KEGG   ORTHOLOGY: K04500Help
Entry
K04500                      KO                                     

Name
SMAD2_3
Definition
mothers against decapentaplegic homolog 2/3
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05321  Inflammatory bowel disease (IBD)
Disease
H00020  Colorectal cancer
H00800  Loeys-Dietz syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04390 Hippo signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04371 Apelin signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04068 FoxO signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09143 Cell growth and death
   04110 Cell cycle
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04218 Cellular senescence
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   04550 Signaling pathways regulating pluripotency of stem cells
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05212 Pancreatic cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05225 Hepatocellular carcinoma
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05226 Gastric cancer
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
   05161 Hepatitis B
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04500  SMAD2_3; mothers against decapentaplegic homolog 2/3
BRITE hierarchy
Other DBs
GO: 0070410
Genes
HSA: 4087(SMAD2) 4088(SMAD3)
PTR: 455407(SMAD2) 748161(SMAD3)
PPS: 100980706(SMAD2) 100993322(SMAD3)
GGO: 101154310(SMAD2) 109025264(SMAD3)
PON: 100173357(SMAD2) 100448249(SMAD3)
NLE: 100583279(SMAD3) 100589735(SMAD2)
MCC: 697581(SMAD2) 711355(SMAD3)
MCF: 101925163(SMAD2) 102146086(SMAD3)
CSAB: 103222457(SMAD2) 103245436(SMAD3)
RRO: 104657832(SMAD2) 104662580(SMAD3)
RBB: 108514714(SMAD3) 108519603(SMAD2)
CJC: 100393808(SMAD3) 100396826(SMAD2)
SBQ: 101039593(SMAD3) 101040653(SMAD2)
MMU: 17126(Smad2) 17127(Smad3)
MCAL: 110284497(Smad2) 110301346(Smad3)
MPAH: 110327577(Smad3) 110332834(Smad2)
RNO: 25631(Smad3) 29357(Smad2)
CGE: 100759220(Smad3) 100771578(Smad2)
NGI: 103727836(Smad2) 103736807(Smad3)
HGL: 101713378(Smad3) 101714203(Smad2) 101723857
CCAN: 109700302 109701514(Smad3)
OCU: 100346303(SMAD3) 100359137(SMAD2)
TUP: 102473158(SMAD3) 102499541(SMAD2)
CFA: 480144(SMAD2) 610902(SMAD3)
VVP: 112918856(SMAD2) 112929830(SMAD3)
AML: 100467069(SMAD2) 100479304(SMAD3)
UMR: 103663939(SMAD2) 103679154(SMAD3)
UAH: 113240893(SMAD3) 113253394(SMAD2)
ORO: 101367515(SMAD3) 101385419(SMAD2)
FCA: 101087179(SMAD2) 101101387(SMAD3)
PTG: 102971687(SMAD2) 102971888(SMAD3)
AJU: 106972947(SMAD2) 106980367(SMAD3)
BTA: 515125(SMAD3) 516010(SMAD2)
BOM: 102282627(SMAD3) 102286495(SMAD2)
BIU: 109564704(SMAD3) 109577854(SMAD2)
BBUB: 102400710(SMAD3) 102406564(SMAD2)
PHD: 102323907(SMAD2) 102333447(SMAD3)
CHX: 102169293(SMAD3) 102188455(SMAD2)
OAS: 101114231(SMAD2) 443169(SMAD3)
SSC: 100155304(SMAD2) 397260(SMAD3)
CFR: 102508588(SMAD2) 102523073(SMAD3)
CDK: 105093274(SMAD3) 105097587(SMAD2)
BACU: 103005078(SMAD2) 103019152(SMAD3)
LVE: 103069124(SMAD2) 103085090(SMAD3)
OOR: 101278299(SMAD2) 101288074(SMAD3)
DLE: 111177751(SMAD3) 111180276(SMAD2)
ECB: 100033843(SMAD2) 100033845(SMAD3)
EPZ: 103548562(SMAD2) 103549637(SMAD3)
EAI: 106831216(SMAD2) 106840608(SMAD3)
MYB: 102256193(SMAD2) 102259468(SMAD3)
MYD: 102758819(SMAD2) 102769241(SMAD3)
MNA: 107525935(SMAD3) 107546622(SMAD2)
