KEGG   ORTHOLOGY: K04467
Entry
K04467                      KO                                     

Name
IKBKA, IKKA, CHUK
Definition
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04068  FoxO signaling pathway
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04920  Adipocytokine signaling pathway
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05142  Chagas disease
map05145  Toxoplasmosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00882  Cocoon syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04014 Ras signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04064 NF-kappa B signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04668 TNF signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04068 FoxO signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04151 PI3K-Akt signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04150 mTOR signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04621 NOD-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04622 RIG-I-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04623 Cytosolic DNA-sensing pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04625 C-type lectin receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04660 T cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04658 Th1 and Th2 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04659 Th17 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04657 IL-17 signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04662 B cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04062 Chemokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05208 Chemical carcinogenesis - reactive oxygen species
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05221 Acute myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05220 Chronic myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05215 Prostate cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05222 Small cell lung cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05170 Human immunodeficiency virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05161 Hepatitis B
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05160 Hepatitis C
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05171 Coronavirus disease - COVID-19
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05164 Influenza A
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05162 Measles
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05168 Herpes simplex virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05163 Human cytomegalovirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05169 Epstein-Barr virus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05165 Human papillomavirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05130 Pathogenic Escherichia coli infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05132 Salmonella infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05131 Shigellosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05135 Yersinia infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05142 Chagas disease
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05418 Fluid shear stress and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Other DBs
GO: 0008384
Genes
HSA: 1147(CHUK)
PTR: 450673(CHUK)
PPS: 100995228(CHUK)
GGO: 101137405(CHUK)
PON: 100174735(CHUK)
NLE: 100596225(CHUK)
MCC: 709511(CHUK)
MCF: 102115964(CHUK)
CSAB: 103216382(CHUK)
CATY: 105581830(CHUK)
PANU: 100998877(CHUK)
RRO: 104656469(CHUK)
RBB: 108535077(CHUK)
TFN: 117068535(CHUK)
PTEH: 111538794(CHUK)
SBQ: 101044006(CHUK)
MMUR: 105867131 105873508(CHUK)
MMU: 12675(Chuk)
MCAL: 110285285(Chuk)
