KEGG   ORTHOLOGY: K04416
Entry
K04416                      KO                                     

Name
MAP3K1, MEKK1
Definition
mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04530  Tight junction
ko04622  RIG-I-like receptor signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko04935  Growth hormone synthesis, secretion and action
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   04935 Growth hormone synthesis, secretion and action
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
   05161 Hepatitis B
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K04416  MAP3K1, MEKK1; mitogen-activated protein kinase kinase kinase 1
Other DBs
GO: 0004709
Genes
HSA: 4214(MAP3K1)
PTR: 471543(MAP3K1)
PPS: 100994796(MAP3K1)
GGO: 101136722(MAP3K1)
PON: 100453309(MAP3K1)
NLE: 100606554(MAP3K1)
MCC: 710979(MAP3K1)
MCF: 102123041(MAP3K1)
CSAB: 103221701(MAP3K1)
RRO: 104657086(MAP3K1)
RBB: 108530959(MAP3K1)
CJC: 100389500(MAP3K1)
SBQ: 101054366(MAP3K1)
MMU: 26401(Map3k1)
MCAL: 110307741(Map3k1)
MPAH: 110328949(Map3k1)
RNO: 100912399 116667(Map3k1)
MUN: 110546648(Map3k1)
CGE: 100770540(Map3k1)
NGI: 103739909(Map3k1)
HGL: 101720769(Map3k1)
CCAN: 109695531(Map3k1)
OCU: 100348484(MAP3K1)
TUP: 102483890(MAP3K1)
CFA: 478061(MAP3K1)
VVP: 112935233(MAP3K1)
AML: 100466442(MAP3K1)
UMR: 103663891(MAP3K1)
UAH: 113255319(MAP3K1)
ORO: 101366511(MAP3K1)
ELK: 111156879
FCA: 101090328(MAP3K1)
PTG: 102971191(MAP3K1)
PPAD: 109246346(MAP3K1)
AJU: 106975243(MAP3K1)
BTA: 523962(MAP3K1)
BOM: 102267592(MAP3K1)
BIU: 109574889(MAP3K1)
BBUB: 102399327(MAP3K1)
CHX: 102187530(MAP3K1)
OAS: 101112260(MAP3K1)
SSC: 396617(MAP3K1)
CFR: 102505358(MAP3K1)
CDK: 105087133(MAP3K1)
BACU: 103002185(MAP3K1)
LVE: 103083385(MAP3K1)
OOR: 101288918(MAP3K1)
DLE: 111186550(MAP3K1)
PCAD: 102979076(MAP3K1)
ECB: 100061688(MAP3K1)
EPZ: 103548212(MAP3K1)
EAI: 106843371(MAP3K1)
MYB: 102258632(MAP3K1)
MYD: 102763786(MAP3K1)
MNA: 107527145(MAP3K1)
HAI: 109385705(MAP3K1)
DRO: 112315269(MAP3K1)
PALE: 102886741(MAP3K1)
RAY: 107518617(MAP3K1)
MJV: 108384016(MAP3K1)
LAV: 100655149(MAP3K1)
TMU: 101361190
MDO: 100032065(MAP3K1)
SHR: 100913571(MAP3K1)
PCW: 110215703(MAP3K1)
OAA: 100076612(MAP3K1)
GGA: 427144(MAP3K1)
MGP: 100550623(MAP3K1)
CJO: 107306009(MAP3K1)
NMEL: 110390387(MAP3K1)
APLA: 101793656(MAP3K1)
ACYG: 106035615(MAP3K1)
TGU: 100225825(MAP3K1)
LSR: 110472556(MAP3K1)
SCAN: 103821035(MAP3K1)
GFR: 102044899(MAP3K1)
FAB: 101807669(MAP3K1)
PHI: 102103765(MAP3K1)
PMAJ: 107216401(MAP3K1)
CCAE: 111941445(MAP3K1)
CCW: 104686679(MAP3K1)
ETL: 114055129(MAP3K1)
FPG: 101911178(MAP3K1)
FCH: 102045898(MAP3K1)
CLV: 102097744(MAP3K1)
EGZ: 104134700(MAP3K1)
NNI: 104011958(MAP3K1)
ACUN: 113489657(MAP3K1)
PADL: 103919424(MAP3K1)
ASN: 102376941(MAP3K1)
