KEGG   ORTHOLOGY: K04365
Entry
K04365                      KO                                     

Name
BRAF
Definition
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04214  Apoptosis - fly
ko04270  Vascular smooth muscle contraction
ko04320  Dorso-ventral axis formation
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00032  Thyroid cancer
H00038  Melanoma
H00523  Noonan syndrome and related disorders
H01512  Langerhans cell histiocytosis
H01738  Noonan syndrome
H01745  Cardiofaciocutaneous syndrome
H01984  Leopard syndrome
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04013 MAPK signaling pathway - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05216 Thyroid cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase
Genes
HSA: 673(BRAF)
PTR: 463781(BRAF)
PPS: 100971666(BRAF)
GGO: 101145098(BRAF)
PON: 100442288(BRAF)
NLE: 100582848(BRAF)
MCC: 693554(BRAF)
MCF: 101866436(BRAF)
CSAB: 103227022(BRAF)
RRO: 104659700(BRAF)
RBB: 108541537(BRAF)
CJC: 100403091(BRAF)
SBQ: 101052142(BRAF)
MMU: 109880(Braf)
MCAL: 110295945(Braf)
MPAH: 110316269(Braf)
RNO: 114486(Braf)
MUN: 110545779(Braf)
CGE: 100771486(Braf)
NGI: 103726107(Braf)
HGL: 101702762(Braf)
OCU: 100351964(BRAF)
TUP: 102477389(BRAF)
CFA: 475526(BRAF)
VVP: 112907060(BRAF)
AML: 100469346(BRAF)
UMR: 103669103(BRAF)
UAH: 113265167(BRAF)
ORO: 101377465(BRAF)
ELK: 111151941
FCA: 101092346(BRAF)
PTG: 102951082(BRAF)
PPAD: 109269114(BRAF)
AJU: 106970441(BRAF)
BTA: 536051(BRAF)
BOM: 102278631(BRAF)
BIU: 109557698(BRAF)
BBUB: 102401079(BRAF)
CHX: 102174360(BRAF)
OAS: 101107438(BRAF)
SSC: 100514612(BRAF)
CFR: 102524100(BRAF)
CDK: 105091663(BRAF)
BACU: 103002372(BRAF)
LVE: 103079256(BRAF)
OOR: 101277195(BRAF)
DLE: 111177653(BRAF)
PCAD: 102986916(BRAF)
ECB: 100065760(BRAF)
EPZ: 103555338(BRAF)
EAI: 106842618(BRAF)
MYB: 102260644(BRAF)
MYD: 102760422(BRAF)
MNA: 107531103(BRAF)
HAI: 109395605(BRAF)
DRO: 112299790(BRAF)
PALE: 102878393(BRAF)
RAY: 107504052(BRAF)
MJV: 108387830(BRAF)
LAV: 100664119(BRAF)
TMU: 101353421
MDO: 100024057(BRAF)
SHR: 100934801(BRAF)
PCW: 110216339(BRAF)
OAA: 100086380(BRAF)
GGA: 396239(BRAF)
MGP: 100550268
CJO: 107315883(BRAF)
NMEL: 110394457(BRAF)
APLA: 101794380(BRAF)
ACYG: 106030997(BRAF)
TGU: 100219601(BRAF)
LSR: 110482598(BRAF)
SCAN: 103819614(BRAF)
GFR: 102032961(BRAF)
FAB: 101806469(BRAF)
PHI: 102104959(BRAF)
PMAJ: 107204658(BRAF)
CCAE: 111936843(BRAF)
CCW: 104696191(BRAF)
ETL: 114056183(BRAF)
FPG: 101919653(BRAF)
FCH: 102056938(BRAF)
CLV: 102088487(BRAF)
EGZ: 104135588(BRAF)
NNI: 104012385(BRAF)
ACUN: 113475894(BRAF)
PADL: 103924405(BRAF)
AAM: 106488842(BRAF)
ASN: 102380007(BRAF)
AMJ: 106737102(BRAF)
PSS: 102448997(BRAF)
CMY: 102938595(BRAF)
CPIC: 101945568(BRAF)
ACS: 100556317(braf)
PVT: 110082693(BRAF)
PBI: 103054585(BRAF)
PMUR: 107288626(BRAF)
