KEGG   ORTHOLOGY: K04452
Entry
K04452                      KO                                     

Name
DDIT3, GADD153
Definition
DNA damage-inducible transcript 3
Pathway
ko04010  MAPK signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05202  Transcriptional misregulation in cancer
Disease
H00049  Myxoid liposarcoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
   05012 Parkinson disease
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
   05014 Amyotrophic lateral sclerosis
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
   05020 Prion disease
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
   05022 Pathways of neurodegeneration - multiple diseases
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   C/EBP-like factors
    K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
Genes
HSA: 1649(DDIT3)
PTR: 452017(DDIT3)
PPS: 100982590(DDIT3)
GGO: 101140706(DDIT3)
PON: 100439399(DDIT3)
NLE: 100600067(DDIT3)
MCC: 714901(DDIT3)
MCF: 102131632(DDIT3)
CSAB: 103238566(DDIT3)
RRO: 104682361(DDIT3)
RBB: 108519685(DDIT3)
CJC: 100385367(DDIT3) 103794361
SBQ: 104651132(DDIT3)
MMU: 13198(Ddit3)
MCAL: 110302857(Ddit3)
MPAH: 110326609(Ddit3)
RNO: 29467(Ddit3)
MUN: 110561450(Ddit3)
CGE: 100763514(Ddit3)
NGI: 103742913(Ddit3)
HGL: 101715873(Ddit3)
CCAN: 109675714 109686362(Ddit3)
OCU: 100338439(DDIT3)
TUP: 102500216(DDIT3)
CFA: 607439(DDIT3)
VVP: 112922347(DDIT3)
AML: 100479063(DDIT3)
UMR: 103656598(DDIT3)
UAH: 113256381(DDIT3)
ORO: 101380889(DDIT3)
ELK: 111160240
FCA: 101081819(DDIT3)
PTG: 102965918(DDIT3)
PPAD: 109270377(DDIT3)
AJU: 106975861(DDIT3)
BTA: 777788(DDIT3)
BOM: 102284065(DDIT3)
BIU: 109559326(DDIT3)
BBUB: 102405069(DDIT3)
CHX: 102175557(DDIT3)
OAS: 541600(DDIT3)
SSC: 100240743(DDIT3)
CFR: 102517621(DDIT3)
CDK: 105100346(DDIT3)
BACU: 103018481(DDIT3)
LVE: 103069139(DDIT3)
OOR: 101278090(DDIT3)
DLE: 111173840(DDIT3)
PCAD: 102979652(DDIT3)
ECB: 100053417(DDIT3)
EPZ: 103559784(DDIT3)
EAI: 106833003(DDIT3)
MYB: 102255226(DDIT3)
MYD: 102764039(DDIT3)
MNA: 107546204(DDIT3)
HAI: 109390744(DDIT3)
DRO: 112319047(DDIT3)
PALE: 102890557(DDIT3)
RAY: 107501502(DDIT3)
MJV: 108409974(DDIT3)
LAV: 100660941(DDIT3)
TMU: 101361189
SHR: 100931338(DDIT3)
PCW: 110210977(DDIT3)
OAA: 103167225(DDIT3)
GGA: 100857832(DDIT3)
NMEL: 110402723
APLA: 101802390(DDIT3)
ACYG: 106049589(DDIT3)
LSR: 116184551(DDIT3)
PMAJ: 107199033(DDIT3)
NNI: 104019181(DDIT3)
ASN: 102384643(DDIT3)
AMJ: 102574043(DDIT3)
PSS: 102448363(DDIT3)
CMY: 102934528(DDIT3)
CPIC: 101947222(DDIT3)
ACS: 100567470(ddit3)
PVT: 110070828(DDIT3)
PBI: 103050195(DDIT3)
PMUR: 107293466(DDIT3)
TSR: 106552745(DDIT3)
PMUA: 114592937(DDIT3)
GJA: 107118957(DDIT3)
XLA: 108709861(ddit3.S) 398615(ddit3.L)
XTR: 733816(ddit3)
NPR: 108797835(DDIT3)
DRE: 561924(ddit3)
SRX: 107734605(ddit3)
SANH: 107683613(ddit3)
SGH: 107566410(ddit3)
IPU: 108271880(ddit3)
PHYP: 113533348(ddit3)
AMEX: 103022996(ddit3)
EEE: 113578011(ddit3)
TRU: 101061813(ddit3)
LCO: 104919971(ddit3)
NCC: 104968149(ddit3)
MZE: 101473986(ddit3)
ONL: 100711221(ddit3)
OLA: 101163653(ddit3)
XMA: 102237930(ddit3)
XCO: 114135476(ddit3)
PRET: 103464404(ddit3)
CVG: 107102812(ddit3)
NFU: 107385332(ddit3)
KMR: 108231469(ddit3)
ALIM: 106514742(ddit3)
AOCE: 111576947(ddit3)
CSEM: 103386391(ddit3)
POV: 109635636(ddit3)
LCF: 108884828(ddit3)
SDU: 111223952(ddit3)
SLAL: 111659798(ddit3)
HCQ: 109510628(ddit3)
BPEC: 110154550(ddit3)
MALB: 109965745(ddit3)
SASA: 106582666
OTW: 112254144
SALP: 111969676
ELS: 105028306(ddit3)
SFM: 108928403(ddit3)
PKI: 111835263(ddit3)
LCM: 102361121(DDIT3)
CMK: 103189067(ddit3)
 » show all
Reference
  Authors
Oyadomari S, Mori M
  Title
Roles of CHOP/GADD153 in endoplasmic reticulum stress.
  Journal
Cell Death Differ 11:381-9 (2004)
DOI:10.1038/sj.cdd.4401373
Reference
  Authors
Yamaguchi H, Wang HG
  Title
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.
  Journal
J Biol Chem 279:45495-502 (2004)
DOI:10.1074/jbc.M406933200
  Sequence
[hsa:1649]
Reference
PMID:1339368
  Authors
Park JS, Luethy JD, Wang MG, Fargnoli J, Fornace AJ Jr, McBride OW, Holbrook NJ
  Title
Isolation, characterization and chromosomal localization of the human GADD153 gene.
  Journal
Gene 116:259-67 (1992)
DOI:10.1016/0378-1119(92)90523-r
  Sequence
[hsa:1649]
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