AMJ: 102562794(MAP3K1)
PSS: 102463619(MAP3K1)
CMY: 102938448(MAP3K1)
CPIC: 101933464(MAP3K1)
ACS: 100561745(map3k1)
PVT: 110085400(MAP3K1)
PBI: 103048285(MAP3K1)
PMUR: 107292307(MAP3K1)
TSR: 106540861(MAP3K1)
PMUA: 114606892(MAP3K1)
GJA: 107123377(MAP3K1)
XLA: 108704427(map3k1.S) 108718321(map3k1.L)
XTR: 100490504(map3k1)
NPR: 108792018(MAP3K1)
DRE: 100334486(map3k1)
SGH: 107558252 107560413(map3k1)
IPU: 108277254(map3k1)
PHYP: 113543563(map3k1)
AMEX: 103042517(map3k1)
EEE: 113576764(map3k1)
SASA: 106562896 106571505(map3k1)
OTW: 112220130(map3k1) 112230734
SALP: 111961944(map3k1) 111963818
ELS: 105021721(map3k1)
SFM: 108929962(map3k1)
PKI: 111834485(map3k1)
LCM: 102355070(MAP3K1)
CMK: 103177870(map3k1)
RTP: 109930444(map3k1)
BFO: 118431366
SPU: 590478
APLC: 110989629
SKO: 102807412
ZNE: 110828229
PVM: 113823456
PCAN: 112573155
CRG: 105331404
MYI: 110443661
OBI: 106881243
SHX: MS3_10207
NVE: 5507587
EPA: 110255124
ADF: 107327485
AMIL: 114956505
PDAM: 113667850
SPIS: 111334523
DGT: 114527122
HMG: 100202032
 » show all
Reference
  Authors
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T
  Title
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
  Journal
Mol Cell 9:945-56 (2002)
DOI:10.1016/S1097-2765(02)00519-1
Reference
PMID:9808624
  Authors
Xia Y, Wu Z, Su B, Murray B, Karin M
  Title
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
  Journal
Genes Dev 12:3369-81 (1998)
DOI:10.1101/gad.12.21.3369
  Sequence
[hsa:4214]
LinkDB

KEGG   ORTHOLOGY: K04420
Entry
K04420                      KO                                     

Name
MAP3K2, MEKK2
Definition
mitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04540  Gap junction
ko04912  GnRH signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04420  MAP3K2, MEKK2; mitogen-activated protein kinase kinase kinase 2
Other DBs
GO: 0004709
Genes
HSA: 10746(MAP3K2)
PTR: 736244(MAP3K2)
PPS: 100973371(MAP3K2)
GGO: 101149805(MAP3K2)
PON: 100450054(MAP3K2)
NLE: 100601802(MAP3K2)
MCC: 100424131(MAP3K2)
MCF: 102138136(MAP3K2)
CSAB: 103216879(MAP3K2)
RRO: 104662431(MAP3K2)
RBB: 108533000(MAP3K2)
CJC: 100406711(MAP3K2)
SBQ: 101035799(MAP3K2)
MMU: 26405(Map3k2)
MCAL: 110284747(Map3k2)
MPAH: 110333106(Map3k2)
RNO: 171492(Map3k2)
MUN: 110553443
CGE: 100772559(Map3k2)
NGI: 103732132(Map3k2)
HGL: 101726195(Map3k2)
CCAN: 109699113(Map3k2)
OCU: 100355693(MAP3K2)
TUP: 102485186(MAP3K2)
CFA: 612902(MAP3K2)
VVP: 112932690(MAP3K2)
AML: 100475426(MAP3K2)
UMR: 103658571(MAP3K2)
UAH: 113263482(MAP3K2)
ORO: 101368270(MAP3K2)
ELK: 111160868
FCA: 101096406(MAP3K2)
PTG: 102957925(MAP3K2)
PPAD: 109278797(MAP3K2)
AJU: 106966378(MAP3K2)
BTA: 504592(MAP3K2)
BOM: 102273125(MAP3K2)
BIU: 109565311(MAP3K2)
BBUB: 102406531(MAP3K2)
CHX: 102175623(MAP3K2)
