KEGG   ORTHOLOGY: K04462
Entry
K04462                      KO                                     

Name
MECOM, EVI1, PRDM3
Definition
[histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein) [EC:2.1.1.367]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko04010  MAPK signaling pathway
ko05200  Pathways in cancer
ko05220  Chronic myeloid leukemia
Disease
H00004  Chronic myeloid leukemia
H00867  Radioulnar synostosis with amegakaryocytic thrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
   03036 Chromosome and associated proteins
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.367  [histone H3]-lysine9 N-methyltransferase
     K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 others
    K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K04462  MECOM, EVI1, PRDM3; [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
Other DBs
RN: R03875
GO: 0046974
Genes
HSA: 2122(MECOM)
PTR: 460837(MECOM)
PPS: 100994741(MECOM)
GGO: 101143561(MECOM)
PON: 100431606(MECOM)
NLE: 100591579(MECOM)
MCC: 698603(MECOM)
MCF: 102139452(MECOM)
CSAB: 103221284(MECOM)
RRO: 104677766(MECOM)
RBB: 108516319(MECOM)
CJC: 100403987(MECOM)
SBQ: 101051357(MECOM)
MMU: 14013(Mecom)
MCAL: 110290693(Mecom)
MPAH: 110319807(Mecom)
RNO: 294924(Mecom)
MUN: 110545680(Mecom)
CGE: 100768628(Mecom)
NGI: 103731713(Mecom)
HGL: 101718355(Mecom)
CCAN: 109700158(Mecom)
OCU: 100343228(MECOM)
TUP: 102488385(MECOM)
CFA: 488148(MECOM)
VVP: 112926657(MECOM)
AML: 100482997(MECOM)
UMR: 103680825(MECOM)
UAH: 113255350(MECOM)
ORO: 101384287(MECOM)
ELK: 111148284
FCA: 101088775(MECOM)
PTG: 102955865(MECOM)
PPAD: 109262104(MECOM)
AJU: 106990036(MECOM)
BTA: 532209(MECOM)
BOM: 102288339(MECOM)
BIU: 109558403(MECOM)
BBUB: 102404893(MECOM)
CHX: 102182261(MECOM)
OAS: 101121055(MECOM)
SSC: 100518275(MECOM)
CFR: 102519252(MECOM)
CDK: 105085966(MECOM)
BACU: 103008158(MECOM)
LVE: 103078502(MECOM)
OOR: 101289893(MECOM)
DLE: 111174247(MECOM)
PCAD: 102976185(MECOM)
ECB: 100057450(MECOM)
EPZ: 103558280(MECOM)
EAI: 106834666(MECOM)
MYB: 102249519(MECOM)
MYD: 102766636(MECOM)
MNA: 107539280(MECOM)
HAI: 109383470(MECOM)
DRO: 112307202(MECOM)
PALE: 102878481(MECOM)
RAY: 107512516(MECOM)
MJV: 108404714
LAV: 100664202(MECOM)
TMU: 101350664
MDO: 100012479(MECOM)
SHR: 100928711(MECOM)
PCW: 110203730(MECOM)
OAA: 100084365(MECOM)
GGA: 424997(MECOM)
MGP: 100541414(MECOM)
CJO: 107318330(MECOM)
NMEL: 110398567(MECOM)
APLA: 101793295(MECOM)
ACYG: 106031974(MECOM)
TGU: 100230662(MECOM)
LSR: 110480337(MECOM)
SCAN: 103815279(MECOM)
GFR: 102039580(MECOM)
FAB: 101806754(MECOM)
PHI: 102104707(MECOM)
PMAJ: 107208729(MECOM)
CCAE: 111933313(MECOM)
CCW: 104688053(MECOM)
FPG: 101924233(MECOM)
FCH: 102055141(MECOM)
CLV: 102089407(MECOM)
EGZ: 104132485(MECOM)
NNI: 104022029(MECOM)
ACUN: 113483543(MECOM)
PADL: 103924951(MECOM)
AAM: 106486591
ASN: 102388244(MECOM)
AMJ: 102561786(MECOM)
PSS: 102446951(MECOM)
CMY: 102944134(MECOM)
CPIC: 101944916(MECOM)
ACS: 100555060(mecom)
PVT: 110085535(MECOM)
PBI: 103065321(MECOM)
PMUR: 107292215(MECOM)
TSR: 106556923(MECOM)
PMUA: 114597957(MECOM)
