ORTHOLOGY: K04398
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Entry
K04398 KO
Name
CASP8
Definition
caspase 8 [EC:
3.4.22.61
]
Pathway
ko01524
Platinum drug resistance
ko04115
p53 signaling pathway
ko04210
Apoptosis
ko04214
Apoptosis - fly
ko04215
Apoptosis - multiple species
ko04217
Necroptosis
ko04620
Toll-like receptor signaling pathway
ko04621
NOD-like receptor signaling pathway
ko04622
RIG-I-like receptor signaling pathway
ko04624
Toll and Imd signaling pathway
ko04625
C-type lectin receptor signaling pathway
ko04657
IL-17 signaling pathway
ko04668
TNF signaling pathway
ko04932
Non-alcoholic fatty liver disease
ko05010
Alzheimer disease
ko05016
Huntington disease
ko05022
Pathways of neurodegeneration - multiple diseases
ko05130
Pathogenic Escherichia coli infection
ko05132
Salmonella infection
ko05134
Legionellosis
ko05142
Chagas disease
ko05145
Toxoplasmosis
ko05152
Tuberculosis
ko05160
Hepatitis C
ko05161
Hepatitis B
ko05162
Measles
ko05163
Human cytomegalovirus infection
ko05164
Influenza A
ko05165
Human papillomavirus infection
ko05167
Kaposi sarcoma-associated herpesvirus infection
ko05168
Herpes simplex virus 1 infection
ko05169
Epstein-Barr virus infection
ko05170
Human immunodeficiency virus 1 infection
ko05200
Pathways in cancer
ko05203
Viral carcinogenesis
ko05416
Viral myocarditis
Disease
H00108
Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09130 Environmental Information Processing
09132 Signal transduction
04668 TNF signaling pathway
K04398 CASP8; caspase 8
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
K04398 CASP8; caspase 8
04214 Apoptosis - fly
K04398 CASP8; caspase 8
04215 Apoptosis - multiple species
K04398 CASP8; caspase 8
04217 Necroptosis
K04398 CASP8; caspase 8
04115 p53 signaling pathway
K04398 CASP8; caspase 8
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
K04398 CASP8; caspase 8
04624 Toll and Imd signaling pathway
K04398 CASP8; caspase 8
04621 NOD-like receptor signaling pathway
K04398 CASP8; caspase 8
04622 RIG-I-like receptor signaling pathway
K04398 CASP8; caspase 8
04625 C-type lectin receptor signaling pathway
K04398 CASP8; caspase 8
04657 IL-17 signaling pathway
K04398 CASP8; caspase 8
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04398 CASP8; caspase 8
05203 Viral carcinogenesis
K04398 CASP8; caspase 8
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
K04398 CASP8; caspase 8
05161 Hepatitis B
K04398 CASP8; caspase 8
05160 Hepatitis C
K04398 CASP8; caspase 8
05164 Influenza A
K04398 CASP8; caspase 8
05162 Measles
K04398 CASP8; caspase 8
05168 Herpes simplex virus 1 infection
K04398 CASP8; caspase 8
05163 Human cytomegalovirus infection
K04398 CASP8; caspase 8
05167 Kaposi sarcoma-associated herpesvirus infection
K04398 CASP8; caspase 8
05169 Epstein-Barr virus infection
K04398 CASP8; caspase 8
05165 Human papillomavirus infection
K04398 CASP8; caspase 8
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
K04398 CASP8; caspase 8
05132 Salmonella infection
K04398 CASP8; caspase 8
05134 Legionellosis
K04398 CASP8; caspase 8
05152 Tuberculosis
K04398 CASP8; caspase 8
09174 Infectious disease: parasitic
05145 Toxoplasmosis
K04398 CASP8; caspase 8
05142 Chagas disease
K04398 CASP8; caspase 8
09164 Neurodegenerative disease
05010 Alzheimer disease
K04398 CASP8; caspase 8
05016 Huntington disease
