KEGG   ORTHOLOGY: K04526
Entry
K04526                      KO                                     

Name
INS
Definition
insulin
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04911  Insulin secretion
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04917  Prolactin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04940  Type I diabetes mellitus
ko04950  Maturity onset diabetes of the young
ko04960  Aldosterone-regulated sodium reabsorption
ko05010  Alzheimer disease
ko05215  Prostate cancer
Disease
H00408  Type 1 diabetes mellitus
H00410  Maturity onset diabetes of the young (MODY)
H00512  Permanent neonatal diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04526  INS; insulin
   04014 Ras signaling pathway
    K04526  INS; insulin
   04015 Rap1 signaling pathway
    K04526  INS; insulin
   04066 HIF-1 signaling pathway
    K04526  INS; insulin
   04068 FoxO signaling pathway
    K04526  INS; insulin
   04072 Phospholipase D signaling pathway
    K04526  INS; insulin
   04022 cGMP-PKG signaling pathway
    K04526  INS; insulin
   04151 PI3K-Akt signaling pathway
    K04526  INS; insulin
   04152 AMPK signaling pathway
    K04526  INS; insulin
   04150 mTOR signaling pathway
    K04526  INS; insulin
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04526  INS; insulin
  09143 Cell growth and death
   04114 Oocyte meiosis
    K04526  INS; insulin
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04526  INS; insulin
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04526  INS; insulin
   04910 Insulin signaling pathway
    K04526  INS; insulin
   04923 Regulation of lipolysis in adipocytes
    K04526  INS; insulin
   04913 Ovarian steroidogenesis
    K04526  INS; insulin
   04914 Progesterone-mediated oocyte maturation
    K04526  INS; insulin
   04917 Prolactin signaling pathway
    K04526  INS; insulin
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04526  INS; insulin
  09149 Aging
   04211 Longevity regulating pathway
    K04526  INS; insulin
   04213 Longevity regulating pathway - multiple species
    K04526  INS; insulin
 09160 Human Diseases
  09162 Cancer: specific types
   05215 Prostate cancer
    K04526  INS; insulin
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04526  INS; insulin
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04526  INS; insulin
   04940 Type I diabetes mellitus
    K04526  INS; insulin
   04950 Maturity onset diabetes of the young
    K04526  INS; insulin
   04932 Non-alcoholic fatty liver disease
    K04526  INS; insulin
   04931 Insulin resistance
    K04526  INS; insulin
Genes
HSA: 3630(INS)
PTR: 449570(INS)
PPS: 100969387(INS)
GGO: 101132604(INS)
PON: 100453978(INS)
NLE: 100586809(INS)
MCC: 704534(INS)
MCF: 102133184(INS)
CSAB: 103239029(INS)
RRO: 104677102(INS)
RBB: 108539226(INS)
CJC: 100393089(INS)
SBQ: 101038116(INS)
MMU: 16333(Ins1) 16334(Ins2)
RNO: 24505(Ins1) 24506(Ins2)
MUN: 110547298
CGE: 100760716(Ins)
NGI: 103738986(Ins)
HGL: 101719971(Ins)
CCAN: 109689794