OAS: 101109858(MAP3K2)
SSC: 100621234(MAP3K2)
CFR: 102505073(MAP3K2)
CDK: 105084487(MAP3K2)
BACU: 103017845(MAP3K2)
LVE: 103083140(MAP3K2)
OOR: 101270305(MAP3K2)
DLE: 111183352(MAP3K2)
PCAD: 102985391(MAP3K2)
ECB: 100050628(MAP3K2)
EPZ: 103562194(MAP3K2)
EAI: 106834092(MAP3K2)
MYB: 102245865(MAP3K2)
MYD: 102753581(MAP3K2)
MNA: 107528582(MAP3K2)
HAI: 109371823(MAP3K2)
DRO: 112313010(MAP3K2)
PALE: 102880422(MAP3K2)
RAY: 107516884(MAP3K2)
MJV: 108400895(MAP3K2)
LAV: 100665139(MAP3K2)
TMU: 101349577
MDO: 100026735(MAP3K2)
SHR: 100916713(MAP3K2)
PCW: 110194666(MAP3K2)
OAA: 100087843(MAP3K2)
GGA: 424225(MAP3K2)
MGP: 100543830(MAP3K2)
CJO: 107316800(MAP3K2)
NMEL: 110399799(MAP3K2)
APLA: 101798043(MAP3K2)
ACYG: 106045922(MAP3K2)
TGU: 100219827(MAP3K2) 116808715
LSR: 110468326(MAP3K2)
SCAN: 103814336(MAP3K2)
GFR: 102033648(MAP3K2)
FAB: 101811653(MAP3K2)
PHI: 102113050(MAP3K2)
PMAJ: 107207590(MAP3K2)
CCAE: 111932210(MAP3K2)
CCW: 104693990(MAP3K2)
ETL: 114055550(MAP3K2)
FPG: 101921462(MAP3K2)
FCH: 102052668(MAP3K2)
CLV: 102092494(MAP3K2)
EGZ: 104133722(MAP3K2)
NNI: 104018989(MAP3K2)
ACUN: 113482266(MAP3K2)
PADL: 103916532(MAP3K2)
AAM: 106499278(MAP3K2)
AMJ: 102574412(MAP3K2)
PSS: 102448094(MAP3K2)
CMY: 102941356(MAP3K2)
CPIC: 101934711(MAP3K2)
ACS: 100558170(map3k2)
PVT: 110085271(MAP3K2)
PBI: 103049938(MAP3K2)
PMUR: 107302054(MAP3K2)
TSR: 106548568(MAP3K2)
PMUA: 114603537(MAP3K2)
GJA: 107117807(MAP3K2)
XLA: 108701261(map3k2.L) 108702901(map3k2.S)
XTR: 100493570(map3k2)
NPR: 108785393(MAP3K2)
DRE: 558321(map3k2)
CCAR: 109057196(map3k2) 109089690
IPU: 108272715(map3k2)
PHYP: 113538380(map3k2)
AMEX: 103026704(map3k2)
EEE: 113584100(map3k2)
TRU: 101069746(map3k2)
LCO: 104934606(map3k2)
MZE: 101464541(map3k2)
ONL: 100705497(map3k2)
OLA: 101160297(map3k2)
XMA: 102232571(map3k2)
XCO: 114140552(map3k2)
PRET: 103457092(map3k2)
CVG: 107103639(map3k2)
NFU: 107384647(map3k2)
KMR: 108246834(map3k2)
ALIM: 106531440(map3k2)
AOCE: 111562626(map3k2)
CSEM: 103389509(map3k2)
POV: 109640231(map3k2)
LCF: 108873167
SDU: 111222725(map3k2)
SLAL: 111672426(map3k2)
HCQ: 109520183(map3k2)
BPEC: 110165688(map3k2)
MALB: 109955649(map3k2)
ELS: 105019952(map3k2)
SFM: 108920647(map3k2)
PKI: 111840805(map3k2)
LCM: 102350566(MAP3K2)
CMK: 103189809(map3k2)
RTP: 109935279(map3k2)
BFO: 118405651
CIN: 100174992
SPU: 577291
APLC: 110986656
SKO: 100376570
BMY: Bm1_11350
PCAN: 112574465
CRG: 105335847
MYI: 110442962
OBI: 106869103
LAK: 106178012
ADF: 107347933
AQU: 100632568
EGR: 104449352
CANN: 107853292
SIND: 105166311
HAN: 110911116
LSV: 111919178
CCAV: 112509688
JAG: GJA_3447
 » show all
Reference
  Authors
Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD
  Title
MAP3Ks as central regulators of cell fate during development.