GJA: 107125967(MECOM)
XLA: 100301954(mecom.S) 733318(evi1) 734157(mecom.L)
XTR: 100496511(mecom)
NPR: 108788059(MECOM)
DRE: 497407(mecom)
PHYP: 113544589(mecom)
AMEX: 103042447(mecom)
EEE: 113568060(mecom)
TRU: 101069476(mecom)
LCO: 104936038(mecom)
NCC: 104952759
MZE: 101468114(mecom)
ONL: 100699103
OLA: 101169474(mecom)
XMA: 102224242(mecom)
XCO: 114133278(mecom)
PRET: 103474425(mecom)
CVG: 107094210(mecom)
NFU: 107380509(mecom)
KMR: 108240489(mecom)
ALIM: 106523993(mecom)
AOCE: 111573022(mecom)
CSEM: 103377560(mecom)
POV: 109634633(mecom)
LCF: 108886333(mecom)
SDU: 111224094(mecom)
SLAL: 111649993(mecom)
HCQ: 109525487(mecom)
BPEC: 110174294(mecom)
MALB: 109960327(mecom)
OTW: 112265381(mecom) 112267385
ELS: 105024028(mecom)
SFM: 108922168(mecom)
PKI: 111834017(mecom)
LCM: 102358043(MECOM)
CMK: 103180852(mecom)
BFO: 118430266
SPU: 100892779
APLC: 110987571
SKO: 100375728
DME: Dmel_CG31753(ham)
DER: 6549240
DSE: 6614589
DSI: Dsimw501_GD21809(Dsim_GD21809)
DAN: 6497312
DSR: 110176918
DPE: 113565837
DMN: 108161703
DWI: 6642468
DAZ: 108611799
DNV: 115564378
DHE: 111605541
DVI: 6629252
MDE: 101890702
LCQ: 111685049
AAG: 23687649
AME: 725792
BIM: 100741168
BTER: 100649991
CCAL: 108628568
OBB: 114876584
SOC: 105201991
MPHA: 105839733
AEC: 105148914
ACEP: 105627074
PBAR: 105427721
VEM: 105565473
HST: 105181576
DQU: 106744786
CFO: 105256434
LHU: 105667426
PGC: 109861821
OBO: 105276834
PCF: 106787643
NVI: 100122721
CSOL: 105368679
MDL: 103575493
TCA: 664087
DPA: 109536933
ATD: 109598666
NVL: 108561063
BMOR: 101735622
BMAN: 114248966
PMAC: 106721039
PRAP: 111003498
HAW: 110375373
TNL: 113493168
PXY: 105380101
API: 100166991
DNX: 107169860
RMD: 113554894
BTAB: 109041352
CLEC: 106665084
ZNE: 110831782
FCD: 110847627
PVM: 113827214
CSCU: 111618434
PTEP: 107436282
PCAN: 112555872
CRG: 105330257
MYI: 110452387
LAK: 106161219
 » show all
Reference
  Authors
Jolkowska J, Witt M
  Title
The EVI-1 gene--its role in pathogenesis of human leukemias.
  Journal
Leuk Res 24:553-8 (2000)
DOI:10.1016/S0145-2126(00)00031-X
  Sequence
[mmu:14013]
Reference
  Authors
Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T
  Title
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
  Journal
Cell 150:948-60 (2012)
DOI:10.1016/j.cell.2012.06.048
LinkDB

KEGG   ORTHOLOGY: K08367
Entry
K08367                      KO                                     

Name
RUNX1, AML1
Definition
runt-related transcription factor 1
Pathway
ko04530  Tight junction
ko04659  Th17 cell differentiation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
Disease
H00001  B-cell acute lymphoblastic leukemia
H00003  Acute myeloid leukemia
H00004  Chronic myeloid leukemia
H00978  Thrombocytopenia (THC)
H01481  Myelodysplastic syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1
Genes
HSA: 861(RUNX1)
PTR: 101058316(RUNX1)
PPS: 100985479(RUNX1)
GGO: 101124359(RUNX1)
PON: 100449725(RUNX1)
NLE: 100594110(RUNX1)
MCC: 696749(RUNX1)
MCF: 102145008(RUNX1)
CSAB: 103218488(RUNX1)
RRO: 104658772(RUNX1)
RBB: 108536870(RUNX1)
CJC: 100385071(RUNX1)
SBQ: 101047789(RUNX1)
MMU: 12394(Runx1)
