KEGG   ORTHOLOGY: K04380
Entry
K04380                      KO                                     

Name
MAPT, TAU
Definition
microtubule-associated protein tau
Pathway
ko04010  MAPK signaling pathway
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
Disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00077  Progressive supranuclear palsy
H00078  Frontotemporal lobar degeneration
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04380  MAPT, TAU; microtubule-associated protein tau
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04380  MAPT, TAU; microtubule-associated protein tau
   05012 Parkinson disease
    K04380  MAPT, TAU; microtubule-associated protein tau
   05022 Pathways of neurodegeneration - multiple diseases
    K04380  MAPT, TAU; microtubule-associated protein tau
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04380  MAPT, TAU; microtubule-associated protein tau
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04380  MAPT, TAU; microtubule-associated protein tau
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K04380  MAPT, TAU; microtubule-associated protein tau
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K04380  MAPT, TAU; microtubule-associated protein tau
Membrane trafficking [BR:ko04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    K04380  MAPT, TAU; microtubule-associated protein tau
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     K04380  MAPT, TAU; microtubule-associated protein tau
Genes
HSA: 4137(MAPT)
PTR: 450177(MAPT)
PPS: 100987023(MAPT)
GGO: 101142624(MAPT)
PON: 100432958(MAPT)
NLE: 100601409(MAPT)
MCC: 574327(MAPT) 712421
MCF: 102119414(MAPT) 102119722
CSAB: 103243264(MAPT)
RRO: 104682393(MAPT)
RBB: 108529371(MAPT)
CJC: 100403309(MAPT)
SBQ: 101029753(MAPT)
MMU: 17762(Mapt)
MCAL: 110304807(Mapt)
MPAH: 110331493(Mapt)
RNO: 29477(Mapt)
MUN: 110545637(Mapt)
CGE: 100765120
NGI: 103724766(Mapt)
HGL: 101719489(Mapt)
CCAN: 109684813(Mapt)
OCU: 100344003(MAPT)
TUP: 102487338(MAPT)
CFA: 480488(MAPT)
VVP: 112920687(MAPT)
AML: 100476507(MAPT)
UAH: 113265313(MAPT)
ORO: 101371518(MAPT)
ELK: 111158157
FCA: 101089557(MAPT)
PTG: 102967519(MAPT)
PPAD: 109259745(MAPT)
AJU: 106988843(MAPT)
BTA: 281296(MAPT)
BOM: 102270620(MAPT)
BIU: 109573661(MAPT)
BBUB: 102415365(MAPT)
CHX: 100860820(MAPT)
OAS: 101121024(MAPT)
SSC: 100738351(MAPT)
CFR: 102508974(MAPT)
CDK: 105090432(MAPT)
BACU: 103009499(MAPT)
LVE: 103090402(MAPT)
OOR: 101276955(MAPT)
DLE: 111182584(MAPT)
PCAD: 102996376(MAPT)
ECB: 100054638(MAPT)
EPZ: 103552915(MAPT)
EAI: 106836496(MAPT)
MYB: 102260052(MAPT)
MYD: 102757836(MAPT)
MNA: 107530997(MAPT)
HAI: 109380299(MAPT)
DRO: 112316173(MAPT)
PALE: 102878980(MAPT)
RAY: 107508176(MAPT)
MJV: 108398647(MAPT)
LAV: 100663624(MAPT)
TMU: 101360746
MDO: 100025077(MAPT) 100620008
SHR: 100920214(MAPT)
PCW: 110215713(MAPT)
OAA: 100088033(MAPT)
GGA: 426737(MAPT)
MGP: 100545041
CJO: 107325179(MAPT)
NMEL: 110388458(MAPT)
APLA: 101803342(MAPT)
ACYG: 106045980(MAPT)
TGU: 100225617(MAPT)
LSR: 110474819(MAPT)
SCAN: 103821801(MAPT)
GFR: 102033466
FAB: 101818271(MAPT)
PHI: 102103099(MAPT)
PMAJ: 107215247(MAPT)
CCAE: 111940054(MAPT)
CCW: 104698638(MAPT)
ETL: 114071148(MAPT)
FPG: 101924165(MAPT)
FCH: 102046942(MAPT)
CLV: 102098028(MAPT)
EGZ: 104127025(MAPT)
NNI: 104012255(MAPT)
ACUN: 113489247(MAPT)
PADL: 103913879(MAPT)
AAM: 106497424(MAPT)
ASN: 102385004(MAPT)
AMJ: 102570040(MAPT)
PSS: 102450787(MAPT)
CMY: 102932440
CPIC: 101932261(MAPT)
ACS: 100563934(mapt)
PVT: 110082048
PBI: 103060127(MAPT)
PMUR: 107303054(MAPT)
TSR: 106545992(MAPT)
PMUA: 114582250(MAPT)
GJA: 107109638
XLA: 100158413 398307(mapt.S)
XTR: 779920(mapt)
NPR: 108802437
DRE: 100000342(mapta) 567833(maptb)
PHYP: 113527224(mapt) 113543880
TRU: 101068735(mapt)
NCC: 104957078(mapt)
OLA: 101160113
CSEM: 103381620
POV: 109647001
HCQ: 109518637
BPEC: 110154182
ELS: 105006079(mapt) 105023364
PKI: 111856785(mapt)
LCM: 102357089
CMK: 103190781
CIN: 100185955
APLC: 110974521
SKO: 100313749
DME: Dmel_CG45110(tau)
DER: 6554507
DSI: Dsimw501_GD18068(Dsim_GD18068)
DSR: 110177330
DPE: 6595118
DMN: 108156648
DWI: 6647209
DAZ: 108613951
DNV: 108649535
DHE: 111603504
MDE: 101897808
LCQ: 111681975
AAG: 5580230
AME: 409539
BIM: 100743933
CCAL: 108631889
OBB: 114883092
SOC: 105201483
MPHA: 105835904
AEC: 105145912
ACEP: 105622006
PBAR: 105429082
VEM: 105565285
DQU: 106741548
LHU: 105671692
PGC: 109863841
OBO: 105284372
PCF: 106785461
NVI: 100117754
CSOL: 105366194
MDL: 103570449
TCA: 663860
DPA: 109546271
ATD: 109602690
NVL: 108564225
BMOR: 100302034(Tau)
BMAN: 114239534
PMAC: 106718613
PRAP: 111001631
HAW: 110379486
TNL: 113496440
PXY: 105383857
API: 100160462
DNX: 107166375
AGS: 114127442
RMD: 113548925
BTAB: 109033820
CLEC: 106672236
FCD: 110842710
PVM: 113824507
TUT: 107372018
CSCU: 111612508
PTEP: 107449327
CBR: CBG15240(Cbr-ptl-1)
CRG: 109617376
OBI: 106878541
LAK: 106167730
SHX: MS3_01945
 » show all
Reference
PMID:3131773
  Authors
Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A
  Title
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
  Journal
Proc Natl Acad Sci U S A 85:4051-5 (1988)
DOI:10.1073/pnas.85.11.4051
  Sequence
[hsa:4137]
Reference
  Authors
Yoshida H, Goedert M
  Title
Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.
  Journal
J Neurochem 120:165-76 (2012)
DOI:10.1111/j.1471-4159.2011.07523.x
  Sequence
[hsa:4137]
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