MPAH: 110334538(Chuk)
RNO: 309361(Chuk)
MCOC: 116103881(Chuk)
MUN: 110552966(Chuk)
CGE: 100754432(Chuk)
PLEU: 114706431(Chuk)
NGI: 103743976(Chuk)
HGL: 101719306(Chuk)
CCAN: 109681514(Chuk)
OCU: 100355888(CHUK)
TUP: 102501308(CHUK)
CFA: 477796(CHUK)
VVP: 112914804(CHUK)
VLG: 121484113(CHUK)
AML: 100464675(CHUK)
UMR: 103658916(CHUK)
UAH: 113251823(CHUK)
ORO: 101364103(CHUK)
ELK: 111144921
MPUF: 101680658(CHUK)
EJU: 114205217(CHUK)
MLX: 118024839(CHUK)
FCA: 101095617(CHUK)
PTG: 102949289(CHUK)
PPAD: 109272766(CHUK)
AJU: 106966935(CHUK)
HHV: 120243217(CHUK)
BTA: 281073(CHUK)
BOM: 102281886(CHUK)
BIU: 109553086(CHUK)
BBUB: 102399613(CHUK)
CHX: 102181262(CHUK)
OAS: 101111143(CHUK)
ODA: 120873530(CHUK)
SSC: 100135662(CHUK)
CFR: 102503497(CHUK)
CDK: 105084316(CHUK)
BACU: 103015414(CHUK)
LVE: 103085220(CHUK)
OOR: 101281072(CHUK)
DLE: 111172396(CHUK)
PCAD: 102977668(CHUK)
ECB: 100070393(CHUK)
EPZ: 103567228(CHUK)
EAI: 106846705(CHUK)
MYB: 102261467(CHUK)
MYD: 102760888(CHUK)
MMYO: 118669852(CHUK)
MNA: 107542599(CHUK)
HAI: 109379632(CHUK)
DRO: 112300474(CHUK)
SHON: 118999523(CHUK)
AJM: 119064546(CHUK)
MMF: 118632312(CHUK)
PALE: 102879469(CHUK)
RAY: 107499756(CHUK)
MJV: 108409586(CHUK)
TOD: 119233588(CHUK)
LAV: 100664361(CHUK)
TMU: 101341290
MDO: 100027952(CHUK)
SHR: 100913624(CHUK)
PCW: 110213919(CHUK)
OAA: 100082351(CHUK)
GGA: 423669(CHUK)
PCOC: 116234780(CHUK)
MGP: 100542478(CHUK)
CJO: 107315625(CHUK)
NMEL: 110390496(CHUK)
ACYG: 106030064(CHUK)
TGU: 100221281(CHUK)
LSR: 110474031(CHUK)
SCAN: 103814234(CHUK)
PMOA: 120499710(CHUK)
GFR: 102042264(CHUK)
FAB: 101812706(CHUK)
PHI: 102107801(CHUK)
PMAJ: 107206726(CHUK)
CCW: 104695067(CHUK)
ETL: 114067570(CHUK)
FCH: 102053491(CHUK)
CLV: 102084658(CHUK)
EGZ: 104125140(CHUK)
ACUN: 113481883(CHUK)
PADL: 103924297(CHUK)
AAM: 106495295(CHUK)
ASN: 102374729(CHUK)
AMJ: 106736873(CHUK)
CPOO: 109318435(CHUK)
GGN: 109293915(CHUK)
PSS: 102454064(CHUK)
CMY: 102932800(CHUK)
CPIC: 101931080(CHUK)
TST: 117879818(CHUK)
CABI: 116834403(CHUK)
ACS: 100565922(chuk)
PVT: 110087236(CHUK)
PBI: 103061898(CHUK)
PMUR: 107291445(CHUK) 114923654
TSR: 106548462(CHUK)
PGUT: 117667309(CHUK)
PMUA: 114596983(CHUK)
ZVI: 118096210(CHUK)
GJA: 107117758(CHUK)
XLA: 444556(chuk.S)
XTR: 549654(chuk)
NPR: 108797654(CHUK)
DRE: 393287(chuk)
SANH: 107655432(chuk) 107666359
CCAR: 109092137 109100658(chuk)
IPU: 108263650(chuk)
PHYP: 113542836(chuk)
AMEX: 103033415(chuk)
EEE: 113582078(chuk)
OML: 112154264(chuk) 112162018
NFU: 107375593 107387313(chuk)
ALIM: 106521989(chuk) 106533626
MALB: 109961044 109962729(kctd2)
SFM: 108933554(chuk)
PKI: 111836749(chuk)
LOC: 102691336(chuk)
PSPA: 121321809(chuk)
ARUT: 117416037(chuk)
LCM: 102361819(CHUK)
CMK: 103181859(chuk)
RTP: 109918795(chuk)
SCLV: 120347579
OBB: 114871896
NMEA: 116434059
CGIG: 122402233
PCF: 106785497
CSOL: 105359082
MDL: 103578013
AGB: 108913950
NLU: 111048096
ZNE: 110838212
CSEC: 111866549
FCD: 110852083
PVM: 113819389
HAME: 121859114
DSV: 119436697
RSAN: 119396275
RMP: 119161269
SDM: 118199832
PCAN: 112557750
GAE: 121379525
MYI: 110456994
PMAX: 117328789
LAK: 106170753
EPA: 110254140
ATEN: 116302916
HMG: 100207607
 » show all
Reference
PMID:9244310
  Authors
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
  Title
Identification and characterization of an IkappaB kinase.
  Journal
Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X
  Sequence
[hsa:1147]
Reference
  Authors
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G
  Title
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
  Journal
Sci Signal 3:ra41 (2010)
DOI:10.1126/scisignal.2000778
LinkDB

KEGG   ORTHOLOGY: K07209
Entry
K07209                      KO                                     