TSR: 106550529(BRAF)
PMUA: 114604938(BRAF)
GJA: 107108795(BRAF)
XLA: 398973(braf.S) 447268(braf.L)
XTR: 779570(braf)
NPR: 108793029(BRAF)
DRE: 403065(braf)
SANH: 107655608 107694295(braf)
SGH: 107560707 107594271(braf)
IPU: 108279928(braf)
PHYP: 113532073(braf)
AMEX: 103036930(braf)
EEE: 113572532(braf)
TRU: 653021(braf)
LCO: 104938610(braf)
NCC: 104967463(braf)
MZE: 101476445(braf)
ONL: 100708231(braf)
OLA: 101155814(braf)
XMA: 102231368(braf)
XCO: 114161014(braf)
PRET: 103459555(braf)
CVG: 107098826(braf)
NFU: 107381355(braf)
KMR: 108241884(braf)
ALIM: 106527181(braf)
AOCE: 111573494(braf)
CSEM: 103383021(braf)
POV: 109637498(braf)
LCF: 108897545(braf)
SDU: 111224636(braf)
SLAL: 111664218(braf)
HCQ: 109513640(braf)
BPEC: 110162539(braf)
MALB: 109964703(braf)
ELS: 105006078(braf)
SFM: 108936526(braf)
PKI: 111836730(braf)
LCM: 102365161(BRAF)
CMK: 103181856(braf)
RTP: 109917885(braf)
BFO: 118416519
CIN: 778741(raf1)
SPU: 575613
APLC: 110986911
SKO: 100370381
DME: Dmel_CG2845(Raf)
DER: 6555595
DSE: 6616144
DSI: Dsimw501_GD16607(Dsim_phl)
DAN: 6504877
DSR: 110179440
DPE: 6600090
DMN: 108155566
DWI: 6648391
DAZ: 108619185
DNV: 108656664
DHE: 111602415
DVI: 6633354
MDE: 101891362
LCQ: 111691044
AAG: 5579530
AALB: 109418642
AME: 413448
BIM: 100741263
BTER: 100645437
CCAL: 108628617
OBB: 114877595
SOC: 105202082
MPHA: 105840022
AEC: 105146178
ACEP: 105623044
VEM: 105562489
HST: 105192683
DQU: 106748587
CFO: 105253402
LHU: 105678021
PGC: 109860595
OBO: 105277811
PCF: 106786260
NVI: 100121496
CSOL: 105368960
MDL: 103572940
TCA: 655334(raf)
DPA: 109543674
NVL: 108559414
BMOR: 100529216(raf)
BMAN: 114242624
PMAC: 106708128
PRAP: 110991813
HAW: 110374645
TNL: 113493668
PXY: 105394443
API: 100169206
DNX: 107170145
AGS: 114130019
RMD: 113549510
BTAB: 109030122
CLEC: 106668148
ZNE: 110836363
FCD: 110858255
TUT: 107365833
CSCU: 111640304
PTEP: 107445892
CEL: CELE_Y73B6A.5(lin-45)
CBR: CBG05382(Cbr-lin-45)
BMY: Bm1_40290
TSP: Tsp_05804
PCAN: 112564136
CRG: 105321795
OBI: 106874195
LAK: 106171322
SHX: MS3_01526
EGL: EGR_04277
NVE: 5519181
EPA: 110238451
ADF: 107343857
AMIL: 114976018
PDAM: 113668705
SPIS: 111334882
DGT: 114538412
HMG: 100201878
AQU: 100640705
SMIN: v1.2.019335.t1(symbB.v1.2.019335.t1)
 » show all
Reference
PMID:2284096
  Authors
Sithanandam G, Kolch W, Duh FM, Rapp UR
  Title
Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
  Journal
Oncogene 5:1775-80 (1990)
  Sequence
[hsa:673]
Reference
  Authors
Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D
  Title
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
  Journal
Nature 472:366-9 (2011)
DOI:10.1038/nature09860
  Sequence
[hsa:673]
LinkDB

KEGG   ORTHOLOGY: K04366
Entry
K04366                      KO                                     

Name
RAF1
Definition
