KEGG   ORTHOLOGY: K04443
Entry
K04443                      KO                                     

Name
MAPKAPK2
Definition
mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04218  Cellular senescence
ko04361  Axon regeneration
ko04370  VEGF signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04722  Neurotrophin signaling pathway
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
   04370 VEGF signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09158 Development and regeneration
   04361 Axon regeneration
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2
Genes
HSA: 9261(MAPKAPK2)
PTR: 744091(MAPKAPK2)
PPS: 100968858(MAPKAPK2)
GGO: 101151250(MAPKAPK2)
PON: 100446757(MAPKAPK2)
NLE: 100579643(MAPKAPK2)
MCC: 695044(MAPKAPK2)
MCF: 102131033(MAPKAPK2)
CSAB: 103230194(MAPKAPK2)
RRO: 104661739(MAPKAPK2)
RBB: 108535144(MAPKAPK2)
CJC: 100393258(MAPKAPK2)
SBQ: 101052249(MAPKAPK2)
MMU: 17164(Mapkapk2)
MCAL: 110294905(Mapkapk2)
MPAH: 110321250(Mapkapk2)
RNO: 289014(Mapkapk2)
MUN: 110550321(Mapkapk2)
CGE: 100762218(Mapkapk2)
NGI: 103725934(Mapkapk2)
HGL: 101708612(Mapkapk2)
CCAN: 109688375(Mapkapk2)
OCU: 100009438(MAPKAPK2)
TUP: 102483974(MAPKAPK2)
CFA: 490263(MAPKAPK2)
VVP: 112910998(MAPKAPK2)
AML: 100483931(MAPKAPK2)
UMR: 103657756(MAPKAPK2)
UAH: 113242594(MAPKAPK2)
ORO: 101380197(MAPKAPK2)
ELK: 111151153
FCA: 101090833(MAPKAPK2)
PTG: 102961644(MAPKAPK2)
PPAD: 109250406(MAPKAPK2)
AJU: 106981771(MAPKAPK2)
BTA: 788091(MAPKAPK2)
BOM: 102274647(MAPKAPK2)
BIU: 109570101(MAPKAPK2)
BBUB: 102401914(MAPKAPK2)
CHX: 102184079(MAPKAPK2)
OAS: 101118118(MAPKAPK2)
SSC: 100521986(MAPKAPK2)
CFR: 102508766(MAPKAPK2)
CDK: 105098610(MAPKAPK2)
BACU: 102999332(MAPKAPK2)
LVE: 103082742(MAPKAPK2)
OOR: 101272142(MAPKAPK2)
DLE: 111184749(MAPKAPK2)
PCAD: 102974346(MAPKAPK2)
ECB: 100055510(MAPKAPK2) 102147500
EPZ: 103567219(MAPKAPK2)
EAI: 106823339
MYD: 102775090(MAPKAPK2)
MNA: 107538913(MAPKAPK2)
HAI: 109374513(MAPKAPK2)
DRO: 112318256(MAPKAPK2)
PALE: 102887540(MAPKAPK2)
RAY: 107502219(MAPKAPK2)
MJV: 108403019(MAPKAPK2)
LAV: 100658205(MAPKAPK2)
TMU: 101342996
MDO: 100014871(MAPKAPK2)
SHR: 100917693(MAPKAPK2)
PCW: 110219609(MAPKAPK2)
OAA: 100092220(MAPKAPK2)
GGA: 419847(MAPKAPK2)
MGP: 100548519(MAPKAPK2)
CJO: 107324781(MAPKAPK2)
NMEL: 110388241(MAPKAPK2)
APLA: 101789944(MAPKAPK2)
ACYG: 106041349(MAPKAPK2)
TGU: 115498549(MAPKAPK2)
LSR: 110473090(MAPKAPK2)
SCAN: 103822392(MAPKAPK2)
GFR: 102044089(MAPKAPK2)
PHI: 102106065(MAPKAPK2)
PMAJ: 107214766(MAPKAPK2)
CCAE: 111939739(MAPKAPK2)
CCW: 104692513(MAPKAPK2)
ETL: 114063132(MAPKAPK2)
FPG: 101911197(MAPKAPK2)
FCH: 102050830(MAPKAPK2)
