KEGG   ORTHOLOGY: K04366
Entry
K04366                      KO                                     

Symbol
RAF1
Name
RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04068  FoxO signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04218  Cellular senescence
map04270  Vascular smooth muscle contraction
map04360  Axon guidance
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04510  Focal adhesion
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04613  Neutrophil extracellular trap formation
map04625  C-type lectin receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04726  Serotonergic synapse
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04929  GnRH secretion
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05034  Alcoholism
map05132  Salmonella infection
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00294  Dilated cardiomyopathy
H01984  Leopard syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04012 ErbB signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04014 Ras signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04015 Rap1 signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04370 VEGF signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04371 Apelin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04630 JAK-STAT signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04072 Phospholipase D signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04071 Sphingolipid signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04024 cAMP signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04022 cGMP-PKG signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04151 PI3K-Akt signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04150 mTOR signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09143 Cell growth and death
   04210 Apoptosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04218 Cellular senescence
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04540 Gap junction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04550 Signaling pathways regulating pluripotency of stem cells
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04625 C-type lectin receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04650 Natural killer cell mediated cytotoxicity
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04660 T cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04662 B cell receptor signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04664 Fc epsilon RI signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04666 Fc gamma R-mediated phagocytosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04062 Chemokine signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04929 GnRH secretion
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04912 GnRH signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04915 Estrogen signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04917 Prolactin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04921 Oxytocin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04926 Relaxin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04935 Growth hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04919 Thyroid hormone signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04928 Parathyroid hormone synthesis, secretion and action
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04916 Melanogenesis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09156 Nervous system
   04726 Serotonergic synapse
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   04722 Neurotrophin signaling pathway
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09158 Development and regeneration
   04360 Axon guidance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05206 MicroRNAs in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05207 Chemical carcinogenesis - receptor activation
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05208 Chemical carcinogenesis - reactive oxygen species
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05230 Central carbon metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05231 Choline metabolism in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05225 Hepatocellular carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05226 Gastric cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05224 Breast cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05161 Hepatitis B
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05160 Hepatitis C
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05164 Influenza A
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05163 Human cytomegalovirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05165 Human papillomavirus infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05152 Tuberculosis
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   05022 Pathways of neurodegeneration - multiple diseases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09165 Substance dependence
