677192(IGF1R)
RBB: 108538668(IGF1R)
CJC: 100408399(IGF1R)
SBQ: 101039763(IGF1R)
MMU: 16001(Igf1r)
MCAL: 110297825(Igf1r)
MPAH: 110324292(Igf1r)
RNO: 25718(Igf1r)
MUN: 110547261(Igf1r)
CGE: 100768531(Igf1r)
NGI: 103749467(Igf1r)
HGL: 101710224(Igf1r)
CCAN: 109687530
OCU: 100144342(IGF1R)
TUP: 102473496(IGF1R)
CFA: 442951(IGF1R)
VVP: 112922150(IGF1R)
AML: 100471374(IGF1R)
UMR: 103660044
UAH: 113263646(IGF1R)
ORO: 101386211(IGF1R)
ELK: 111152643
FCA: 100500937(IGF1R)
PTG: 102949680(IGF1R)
PPAD: 109273360(IGF1R)
AJU: 106975144(IGF1R)
BTA: 281848(IGF1R)
BOM: 102278105(IGF1R)
BIU: 109575129
BBUB: 102403092(IGF1R)
CHX: 100861165(IGF1R)
OAS: 443515(IGF1R)
SSC: 397350(IGF1R)
CFR: 102524338(IGF1R)
CDK: 105093441(IGF1R)
BACU: 103015537(IGF1R)
LVE: 103081291(IGF1R)
OOR: 101281976(IGF1R)
DLE: 111187347(IGF1R)
PCAD: 102977826(IGF1R)
ECB: 100055698(IGF1R)
EPZ: 103559577(IGF1R)
EAI: 106836604(IGF1R)
MYB: 102253516(IGF1R)
MYD: 102770795(IGF1R)
MNA: 107527774(IGF1R)
HAI: 109380372(IGF1R)
DRO: 112306076(IGF1R)
PALE: 102885962(IGF1R)
RAY: 107509347
MJV: 108403280(IGF1R)
LAV: 100655087(IGF1R)
TMU: 101355333
MDO: 100020095(IGF1R)
SHR: 100916673(IGF1R)
PCW: 110192705(IGF1R)
OAA: 100077556(IGF1R)
GGA: 395889(IGF1R)
MGP: 100539720(IGF1R)
CJO: 107318870(IGF1R)
NMEL: 110403525(IGF1R)
APLA: 101802018(IGF1R)
ACYG: 106036418(IGF1R)
TGU: 100227374(IGF1R)
LSR: 110482986(IGF1R)
SCAN: 103816222(IGF1R)
GFR: 102036037(IGF1R)
FAB: 101819893(IGF1R)
PHI: 102103364(IGF1R)
PMAJ: 107209439(IGF1R)
CCAE: 111933868(IGF1R)
CCW: 104684080(IGF1R)
ETL: 114054644(IGF1R)
FPG: 101914715(IGF1R)
FCH: 102046128(IGF1R)
CLV: 102089963(IGF1R)
EGZ: 104122851(IGF1R)
NNI: 104017228(IGF1R)
ACUN: 113483985(IGF1R)
PADL: 103914830(IGF1R)
AAM: 106485327(IGF1R)
ASN: 102387852(IGF1R)
AMJ: 106736787(IGF1R)
PSS: 102455576(IGF1R)
CMY: 102941686(IGF1R)
CPIC: 101952328(IGF1R)
ACS: 100554064(igf1r)
PVT: 110072986(IGF1R)
PBI: 103049336(IGF1R)
PMUR: 107290589(IGF1R)
TSR: 106545511(IGF1R) 106555187
PMUA: 114584984(IGF1R)
GJA: 107121607(IGF1R)
XLA: 108711478(igf1r.L) 398022(igf1r.S)
XTR: 100329112(igf1r)
NPR: 108787513(IGF1R)
DRE: 245701(igf1ra) 245702(igf1rb)
IPU: 100304999(igf1r) 108271091(Igf1r)
PHYP: 113534424(igf1r) 113536568
LCO: 104920736(igf1r) 104921706
MZE: 101469217 101479543(igf1r)
CVG: 107087242(igf1r) 107097409
ALIM: 106514315 106531111(igf1r)
CSEM: 103379307
POV: 109624556 109625052(igf1r)
HCQ: 109513166 109513874(igf1r)
SALP: 111952526 111962390(igf1r)
ELS: 105016672 105023472(igf1r)
SFM: 108926605(igf1r) 108941092
PKI: 111845000(igf1r) 111845734
LCM: 102367342(IGF1R)
CMK: 103188389(igf1r)
DME: Dmel_CG18402(InR)
DER: 6553414
DSE: 6614334
DSI: Dsimw501_GD19971(Dsim_GD19971)
DSR: 110188261
DPE: 6591473
DMN: 108155588
DAZ: 108621684
MDE: 101894251
HAW: 110369826
TNL: 113496051
TSP: Tsp_12077
HMG: 100214733(HTK7)
 » show all
Reference
PMID:8257688
  Authors
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y
  Title
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
  Journal
Biochemistry 32:13531-6 (1993)
DOI:10.1021/bi00212a019
  Sequence
[hsa:3480]
Reference
PMID:2877871
  Authors
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al.