OCU: 100009181(INS)
TUP: 102481191(INS)
CFA: 483665(INS)
VVP: 112924140(INS)
AML: 100483432(INS)
UMR: 103671056
UAH: 113243960
ORO: 101383590(INS)
ELK: 111150279
FCA: 493804(INS)
PPAD: 109259395(INS)
AJU: 113595531(INS)
BTA: 280829(INS)
BOM: 102274400(INS)
BIU: 109554336(INS)
BBUB: 102396436(INS)
CHX: 108634241(INS)
OAS: 114110121(INS)
SSC: 397415(INS)
CFR: 116666555(INS)
CDK: 116152037(INS)
BACU: 103021022(INS)
LVE: 103085742(INS)
OOR: 101278494(INS)
DLE: 111183606(INS)
PCAD: 112062628(INS)
ECB: 111776000(INS)
EPZ: 103567614(INS)
EAI: 106824100(INS)
MYB: 102254396
MYD: 102753598(INS)
HAI: 109395936(INS)
DRO: 112317432
PALE: 102881117
RAY: 107513269(INS)
MJV: 108402614(INS)
LAV: 100661112(INS)
TMU: 101346705
PCW: 110197190(INS)
OAA: 114810063(INS)
GGA: 396145(INS-IGF2)
MGP: 100540225(INS)
CJO: 107314531(INS)
NMEL: 110400779(INS)
APLA: 101794427(INS)
ACYG: 106042601(INS)
TGU: 100231606(INS)
LSR: 110468670(INS)
SCAN: 103826754(INS)
GFR: 102044590(INS)
FAB: 101812165(INS)
PHI: 102111203(INS)
PMAJ: 107205419(INS)
CCAE: 111930707(INS)
CCW: 104687554(INS)
ETL: 114059852(INS)
FPG: 101915745(INS)
FCH: 102054961(INS)
CLV: 102092033(INS)
EGZ: 104124907
NNI: 104010412
ACUN: 113481160
PADL: 103920695(INS)
AAM: 106497062(INS)
ASN: 102378642(INS)
AMJ: 102565762(INS)
PSS: 102445198(INS)
CMY: 102935680(INS)
CPIC: 101937524(INS)
ACS: 100565615(ins)
PVT: 110076559(INS)
PBI: 103061255(INS)
PMUR: 107294042(INS)
TSR: 106547000(INS)
PMUA: 114585088
GJA: 107123376(INS)
XLA: 108696734 378695(ins.L) 378696(ins.S)
XTR: 100101718(ins)
NPR: 108792002(INS)
DRE: 100534937 30262(ins) 566735(insb)
PHYP: 113525002 113531241(ins)
EEE: 113591428(ins)
TRU: 101065226
NCC: 104961913(ins)
MZE: 101468103(ins) 101469513
ONL: 100692120(ins) 100704156
XMA: 102225241(ins) 102229304
XCO: 114139621 114153755(ins)
CVG: 107086316 107090300(ins)
CSEM: 103395680(ins)
SASA: 106567474(INS) 106603941(INS) 106612054
SFM: 108934283(ins)
PKI: 111850821(ins)
LCM: 102348278(INS)
CMK: 103186003(ins)
RTP: 109921259(ins)
DME: Dmel_CG14167(Ilp3) Dmel_CG14173(Ilp1) Dmel_CG33273(Ilp5) Dmel_CG6736(Ilp4) Dmel_CG8167(Ilp2)
DSI: Dsimw501_GD12890(Dsim_GD12890) Dsimw501_GD12891(Dsim_GD12891) Dsimw501_GD12892(Dsim_GD12892) Dsimw501_GD14217(Dsim_GD14217) Dsimw501_GD14218(Dsim_GD14218)
BIM: 112211977
BTER: 100646077
CCAL: 108629740
OBB: 114873438
SOC: 105200753
MPHA: 105832901
AEC: 105147653
ACEP: 105625577
PBAR: 105432563
VEM: 105559845
HST: 105188195
DQU: 106750697
LHU: 105670049
PGC: 109860861
OBO: 105278524
PCF: 106791661
NVI: 100117514
CSOL: 105364979
MDL: 103569964
TCA: 100142381
BMOR: 100146109(Bbx-e1) 100146110(Bbx-f1) 100169657(Bbx-a4) 100169708(Bbx-a7) 100169712(Bbx-a3) 100169716(Bbx-b7) 100169719(Bbx-b1) 100169720(Bbx-b4) 100169723(Bbx-b6) 100169726(Bbx-g1) 100653512(BmILP) 101736783 101741759
RMD: 113558495
CLEC: 112127432
FCD: 110851216
TSP: Tsp_10902
OBI: 106870869
LAK: 106180359
EGL: EGR_08330
AMIL: 114960007
SPIS: 111326395
 » show all
Reference
  Authors
Lizcano JM, Alessi DR
  Title
The insulin signalling pathway.