   05034 Alcoholism
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
   01522 Endocrine resistance
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase
Genes
HSA: 5894(RAF1)
PTR: 460182(RAF1)
PPS: 100972902(RAF1)
GGO: 101136454(RAF1)
PON: 100173732(RAF1)
NLE: 100582599(RAF1)
MCC: 694725(RAF1)
MCF: 102125312(RAF1)
CSAB: 103228031(RAF1)
CATY: 105585803(RAF1)
PANU: 101009029(RAF1)
RRO: 104673299(RAF1)
RBB: 108517986(RAF1)
TFN: 117083269(RAF1) 117084479
PTEH: 111546904(RAF1)
CJC: 100415300(RAF1)
SBQ: 101054052(RAF1)
MMUR: 105882676(RAF1)
MMU: 110157(Raf1)
MCAL: 110296919(Raf1)
MPAH: 110314893(Raf1)
RNO: 24703(Raf1)
MCOC: 116099433(Raf1)
MUN: 110550814(Raf1)
CGE: 100769018(Raf1)
PLEU: 114689636(Raf1)
NGI: 103751450(Raf1)
HGL: 101721841(Raf1)
CCAN: 109694940(Raf1)
OCU: 100347407(RAF1)
TUP: 102497488(RAF1)
CFA: 484648(RAF1)
VVP: 112933694(RAF1)
VLG: 121494281(RAF1)
AML: 100482255(RAF1)
UMR: 103669540(RAF1)
UAH: 113257190(RAF1)
ORO: 101372149(RAF1)
ELK: 111144322
MPUF: 101690482(RAF1)
EJU: 114207692(RAF1)
MLX: 118005431(RAF1)
FCA: 101096047(RAF1)
PYU: 121041241(RAF1)
PBG: 122487521(RAF1)
PTG: 102955852(RAF1)
PPAD: 109257492(RAF1)
AJU: 106977129(RAF1)
HHV: 120231327(RAF1)
BTA: 521196(RAF1)
BOM: 102288216(RAF1)
BIU: 109576053(RAF1)
BBUB: 102412922(RAF1)
CHX: 108638619(RAF1)
OAS: 101103190(RAF1)
ODA: 120868108(RAF1)
CCAD: 122425059(RAF1)
SSC: 100737448(RAF1)
CFR: 102517521(RAF1)
CBAI: 105067475(RAF1)
CDK: 105093099(RAF1)
BACU: 103014337(RAF1)
LVE: 103087933(RAF1)
OOR: 101272984(RAF1)
DLE: 111168973(RAF1)
PCAD: 102987866(RAF1)
ECB: 100051110(RAF1)
EPZ: 103554541(RAF1)
EAI: 106829345(RAF1)
MYB: 102254003(RAF1)
MYD: 102772748(RAF1)
MMYO: 118668076(RAF1)
MNA: 107534729(RAF1)
HAI: 109384548(RAF1)
DRO: 112301126(RAF1)
SHON: 118990300(RAF1)
AJM: 119044815(RAF1)
MMF: 118633343(RAF1)
PALE: 102893439(RAF1)
PGIG: 120621476(RAF1)
RAY: 107519729(RAF1)
MJV: 108394341(RAF1)
TOD: 119255730(RAF1)
LAV: 100655727(RAF1)
TMU: 101357840
MDO: 100015410(RAF1)
SHR: 100935202(RAF1)
PCW: 110204892(RAF1)
OAA: 100089456(RAF1)
GGA: 396245(RAF1)
PCOC: 116238931(RAF1)
MGP: 100541264(RAF1)
CJO: 107319673(RAF1)
NMEL: 110404723(RAF1)
APLA: 101795633(RAF1)
ACYG: 106040056(RAF1)
TGU: 100218264(RAF1)
LSR: 110470647(RAF1)
SCAN: 103816934(RAF1)
PMOA: 120501778(RAF1)
OTC: 121348231(RAF1)
GFR: 102034977(RAF1)
FAB: 101816261(RAF1)
PHI: 102103825(RAF1)
PMAJ: 107210130(RAF1)
CCAE: 111935240(RAF1)
CCW: 104695743(RAF1)
ETL: 114059216(RAF1)
FPG: 101911761(RAF1)
FCH: 102051503(RAF1)
CLV: 102096788(RAF1)
EGZ: 104124306(RAF1)
NNI: 104022929(RAF1)
ACUN: 113484728(RAF1)
PADL: 103915210(RAF1)
AAM: 106488826(RAF1)
AROW: 112966394(RAF1)
NPD: 112953017(RAF1)
DNE: 112982840(RAF1)
ASN: 102374398(RAF1)
AMJ: 102576986(RAF1)
CPOO: 109311365(RAF1)
GGN: 109289142(RAF1)
PSS: 102458748(RAF1)
CMY: 102929883(RAF1)
CPIC: 101933019(RAF1)
TST: 117879804(RAF1)
CABI: 116820235(RAF1)
ACS: 100557613(raf1)
PVT: 110083799(RAF1)
PBI: 103054563(RAF1)
PMUR: 107295520
TSR: 106541257 106542299(RAF1)
PGUT: 117677681(RAF1)
PMUA: 114591641(RAF1)
ZVI: 118080671(RAF1)
GJA: 107118023(RAF1)
XLA: 397857(raf1.S)
XTR: 549871(raf1)
NPR: 108787573
DRE: 30716(raf1a) 557109(raf1b)
CAUA: 113054940(raf1) 113068641
IPU: 108255012(raf1) 108276324(RAF1)
PHYP: 113537867(raf1) 113545603
TRU: 654310(raf1)
LCO: 104940217(raf1)
NCC: 104958741(raf1)
CGOB: 115010471
ELY: 117258233(raf1a)
PLEP: 121946649(raf1a)
SLUC: 116062082(raf1a)
ECRA: 117947286(raf1a)
PFLV: 114559447(raf1)
GAT: 120829430(raf1a)
MSAM: 119905315(raf1a)
CUD: 121517411(raf1a)
MZE: 101470685(raf1)
ONL: 100709219(raf1)
OAU: 116331070(raf1a)
OLA: 101173784(raf1)
OML: 112159520(raf1a)
XMA: 102234445(raf1)
XCO: 114140577(raf1)
XHE: 116719889(raf1)
PRET: 103467582(raf1)
CVG: 107088168(raf1)
CTUL: 119781396(raf1a)
NFU: 107391092(raf1)
KMR: 108232050(raf1a)
ALIM: 106519055(raf1)
AOCE: 111588716(raf1)
CSEM: 103385533(raf1)
POV: 109635227(raf1)
LCF: 108900163(raf1)
SDU: 111217320(raf1)
SLAL: 111672203(raf1)
XGL: 120803375(raf1a)
HCQ: 109507267(raf1)
BPEC: 110164922(raf1)
MALB: 109966113(raf1)
SASA: 100136351(raf1) 106566757(RAF1a) 106571905(RAF1b)
OMY: 110492413 110531995(raf1a)
SNH: 120059498(raf1a) 120061320
ELS: 105013076(raf1) 105029139
SFM: 108925552 108929807(raf1)
PKI: 111837477(raf1) 111840300
AANG: 118210668(raf1b)
LOC: 102692545(raf1)
LCM: 102357545(RAF1)
CMK: 103185022(raf1)
RTP: 109911534(raf1)
 » show all
Reference
PMID:3003687
  Authors
Bonner TI, Oppermann H, Seeburg P, Kerby SB, Gunnell MA, Young AC, Rapp UR
  Title
The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.
  Journal
Nucleic Acids Res 14:1009-15 (1986)
DOI:10.1093/nar/14.2.1009
  Sequence
[hsa:5894]
Reference
  Authors
Chen J, Fujii K, Zhang L, Roberts T, Fu H
  Title
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.
  Journal
Proc Natl Acad Sci U S A 98:7783-8 (2001)
DOI:10.1073/pnas.141224398
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