Name
IKBKB, IKKB
Definition
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04068  FoxO signaling pathway
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04624  Toll and Imd signaling pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map05010  Alzheimer disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05142  Chagas disease
map05145  Toxoplasmosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04624 Toll and Imd signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04625 C-type lectin receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04658 Th1 and Th2 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04659 Th17 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04657 IL-17 signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05208 Chemical carcinogenesis - reactive oxygen species
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05170 Human immunodeficiency virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05171 Coronavirus disease - COVID-19
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05162 Measles
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05163 Human cytomegalovirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05165 Human papillomavirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05130 Pathogenic Escherichia coli infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05132 Salmonella infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05135 Yersinia infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05418 Fluid shear stress and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04931 Insulin resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Other DBs
GO: 0008384
Genes
HSA: 3551(IKBKB)
PTR: 472749(IKBKB)
PPS: 100989390(IKBKB)
GGO: 101141659(IKBKB)
PON: 100440586(IKBKB)
NLE: 100588081(IKBKB)
MCC: 704683(IKBKB)
MCF: 102146604(IKBKB)
CSAB: 103215686(IKBKB)
CATY: 105595759(IKBKB)
PANU: 101016447(IKBKB)
RRO: 104666046(IKBKB)
RBB: 108540719(IKBKB)
TFN: 117095630(IKBKB)
PTEH: 111544093(IKBKB)
CJC: 100393096(IKBKB)
SBQ: 101052971(IKBKB)
MMUR: 105878144(IKBKB)
MMU: 16150(Ikbkb)
MCAL: 110300158(Ikbkb)
MPAH: 110336182(Ikbkb)
RNO: 84351(Ikbkb)
MCOC: 116069014(Ikbkb)
MUN: 110556613(Ikbkb)
CGE: 100750488(Ikbkb)
PLEU: 114705738(Ikbkb)
NGI: 103726621(Ikbkb)
HGL: 101711077(Ikbkb)
CCAN: 109696400(Ikbkb)
OCU: 100356401(IKBKB)
TUP: 102467954(IKBKB)
CFA: 482839(IKBKB)
VVP: 112916156(IKBKB)
VLG: 121489510(IKBKB)
AML: 100471679(IKBKB)
UMR: 103677059(IKBKB)
UAH: 113245546(IKBKB)
ORO: 101375346(IKBKB)
ELK: 111144397
MPUF: 101686932(IKBKB)
EJU: 114224851(IKBKB)
MLX: 118009921(IKBKB)
FCA: 100142682(IKBKB)
PTG: 102963734(IKBKB)
PPAD: 109262264(IKBKB)
AJU: 106990012(IKBKB)
HHV: 120233999(IKBKB)
BTA: 281854(IKBKB)
BOM: 102281443(IKBKB)
BIU: 109553353(IKBKB)
BBUB: 102398886(IKBKB)
CHX: 102177406(IKBKB)
OAS: 780484(IKBKB)
ODA: 120865846(IKBKB)
SSC: 100101471(IKBKB)
CFR: 102508142(IKBKB)
CDK: 105086448(IKBKB)
BACU: 103015119(IKBKB)
LVE: 103088633(IKBKB)
OOR: 101285763(IKBKB)
DLE: 111173552(IKBKB)
PCAD: 102976706(IKBKB)
ECB: 100050167(IKBKB)
EPZ: 103562903(IKBKB)
EAI: 106828957(IKBKB)
MYB: 102261405(IKBKB)
MYD: 102773824(IKBKB)
MMYO: 118650776(IKBKB)
MNA: 107523913(IKBKB)
HAI: 109386279(IKBKB)
DRO: 112321547(IKBKB)
SHON: 118993207(IKBKB)
AJM: 119047140(IKBKB)
MMF: 118622317(IKBKB)
PALE: 102893261(IKBKB)
RAY: 107501353(IKBKB)
MJV: 108399795(IKBKB)
TOD: 119257853(IKBKB)
LAV: 100657363(IKBKB)
TMU: 101351256
MDO: 100033031(IKBKB)
SHR: 100928932(IKBKB)
PCW: 110196387(IKBKB)
OAA: 100078925(IKBKB)
GGA: 426792(IKBKB)
PCOC: 116234507(IKBKB)
MGP: 100542558(IKBKB)
CJO: 107323740(IKBKB)
NMEL: 110387184(IKBKB)
APLA: 101790255(IKBKB)