  Journal
Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750
LinkDB

KEGG   ORTHOLOGY: K04421
Entry
K04421                      KO                                     

Name
MAP3K3, MEKK3
Definition
mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko05166  Human T-cell leukemia virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04421  MAP3K3, MEKK3; mitogen-activated protein kinase kinase kinase 3
Other DBs
GO: 0004709
Genes
HSA: 4215(MAP3K3)
PTR: 468286(MAP3K3)
PPS: 100969705(MAP3K3)
GGO: 101148044(MAP3K3)
PON: 100444678(MAP3K3)
NLE: 100601763(MAP3K3)
MCC: 717866(MAP3K3)
MCF: 102132095(MAP3K3)
CSAB: 103243225(MAP3K3)
RRO: 104675466(MAP3K3)
RBB: 108536280(MAP3K3)
CJC: 100409608(MAP3K3)
SBQ: 101035755(MAP3K3) 101043439
MMU: 26406(Map3k3)
MCAL: 110305762(Map3k3)
MPAH: 110331495(Map3k3)
RNO: 303604(Map3k3)
MUN: 110547048(Map3k3)
CGE: 100753508(Map3k3)
NGI: 103744757(Map3k3)
HGL: 101704335(Map3k3)
CCAN: 109703189(Map3k3)
OCU: 100355324(MAP3K3)
TUP: 102477673(MAP3K3)
CFA: 480481(MAP3K3)
VVP: 112920702(MAP3K3)
AML: 100475740(MAP3K3)
UMR: 103665628(MAP3K3)
UAH: 113265289(MAP3K3)
ORO: 101375291(MAP3K3)
ELK: 111158066
FCA: 101083633(MAP3K3)
PTG: 102966576(MAP3K3)
PPAD: 109277107(MAP3K3)
AJU: 106978686(MAP3K3)
BTA: 508943(MAP3K3)
BOM: 102275307(MAP3K3)
BIU: 109573385(MAP3K3)
BBUB: 102413611(MAP3K3)
CHX: 102173036(MAP3K3)
OAS: 101122537(MAP3K3)
SSC: 100513491(MAP3K3)
CFR: 102505759(MAP3K3)
CDK: 105090412(MAP3K3)
BACU: 102999255(MAP3K3)
LVE: 103076636(MAP3K3)
OOR: 101273961(MAP3K3)
DLE: 111182605(MAP3K3)
PCAD: 102985586(MAP3K3)
ECB: 100064751(MAP3K3)
EPZ: 103549765(MAP3K3)
EAI: 106835525(MAP3K3)
MYB: 102242308(MAP3K3)
MYD: 102762787(MAP3K3)
MNA: 107530487(MAP3K3)
HAI: 109380266(MAP3K3)
DRO: 112316249(MAP3K3)
PALE: 102889570(MAP3K3)
RAY: 107501901(MAP3K3)
MJV: 108401834(MAP3K3)
LAV: 100662122(MAP3K3)
TMU: 101341472
MDO: 100025970(MAP3K3)
SHR: 100933837(MAP3K3)
PCW: 110215942(MAP3K3)
OAA: 100083301 100092024(MAP3K3)
GGA: 419954(MAP3K3) 420419(MAPKKK3L)
MGP: 100542691 100542719(MAP3K3)
CJO: 107308787 107325133(MAP3K3)
NMEL: 110388470(MAP3K3) 110394259
APLA: 101795869 101801284(MAP3K3)
ACYG: 106036842 106045975(MAP3K3)
TGU: 100223633(MAP3K3) 100226503
LSR: 110474827(MAP3K3) 110484542
SCAN: 103812700 103821658(MAP3K3)
GFR: 102032306(MAP3K3) 102044243
FAB: 101813992(MAP3K3) 101817004
PHI: 102108460 102112033(MAP3K3)
PMAJ: 107200237 107215258(MAP3K3)
CCAE: 111925531 111939927(MAP3K3)
CCW: 104686414 104698629(MAP3K3)
ETL: 114065134 114066926(MAP3K3)
FPG: 101912446(MAP3K3) 101923251
FCH: 102047801(MAP3K3) 102050351
CLV: 102085060(MAP3K3) 102088147
