KEGG   ORTHOLOGY: K04388Help
Entry
K04388                      KO                                     

Name
TGFBR2
Definition
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05161 Hepatitis B
    K04388  TGFBR2; TGF-beta receptor type-2
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
BRITE hierarchy
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
MCC: 703088(TGFBR2)
MCF: 102134273(TGFBR2)
CSAB: 103241808(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
MMU: 21813(Tgfbr2)
MCAL: 110301725(Tgfbr2)
MPAH: 110327573(Tgfbr2)
RNO: 81810(Tgfbr2)
MUN: 110547249(Tgfbr2)
CGE: 100773953(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CCAN: 109681522(Tgfbr2)
OCU: 100344335(TGFBR2)
TUP: 102486518(TGFBR2)
CFA: 477039(TGFBR2)
VVP: 112921591(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
UAH: 113253847(TGFBR2)
ORO: 101364575(TGFBR2)
FCA: 101091725(TGFBR2)
PTG: 102958413(TGFBR2)
PPAD: 109251365(TGFBR2)
AJU: 106984570(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
BBUB: 102415303(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CDK: 105087202(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
DLE: 111164342(TGFBR2)
PCAD: 102995949(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103566847 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
MNA: 107526381(TGFBR2)
HAI: 109394441(TGFBR2)
DRO: 112309970(TGFBR2)
PALE: 102889618(TGFBR2)
RAY: 107508791(TGFBR2)
MJV: 108391859(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
MDO: 100031897(TGFBR2)
SHR: 100913352(TGFBR2)
PCW: 110212998(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
NMEL: 110393465(TGFBR2) 110399236
APLA: 101794795(TGFBR2) 101801641
TGU: 100220619(TGFBR2) 100224677
LSR: 110468201(TGFBR2) 110468281
SCAN: 103813156(TGFBR2) 103814641
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCAE: 111923501(TGFBR2) 111932269
CCW: 104689295(TGFBR2) 104694032
ETL: 114064578(TGFBR2) 114067323
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
NNI: 104013882(TGFBR2) 104020241
ACUN: 113477102(TGFBR2) 113482298
PADL: 103917105(TGFBR2) 103919595
AAM: 106491249(TGFBR2) 106498480
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
PSS: 102444710(TGFBR2) 102457599
CMY: 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
PBI: 103057562(TGFBR2) 103063579
PMUR: 107284378(TGFBR2) 107290268
TSR: 106543204 106547952(TGFBR2)
PMUA: 114604090 114607243(TGFBR2)
XLA: 108702885 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2.2.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
LCO: 104922506(tgfbr2) 104923102
OLA: 101170689(tgfbr2) 101174785
PRET: 103465886(tgfbr2) 103472661
CVG: 107086189(tgfbr2) 107098322
HCQ: 109516370(tgfbr2) 109530278
SFM: 108918826 108935840(tgfbr2)
PKI: 111857200 111857846(tgfbr2)
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2) 103188937
CIN: 778778(tgfbr-iib)
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]
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