KEGG   ORTHOLOGY: K04513
Entry
K04513                      KO                                     

Name
RHOA
Definition
Ras homolog gene family, member A
Pathway
map04011  MAPK signaling pathway - yeast
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04150  mTOR signaling pathway
map04270  Vascular smooth muscle contraction
map04310  Wnt signaling pathway
map04350  TGF-beta signaling pathway
map04360  Axon guidance
map04361  Axon regeneration
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map04611  Platelet activation
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map04660  T cell receptor signaling pathway
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04972  Pancreatic secretion
map05100  Bacterial invasion of epithelial cells
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05152  Tuberculosis
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05210  Colorectal cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H02456  Ectodermal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04011 MAPK signaling pathway - yeast
    K04513  RHOA; Ras homolog gene family, member A
   04014 Ras signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04015 Rap1 signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04310 Wnt signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04350 TGF-beta signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04072 Phospholipase D signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04071 Sphingolipid signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04024 cAMP signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04022 cGMP-PKG signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04150 mTOR signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04513  RHOA; Ras homolog gene family, member A
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04513  RHOA; Ras homolog gene family, member A
   04520 Adherens junction
    K04513  RHOA; Ras homolog gene family, member A
   04530 Tight junction
    K04513  RHOA; Ras homolog gene family, member A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04513  RHOA; Ras homolog gene family, member A
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04513  RHOA; Ras homolog gene family, member A
   04621 NOD-like receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04625 C-type lectin receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04660 T cell receptor signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04670 Leukocyte transendothelial migration
    K04513  RHOA; Ras homolog gene family, member A
   04062 Chemokine signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
   04928 Parathyroid hormone synthesis, secretion and action
    K04513  RHOA; Ras homolog gene family, member A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04513  RHOA; Ras homolog gene family, member A
  09154 Digestive system
   04972 Pancreatic secretion
    K04513  RHOA; Ras homolog gene family, member A
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04513  RHOA; Ras homolog gene family, member A
  09158 Development and regeneration
   04360 Axon guidance
    K04513  RHOA; Ras homolog gene family, member A
   04361 Axon regeneration
    K04513  RHOA; Ras homolog gene family, member A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05206 MicroRNAs in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05205 Proteoglycans in cancer
    K04513  RHOA; Ras homolog gene family, member A
   05203 Viral carcinogenesis
    K04513  RHOA; Ras homolog gene family, member A
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04513  RHOA; Ras homolog gene family, member A
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04513  RHOA; Ras homolog gene family, member A
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04513  RHOA; Ras homolog gene family, member A
   05132 Salmonella infection
