KEGG   ORTHOLOGY: K04398
Entry
K04398                      KO                                     

Name
CASP8
Definition
caspase 8 [EC:3.4.22.61]
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05016  Huntington disease
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05134  Legionellosis
ko05142  Chagas disease
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05416  Viral myocarditis
Disease
H00108  Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K04398  CASP8; caspase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04214 Apoptosis - fly
    K04398  CASP8; caspase 8
   04215 Apoptosis - multiple species
    K04398  CASP8; caspase 8
   04217 Necroptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04624 Toll and Imd signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04625 C-type lectin receptor signaling pathway
    K04398  CASP8; caspase 8
   04657 IL-17 signaling pathway
    K04398  CASP8; caspase 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04398  CASP8; caspase 8
   05016 Huntington disease
    K04398  CASP8; caspase 8
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04398  CASP8; caspase 8
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04398  CASP8; caspase 8
   05132 Salmonella infection
    K04398  CASP8; caspase 8
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04398  CASP8; caspase 8
   05162 Measles
    K04398  CASP8; caspase 8
   05164 Influenza A
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05160 Hepatitis C
    K04398  CASP8; caspase 8
   05168 Herpes simplex virus 1 infection
    K04398  CASP8; caspase 8
   05163 Human cytomegalovirus infection
    K04398  CASP8; caspase 8
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04398  CASP8; caspase 8
   05169 Epstein-Barr virus infection
    K04398  CASP8; caspase 8
   05165 Human papillomavirus infection
    K04398  CASP8; caspase 8
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease
    K04398  CASP8; caspase 8
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04398  CASP8; caspase 8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8
Other DBs
GO: 0097199
Genes
HSA: 841(CASP8)
PTR: 746477(CASP8)
PPS: 100978497(CASP8)
GGO: 101138898(CASP8)
PON: 100172115(CASP8)
NLE: 100586183(CASP8)
MCC: 702781(CASP8)
MCF: 101865354(CASP8)
CSAB: 103217637(CASP8)
RRO: 104671864(CASP8)
RBB: 108532002(CASP8)
CJC: 100395220(CASP8)
SBQ: 101053601(CASP8)
MMU: 12370(Casp8)
MCAL: 110291975(Casp8)
MPAH: 110321675(Casp8)
RNO: 64044(Casp8)
MUN: 110557662(Casp8)
CGE: 100689369(Casp8)
NGI: 103738672(Casp8)
HGL: 101702773(Casp8)
CCAN: 109689613(Casp8)
OCU: 100348477(CASP8)
TUP: 102498355(CASP8)
CFA: 488473(CASP8)
VVP: 112922873(CASP8)
AML: 100472842(CASP8)
UMR: 103659742(CASP8)
UAH: 113250592(CASP8)
ORO: 101365855(CASP8)
ELK: 111141026
FCA: 100142684(CASP8)
PTG: 102962460(CASP8)
PPAD: 109260762(CASP8)
AJU: 106987995(CASP8)
BTA: 507481(CASP8)
BOM: 102272602(CASP8)
BIU: 109569521(CASP8)
BBUB: 102412929(CASP8)
CHX: 102169919(CASP8)
OAS: 101107334(CASP8)
SSC: 595105(CASP8)
CFR: 102508224(CASP8)
CDK: 105099181(CASP8)
BACU: 103004642(CASP8)
LVE: 103077054(CASP8)
OOR: 101281780(CASP8)
DLE: 111171726(CASP8)
PCAD: 102988082(CASP8)
ECB: 100066502(CASP8)
EPZ: 103565685(CASP8)
EAI: 106823493(CASP8)
MYB: 102246377(CASP8)
MYD: 102761550(CASP8)
MNA: 107533931(CASP8)
HAI: 109379228(CASP8)
DRO: 112307787(CASP8)
PALE: 102878181(CASP8)
RAY: 107503155(CASP8)
MJV: 108398898(CASP8)
LAV: 100660542(CASP8) 100663575
TMU: 101344302
MDO: 100017025(CASP18) 100617599(CASP8)
SHR: 100931580(CASP8)
PCW: 110197193(CASP8)
OAA: 100082949 100087835
GGA: 395284(CASP8) 693266(CASP18)
MGP: 100541513 100541666
CJO: 107316523 107316524
NMEL: 110399293 110400694
APLA: 101803161(CASP8) 106014283
ACYG: 106040002 106040004
TGU: 100222284 100223333
LSR: 110484576(CASP8) 110484625
SCAN: 103814506 103814507(CASP8)
GFR: 102044546 102044717
FAB: 101814031 101815602
PHI: 102110759
CCAE: 111931990
CCW: 104693779