ACYG: 106044397(IKBKB)
TGU: 100225072(IKBKB) 116807244
LSR: 110473406(IKBKB)
SCAN: 103822735(IKBKB)
PMOA: 120504880(IKBKB)
GFR: 102035648(IKBKB)
FAB: 101809821(IKBKB)
PHI: 102100562(IKBKB)
PMAJ: 107213912(IKBKB)
CCAE: 111938770(IKBKB)
CCW: 104694916(IKBKB)
ETL: 114066442(IKBKB)
FPG: 101922064(IKBKB)
FCH: 102058892(IKBKB)
CLV: 102087238(IKBKB)
EGZ: 104135306(IKBKB)
NNI: 104016028(IKBKB)
ACUN: 113488090(IKBKB)
PADL: 103920554(IKBKB)
AAM: 106487776(IKBKB)
ASN: 102377560(IKBKB)
AMJ: 102561936(IKBKB)
CPOO: 109317391(IKBKB)
PSS: 102454676(IKBKB)
CMY: 102932073(IKBKB)
CPIC: 101945515(IKBKB)
TST: 117873054(IKBKB)
CABI: 116819035(IKBKB)
ACS: 100551699(ikbkb)
PVT: 110072148(IKBKB)
PBI: 103052688(IKBKB)
PMUR: 107287960(IKBKB)
TSR: 106550867
PGUT: 117676049(IKBKB)
PMUA: 114602842(IKBKB)
ZVI: 118085966(IKBKB)
GJA: 107107812(IKBKB)
XLA: 432200(ikbkb.L)
XTR: 448125(ikbkb)
NPR: 108791446(IKBKB)
DRE: 563560(ikbkb)
SANH: 107671012
SGH: 107559596(ikbkb)
CCAR: 109095150(ikbkb)
IPU: 108265675(ikbkb)
PHYP: 113533569(ikbkb)
AMEX: 103040024(ikbkb)
EEE: 113584916(ikbkb)
TRU: 101062431(ikbkb)
LCO: 104921662(ikbkb)
NCC: 104956687(ikbkb)
ELY: 117252591(ikbkb)
PLEP: 121944151(ikbkb)
SLUC: 116054000(ikbkb)
ECRA: 117945478(ikbkb)
PFLV: 114555052(ikbkb)
GAT: 120830767(ikbkb)
MSAM: 119891193(ikbkb)
CUD: 121510304(ikbkb)
MZE: 101472803(ikbkb)
ONL: 100698072(ikbkb)
OAU: 116311015(ikbkb)
OLA: 101170684(ikbkb)
OML: 112148770(ikbkb)
XMA: 102223773(ikbkb)
XCO: 114154613(ikbkb)
XHE: 116729844(ikbkb)
PRET: 103470025(ikbkb)
CVG: 107089660(ikbkb)
CTUL: 119778144(ikbkb)
NFU: 107394259(ikbkb)
KMR: 108233707(ikbkb)
ALIM: 106536414(ikbkb)
AOCE: 111577292(ikbkb)
CSEM: 103397763(ikbkb)
POV: 109637101(ikbkb)
LCF: 108881598(ikbkb)
SDU: 111236497(ikbkb)
SLAL: 111665990(ikbkb)
XGL: 120805086(ikbkb)
HCQ: 109525796
BPEC: 110155462(ikbkb)
MALB: 109956664(ikbkb)
SASA: 106580426(ikbkb)
OTW: 112263933
OMY: 110536185(ikbkb)
SALP: 111958214
ELS: 105014298(ikbkb)
SFM: 108920198(ikbkb)
PKI: 111854363(ikbkb)
LOC: 102690045(ikbkb)
ARUT: 117397678
LCM: 102358966(IKBKB)
RTP: 109927975(ikbkb)
BFO: 118411310
CIN: 778921
DME: Dmel_CG4201(IKKbeta)
DER: 6553147
DSE: 6606172
DSI: Dsimw501_GD20310(Dsim_ird5)
DYA: Dyak_GE26340(Dyak_ird5)
DAN: 6494177
DSR: 110191738
DPE: 6594219
DMN: 108156166
DWI: 26529178
DAZ: 108621533
DNV: 108659762
DHE: 111604649
DVI: 6631291
MDE: 101888056
AGA: AgaP_AGAP009166(IKK1)
ACOZ: 120959579
AARA: 120902673
AAG: 5577620
CPII: 120430182
AME: 726760
ACER: 108004488
BIM: 100744732
BTER: 100642917
CCAL: 108632449
MGEN: 117222822
SOC: 105197895
MPHA: 105831917
AEC: 105147535
ACEP: 105623150
VEM: 105563455
HST: 105186757
DQU: 106748819
CFO: 105251219
FEX: 115243813
LHU: 105679052
PGC: 109861528
OBO: 105277074
NVI: 100116284
TCA: 655324 658393(ikkb)
DPA: 109540103
NVL: 108569535
APLN: 108739858
OTU: 111417278
BMOR: 101747125
BMAN: 114244430
MSEX: 115450784
BANY: 112055005
PMAC: 106711966
PPOT: 106101605
PXU: 106113861
PRAP: 111001847
HAW: 110372140
TNL: 113503695
PXY: 105396222
CLEC: 106666374
EAF: 111706894
VDE: 111250664
VJA: 111262983
DPTE: 113792695
CSCU: 111632902
PTEP: 107440477
OBI: 106868427
NVE: 116618481
AMIL: 114963622
DGT: 114531073
 » show all
Reference
  Authors
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC
  Title
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
  Journal
Cell 117:225-37 (2004)
DOI:10.1016/S0092-8674(04)00302-2
Reference
PMID:9346485
  Authors
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV
  Title
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
  Journal
Science 278:866-9 (1997)
DOI:10.1126/science.278.5339.866
  Sequence
[hsa:3551]
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