CLV: 102085947(MAPKAPK2)
EGZ: 104134508(MAPKAPK2)
NNI: 104013194(MAPKAPK2)
ACUN: 113488889(MAPKAPK2)
PADL: 103919783(MAPKAPK2)
AAM: 106495796(MAPKAPK2)
ASN: 102383452(MAPKAPK2)
AMJ: 102563674(MAPKAPK2)
PSS: 102445709(MAPKAPK2)
CMY: 102948283(MAPKAPK2)
CPIC: 101936401(MAPKAPK2)
ACS: 100562891(mapkapk2)
PVT: 110088404(MAPKAPK2)
PBI: 103050162(MAPKAPK2)
TSR: 106544613(MAPKAPK2)
PMUA: 114599328(MAPKAPK2)
GJA: 107124264(MAPKAPK2)
XLA: 432084(mapkapk2.L) 495118
XTR: 550101(mapkapk2)
NPR: 108793180(MAPKAPK2)
DRE: 327321(mapkapk2a) 557648(mapkapk2b)
IPU: 108255116(mapkapk2)
PHYP: 113539676(mapkapk2)
EEE: 113578783 113579161(mapkapk2)
TRU: 101074595
MZE: 101471444
ONL: 100695012(mapkapk2)
OLA: 101157364(mapkapk2)
XMA: 102228209(mapkapk2)
XCO: 114135726(mapkapk2)
PRET: 103464872
CVG: 107083314
NFU: 107385601(mapkapk2)
KMR: 108235782
ALIM: 106513301(mapkapk2)
AOCE: 111566562
CSEM: 103386073(mapkapk2)
POV: 109629213
SLAL: 111667188 111667810(mapkapk2)
HCQ: 109522522
BPEC: 110171263
MALB: 109956193
SASA: 106566648(MAPK2) 106571864(MAPK2) 106583822
ELS: 105013205
PKI: 111834362 111854424(mapkapk2)
LCM: 102362783(MAPKAPK2)
CMK: 103182495(mapkapk2)
RTP: 109917680 109918144(mapkapk2) 109938847
BFO: 118416909
SPU: 582861
APLC: 110983981
DME: Dmel_CG3086(MAPk-Ak2)
DER: 6550842
DSE: 116802035
DSI: Dsimw501_GD16235(Dsim_GD16235)
DAN: 6504147
DSR: 110183053
DPE: 6596887
DMN: 108152380
DWI: 6648676
DAZ: 108618586
DNV: 108657309
DHE: 111592701
DVI: 6633683
MDE: 101898240
LCQ: 111679252
AAG: 5571923
BIM: 105682130
BTER: 105667115
OBB: 114870970
SOC: 105194280
MPHA: 105837757
AEC: 105151682
ACEP: 105623115
PBAR: 105425719
VEM: 105563295
HST: 105181030
DQU: 106742764
CFO: 105250864
LHU: 105670887
PGC: 109851777
OBO: 105283794
PCF: 106785969
NVI: 100120769
CSOL: 105359409
TCA: 662443
DPA: 109537992
ATD: 109608310
NVL: 108558938
BMOR: 101742228
BMAN: 114244194
PMAC: 106721268
PRAP: 110997980
HAW: 110382371
TNL: 113498486
PXY: 105381503
API: 100166092
DNX: 107167186
AGS: 114129461
RMD: 113556474
BTAB: 109034577
CLEC: 106665318
ZNE: 110834585
FCD: 110861760
PVM: 113817177
TUT: 107371283
DPTE: 113796622
CSCU: 111633497
PTEP: 107448225
CEL: CELE_C44C8.6(mak-2)
BMY: Bm1_39660
PCAN: 112571792
CRG: 105320307
MYI: 110443430
OBI: 106882434
LAK: 106160916
SHX: MS3_06219
EGL: EGR_00520
NVE: 5512145
ADF: 107355156
AMIL: 114969353
PDAM: 113674071
SPIS: 111339198
DGT: 114524637
HMG: 100212998
AQU: 100640836
 » show all
Reference
PMID:8179591
  Authors
Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK
  Title
The primary structure of a human MAP kinase activated protein kinase 2.