ETL: 114055714 114055715
FPG: 101916968(CASP8) 106113022
FCH: 106630990(CASP8)
CLV: 102084608 102084797
EGZ: 104130511(CASP8)
NNI: 104010196(CASP8)
ACUN: 113482526 113482527
PADL: 103923440 103924262(CASP8)
AAM: 106492412 106492473(CASP8)
ASN: 102384848 102385102
AMJ: 102573591(CASP8) 102575862(CASP18)
PSS: 102446244 102447455
CMY: 102931356 102934251
CPIC: 101934006(CASP8) 101934828
XLA: 373559(casp8.L)
XTR: 100495471(casp8)
NPR: 108795080
DRE: 100049706(casp8l1) 557302(casp8l2) 561021(casp22) 58022(casp8)
SRX: 107705601 107747226 107748560 107748577 107756543
SANH: 107660005 107660083 107660089 107670339 107672910 107680357 107688858 107688860 107689487
SGH: 107555418 107555445 107560797 107566313 107597346
CCAR: 109052822 109053966 109053967 109053969 109064153 109083181 109090355
IPU: 100304635 108266930 108273098 108273129
PHYP: 113524385 113525919 113538271
AMEX: 103021896 103036076 103036379 103037118
EEE: 113574024 113582334 113588302
TRU: 101061322 101075191 101075631
TNG: GSTEN00031473G001
LCO: 104924422 104938225 104938227
NCC: 104948647 104966261
MZE: 101470036 101475706 101478827 101481407 106674852 106676518 112430088 112430089
ONL: 100702139 100702676 102079913 109194206
OLA: 100049400(casp8) 100125536
XMA: 102237850 111608841
XCO: 114147136 114147894 114151637
PRET: 103459939 103478931 103478932 108167062
CVG: 107082055 107086818 107086824
NFU: 107384290 107384292 107389982
KMR: 108238317 108238318 108239714
ALIM: 106512618 106512902 106517939
AOCE: 111586360 111588089 111588095 111588107
CSEM: 103396237 103396239
POV: 109631024 109637364 109641073
LCF: 108881527 108883888
SDU: 111218362 111229030(casp8)
SLAL: 111648895 111666542(casp8)
HCQ: 109520533
BPEC: 110166585 110173494(casp8) 110173519
MALB: 109958094
SASA: 106569473 106586254
OTW: 112225661 112226687 112245958 112247430 112260780
SALP: 111956905 111957166 111975582 111979249 111979568
ELS: 105006190 105009870 105021259 105021271 105024762
SFM: 108918550 108918555 108920617 108920619(casp8) 108932283
PKI: 111852220 111852221 111859671 111859672
LCM: 102349989 102355925 102356202
CMK: 103171902(casp8)
RTP: 109915462 109929740 109932037
BFO: BRAFLDRAFT_194931
CIN: 100183123
SPU: 105445989 585496
APLC: 110982622 110986601
SKO: 100369664 100375416
DME: Dmel_CG7486(Dredd)
DER: 6555550
DSE: 6615883
DSI: Dsimw501_GD16467(Dsim_Dredd)
DYA: Dyak_GE16575(Dyak_Dredd)
DAN: 6504896
DSR: 110182574
DPO: Dpse_GA20387
DPE: 6599948
DMN: 108153528
DWI: 6644580
DGR: Dgri_GH24782
DMO: Dmoj_GI21675
DAZ: 108619540
DNV: 108656798
DHE: 111592986
DVI: 6633308
MDE: 101900122
LCQ: 111685143 111685144
AGA: AgaP_AGAP011693(CASPL1)
AAG: 5563818
AALB: 115262725
CQU: CpipJ_CPIJ014995
AME: 724930
BIM: 100741190
BTER: 100652115
CCAL: 108627268
OBB: 114878450
SOC: 105205440
MPHA: 105828235
AEC: 105147270
ACEP: 105625685
PBAR: 105429159
VEM: 105558011
HST: 105190451
DQU: 106743797
CFO: 105248277
LHU: 105678455
PGC: 109856665
OBO: 105280305
PCF: 106791240
NVI: 100680000
CSOL: 105360146
MDL: 103579887
TCA: 661095(Dredd)
DPA: 109534720
ATD: 109598530
NVL: 108556913
BMOR: 100141428(Dredd)
BMAN: 114248879
DPL: KGM_212093
PMAC: 106720189
PRAP: 110996855
HAW: 110369675
TNL: 113491750
PXY: 105390324
CLEC: 106661122
PHU: Phum_PHUM574530
ZNE: 110835030
PVM: 113822604
CSCU: 111615099
PCAN: 112560982
CRG: 105318843 105332613 105340890
MYI: 110449259
LAK: 106152179 106171044
SMM: Smp_141270
SHX: MS3_10084
NVE: 5505811
EPA: 110231936
ADF: 107335805
AMIL: 114961919
PDAM: 113682606
SPIS: 111335203
DGT: 114530339 114534211 114539385
HMG: 100203004 100207763 100579132(casp8) 105843821 105846973
AQU: 100638885 105313668 105315966 105316143 105316853 109581722 109584594
 » show all
Reference
PMID:9931493
  Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
  Title
Structure and chromosome localization of the human CASP8 gene.
  Journal
Gene 226:225-32 (1999)
DOI:10.1016/S0378-1119(98)00565-4
  Sequence
[hsa:841]
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