  Title
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
  Journal
EMBO J 5:2503-12 (1986)
DOI:10.1002/j.1460-2075.1986.tb04528.x
  Sequence
[hsa:3480]
Reference
  Authors
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA
  Title
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
  Journal
Biochem Soc Trans 29:513-25 (2001)
DOI:10.1042/bst0290513
LinkDB

KEGG   ORTHOLOGY: K05089
Entry
K05089                      KO                                     

Name
PDGFRB, CD140B
Definition
platelet-derived growth factor receptor beta [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04630  JAK-STAT signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
Disease
H00042  Glioma
H01574  Familial idiopathic basal ganglia calcification
H01910  Infantile myofibromatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04014 Ras signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04015 Rap1 signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04630 JAK-STAT signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04020 Calcium signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04072 Phospholipase D signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04151 PI3K-Akt signaling pathway
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   04540 Gap junction
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05206 MicroRNAs in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05230 Central carbon metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05231 Choline metabolism in cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09162 Cancer: specific types
   05214 Glioma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05218 Melanoma
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
   05215 Prostate cancer
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05089  PDGFRB, CD140B; platelet-derived growth factor receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05089  CD140b, PDGFRB; platelet-derived growth factor receptor, beta polypeptide
Other DBs
GO: 0004992
Genes
HSA: 5159(PDGFRB)
PTR: 462188(PDGFRB)
PPS: 100975853(PDGFRB)
GGO: 101150577(PDGFRB)
PON: 100460001(PDGFRB)
NLE: 100597894(PDGFRB)
MCC: 711353(PDGFRB)
MCF: 101867161(PDGFRB)
CSAB: 103244790(PDGFRB)
RRO: 104670408(PDGFRB)
RBB: 108532047(PDGFRB)
CJC: 100389852(PDGFRB)
SBQ: 101040158(PDGFRB)
MMU: 18596(Pdgfrb)
MCAL: 110284880(Pdgfrb)
MPAH: 110333065(Pdgfrb)
RNO: 24629(Pdgfrb)
MUN: 110546695(Pdgfrb)
CGE: 100764374(Pdgfrb)
NGI: 103747076(Pdgfrb)
HGL: 101721151(Pdgfrb)
CCAN: 109685664(Pdgfrb)
OCU: 100342872(PDGFRB)
TUP: 102492413(PDGFRB)
CFA: 442985(PDGFRB)
VVP: 112927357(PDGFRB)
AML: 100472005(PDGFRB)
UMR: 103664600(PDGFRB)
UAH: 113263944(PDGFRB)
ORO: 101374793(PDGFRB)
ELK: 111140848
FCA: 101084600(PDGFRB)
PTG: 102954207(PDGFRB)
PPAD: 109275948(PDGFRB)
AJU: 106985388(PDGFRB)
BTA: 527165(PDGFRB)
BOM: 102270608(PDGFRB)
BIU: 109562197(PDGFRB)
BBUB: 102392216(PDGFRB)
CHX: 102184426(PDGFRB)
OAS: 101122783(PDGFRB)
SSC: 102166564(PDGFRB)
CFR: 102512951(PDGFRB)
CDK: 105098486(PDGFRB)
BACU: 103019883(PDGFRB)
LVE: 103082363(PDGFRB)
OOR: 101272795(PDGFRB)
DLE: 111183086(PDGFRB)
PCAD: 102995915(PDGFRB)
ECB: 100071665(PDGFRB)
EPZ: 103549125(PDGFRB)
EAI: 106838493(PDGFRB)
MYB: 102241145(PDGFRB)
MYD: 102764172(PDGFRB)
MNA: 107535230(PDGFRB)
HAI: 109375002(PDGFRB)
DRO: 112319577(PDGFRB)
PALE: 102887643(PDGFRB)
RAY: 107497163(PDGFRB)
MJV: 108385397(PDGFRB)
LAV: 100671240(PDGFRB)
TMU: 101360003
MDO: 100028943(PDGFRB)
SHR: 100917212(PDGFRB)
PCW: 110192821(PDGFRB)
OAA: 100079459(PDGFRB)
GGA: 770488(PDGFRB)
MGP: 100550611(PDGFRB)
CJO: 107320191(PDGFRB)
NMEL: 110405265(PDGFRB)
APLA: 101799587(PDGFRB)
ACYG: 106032823(PDGFRB)