K04398 CASP8; caspase 8
05022 Pathways of neurodegeneration - multiple diseases
K04398 CASP8; caspase 8
09166 Cardiovascular disease
05416 Viral myocarditis
K04398 CASP8; caspase 8
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
K04398 CASP8; caspase 8
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
K04398 CASP8; caspase 8
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors
K04398 CASP8; caspase 8
Enzymes [BR:
ko01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.22 Cysteine endopeptidases
3.4.22.61 caspase-8
K04398 CASP8; caspase 8
Peptidases and inhibitors [BR:
ko01002
]
Cysteine peptidases
Family C14: caspase family
K04398 CASP8; caspase 8
BRITE hierarchy
Other DBs
GO:
0097199
Genes
HSA:
841
(CASP8)
PTR:
746477
(CASP8)
PPS:
100978497
(CASP8)
GGO:
101138898
(CASP8)
PON:
100172115
(CASP8)
NLE:
100586183
(CASP8)
MCC:
702781
(CASP8)
MCF:
101865354
(CASP8)
CSAB:
103217637
(CASP8)
RRO:
104671864
(CASP8)
RBB:
108532002
(CASP8)
CJC:
100395220
(CASP8)
SBQ:
101053601
(CASP8)
MMU:
12370
(Casp8)
MCAL:
110291975
(Casp8)
MPAH:
110321675
(Casp8)
RNO:
64044
(Casp8)
MUN:
110557662
(Casp8)
CGE:
100689369
(Casp8)
NGI:
103738672
(Casp8)
HGL:
101702773
(Casp8)
CCAN:
109689613
(Casp8)
OCU:
100348477
(CASP8)
TUP:
102498355
(CASP8)
CFA:
488473
(CASP8)
VVP:
112922873
(CASP8)
AML:
100472842
(CASP8)
UMR:
103659742
(CASP8)
UAH:
113250592
(CASP8)
ORO:
101365855
(CASP8)
ELK:
111141026
FCA:
100142684
(CASP8)
PTG:
102962460
(CASP8)
PPAD:
109260762
(CASP8)
AJU:
106987995
(CASP8)
BTA:
507481
(CASP8)
BOM:
102272602
(CASP8)
BIU:
109569521
(CASP8)
BBUB:
102412929
(CASP8)
CHX:
102169919
(CASP8)
OAS:
101107334
(CASP8)
SSC:
595105
(CASP8)
CFR:
102508224
(CASP8)
CDK:
105099181
(CASP8)
BACU:
103004642
(CASP8)
LVE:
103077054
(CASP8)
OOR:
101281780
(CASP8)
DLE:
111171726
(CASP8)
PCAD:
102988082
(CASP8)
ECB:
100066502
(CASP8)
EPZ:
103565685
(CASP8)
EAI:
106823493
(CASP8)
MYB:
102246377
(CASP8)
MYD:
102761550
(CASP8)
MNA:
107533931
(CASP8)
HAI:
109379228
(CASP8)
DRO:
112307787
(CASP8)
PALE:
102878181
(CASP8)
RAY:
107503155
(CASP8)
MJV:
108398898
(CASP8)
LAV:
100660542
(CASP8)
100663575
TMU:
101344302
MDO:
100017025
(CASP18)
100617599
(CASP8)
SHR:
100931580
(CASP8)
PCW:
110197193
(CASP8)
OAA:
100082949
100087835
GGA:
395284
(CASP8)
693266
(CASP18)
MGP:
100541513
100541666
CJO:
107316523
107316524
NMEL:
110399293
110400694
APLA:
101803161
(CASP8)
106014283
ACYG:
106040002
106040004
TGU:
100222284
100223333
LSR:
110484576
(CASP8)
110484625
SCAN:
103814506
103814507
(CASP8)
GFR:
102044546
102044717
FAB:
101814031
101815602
PHI:
102110759
CCAE:
111931990
CCW:
104693779
ETL:
114055714
114055715
FPG:
101916968
(CASP8)
106113022
FCH:
106630990
(CASP8)
CLV:
102084608
102084797
EGZ:
104130511
(CASP8)
NNI:
104010196
(CASP8)
ACUN:
113482526
113482527
PADL:
103923440
103924262
(CASP8)
AAM:
106492412
106492473
(CASP8)
ASN:
102384848
102385102
AMJ:
102573591
(CASP8)
102575862
(CASP18)
PSS:
102446244
102447455
CMY:
102931356
102934251
(CASP8)
CPIC:
101934006
(CASP8)
101934828
XLA:
373559
(casp8.L)
XTR:
100495471
(casp8)
NPR:
108795080
DRE:
100049706
(casp8l1)
557302
(casp8l2)
561021
(casp22)
58022
(casp8)
SRX:
107705601
107747226
107748560
107748577
107756543
SANH:
107660005
107660083
107660089
107670339
107672910
107680357
107688858
107688860
107689487
SGH:
107555418
107555445
107560797
107566313
107597346
CCAR:
109052822