  Journal
Biochem Biophys Res Commun 200:1118-24 (1994)
DOI:10.1006/bbrc.1994.1566
  Sequence
[hsa:9261]
LinkDB

KEGG   ORTHOLOGY: K04444
Entry
K04444                      KO                                     

Name
MAPKAPK3
Definition
mitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04370  VEGF signaling pathway
Disease
H01890  Pattern dystrophies of the retinal pigment epithelium
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
   04370 VEGF signaling pathway
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04444  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3
Genes
HSA: 7867(MAPKAPK3)
PTR: 460400(MAPKAPK3)
PPS: 100968829(MAPKAPK3)
GGO: 101131430(MAPKAPK3)
PON: 100449366(MAPKAPK3)
NLE: 100597822(MAPKAPK3)
MCC: 701320(MAPKAPK3)
MCF: 102120448(MAPKAPK3)
CSAB: 103227685(MAPKAPK3) 103227687
RRO: 104666815(MAPKAPK3)
RBB: 108526941(MAPKAPK3)
CJC: 100410636(MAPKAPK3)
SBQ: 101035301(MAPKAPK3)
MMU: 102626(Mapkapk3)
MCAL: 110301239(Mapkapk3)
MPAH: 110327440(Mapkapk3)
RNO: 315994(Mapkapk3)
MUN: 110564553(Mapkapk3)
CGE: 100774379(Mapkapk3)
NGI: 103750143(Mapkapk3)
HGL: 101717099(Mapkapk3)
CCAN: 109693236(Mapkapk3)
OCU: 100342292(MAPKAPK3)
TUP: 102493562(MAPKAPK3)
CFA: 484756(MAPKAPK3)
VVP: 112910865(MAPKAPK3)
AML: 100484361(MAPKAPK3)
UMR: 103674786(MAPKAPK3)
UAH: 113256922(MAPKAPK3)
ORO: 101374104(MAPKAPK3)
ELK: 111144154
FCA: 101096794(MAPKAPK3)
PTG: 102970828(MAPKAPK3)
PPAD: 109247859(MAPKAPK3)
AJU: 106979271(MAPKAPK3)
BTA: 615215(MAPKAPK3)
BOM: 102283364(MAPKAPK3)
BIU: 109576279(MAPKAPK3)
BBUB: 102395502(MAPKAPK3)
CHX: 102175629(MAPKAPK3)
OAS: 101118996(MAPKAPK3)
SSC: 100233192(MAPKAPK3)
CFR: 102518308(MAPKAPK3)
CDK: 105087288(MAPKAPK3)
BACU: 103001513(MAPKAPK3)
LVE: 103077980(MAPKAPK3)
OOR: 101281812(MAPKAPK3)
DLE: 111174347(MAPKAPK3)
PCAD: 102990377(MAPKAPK3)
ECB: 100061475(MAPKAPK3)
EPZ: 103559274(MAPKAPK3)
EAI: 106830742(MAPKAPK3)
MYB: 102241413(MAPKAPK3)
MYD: 102757924(MAPKAPK3)
MNA: 107540204(MAPKAPK3)
HAI: 109378052(MAPKAPK3)
DRO: 112309920(MAPKAPK3)
PALE: 102882134(MAPKAPK3)
RAY: 107504157(MAPKAPK3)
MJV: 108404719(MAPKAPK3)
LAV: 100666073(MAPKAPK3)
TMU: 101346344
MDO: 100028919(MAPKAPK3)
SHR: 100918613(MAPKAPK3)
PCW: 110217001(MAPKAPK3)
OAA: 100075476(MAPKAPK3)
GGA: 415917(MAPKAPK3)
MGP: 100544877
CJO: 107319569(MAPKAPK3)
NMEL: 110404941(MAPKAPK3)
APLA: 101801666(MAPKAPK3)
ACYG: 106042816(MAPKAPK3)
TGU: 100225000(MAPKAPK3)
LSR: 110469924(MAPKAPK3)
SCAN: 103816963(MAPKAPK3)
GFR: 102043737(MAPKAPK3)
FAB: 101806698(MAPKAPK3)
PHI: 102114178(MAPKAPK3)
PMAJ: 107210185(MAPKAPK3)
CCAE: 111935195(MAPKAPK3)
CCW: 104683208(MAPKAPK3)
ETL: 114058782(MAPKAPK3)
FPG: 101919073(MAPKAPK3)
FCH: 102047898(MAPKAPK3)
CLV: 102094261(MAPKAPK3)
EGZ: 104126764(MAPKAPK3)
NNI: 104008716(MAPKAPK3)
ACUN: 113484830(MAPKAPK3)
PADL: 103915070(MAPKAPK3)
AAM: 106492166(MAPKAPK3)
ASN: 102380990(MAPKAPK3)
AMJ: 106736633(MAPKAPK3)
PSS: 102463404(MAPKAPK3)
CMY: 102940828(MAPKAPK3)
CPIC: 101934644(MAPKAPK3)
ACS: 100565363(mapkapk3)
PVT: 110076526(MAPKAPK3)
PBI: 103057187(MAPKAPK3)
PMUR: 107285863
TSR: 106551121(MAPKAPK3)
PMUA: 114591548(MAPKAPK3)
GJA: 107123857(MAPKAPK3)
XLA: 108714604 779225(mapkapk3.S)
XTR: 780323(mapkapk3)
NPR: 108802832
DRE: 790934(mapkapk3)
SRX: 107715803(mapkapk3) 107718207
IPU: 108281044
PHYP: 113539717(mapkapk3)
AMEX: 103038695(mapkapk3)
EEE: 113591863(mapkapk3)
LCO: 104938962
ONL: 100696070 100703699(mapkapk3)
HCQ: 109522155(mapkapk3) 109522187
SASA: 100194763(mapk3) 106565558 106565813(MAPK3)
LCM: 102347953(MAPKAPK3)
CMK: 103176715(mapkapk3)
RTP: 109937784
CIN: 100178703
 » show all
Reference
PMID:8626550
  Authors
McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR
  Title
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.
  Journal
J Biol Chem 271:8488-92 (1996)
DOI:10.1074/jbc.271.14.8488
  Sequence
[hsa:7867]
LinkDB

DBGET integrated database retrieval system