  Journal
Curr Biol 12:R236-8 (2002)
DOI:10.1016/S0960-9822(02)00777-7
Reference
PMID:2397023
  Authors
Sawa T, Ohgaku S, Morioka H, Yano S
  Title
Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.
  Journal
J Mol Endocrinol 5:61-7 (1990)
DOI:10.1677/jme.0.0050061
  Sequence
[mmu:16333 16334]
LinkDB

KEGG   ORTHOLOGY: K05459
Entry
K05459                      KO                                     

Name
IGF1
Definition
insulin-like growth factor 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05224  Breast cancer
ko05410  Hypertrophic cardiomyopathy
ko05414  Dilated cardiomyopathy
Disease
H00015  Malignant pleural mesothelioma
H02040  Insulin-like growth factor I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04014 Ras signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04015 Rap1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04066 HIF-1 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04068 FoxO signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04151 PI3K-Akt signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04152 AMPK signaling pathway
    K05459  IGF1; insulin-like growth factor 1
   04150 mTOR signaling pathway
    K05459  IGF1; insulin-like growth factor 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05459  IGF1; insulin-like growth factor 1
   04115 p53 signaling pathway
    K05459  IGF1; insulin-like growth factor 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05459  IGF1; insulin-like growth factor 1
   04550 Signaling pathways regulating pluripotency of stem cells
    K05459  IGF1; insulin-like growth factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05459  IGF1; insulin-like growth factor 1
   04914 Progesterone-mediated oocyte maturation
    K05459  IGF1; insulin-like growth factor 1
   04935 Growth hormone synthesis, secretion and action
    K05459  IGF1; insulin-like growth factor 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K05459  IGF1; insulin-like growth factor 1
  09156 Nervous system
   04730 Long-term depression
    K05459  IGF1; insulin-like growth factor 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05459  IGF1; insulin-like growth factor 1
  09149 Aging
   04211 Longevity regulating pathway
    K05459  IGF1; insulin-like growth factor 1
   04213 Longevity regulating pathway - multiple species
    K05459  IGF1; insulin-like growth factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05459  IGF1; insulin-like growth factor 1
   05202 Transcriptional misregulation in cancer
    K05459  IGF1; insulin-like growth factor 1
   05205 Proteoglycans in cancer
    K05459  IGF1; insulin-like growth factor 1
  09162 Cancer: specific types
   05214 Glioma
    K05459  IGF1; insulin-like growth factor 1
   05218 Melanoma
    K05459  IGF1; insulin-like growth factor 1
   05215 Prostate cancer
    K05459  IGF1; insulin-like growth factor 1
   05224 Breast cancer
    K05459  IGF1; insulin-like growth factor 1
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