MCAL: 110311558(Runx1)
MPAH: 110329713(Runx1)
RNO: 50662(Runx1)
MUN: 110542151(Runx1)
CGE: 100758283(Runx1)
NGI: 103736431(Runx1)
HGL: 101705852(Runx1)
CCAN: 109700411(Runx1)
OCU: 100358993(RUNX1)
TUP: 102496134(RUNX1)
CFA: 487746(RUNX1)
VVP: 112910264(RUNX1)
AML: 100484679(RUNX1)
UMR: 103673224(RUNX1)
UAH: 113262125(RUNX1)
ORO: 101367976(RUNX1)
ELK: 111155817
FCA: 101084898(RUNX1)
PPAD: 109249750(RUNX1)
AJU: 106966472(RUNX1)
BTA: 529631(RUNX1)
BOM: 102282115(RUNX1)
BIU: 109561422(RUNX1)
BBUB: 102392702(RUNX1)
CHX: 102178020(RUNX1)
OAS: 101108280(RUNX1)
SSC: 100512633(RUNX1)
CFR: 102521748(RUNX1)
CDK: 105089882(RUNX1)
BACU: 103006498(RUNX1)
LVE: 103074813(RUNX1)
OOR: 101288785(RUNX1)
DLE: 111163859(RUNX1)
PCAD: 102984857(RUNX1)
ECB: 100051950(RUNX1)
EPZ: 103549174(RUNX1)
EAI: 106832821(RUNX1)
MYB: 102247211(RUNX1)
MYD: 102768477(RUNX1)
MNA: 107533502(RUNX1)
HAI: 109391240(RUNX1)
DRO: 112305670(RUNX1)
PALE: 102879444(RUNX1)
RAY: 107520364(RUNX1)
MJV: 108384793(RUNX1)
LAV: 100665882(RUNX1)
TMU: 101357079
MDO: 100025525(RUNX1)
SHR: 100921236(RUNX1)
PCW: 110214791(RUNX1)
OAA: 100082553(RUNX1)
GGA: 396152(RUNX1)
MGP: 100540674(RUNX1)
CJO: 107323234(RUNX1)
NMEL: 110402700(RUNX1)
APLA: 101799657(RUNX1)
ACYG: 106043406(RUNX1)
TGU: 100222588(RUNX1)
LSR: 110475368(RUNX1)
GFR: 102042762
FAB: 101820379(RUNX1)
PHI: 102099092(RUNX1)
PMAJ: 107207834 107209383(RUNX1)
CCAE: 111929229(RUNX1)
FPG: 101916329(RUNX1) 106112951
FCH: 102053520(RUNX1)
CLV: 102087117(RUNX1)
EGZ: 104128174(RUNX1)
NNI: 104020181(RUNX1)
ACUN: 113478993(RUNX1)
PADL: 103920324(RUNX1)
AAM: 106494897(RUNX1)
ASN: 102385681(RUNX1)
AMJ: 102572910(RUNX1)
PSS: 102455885(RUNX1)
CMY: 102944269(RUNX1)
CPIC: 101938129(RUNX1)
ACS: 100564051(runx1)
PVT: 110076828(RUNX1)
PBI: 103055722(RUNX1)
PMUR: 107291521
TSR: 106549617(RUNX1)
PMUA: 114596073(RUNX1)
GJA: 107117549
XLA: 108709238 379657(runx1.L)
XTR: 100485449(runx1)
NPR: 108791098(RUNX1)
DRE: 58126(runx1)
SRX: 107709287(runx1) 107751097
CCAR: 109071062
IPU: 108259037(runx1)
PHYP: 113537666(runx1)
AMEX: 103025657
EEE: 113582633
TRU: 100049631(runx1)
LCO: 104936698
NCC: 104961881
MZE: 101482179
ONL: 100691239
OLA: 101173202
XMA: 102230567
XCO: 114140828
PRET: 103477443
CVG: 107098178
NFU: 107384523
ALIM: 106534917
AOCE: 111562778
CSEM: 103389730
POV: 109640042(runx1)
LCF: 108902563
SDU: 111232758
SLAL: 111670267
HCQ: 109528744
BPEC: 110156597
OTW: 112238382(runx1)
ELS: 105019777(runx1)
SFM: 108931706 108938311(runx1)
PKI: 111856070(runx1)
LCM: 102360635(RUNX1)
CMK: 103186755(runx1)
RTP: 109914103(runx1)
BFO: 118423548
CIN: 100178299
SPU: 373468(SpRunt-1) 576197
APLC: 110978851
SKO: 100302713(runt)
AGS: 114126750
NVE: 5504767
EPA: 110249929
ADF: 107351415
AMIL: 114961964
PDAM: 113676023
SPIS: 111342489
DGT: 114535050
AQU: 100638951
 » show all
Reference
PMID:1720541
  Authors
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M
  Title
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
  Journal
Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431
  Sequence
[hsa:861]
LinkDB

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