TGU: 100223375(PDGFRB)
LSR: 110482721(PDGFRB)
SCAN: 103817301(PDGFRB)
GFR: 102045343(PDGFRB)
FAB: 101809926(PDGFRB)
PHI: 102111524(PDGFRB)
PMAJ: 107210844(PDGFRB)
CCAE: 111935543(PDGFRB)
CCW: 104689579(PDGFRB)
ETL: 114063193(PDGFRB)
FPG: 101918438(PDGFRB)
FCH: 102052718(PDGFRB)
CLV: 102096790(PDGFRB)
EGZ: 104123312(PDGFRB)
NNI: 104014196(PDGFRB)
ACUN: 113485173(PDGFRB)
PADL: 103915745(PDGFRB)
AAM: 106493441(PDGFRB)
ASN: 102372962(PDGFRB)
AMJ: 102566175(PDGFRB)
PSS: 102460895(PDGFRB)
CMY: 102944650(PDGFRB)
CPIC: 101940553(PDGFRB)
ACS: 100555784(pdgfrb)
PVT: 110086089(PDGFRB)
PBI: 103051588(PDGFRB)
PMUR: 107294993
TSR: 106547766(PDGFRB)
PMUA: 114591343(PDGFRB)
XLA: 108712643(pdgfrb.S)
XTR: 100487523(pdgfrb)
NPR: 108785807(PDGFRB)
DRE: 559529(pdgfrb)
IPU: 108274697(pdgfrb)
PHYP: 113529620(pdgfrb)
AMEX: 103036483
EEE: 113575581(pdgfrb)
TRU: 101061130 101074724(pdgfrb)
NCC: 104965701(pdgfrb)
MZE: 101466822 101484671(pdgfrb)
ONL: 100695603(pdgfrb) 100709470
OLA: 101155039(pdgfrb) 101156428
XMA: 102229755 102233464(pdgfrb)
XCO: 114139478(pdgfrb) 114153115
PRET: 103459902 103471279(pdgfrb)
CVG: 107095000(pdgfrb) 107102292
NFU: 107375657(pdgfrb)
KMR: 108228837 108240544(pdgfrb)
ALIM: 106517359(pdgfrb) 106532997
AOCE: 111569523(pdgfrb) 111575719
CSEM: 103391002(pdgfrb) 103392104
POV: 109626437(pdgfrb)
LCF: 108873646 108899186(pdgfrb)
SDU: 111226471(pdgfrb) 111239485
SLAL: 111646633(pdgfrb) 111671142
HCQ: 109518748(pdgfrb) 109528881
SFM: 108936824(pdgfrb)
PKI: 111855164(pdgfrb)
LCM: 102361386(PDGFRB)
CMK: 103188232(pdgfrb)
 » show all
Reference
  Authors
Jones AV, Cross NC
  Title
Oncogenic derivatives of platelet-derived growth factor receptors.
  Journal
Cell Mol Life Sci 61:2912-23 (2004)
DOI:10.1007/s00018-004-4272-z
Reference
PMID:2835772
  Authors
Gronwald RG, Grant FJ, Haldeman BA, Hart CE, O'Hara PJ, Hagen FS, Ross R, Bowen-Pope DF, Murray MJ
  Title
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
  Journal
Proc Natl Acad Sci U S A 85:3435-9 (1988)
DOI:10.1073/pnas.85.10.3435
  Sequence
[hsa:5159]
LinkDB

KEGG   ORTHOLOGY: K05099
Entry
K05099                      KO                                     

Name
MET, HGFR
Definition
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04360  Axon guidance
ko04361  Axon regeneration
ko04510  Focal adhesion
ko04520  Adherens junction
ko05100  Bacterial invasion of epithelial cells
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05144  Malaria
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05211  Renal cell carcinoma
ko05218  Melanoma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00014  Non-small cell lung cancer
H00018  Gastric cancer
H00021  Renal cell carcinoma
H00046  Cholangiocarcinoma
H00048  Hepatocellular carcinoma
H00605  Deafness, autosomal recessive
H01985  Desmoplastic small round cell tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04014 Ras signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04015 Rap1 signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04151 PI3K-Akt signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04520 Adherens junction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04361 Axon regeneration
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05202 Transcriptional misregulation in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05206 MicroRNAs in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05205 Proteoglycans in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05230 Central carbon metabolism in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05226 Gastric cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05218 Melanoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05211 Renal cell carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05223 Non-small cell lung cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05100 Bacterial invasion of epithelial cells