   05414 Dilated cardiomyopathy
    K05459  IGF1; insulin-like growth factor 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05459  IGF1; insulin-like growth factor 1
   01522 Endocrine resistance
    K05459  IGF1; insulin-like growth factor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05459  IGF1; insulin-like growth factor 1
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05459  IGF1; insulin-like growth factor 1
Other DBs
GO: 0005159
Genes
HSA: 3479(IGF1)
PTR: 741055(IGF1)
PPS: 100982978(IGF1)
GGO: 101154397(IGF1)
PON: 100444645(IGF1)
NLE: 100595306(IGF1)
MCC: 698444(IGF1)
MCF: 102128018(IGF1)
CSAB: 103238957(IGF1)
RRO: 104657459(IGF1)
RBB: 108543134(IGF1)
CJC: 100394985(IGF1)
SBQ: 101036963(IGF1)
MMU: 16000(Igf1)
MCAL: 110304009(Igf1)
MPAH: 110326668(Igf1)
RNO: 24482(Igf1)
MUN: 110561622(Igf1)
CGE: 100751642(Igf1)
NGI: 103733723(Igf1)
HGL: 101707684(Igf1)
CCAN: 109677734 109697466(Igf1)
OCU: 100008668(IGF1)
TUP: 102490248(IGF1)
CFA: 610255(IGF1)
VVP: 112930717(IGF1)
AML: 100473254(IGF1)
UMR: 103676495(IGF1)
UAH: 113256079(IGF1)
ORO: 101386334(IGF1)
FCA: 101101237(IGF1)
PTG: 102962543(IGF1)
PPAD: 109265419(IGF1)
AJU: 106971906(IGF1)
BTA: 281239(IGF1)
BOM: 102272009(IGF1)
BIU: 109559448(IGF1)
BBUB: 102392528(IGF1)
CHX: 100860838(IGF1)
OAS: 443318(IGF1)
SSC: 397491(IGF1)
CFR: 102506236(IGF1)
CDK: 105097468(IGF1)
BACU: 103014780(IGF1)
LVE: 103078928(IGF1)
OOR: 101269950(IGF1)
DLE: 111187819(IGF1)
PCAD: 102990550(IGF1)
ECB: 100034198(IGF1)
EPZ: 103549360(IGF1)
EAI: 106827264(IGF1)
MYB: 102252071(IGF1)
MYD: 102752580(IGF1)
MNA: 107545147(IGF1)
HAI: 109387785(IGF1)
DRO: 112321846(IGF1)
PALE: 102890331(IGF1)
RAY: 107501166(IGF1)
MJV: 108410340(IGF1)
LAV: 100664710(IGF1)
TMU: 101361934
MDO: 100021295(IGF1)
SHR: 100918816(IGF1)
PCW: 110205653(IGF1)
OAA: 100075905(IGF1)
GGA: 418090(IGF1)
CJO: 107316281(IGF1)
NMEL: 110393921(IGF1)
APLA: 101793597(IGF1)
ACYG: 106035916(IGF1)
TGU: 100226283(IGF1)
LSR: 110473651(IGF1)
SCAN: 103819655(IGF1)
GFR: 102032215(IGF1)
FAB: 101808710(IGF1)
PHI: 102112946(IGF1)
PMAJ: 107204610(IGF1)
CCAE: 111936136(IGF1)
CCW: 104696228(IGF1)
ETL: 114056148(IGF1)
FPG: 101922655(IGF1)
FCH: 102060062(IGF1)
CLV: 102092089(IGF1)
EGZ: 104135582(IGF1)
NNI: 104013358(IGF1)
ACUN: 113491340(IGF1)
PADL: 103924427(IGF1)
AAM: 106488383(IGF1)
ASN: 102372626(IGF1)
AMJ: 102559209(IGF1)
PSS: 102454948(IGF1)
CMY: 102932263(IGF1)
CPIC: 101939474(IGF1)
ACS: 100566682(igf1)
PVT: 110084792(IGF1)
PBI: 103062109(IGF1)
PMUR: 107289460(IGF1)
PMUA: 114605733(IGF1)
GJA: 107119991(IGF1)
XLA: 108711020(igf1.L) 108712492 378699(igf1.S)
XTR: 100486334(igf1)
NPR: 108789614(IGF1)
DRE: 114433(igf1)
IPU: 100305062(igf1)
PHYP: 113532358(igf1) 113535157
AMEX: 103036238(igf1)
EEE: 113584584(igf1)
TRU: 100462939(igf1)
LCO: 104926290(igf1) 104935275
NCC: 104956990
MZE: 101464291 101476517(igf1)
ONL: 100534428 100534565(igf1)
OLA: 101168167(igf1) 105354483
XMA: 102221578 102222602(igf1)
XCO: 114142519 114160998(igf1)