    K04513  RHOA; Ras homolog gene family, member A
   05131 Shigellosis
    K04513  RHOA; Ras homolog gene family, member A
   05135 Yersinia infection
    K04513  RHOA; Ras homolog gene family, member A
   05133 Pertussis
    K04513  RHOA; Ras homolog gene family, member A
   05152 Tuberculosis
    K04513  RHOA; Ras homolog gene family, member A
   05100 Bacterial invasion of epithelial cells
    K04513  RHOA; Ras homolog gene family, member A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04513  RHOA; Ras homolog gene family, member A
   05418 Fluid shear stress and atherosclerosis
    K04513  RHOA; Ras homolog gene family, member A
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04513  RHOA; Ras homolog gene family, member A
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04513  RHOA; Ras homolog gene family, member A
   04031 GTP-binding proteins
    K04513  RHOA; Ras homolog gene family, member A
Membrane trafficking [BR:ko04131]
 Endocytosis
  Lipid raft mediated endocytosis
   RhoA-dependent endocytosis
    K04513  RHOA; Ras homolog gene family, member A
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of other body fluids (saliva and urine)
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of colorectal cancer cells
   K04513  RHOA; Ras homolog gene family, member A
  Exosomal proteins of bladder cancer cells
   K04513  RHOA; Ras homolog gene family, member A
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Rho Family
   RhoA/B/C [OT]
    K04513  RHOA; Ras homolog gene family, member A
Other DBs
COG: COG1100
Genes
HSA: 387(RHOA)
PTR: 461014(RHOA)
PPS: 100995642(RHOA)
GGO: 101134778(RHOA)
PON: 100171605(RHOA)
NLE: 100607291(RHOA)
MCC: 706455(RHOA)
MCF: 101865630(RHOA)
CSAB: 103227629(RHOA)
CATY: 105573691(RHOA)
PANU: 101023586(RHOA)
RRO: 104667372(RHOA)
RBB: 108526989(RHOA)
TFN: 117081433(RHOA)
PTEH: 111555593(RHOA)
CJC: 100393236(RHOA)
SBQ: 101052068(RHOA) 104650592 104652261(RHOC)
MMUR: 105874961(RHOA) 105881031
MMU: 11848(Rhoa) 67653(4930544G11Rik)
MCAL: 110292411 110302438(Rhoa)
MPAH: 110326378 110327907(Rhoa)
RNO: 117273(Rhoa) 297173(RSA-14-44)
MCOC: 116073981(Rhoa) 116076329
MUN: 110540728 110565123(Rhoa)
CGE: 100757042 100762797(Rhoa)
PLEU: 114700910 114705216(Rhoa)
NGI: 103743359 103750189(Rhoa)
HGL: 101710109(Rhoa)
CCAN: 109690388 109697844(Rhoa)
TUP: 102487039(RHOA)
CFA: 403954(RHOA)
VVP: 112911519(RHOA)
VLG: 121494185(RHOA)
AML: 100476723(RHOA)
UMR: 103674825(RHOA)
UAH: 113256876(RHOA)
ORO: 101383468(RHOA)
ELK: 111144026
MPUF: 101679891(RHOA)
EJU: 114225106(RHOA)
MLX: 118005670(RHOA)
FCA: 101084011(RHOA)
PTG: 102952555(RHOA)
PPAD: 109247805(RHOA)
AJU: 106979239(RHOA)
HHV: 120229394(RHOA) 120249159
BTA: 338049(RHOA)
BOM: 102280554(RHOA)
BIU: 109576171(RHOA)
BBUB: 102402025(RHOA)
CHX: 102181169(RHOA)
OAS: 100302078(RHOA)
ODA: 120868267(RHOA)
SSC: 396849(RHOA)
CFR: 102507993(RHOA)
CDK: 105087723(RHOA)
BACU: 103019793(RHOA)
LVE: 103074732(RHOA)
OOR: 101273830(RHOA)
DLE: 111174398(RHOA)
PCAD: 102983639(RHOA)
ECB: 100053343(RHOA)
EPZ: 103553409(RHOA)
EAI: 106830690(RHOA)
MYB: 102244315(RHOA)
MYD: 102751353(RHOA)
MMYO: 118664539 118668483(RHOA)
MNA: 107529450(RHOA)
HAI: 109376114(RHOA)
DRO: 112307557 112309492(RHOA)
SHON: 118989480(RHOA)
MMF: 118632939(RHOA)
PALE: 102891515(RHOA)
RAY: 107513350(RHOA)
MJV: 108383250(RHOA)
TOD: 119242628 119260155(RHOA)
LAV: 100677447(RHOA)
TMU: 101356840
MDO: 100021110(RHOA)
SHR: 100921931(RHOA)
PCW: 110209670 110216905(RHOA)
OAA: 100073519(RHOA) 100079193
GGA: 395442(RHOA)
PCOC: 116240932(RHOA)
MGP: 100542834 100547488(RHOA)
CJO: 107319611(RHOA)
NMEL: 110404968(RHOA)
APLA: 101797910(RHOA)
ACYG: 106049491(RHOA)
TGU: 100190386(RHOA)
LSR: 110472045(RHOA)
SCAN: 103816985(RHOA)
PMOA: 120513976(RHOA)
GFR: 102034459(RHOA)
FAB: 101806310(RHOA)
PHI: 102104637(RHOA)
PMAJ: 107210352(RHOA)
CCAE: 111935135(RHOA)
CCW: 104683253(RHOA)
ETL: 114058660(RHOA)
FPG: 101911200(RHOA)