109053966
109053967
109053969
109064153
109083181
109090355
IPU:
100304635
108266930
108273098
108273129
PHYP:
113524385
113525919
113538271
AMEX:
103021896
103036076
103036379
103037118
EEE:
113574024
113582334
113588302
TRU:
101061322
101075191
101075631
TNG:
GSTEN00031473G001
LCO:
104924422
104938225
104938227
NCC:
104948647
104966261
MZE:
101470036
101475706
101478827
101481407
106674852
106676518
112430088
112430089
ONL:
100702139
100702676
102079913
109194206
OLA:
100049400
(casp8)
100125536
XMA:
102237850
111608841
XCO:
114147136
114147894
114151637
PRET:
103459939
103478931
103478932
108167062
CVG:
107082055
107086818
107086824
NFU:
107384290
107384292
107389982
KMR:
108238317
(casp8)
108238318
108239714
(casp10)
ALIM:
106512618
106512902
106517939
AOCE:
111586360
111588089
111588095
111588107
CSEM:
103396237
103396239
POV:
109631024
109637364
109641073
LCF:
108881527
108883888
SDU:
111218362
111229030
(casp8)
SLAL:
111648895
111666542
(casp8)
HCQ:
109520533
BPEC:
110166585
110173494
(casp8)
110173519
MALB:
109958094
SASA:
106569473
106586254
OTW:
112225661
112226687
112245958
112247430
112260780
SALP:
111956905
111957166
111975582
111979249
111979568
ELS:
105006190
105009870
105021259
105021271
105024762
SFM:
108918550
108918555
108920617
108920619
(casp8)
108932283
PKI:
111852220
111852221
111859671
111859672
LCM:
102349989
102355925
102356202
CMK:
103171902
(casp8)
RTP:
109915462
109929740
109932037
BFO:
118406076
118419602
118420396
118420457
118428976
118430951
CIN:
100183123
SPU:
105445989
585496
APLC:
110982622
110986601
SKO:
100369664
100375416
DME:
Dmel_CG7486
(Dredd)
DER:
6555550
DSE:
6615883
DSI:
Dsimw501_GD16467
(Dsim_Dredd)
DYA:
Dyak_GE16575
(Dyak_Dredd)
DAN:
6504896
DSR:
110182574
DPO:
Dpse_GA20387
DPE:
6599948
DMN:
108153528
DWI:
6644580
DGR:
Dgri_GH24782
DMO:
Dmoj_GI21675
DAZ:
108619540
DNV:
108656798
DHE:
111592986
DVI:
6633308
MDE:
101900122
LCQ:
111685143
111685144
AGA:
AgaP_AGAP011693
(CASPL1)
AAG:
5563818
AALB:
115262725
CQU:
CpipJ_CPIJ014995
AME:
724930
BIM:
100741190
BTER:
100652115
CCAL:
108627268
OBB:
114878450
SOC:
105205440
MPHA:
105828235
AEC:
105147270
ACEP:
105625685
PBAR:
105429159
VEM:
105558011
HST:
105190451
DQU:
106743797
CFO:
105248277
LHU:
105678455
PGC:
109856665
OBO:
105280305
PCF:
106791240
NVI:
100680000
CSOL:
105360146
MDL:
103579887
TCA:
661095
(Dredd)
DPA:
109534720
ATD:
109598530
NVL:
108556913
BMOR:
100141428
(Dredd)
BMAN:
114248879
DPL:
KGM_212093
PMAC:
106720189
PRAP:
110996855
HAW:
110369675
TNL:
113491750
PXY:
105390324
CLEC:
106661122
PHU:
Phum_PHUM574530
ZNE:
110835030
PVM:
113822604
CSCU:
111615099
PCAN:
112560982
CRG:
105318843
105332613
105340890
MYI:
110449259
LAK:
106152179
106171044
SMM:
Smp_141270
SHX:
MS3_10084
NVE:
5505811
EPA:
110231936
ADF:
107335805
AMIL:
114961919
PDAM:
113682606
SPIS:
111335203
DGT:
114530339
114534211
114539385
HMG:
100203004
100207763
100579132
(casp8)
105843821
105846973
AQU:
100638885
105313668
105315966
105316143
105316853
109581722
109584594
» show all
Taxonomy
UniProt
Reference
PMID:
9931493
Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
Title
Structure and chromosome localization of the human CASP8 gene.
Journal
Gene 226:225-32 (1999)
DOI:
10.1016/S0378-1119(98)00565-4
Sequence
[hsa:
841
]
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integrated database retrieval system