HAI: 109385242(SMAD3) 109388212(SMAD2)
RSS: 109441075(SMAD2) 109444315(SMAD3)
DRO: 112311955(SMAD3) 112322688(SMAD2)
PALE: 102893928(SMAD2) 102895268(SMAD3)
LAV: 100663495(SMAD2) 100677673(SMAD3)
MDO: 100014493(SMAD2) 100018703(SMAD3)
SHR: 100914956(SMAD2) 100923201(SMAD3)
PCW: 110205871(SMAD3) 110207982(SMAD2)
OAA: 100073364(SMAD2) 100085963(SMAD3)
GGA: 395132(SMAD3) 395247(SMAD2Z)
MGP: 100544037(SMAD3) 100544369(SMAD2)
CJO: 107305704(SMAD2) 107318915(SMAD3)
APLA: 101801230(SMAD3) 101803787 101805334(SMAD2)
ACYG: 106037327(SMAD2) 106043666(SMAD3)
TGU: 100225108(SMAD2) 100228359(SMAD3)
LSR: 110473205(SMAD2) 110483002(SMAD3)
SCAN: 103816118(SMAD3) 103820639(SMAD2) 103824734
GFR: 102040325(SMAD3) 102040865 102044404(SMAD2)
FAB: 101806307(SMAD3) 101818681(SMAD2)
PHI: 102100805(SMAD2) 102110827(SMAD3)
PMAJ: 107198156(SMAD2) 107209417(SMAD3)
CCAE: 111933962(SMAD3) 111941053(SMAD2) 111943310
CCW: 104683877(SMAD3) 104695695(SMAD2)
FPG: 101918546(SMAD2) 101924726(SMAD3)
FCH: 102053568(SMAD3) 102059402(SMAD2)
CLV: 102085910(SMAD2) 102095468(SMAD3)
EGZ: 104125236(SMAD3) 104134175(SMAD2)
NNI: 104017045(SMAD3)
ACUN: 113484131(SMAD3) 113489639(SMAD2)
AAM: 106487670(SMAD3) 106497650(SMAD2)
ASN: 102370509(SMAD2) 102379863(SMAD3)
AMJ: 102564680(SMAD3) 102564903(SMAD2)
PSS: 102449871(SMAD3) 102457921(SMAD2)
CMY: 102940642(SMAD2) 102942832 102946629(SMAD3)
CPIC: 101939963(SMAD2) 101949856(SMAD3)
ACS: 100554929(smad2) 100562178(smad3)
PVT: 110085053(SMAD2) 110087999(SMAD3)
PBI: 103058841 103067237(SMAD3)
GJA: 107105564(SMAD3) 107118628(SMAD2)
XLA: 108712801(smad3) 378633(smad3.L) 399442(mad2) 432023(smad2.S)
XTR: 493272(smad3) 496586(smad2)
NPR: 108784107(SMAD3) 108786433(SMAD2) 108800436
DRE: 30639(smad2) 58092(smad3a)
IPU: 108259569(SMAD3) 108264458 108277249(smad2)
PHYP: 113534580(smad3) 113540926 113544066(smad2)
MALB: 109959661 109960765(smad2) 109963341 109971207(smad3)
SFM: 108934681(smad3) 108936291(smad2) 108938101
PKI: 111842093(smad2) 111845594(smad3) 111856558
LCM: 102356317(SMAD3) 102360430(SMAD2)
CMK: 103187354(smad2) 103189587(smad3)
CIN: 100178575 778755(smad2/3a)
SPU: 577345
SKO: 100313734(Smad2/3)
DME: Dmel_CG2262(Smox)
DER: 6550310
DPE: 6598361
DSI: Dsimw501_GD24642(Dsim_GD24642)
DWI: 6649109
DAZ: 108617946
DNV: 108655431
DHE: 111595002
MDE: 101890260
AAG: 5570959
AME: 412601
BIM: 100740756
BTER: 100646575
SOC: 105193574
MPHA: 105829212
AEC: 105152835
ACEP: 105624937
PBAR: 105424505
HST: 105184734
DQU: 106747646
CFO: 105256957
LHU: 105679381
PGC: 109857096
OBO: 105279483
PCF: 106785004
NVI: 100114895(Smox)
MDL: 103579049
TCA: 662450
DPA: 109536357
NVL: 108567240
BMOR: 101738552
PRAP: 110993832
HAW: 110369607
TNL: 113500333
API: 100164536
DNX: 107167109
AGS: 114124126
CLEC: 106664471
ZNE: 110837117
FCD: 110849299
TUT: 107364231
DPTE: 113794542
BMY: Bm1_03720
TSP: Tsp_05943
PCAN: 112558140
OBI: 106878050
EPA: 110238115
ADF: 107337755(AdiSmad2/3)
PDAM: 113667438
SPIS: 111337190
HMG: 100205127
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8673135
  Authors
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B
  Title
Mad-related genes in the human.
  Journal
Nat Genet 13:347-9 (1996)
DOI:10.1038/ng0796-347
  Sequence
[hsa:4087 4088]
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