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04218  Cellular senescence
ko04270  Vascular smooth muscle contraction
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04929  GnRH secretion
ko04935  Growth hormone synthesis, secretion and action
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05034  Alcoholism
ko05132  Salmonella infection
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04014 Ras signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04371 Apelin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04630 JAK-STAT signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04072 Phospholipase D signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04071 Sphingolipid signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04022 cGMP-PKG signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09143 Cell growth and death
   04210 Apoptosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04218 Cellular senescence
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04540 Gap junction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04550 Signaling pathways regulating pluripotency of stem cells
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04650 Natural killer cell mediated cytotoxicity
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04929 GnRH secretion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04912 GnRH signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04921 Oxytocin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04926 Relaxin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04935 Growth hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04916 Melanogenesis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09158 Development and regeneration
   04360 Axon guidance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05206 MicroRNAs in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05230 Central carbon metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05231 Choline metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05152 Tuberculosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05161 Hepatitis B
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05164 Influenza A
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05163 Human cytomegalovirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05165 Human papillomavirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Genes
HSA: 5894(RAF1)
PTR: 460182(RAF1)
PPS: 100972902(RAF1)
GGO: 101136454(RAF1)
PON: 100173732(RAF1)
NLE: 100582599(RAF1)
MCC: 694725(RAF1)
MCF: 102125312(RAF1)
CSAB: 103228031(RAF1)
RRO: 104673299(RAF1)
RBB: 108517986(RAF1)
CJC: 100415300(RAF1)
SBQ: 101054052(RAF1)
MMU: 110157(Raf1)
MCAL: 110296919(Raf1)
MPAH: 110314893(Raf1)
RNO: 24703(Raf1)
MUN: 110550814(Raf1)