EGZ: 104130961 104134638(MAP3K3)
NNI: 104009891(MAP3K3) 104021753
ACUN: 113477214 113489126(MAP3K3)
PADL: 103913871(MAP3K3) 103924744
AAM: 106497426(MAP3K3)
ASN: 102368863 102374958(MAP3K3)
AMJ: 102572648 106736961(MAP3K3)
PSS: 102454634(MAP3K3) 102454880
CMY: 102930570(MAP3K3) 102931859
CPIC: 101948589 101953672(MAP3K3)
ACS: 100557698(map3k3) 100562159
PVT: 110080317(MAP3K3) 110085837
PBI: 103064885 103066986(MAP3K3)
PMUR: 107284356 107302364(MAP3K3)
TSR: 106540521(MAP3K3) 106545629
PMUA: 114581713(MAP3K3) 114607438
GJA: 107116392
XTR: 100488360(map3k22) 100490021(map3k3)
NPR: 108784622 108802493(MAP3K3)
DRE: 560211(map3k3)
IPU: 108256020(map3k3) 108256334
PHYP: 113528353(map3k3) 113541066
AMEX: 103034596(map3k3) 103044968
EEE: 113580221(map3k3) 113581205
TRU: 101061953 101072543(map3k3)
LCO: 104930222(map3k3) 104937092
NCC: 104943590(map3k3)
MZE: 101468082(map3k3) 101475626
ONL: 100692691(map3k3) 100711264
OLA: 101156127 101169290(map3k3)
XMA: 102228349 102234853(map3k3)
XCO: 114136809 114160172(map3k3)
PRET: 103456566 103468920(map3k3)
CVG: 107084751(map3k3) 107100967
NFU: 107378534(map3k3) 107382822
ALIM: 106513381 106534689(map3k3)
AOCE: 111565972 111588903(map3k3)
CSEM: 103392663(map3k3)
LCF: 108880564(map3k3) 108881705
SDU: 111217593(map3k3) 111221016
SLAL: 111656266 111660589(map3k3)
HCQ: 109519483 109532434(map3k3)
BPEC: 110160986 110167886(map3k3)
MALB: 109961492 109963171(map3k3)
SALP: 111980991(map3k3) 112077065
ELS: 105007693 105012974(map3k3)
LCM: 102350357 102353974(MAP3K3)
CMK: 103187711(map3k3) 103189852
RTP: 109913314 109936110(map3k3)
HMG: 100205297
ATH: AT1G53570(MAP3KA)
ALY: 9330509
CRB: 17898011
BRP: 103860382
BOE: 106335806
RSZ: 108863113
CIT: 102607672
DZI: 111299762
EGR: 104415891
LJA: Lj1g3v1316910.1(Lj1g3v1316910.1) Lj1g3v1318210.1(Lj1g3v1318210.1) Lj1g3v1318220.1(Lj1g3v1318220.1) Lj4g3v2742830.1(Lj4g3v2742830.1) Lj4g3v2742850.1(Lj4g3v2742850.1)
ADU: 107480227
AIP: 107630938
FVE: 101313251
RCN: 112187320
PPER: 18780007
PMUM: 103327145
PAVI: 110756513
ZJU: 107425633
CSV: 101203907
CMO: 103485282
MCHA: 111005414
RCU: 8264269
VVI: 100243772
SLY: 101243985 543918(MAPKKKalpha)
SIND: 105178081
CCAV: 112511697
DCR: 108204080
BVG: 104895397
DOSA: Os02t0555900-00(Os02g0555900) Os04t0437600-01(Os04g0437600) Os11t0207200-01(Os11g0207200)
ATS: 109750728(LOC109750728) 109758282(LOC109758282)
AOF: 109830282
ATR: 18448262
SMO: SELMODRAFT_144969(MAP3KA3-1)
 » show all
Reference
  Authors
Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD
  Title
MAP3Ks as central regulators of cell fate during development.