FCH: 102049160(RHOA)
CLV: 102086675(RHOA)
EGZ: 104126734(RHOA) 104129583
NNI: 104008684(RHOA) 104014639
ACUN: 113485019(RHOA)
PADL: 103925495(RHOA)
AAM: 106491145(RHOA)
ASN: 102377583(RHOA) 102383248
AMJ: 102560127 102563558(RHOA)
GGN: 109300191
PSS: 102443561(RHOA) 102458580
CMY: 102933456 102939658(RHOA)
TST: 117880295(RHOA) 117888631
CABI: 116816496(RHOA) 116818892
ACS: 100552508 100566989(rhoa)
PVT: 110076866(RHOA) 110081153
PBI: 103048136 103049329(RHOA)
TSR: 106539135(RHOA) 106552511
PGUT: 117675384 117679240(RHOA)
PMUA: 114587551 114591506(RHOA)
ZVI: 118080560(RHOA) 118097793
XLA: 108709436(rhoc.S) 108715815(rhoa.S) 379326(rhoc.L) 379416(rhoa.L) 380133(rhoa.2.S)
XTR: 448080(rhoa) 549323(rhoc) 549402(rhoa.2)
DRE: 100006041(rhoab) 406411(rhoaa) 406659(rhoac) 436718(rhocb) 751630(zgc:153713)
SLUC: 116038421 116040854(rhoab) 116041618 116051439(rhoca) 116058705(rhoaa)
SASA: 106565140(RHOA) 106566794(RHOA) 106566835 106572042(RHOA) 106572261(RHOA) 106572962 106582735(RHOC) 106583462(RHOA) 106592002(RHOA)
LCM: 102348524 102351192(RHOC) 102363105(RHOA)
CMK: 103172913 103176633(rhoa) 103182401(rhoc)
RTP: 109911121(rhoa)
CIN: 445700(rhoc)
APLC: 110974181
SKO: 100370332
DME: Dmel_CG8416(Rho1)
DER: 6548768
DSE: 6609372
DSI: Dsimw501_GD11158(Dsim_GD11158)
DAN: 6494154
DSR: 110188948
DPE: 6601340
DWI: 6652390
MDE: 101900695
LCQ: 111681716
ACOZ: 120951008
AARA: 120895756
AAG: 5577289
CPII: 120427031
AME: 409910
ACER: 107994629
BIM: 100740548
BTER: 100649013
CCAL: 108625093
OBB: 114879804
MGEN: 117229179
NMEA: 116430028
CGIG: 122400024
SOC: 105199785
MPHA: 105828603
AEC: 105148010
ACEP: 105623459
PBAR: 105427880
VEM: 105563805
HST: 105190197
CFO: 105249999
FEX: 115242671
LHU: 105676157
PGC: 109856895
OBO: 105280784
PCF: 106786487
CSOL: 105361334
MDL: 103575406
TCA: 661700 663316 663337(Rho1)
DPA: 109544337
AGB: 108908151
NVL: 108568533
APLN: 108735442
PPYR: 116158907
OTU: 111415062
BMOR: 101739657
BMAN: 114239514
MSEX: 115444587
BANY: 112057279
PMAC: 106716548
PPOT: 106102502
PRAP: 111002669
ZCE: 119832103
HAW: 110378339
TNL: 113503427
CLEC: 106662745
HAME: 121867491
TUT: 107371599
CEL: CELE_Y51H4A.3(rho-1)
CBR: CBG13664(Cbr-rho-1)
BMY: BM_BM10155(Bma-rho-1.1) BM_BM6727(Bm6727) BM_BM9534(Bma-rho-1.2)
TSP: Tsp_08554
PMAX: 117331406
OBI: 106867931
SCE: YPR165W(RHO1)
ERC: Ecym_7212
KMX: KLMA_70268(RHO1)
NCS: NCAS_0A15070(NCAS0A15070) NCAS_0H00220(NCAS0H00220)
NDI: NDAI_0D00180(NDAI0D00180) NDAI_0J00230(NDAI0J00230)
TPF: TPHA_0I03130(TPHA0I03130) TPHA_0I03140(TPHA0I03140)
TBL: TBLA_0J00210(TBLA0J00210)
TDL: TDEL_0H00500(TDEL0H00500)
KAF: KAFR_0A03120(KAFR0A03120) KAFR_0B00480(KAFR0B00480)
CAL: CAALFM_CR02860WA(RHO1)
CDU: CD36_27930(RHO1)
SLB: AWJ20_2815(RHO1) AWJ20_4600(RHO1)
BNN: FOA43_004534(RHO1)
BBRX: BRETT_001883(RHO1)
NCR: NCU01484(rho-1)
NTE: NEUTE1DRAFT117265(NEUTE1DRAFT_117265) NEUTE1DRAFT84606(NEUTE1DRAFT_84606)
SMP: SMAC_06239(putative rho1)
MAJ: MAA_05388
ANI: AN5740.2
ANG: ANI_1_764124(An14g05530) ANI_1_802164(An18g05980)
SPO: SPAC1F7.04(rho1) SPAC20H4.11c(rho5)
CNE: CNG02630
CNB: CNBG2140
TASA: A1Q1_01431
ABP: AGABI1DRAFT87772(AGABI1DRAFT_87772)
ABV: AGABI2DRAFT139932(AGABI2DRAFT_139932)
MGL: MGL_3754
MRT: MRET_1720
MSYM: MSY001_0082(RHO1.1)
 » show all
Reference
  Authors
Stirling L, Williams MR, Morielli AD
  Title
Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.
  Journal
Mol Biol Cell 20:2991-3002 (2009)
DOI:10.1091/mbc.E08-10-1074
Reference
PMID:8195291
  Authors
Yamochi W, Tanaka K, Nonaka H, Maeda A, Musha T, Takai Y
  Title
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.
  Journal
J Cell Biol 125:1077-93 (1994)
DOI:10.1083/jcb.125.5.1077
Reference
PMID:8039707
  Authors
Moscow JA, He R, Gudas JM, Cowan KH
  Title
Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
  Journal
Gene 144:229-36 (1994)
DOI:10.1016/0378-1119(94)90382-4
  Sequence
[hsa:387]
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