CGE: 100769018(Raf1)
NGI: 103751450(Raf1)
HGL: 101721841(Raf1)
CCAN: 109694940(Raf1)
OCU: 100347407(RAF1)
TUP: 102497488(RAF1)
CFA: 484648(RAF1)
VVP: 112933694(RAF1)
AML: 100482255(RAF1)
UMR: 103669540(RAF1)
UAH: 113257190(RAF1)
ORO: 101372149(RAF1)
ELK: 111144322
FCA: 101096047(RAF1)
PTG: 102955852(RAF1)
PPAD: 109257492(RAF1)
AJU: 106977129(RAF1)
BTA: 521196(RAF1)
BOM: 102288216(RAF1)
BIU: 109576053(RAF1)
BBUB: 102412922(RAF1)
CHX: 108638619(RAF1)
OAS: 101103190(RAF1)
SSC: 100737448(RAF1)
CFR: 102517521(RAF1)
CDK: 105093099(RAF1)
BACU: 103014337(RAF1)
LVE: 103087933(RAF1)
OOR: 101272984(RAF1)
DLE: 111168973(RAF1)
PCAD: 102987866(RAF1)
ECB: 100051110(RAF1)
EPZ: 103554541(RAF1)
EAI: 106829345(RAF1)
MYB: 102254003(RAF1)
MYD: 102772748(RAF1)
MNA: 107534729(RAF1)
HAI: 109384548(RAF1)
DRO: 112301126(RAF1)
PALE: 102893439(RAF1)
RAY: 107519729(RAF1)
MJV: 108394341(RAF1)
LAV: 100655727(RAF1)
TMU: 101357840
MDO: 100015410(RAF1)
SHR: 100935202(RAF1)
PCW: 110204892(RAF1)
OAA: 100089456(RAF1)
GGA: 396245(RAF1)
MGP: 100541264(RAF1)
CJO: 107319673(RAF1)
NMEL: 110404723(RAF1)
APLA: 101795633(RAF1)
ACYG: 106040056(RAF1)
TGU: 100218264(RAF1)
LSR: 110470647(RAF1)
SCAN: 103816934(RAF1)
GFR: 102034977(RAF1)
FAB: 101816261(RAF1)
PHI: 102103825(RAF1)
PMAJ: 107210130(RAF1)
CCAE: 111935240(RAF1)
CCW: 104695743(RAF1)
ETL: 114059216(RAF1)
FPG: 101911761(RAF1)
FCH: 102051503(RAF1)
CLV: 102096788(RAF1)
EGZ: 104124306(RAF1)
NNI: 104022929(RAF1)
ACUN: 113484728(RAF1)
PADL: 103915210(RAF1)
AAM: 106488826(RAF1)
ASN: 102374398(RAF1)
AMJ: 102576986(RAF1)
PSS: 102458748(RAF1)
CMY: 102929883(RAF1)
CPIC: 101933019(RAF1)
ACS: 100557613(raf1)
PVT: 110083799(RAF1)
PBI: 103054563(RAF1)
PMUR: 107295520
TSR: 106541257 106542299(RAF1)
PMUA: 114591641(RAF1)
GJA: 107118023(RAF1)
XLA: 397857(raf1.S)
XTR: 549871(raf1)
NPR: 108787573
DRE: 30716(raf1a) 557109(raf1b)
IPU: 108255012(raf1) 108276324(RAF1)
PHYP: 113537867(raf1) 113545603
TRU: 654310(raf1)
LCO: 104940217(raf1)
NCC: 104958741(raf1)
MZE: 101470685(raf1)
ONL: 100709219(raf1)
OLA: 101173784(raf1)
XMA: 102234445(raf1)
XCO: 114140577(raf1)
PRET: 103467582(raf1)
CVG: 107088168(raf1)
NFU: 107391092(raf1)
KMR: 108232050(raf1)
ALIM: 106519055(raf1)
AOCE: 111588716(raf1)
CSEM: 103385533(raf1)
POV: 109635227(raf1)
LCF: 108900163(raf1)
SDU: 111217320(raf1)
SLAL: 111672203(raf1)
HCQ: 109507267(raf1)
BPEC: 110164922(raf1)
MALB: 109966113(raf1)
SASA: 100136351(raf1) 106566757(RAF1a) 106571905(RAF1b)
ELS: 105013076(raf1) 105029139
SFM: 108925552 108929807(raf1)
PKI: 111837477(raf1) 111840300
LCM: 102357545(RAF1)
CMK: 103185022(raf1)
RTP: 109911534(raf1)
 » show all
Reference
PMID:3003687
  Authors
Bonner TI, Oppermann H, Seeburg P, Kerby SB, Gunnell MA, Young AC, Rapp UR
  Title
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.