  Journal
Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750
Reference
PMID:9006902
  Authors
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U
  Title
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated  protein Kinase/ERK kinase kinase 3 (MEKK) derivative.
  Journal
J Biol Chem 272:2668-74 (1997)
DOI:10.1074/jbc.272.5.2668
  Sequence
[hsa:4215]
LinkDB

KEGG   ORTHOLOGY: K04428
Entry
K04428                      KO                                     

Name
MAP3K4, MEKK4
Definition
mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04624  Toll and Imd signaling pathway
ko04912  GnRH signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE11 family
   K04428  MAP3K4, MEKK4; mitogen-activated protein kinase kinase kinase 4
Other DBs
GO: 0004709
Genes
HSA: 4216(MAP3K4)
PTR: 463119(MAP3K4)
PPS: 100981441(MAP3K4)
GGO: 101152649(MAP3K4)
PON: 100442172(MAP3K4)
NLE: 100602313(MAP3K4)
MCC: 710360(MAP3K4)
MCF: 101865276(MAP3K4)
CSAB: 103240840(MAP3K4)
RRO: 104669999(MAP3K4)
RBB: 108527990(MAP3K4)
CJC: 100413660(MAP3K4)
SBQ: 101042401(MAP3K4)
MMU: 26407(Map3k4)
MCAL: 110312545(Map3k4)
MPAH: 110338018(Map3k4)
RNO: 308106(Map3k4)
MUN: 110554862(Map3k4)
CGE: 100764060(Map3k4)
NGI: 103737023(Map3k4)
HGL: 101701961(Map3k4)
CCAN: 109700149(Map3k4)
OCU: 100358104(MAP3K4)
TUP: 102479582(MAP3K4)
CFA: 476262(MAP3K4)
VVP: 112932971(MAP3K4)
AML: 100465667(MAP3K4)
UMR: 103660898(MAP3K4)
UAH: 113259629(MAP3K4)
ORO: 101379514(MAP3K4)
ELK: 111158665
FCA: 101097977(MAP3K4)
PTG: 102952700(MAP3K4)
PPAD: 109245401(MAP3K4)
AJU: 106985032(MAP3K4)
BTA: 511779(MAP3K4)
BOM: 102283969(MAP3K4)
BIU: 109563601(MAP3K4)
BBUB: 102412509(MAP3K4)
CHX: 102172543(MAP3K4)
OAS: 101113246(MAP3K4)
SSC: 100154202(MAP3K4)
CFR: 102509815(MAP3K4)
CDK: 105086293(MAP3K4)
BACU: 103006512(MAP3K4)
LVE: 103075844(MAP3K4)
OOR: 101277039(MAP3K4)
DLE: 111168464(MAP3K4)
PCAD: 102977794(MAP3K4)
ECB: 100058153(MAP3K4)
EPZ: 103556184(MAP3K4)
EAI: 106842047(MAP3K4)
MYB: 102262729(MAP3K4)
MYD: 102757393(MAP3K4)
MNA: 107535728(MAP3K4)
HAI: 109394013(MAP3K4)
DRO: 112297294(MAP3K4)
PALE: 102888506(MAP3K4)
RAY: 107514741(MAP3K4)
MJV: 108403112(MAP3K4)
LAV: 100664871(MAP3K4)
TMU: 101342450
MDO: 100032495(MAP3K4)
SHR: 100928208(MAP3K4)
PCW: 110208619(MAP3K4)
OAA: 100081562(MAP3K4)
GGA: 421579(MAP3K4)
MGP: 100548383(MAP3K4)
CJO: 107311515(MAP3K4)
NMEL: 110395417(MAP3K4)
APLA: 101795899(MAP3K4)
ACYG: 106039514(MAP3K4)
TGU: 100229845(MAP3K4)
LSR: 110477918(MAP3K4)
SCAN: 103821627(MAP3K4)
GFR: 102043718(MAP3K4)
FAB: 101814940(MAP3K4)
PHI: 102101107(MAP3K4)
PMAJ: 107201928(MAP3K4)
CCAE: 111926951(MAP3K4)
CCW: 104684463(MAP3K4)
ETL: 114055651(MAP3K4)
FPG: 101918017(MAP3K4)