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09174 Infectious disease: parasitic
   05144 Malaria
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  MET family
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Genes
HSA: 4233(MET)
PTR: 463671(MET)
PPS: 100991777(MET)
GGO: 101127399(MET)
PON: 100137030(MET)
NLE: 100597172(MET)
MCC: 704562(MET)
MCF: 102123512(MET)
CSAB: 103226771(MET)
RRO: 104682633(MET)
RBB: 108528695(MET)
CJC: 100408551(MET)
SBQ: 101038696(MET)
MMU: 17295(Met)
MCAL: 110295947(Met)
MPAH: 110316104(Met)
RNO: 24553(Met)
MUN: 110558703(Met)
CGE: 100751933(Met)
NGI: 103737431(Met)
HGL: 101725772(Met)
CCAN: 109689877(Met)
OCU: 100126565(MET)
TUP: 102485847(MET)
CFA: 403438(MET)
VVP: 112929871(MET)
AML: 100480742(MET)
UMR: 103676585(MET)
UAH: 113263211(MET)
ORO: 101365730(MET)
ELK: 111151956
FCA: 493669(MET)
PTG: 102953616(MET)
PPAD: 109248389(MET)
AJU: 106970667(MET)
BTA: 280855(MET)
BOM: 102285634(MET)
BIU: 109557411(MET)
BBUB: 102393442(MET)
CHX: 102181186(MET)
OAS: 443076(MET)
SSC: 654328(MET)
CFR: 102504138
CDK: 105085321
BACU: 103002086(MET)
LVE: 103090984(MET)
OOR: 101280136(MET)
DLE: 111179292(MET)
PCAD: 102987522(MET)
ECB: 100056013(MET)
EPZ: 103562070(MET)
EAI: 106829287(MET)
MYB: 102263347(MET)
MYD: 102753524
MNA: 107528536(MET)
HAI: 109389346(MET)
DRO: 112300421(MET)
PALE: 102885990(MET)
RAY: 107497465(MET)
MJV: 108399322(MET)
LAV: 100656285(MET)
TMU: 101345595
MDO: 100013788(MET)
SHR: 100917007(MET)
PCW: 110202946(MET)
OAA: 100079345(MET)
GGA: 396134(MET)
MGP: 100544894(MET)
CJO: 107309125(MET)
NMEL: 110392601(MET)
APLA: 101801559(MET)
ACYG: 106042077(MET)
TGU: 100227998(MET)
LSR: 110477141(MET)
SCAN: 103813465(MET)
GFR: 102035281(MET)
FAB: 101822032(MET)
PHI: 102099870(MET)
PMAJ: 107204940(MET)
CCAE: 111931552(MET) 111943846
CCW: 104698290(MET)
ETL: 114062356(MET)
FPG: 101921590(MET)
FCH: 102046148(MET)
CLV: 102091194(MET)
EGZ: 104133409(MET)
NNI: 104013588(MET)
ACUN: 113491414(MET)
PADL: 103916977(MET)
AAM: 106488808(MET)
ASN: 102387009(MET)
AMJ: 102568767(MET)
PSS: 102447079(MET)
CMY: 102932026
CPIC: 101931256(MET)
ACS: 100561443(met)
PVT: 110077032(MET)
PBI: 103067929(MET)
PMUR: 107285371(MET)
TSR: 106557423(MET)
PMUA: 114605269(MET)
GJA: 107114504(MET)
XLA: 108712362(met.S) 373551(met.L)
XTR: 100485823(met)
NPR: 108788984(MET)
DRE: 100150664(met)
SRX: 107716667
IPU: 108268944(met)
PHYP: 113546663(met)
AMEX: 103023930
EEE: 113581523(met) 113584980
TRU: 100137507(met)
LCO: 104931751(met)
MZE: 101465566(met)
ONL: 100709985(met)
OLA: 101174570(met)
XMA: 102219516(met)
XCO: 114142761(met)
PRET: 103465633(met)
CVG: 107083224(met)
NFU: 107388350(met)
ALIM: 106511318 106518848(met)
AOCE: 111572785(met)
CSEM: 103379587(met)
POV: 109624638(met)
LCF: 108893984(met)
SDU: 111220524(met)
SLAL: 111672169(met)
HCQ: 109530899(met)
BPEC: 110155115(met)
MALB: 109956390(met)
ELS: 105029522(met)
PKI: 111836018 111842454(met)
LCM: 102366006(MET)
CMK: 103179355(met)
CIN: 445767
SPU: 589012
APLC: 110983946
SKO: 100366742
TUT: 107359841
DPTE: 113794711
CSCU: 111618069
PTEP: 107436100
CEL: CELE_T14E8.1(svh-2)
CBR: CBG10839
BMY: Bm1_37575
OBI: 106879211
 » show all
Reference
PMID:2819873
  Authors
Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G
  Title
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
  Journal
Proc Natl Acad Sci U S A 84:6379-83 (1987)
DOI:10.1073/pnas.84.18.6379
  Sequence
[hsa:4233]
LinkDB

DBGET integrated database retrieval system