  Journal
Nucleic Acids Res 14:1009-15 (1986)
DOI:10.1093/nar/14.2.1009
  Sequence
[hsa:5894]
Reference
  Authors
Chen J, Fujii K, Zhang L, Roberts T, Fu H
  Title
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
  Journal
Proc Natl Acad Sci U S A 98:7783-8 (2001)
DOI:10.1073/pnas.141224398
LinkDB

KEGG   ORTHOLOGY: K08845
Entry
K08845                      KO                                     

Name
ARAF, ARAF1
Definition
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04068  FoxO signaling pathway
ko04270  Vascular smooth muscle contraction
ko04650  Natural killer cell mediated cytotoxicity
ko04720  Long-term potentiation
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04928  Parathyroid hormone synthesis, secretion and action
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00523  Noonan syndrome and related disorders
H01738  Noonan syndrome
H02425  Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05161 Hepatitis B
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Genes
HSA: 369(ARAF)
PTR: 100614256(ARAF)
PPS: 100990590(ARAF)
GGO: 101134493(ARAF)
PON: 100431871(ARAF)
NLE: 100595311(ARAF)
MCC: 707169(ARAF)
MCF: 101925249(ARAF)
CSAB: 103231895(ARAF)
RRO: 104664593(ARAF)
RBB: 108530908(ARAF)
CJC: 100387961(ARAF)
SBQ: 101043605(ARAF)
MMU: 11836(Araf)
MCAL: 110287540(Araf)
MPAH: 110314283(Araf)
RNO: 64363(Araf)
MUN: 110541705(Araf)
CGE: 100751432(Araf)
NGI: 103741627(Araf)
HGL: 101723157(Araf)
CCAN: 109696670(Araf)
OCU: 100340437(ARAF)
TUP: 102493239(ARAF)
CFA: 491857(ARAF)
VVP: 112907269(ARAF)
AML: 100475955(ARAF)
UAH: 113265980(ARAF)
ORO: 101372839(ARAF)
ELK: 111150582
FCA: 101089839(ARAF)
PTG: 102956086(ARAF)
PPAD: 109248156(ARAF)
AJU: 106972677(ARAF)
BTA: 540421(ARAF)
BOM: 102285079(ARAF)
BIU: 109555027(ARAF)
BBUB: 102392863(ARAF)
CHX: 102169370(ARAF)
OAS: 100305131(ARAF)
SSC: 397601(ARAF)
CFR: 102506774(ARAF)
CDK: 105102848(ARAF)
BACU: 103020975(ARAF)
LVE: 103090018(ARAF)
OOR: 101271966(ARAF)
DLE: 111165554(ARAF)
PCAD: 102974274(ARAF)
ECB: 100061212(ARAF)
EAI: 106847984(ARAF)
MYB: 102241454(ARAF)
MYD: 102755690(ARAF)
MNA: 107541381(ARAF)
HAI: 109376563(ARAF)
DRO: 112322484(ARAF)
PALE: 102877877(ARAF)
RAY: 107509353(ARAF)
MJV: 108398550(ARAF)
LAV: 100671404(ARAF)
TMU: 101351589
MDO: 100017615(ARAF)
SHR: 100913901(ARAF)
PCW: 110201017(ARAF)
OAA: 100084423(ARAF)
CPIC: 101949192(ARAF)
ACS: 100562070(araf)
PVT: 110081172(ARAF)
PBI: 103066155(ARAF)
PMUR: 107297295(ARAF)
TSR: 106553001
PMUA: 114587447(ARAF)
GJA: 107119310(ARAF) 107120717
XLA: 398892(araf.L) 399056(araf.S)
XTR: 100495479(araf)
NPR: 108801347(ARAF)
DRE: 403063(araf)
IPU: 108255753
PHYP: 113542410
AMEX: 103043654(araf)
EEE: 113588109(araf)
TRU: 654307(araf)
LCO: 104930864
NCC: 104953267
MZE: 101471760
ONL: 100698373
OLA: 101159594(araf)
XMA: 102235904
XCO: 114154407
PRET: 103469576
CVG: 107104990
NFU: 107393473(araf)
KMR: 108249882
ALIM: 106533959(araf)
AOCE: 111568015
POV: 109633665
LCF: 108878154(araf)
SDU: 111227828
SLAL: 111647945
HCQ: 109510536
BPEC: 110162179
MALB: 109959639
ELS: 105014388(araf)
SFM: 108931249(araf)
PKI: 111844715(araf)
LCM: 102351967
RTP: 109925193
 » show all
Reference
PMID:8020955
  Authors
Lee JE, Beck TW, Brennscheidt U, DeGennaro LJ, Rapp UR
  Title
The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1).
  Journal
Genomics 20:43-55 (1994)
DOI:10.1006/geno.1994.1125
  Sequence
[hsa:369]
Reference
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)
DOI:10.1016/j.bbrc.2010.07.092
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