FCH: 102048037(MAP3K4)
CLV: 102086486(MAP3K4)
EGZ: 104124823(MAP3K4)
NNI: 104018435(MAP3K4)
ACUN: 113477881(MAP3K4)
PADL: 103914152(MAP3K4)
AAM: 106486799(MAP3K4)
ASN: 102382136(MAP3K4)
AMJ: 102573918(MAP3K4)
PSS: 102446659(MAP3K4)
CMY: 102936228(MAP3K4)
CPIC: 101946795(MAP3K4)
ACS: 100560027(map3k4)
PVT: 110087352(MAP3K4)
PBI: 103059578(MAP3K4)
PMUR: 107292071(MAP3K4)
TSR: 106549188(MAP3K4)
PMUA: 114594310(MAP3K4)
GJA: 107113333(MAP3K4)
XLA: 100126613(map3k4.S)
XTR: 100497217(map3k4)
NPR: 108795048(MAP3K4)
DRE: 325488(map3k4)
SGH: 107553172 107602945(map3k4)
IPU: 108260840(map3k4)
PHYP: 113544293(map3k4)
AMEX: 103046281(map3k4)
EEE: 113581424(map3k4)
LCO: 104940016(map3k4)
NCC: 104953033(map3k4)
MZE: 101485830(map3k4)
ONL: 100701169(map3k4)
OLA: 101174856(map3k4)
XMA: 102230475(map3k4)
XCO: 114137786(map3k4)
PRET: 103477032(map3k4)
CVG: 107103016(map3k4)
NFU: 107373664(map3k4)
KMR: 108234108(map3k4)
ALIM: 106518124(map3k4)
AOCE: 111562975(map3k4)
CSEM: 103387276(map3k4)
POV: 109634498(map3k4)
LCF: 108894538(map3k4)
SDU: 111234458(map3k4)
SLAL: 111658959(map3k4)
HCQ: 109516250(map3k4)
BPEC: 110157029(map3k4)
MALB: 109961895(map3k4)
ELS: 105008100(map3k4)
SFM: 108942741(map3k4)
PKI: 111853413(map3k4)
LCM: 102366133(MAP3K4)
CMK: 103175928(map3k4)
RTP: 109926885(map3k4)
CIN: 778975
SPU: 592876
APLC: 110978862
DME: Dmel_CG7717(Mekk1)
DER: 6553864
DSE: 6613723
DSI: Dsimw501_GD20154(Dsim_GD20154)
DAN: 6500649
DSR: 110186557
DPE: 6588314
DMN: 108156359
DWI: 6650423
DAZ: 108620887
DNV: 108659620
DHE: 111602613
DVI: 6634984
MDE: 101888375
LCQ: 111681513
AAG: 5573381
AALB: 109430716
AME: 409125
BIM: 100746363
BTER: 100650064
CCAL: 108625647
OBB: 114879059
SOC: 105197492
MPHA: 105831896
AEC: 105143118
ACEP: 105623324
PBAR: 105427085
VEM: 105569890
HST: 105190825
DQU: 106741914
CFO: 105252125
LHU: 105671571
PGC: 109853389
OBO: 105279741
PCF: 106786486
MDL: 103580841
TCA: 663503
DPA: 109542479
ATD: 109600009
NVL: 108565768
BMOR: 101743223
BMAN: 114240977
PRAP: 111001775
HAW: 110378274
TNL: 113493354
PXY: 105387876
API: 100165908
DNX: 107163878
AGS: 114121966
RMD: 113551977
BTAB: 109036367
CLEC: 106674197
ZNE: 110838032
PVM: 113822618
CEL: CELE_B0414.7(mtk-1)
CBR: CBG04061(Cbr-mtk-1)
BMY: Bm1_52175
PCAN: 112565561
MYI: 110456425
LAK: 106171976
EPA: 110234581
ADF: 107350483
AMIL: 114968329
PDAM: 113678862
SPIS: 111322508
DGT: 114534159
AQU: 100634854
 » show all
Reference
PMID:9079650
  Authors
Gerwins P, Blank JL, Johnson GL
  Title
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
  Journal
J Biol Chem 272:8288-95 (1997)
DOI:10.1074/jbc.272.13.8288
  Sequence
[mmu:26407]
LinkDB

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