KEGG   ORTHOLOGY: K04501Help
Entry
K04501                      KO                                     

Name
SMAD4
Definition
mothers against decapentaplegic homolog 4
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04310  Wnt signaling pathway
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04659  Th17 cell differentiation
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00533  Hereditary hemorrhagic telangiectasia
H01023  Juvenile polyposis syndrome
H02102  Myhre syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04350 TGF-beta signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04390 Hippo signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04371 Apelin signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04068 FoxO signaling pathway
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   04550 Signaling pathways regulating pluripotency of stem cells
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04501  SMAD4; mothers against decapentaplegic homolog 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05212 Pancreatic cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05225 Hepatocellular carcinoma
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05226 Gastric cancer
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05220 Chronic myeloid leukemia
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04501  SMAD4; mothers against decapentaplegic homolog 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04501  SMAD4; mothers against decapentaplegic homolog 4
   05161 Hepatitis B
    K04501  SMAD4; mothers against decapentaplegic homolog 4
BRITE hierarchy
Other DBs
GO: 0070412
Genes
HSA: 4089(SMAD4)
PTR: 468537(SMAD4)
PPS: 100991127(SMAD4)
GGO: 101153595(SMAD4) 101153944
PON: 100439171(SMAD4)
NLE: 100599586(SMAD4)
MCC: 701803(SMAD4)
MCF: 102142438(SMAD4)
CSAB: 103222414(SMAD4)
RRO: 104672916(SMAD4)
RBB: 108533135(SMAD4)
CJC: 100409302(SMAD4)
SBQ: 101032066(SMAD4)
MMU: 17128(Smad4)
MCAL: 110284933(Smad4)
MPAH: 110333204(Smad4)
RNO: 50554(Smad4)
MUN: 110550715(Smad4)
CGE: 100770737(Smad4)
NGI: 103726635(Smad4)
HGL: 101703764(Smad4)
CCAN: 109687032(Smad4)
OCU: 100342294(SMAD4)
TUP: 102494008(SMAD4)
CFA: 476196(SMAD4)
VVP: 112919269(SMAD4)
AML: 100465063(SMAD4)
UMR: 103664305(SMAD4)
UAH: 113253422(SMAD4)
ORO: 101374152(SMAD4)
FCA: 101093650(SMAD4)
PTG: 102961093(SMAD4)
PPAD: 109275709(SMAD4)
AJU: 106974966(SMAD4)
BTA: 540248(SMAD4)
BOM: 102265995(SMAD4)
BIU: 109577834(SMAD4)
BBUB: 102390834(SMAD4)
CHX: 100861019(SMAD4)
OAS: 443171(SMAD4)
SSC: 397142(SMAD4)
CFR: 102507868(SMAD4)
CDK: 105103392(SMAD4)
BACU: 103014916(SMAD4)
LVE: 103084261(SMAD4)
OOR: 101285250(SMAD4)
DLE: 111180252(SMAD4)
PCAD: 102986517(SMAD4)
ECB: 100033846(SMAD4)
EPZ: 103558026(SMAD4)
EAI: 106834799(SMAD4)
MYB: 102259994(SMAD4)
MYD: 102752949(SMAD4)
MNA: 107546640(SMAD4)
HAI: 109373579(SMAD4)
DRO: 112322994(SMAD4)
PALE: 102886521(SMAD4)
RAY: 107512852(SMAD4)
MJV: 108394195(SMAD4)
LAV: 100659509(SMAD4)
TMU: 101358763
MDO: 100010143(SMAD4)
SHR: 100923569(SMAD4)
PCW: 110198138(SMAD4)
OAA: 100077136(SMAD4)
GGA: 107055136(SMAD4)
CJO: 107306999(SMAD4) 107324374
APLA: 101805274(SMAD4)
ACYG: 106037328(SMAD4)
TGU: 101232943(SMAD4)
SCAN: 103824828(SMAD4)
GFR: 102041942 102043998(SMAD4)
FAB: 101815515(SMAD4)
PHI: 102111851 102113882(SMAD4)
PMAJ: 107198457(SMAD4) 107214624
CCAE: 111940984(SMAD4)
CCW: 104686787(SMAD4)
FPG: 101918184(SMAD4) 101924446
FCH: 102048236 102057734(SMAD4)
CLV: 102095020(SMAD4)
EGZ: 104122971(SNAPIN) 104134164(SMAD4)
NNI: 104010840(SMAD4) 104018277(SNAPIN)
ACUN: 113490495(SMAD4)
PADL: 103916117(SMAD4)
AAM: 106494875(SMAD4)
ASN: 102373921 102375399(SMAD4)
AMJ: 102572775 102576984(SMAD4)
PSS: 102451711(SMAD4)
CMY: 102945070 102945563(SMAD4)
CPIC: 101944321 101946126(SMAD4)
ACS: 100552093(smad4)
PVT: 110088492 110088634(SMAD4)
PBI: 103061201(SMAD4)
PMUR: 107284129(SMAD4)
TSR: 106556453(SMAD4)
PMUA: 114586471 114606190(SMAD4)
GJA: 107110886 107122009(SMAD4)
XLA: 108700426 108707339 403356(smad4.2.L) 403398(smad4.2.S) 779167 780764(smad4.1.L)
XTR: 100038088(smad4.1)
DRE: 559111(smad4a) 560317(si:dkey-222b8.1)
PKI: 111838434 111856532(smad4)
LCM: 102353847(SMAD4) 102358988
CMK: 103187334(smad4)
CIN: 778905(smad4)
SPU: 575230
APLC: 110974480
SKO: 100369846
DME: Dmel_CG1775(Med)
DER: 6554734
DSI: Dsimw501_GD21590(Dsim_GD21590)
DSR: 110186250
DPE: 6588525
DMN: 108156482
DWI: 6647945
DAZ: 108610346
DNV: 108654126
DHE: 111594485
MDE: 101896100
LCQ: 111682411
AAG: 5578896
AME: 409321
BIM: 100745462
BTER: 100644192
CCAL: 108630884
OBB: 114875096
SOC: 105196014
MPHA: 105831004
AEC: 105151202
PBAR: 105424697
VEM: 105568407
HST: 105185083
CFO: 105249584
LHU: 105675683
PGC: 109853770
OBO: 105276105
PCF: 106784432
CSOL: 105362107
MDL: 103571057
TCA: 660074(Med)
ATD: 109598093
NVL: 108564214
BMOR: 101745398
PMAC: 106721123
PRAP: 110994482
HAW: 110383006
TNL: 113499255
PXY: 105390488
DNX: 107162437
AGS: 114127172
CLEC: 106661881
ZNE: 110836883
FCD: 110848123
PVM: 113805492
TUT: 107363666
DPTE: 113789239
CSCU: 111630983
PTEP: 107442576
CEL: CELE_F25E2.5(daf-3) CELE_R12B2.1(sma-4)
CBR: CBG08108(Cbr-daf-3) CBG09090(Cbr-sma-4)
BMY: Bm1_38760
PCAN: 112556742
CRG: 105331371
MYI: 110466964
OBI: 106876392
SHX: MS3_10165
EGL: EGR_08649
EPA: 110239172
ADF: 107335512 107357814(AdiSmad4)
AMIL: 114958820
PDAM: 113670804
DGT: 114525393
HMG: 100198878
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8553070
  Authors
Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE
  Title
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
  Journal
Science 271:350-3 (1996)
DOI:10.1126/science.271.5247.350
  Sequence
[hsa:4089]
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