PRET: 103459389(igf1) 103466958
CVG: 107085823(igf1) 107097451
NFU: 107386743(igf1) 107391385
KMR: 108228312 108233311(igf1)
ALIM: 106529338 106530265(igf1)
AOCE: 111568767(igf1) 111587489
CSEM: 103382578(igf1) 103384875
POV: 109639654 109640767(igf1)
LCF: 108897582(igf1) 108900498
SDU: 111225018(igf1) 111233786
SLAL: 111658878 111664700(igf1)
HCQ: 109528351 109530129(igf1)
MALB: 109967822(igf1) 109971005
ELS: 105013816 105030158(igf1)
SFM: 108931632(igf1) 114909159
PKI: 111834375 111846569(igf1)
LCM: 102361051(IGF1) 102365620
CMK: 103179868(igf1)
RTP: 109914145(igf1)
BFO: 118407319
CIN: 100170003(ins-l1)
DME: Dmel_CG14049(Ilp6)
DER: 6555537
DSE: 6616142
DSI: Dsimw501_GD28130(Dsim_GD28130)
DSR: 110183267
DPE: 6600159
DMN: 108164895
DWI: 6638043
DAZ: 108619735
DNV: 108658570
DHE: 111596753
MDE: 101896013
LCQ: 111675152
BIM: 105680848
BTER: 100648980
CCAL: 108632922
OBB: 114879882
SOC: 105197201
MPHA: 105840254
AEC: 105154102
ACEP: 105617935
VEM: 105562165
HST: 105186969
DQU: 106741669
CFO: 105257619
PGC: 109855579
OBO: 105283606
NVI: 100679703
CSOL: 105365464
TCA: 103315192
BMOR: 100147697(Bbx-c2) 100169656(Bbx-b11) 100169707(Bbx-a10) 100169715(Bbx-b10) 100169718(Bbx-b8) 100169722(Bbx-b3) 100169724(Bbx-b5) 100270769(Igflp) 101740144
PRAP: 110996560
TNL: 113497883
API: 100169635
CLEC: 106672819
ZNE: 110826827
CSCU: 111624540
CRG: 105319754
NVE: 5512419
EPA: 110241415
SPIS: 111342911
 » show all
Reference
PMID:3002851
  Authors
de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  Title
Organization of the human genes for insulin-like growth factors I and II.
  Journal
FEBS Lett 195:179-84 (1986)
DOI:10.1016/0014-5793(86)80156-9
  Sequence
[hsa:3479]
Reference
  Authors
Zoidis E, Ghirlanda-Keller C, Schmid C
  Title
Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.
  Journal
Mol Cell Biochem 348:33-42 (2011)
DOI:10.1007/s11010-010-0634-z
  Sequence
[hsa:3479]
LinkDB

KEGG   ORTHOLOGY: K19805
Entry
K19805                      KO                                     

Name
ILP7
Definition
insulin-like peptide 7
Pathway
ko04213  Longevity regulating pathway - multiple species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    K19805  ILP7; insulin-like peptide 7
Other DBs
GO: 0005158
Genes
APLC: 110973101 110975792 110976348
SKO: 100375961 102808381
DME: Dmel_CG13317(Ilp7)
DER: 6550903
DSE: 6612576
DSI: Dsimw501_GD16647(Dsim_GD16647)
DYA: Dyak_GE16307
DAN: 6505299
DSR: 110184439
DPO: Dpse_GA12198
DPE: 6599329
DMN: 108164573
DWI: 6653107
DAZ: 108618322
DNV: 115565395
DHE: 111604740
DVI: 6631645
MDE: 101895895
LCQ: 111675333
AAG: 5580310
TCA: 664355
NVL: 108560434
ZNE: 110826829
FCD: 110850873
TUT: 107362567
PTEP: 107446188
PCAN: 112566375
CRG: 105333726
OBI: 106878236
 » show all
Reference
  Authors
Miguel-Aliaga I, Thor S, Gould AP
  Title
Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons.
  Journal
PLoS Biol 6:e58 (2008)
DOI:10.1371/journal.pbio.0060058
  Sequence
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