KEGG   ORTHOLOGY: K04556
Entry
K04556                      KO                                     

Name
PARK2
Definition
parkin [EC:2.3.2.31]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04137  Mitophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05022  Pathways of neurodegeneration - multiple diseases
Disease
H00057  Parkinson disease
H00344  Leprosy
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04556  PARK2; parkin
   04120 Ubiquitin mediated proteolysis
    K04556  PARK2; parkin
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04556  PARK2; parkin
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04556  PARK2; parkin
   05014 Amyotrophic lateral sclerosis
    K04556  PARK2; parkin
   05022 Pathways of neurodegeneration - multiple diseases
    K04556  PARK2; parkin
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04556  PARK2; parkin
   04121 Ubiquitin system
    K04556  PARK2; parkin
   03029 Mitochondrial biogenesis
    K04556  PARK2; parkin
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K04556  PARK2; parkin
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K04556  PARK2; parkin
  Aggrephagy
   Other aggrephagy associated proteins
    K04556  PARK2; parkin
  Xenophagy
   Other xenophagy associated proteins
    K04556  PARK2; parkin
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K04556  PARK2; parkin
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K04556  PARK2; parkin
Genes
HSA: 5071(PRKN)
PTR: 741350(PRKN)
PPS: 100978701(PARK2)
GGO: 101154322(PRKN)
PON: 100172433(PRKN)
NLE: 100589757(PRKN)
MCC: 710899(PRKN)
MCF: 102134446(PARK2)
CSAB: 103240862(PARK2)
RRO: 104669996(PRKN)
RBB: 108527984(PARK2)
CJC: 100390242(PARK2)
SBQ: 101029277(PARK2)
MMU: 50873(Prkn)
MCAL: 110312630(Prkn)
MPAH: 110338080(Prkn)
RNO: 56816(Park2)
CGE: 100764359(Prkn)
NGI: 103729225 103737054(Park2)
HGL: 101700770(Park2)
CCAN: 109688031
OCU: 100358886(PARK2)
TUP: 102469732(PARK2)
CFA: 612316(PRKN)
VVP: 112932949(PRKN)
AML: 100465415(PRKN)
UMR: 103660821(PARK2)
UAH: 113259330(PRKN)
ORO: 101385500(PARK2)
ELK: 111158711
FCA: 101098228(PRKN)
PTG: 102964689(PARK2)
PPAD: 109245483(PARK2)
AJU: 106985022(PRKN)
BTA: 530858(PARK2)
BIU: 109564101(PARK2)
BBUB: 102406619(PRKN)
CHX: 102172812(PARK2)
OAS: 101113503(PRKN)
SSC: 733673(PRKN)
CFR: 102508809(PRKN)
CDK: 105086287(PRKN)
BACU: 103006032(PARK2)
LVE: 103072488(PARK2)
OOR: 101286051(PARK2)
DLE: 111168498(AGPAT4)
PCAD: 102982022(PRKN)
ECB: 100057832(PRKN)
EAI: 106842050(PARK2)
MYB: 102255484(PARK2)
MYD: 102757960(PARK2)
MNA: 107535732(PARK2)
HAI: 109394305
DRO: 112297296
PALE: 102888747(PRKN)
RAY: 107501685(PARK2)
LAV: 100665442(PRKN)
TMU: 101340669
MDO: 100032502(PARK2)
SHR: 100928463(PRKN)
PCW: 110208624(PRKN)
OAA: 114808913 114809162(PRKN)
GGA: 421577(PARK2)
CJO: 107311526(PRKN)
NMEL: 110395954(PRKN)
APLA: 101796091(PRKN)
ACYG: 106039539(PARK2)
TGU: 100221229(PRKN)
LSR: 110477920(PRKN)
SCAN: 103821619(PRKN)
GFR: 102043879(PARK2)
FAB: 101810988(PARK2)
PHI: 102105199(PARK2)
PMAJ: 107202287(PARK2)
CCAE: 111926948(PRKN)
CCW: 104684351(PRKN)
ETL: 114055652(PRKN)
FPG: 101918371(PARK2)
FCH: 102048210(PRKN)
CLV: 102084040(PRKN)
NNI: 104018425(PARK2)
ACUN: 113477882(PRKN)
PADL: 103914151(PARK2)
AAM: 106486766(PARK2)
ASN: 102381887(PRKN)
AMJ: 102573688(PARK2)
PSS: 102451562(PRKN)
CMY: 102935998(PARK2)
CPIC: 101941171(PARK2)
ACS: 100559435(park2)
PVT: 110087285(PRKN)
PBI: 103051791
PMUR: 107295102(PRKN)
TSR: 106550720(PARK2)
PMUA: 114594313(PRKN)
GJA: 107113335(PARK2) 107118842
DRE: 550328(prkn)
SRX: 107739476
SGH: 107586494(park2)
CCAR: 109081461(park2)
IPU: 108263700(park2)
PHYP: 113545038(prkn)
AMEX: 103027813(prkn)
EEE: 113572720(prkn)
TRU: 101073892(prkn)
LCO: 104934697(prkn)
MZE: 101482320(prkn)
ONL: 100708029(prkn)
OLA: 101170614(prkn)
XMA: 102219281(prkn)
CVG: 107101386(park2)
NFU: 107396230(park2)
KMR: 108246747(prkn)
ALIM: 106531494(park2)
CSEM: 103387132(park2)
POV: 109644595(park2)
SDU: 111223871(prkn)
SLAL: 111656069(prkn)
BPEC: 110168027(prkn)
MALB: 109973015(prkn)
SASA: 106576740(park2)
OTW: 112252884(prkn)
SALP: 111951983(prkn)
ELS: 105025493(prkn)
SFM: 108942718(prkn)
PKI: 111848830(prkn)
CMK: 103176050(park2)
RTP: 109915425
SPU: 594188
APLC: 110978897
SKO: 100368482
DME: Dmel_CG10523(park)
DER: 6546488
DSE: 6616405
DSI: Dsimw501_GD12138(Dsim_GD12138)
DAN: 6493058
DSR: 110190005
DPE: 6601156
DMN: 108152308
DWI: 6639572
DAZ: 108613104
DNV: 115563451
DHE: 111594380
DVI: 6623567
MDE: 101899448
LCQ: 111685242
AAG: 5564457
AME: 412975
BIM: 100747344
BTER: 100649117
CCAL: 108627940
OBB: 114876354
SOC: 105205525
MPHA: 105828522
AEC: 105144380
ACEP: 105622910
PBAR: 105428684
VEM: 105565195
HST: 105187377
DQU: 106751821
CFO: 105251913
LHU: 105667495
PGC: 109857665
OBO: 105278436
PCF: 106789812
NVI: 100122062
CSOL: 105361944
MDL: 103579205
TCA: 657490
DPA: 109546411
ATD: 109601762
NVL: 108569438
API: 100166503
DNX: 107171531
AGS: 114128629
RMD: 113553168
BTAB: 109038844
ZNE: 110826528
FCD: 110855883
TUT: 107362791
CSCU: 111622201
PTEP: 107455549
CEL: CELE_K08E3.7(pdr-1)
CBR: CBG18262(Cbr-pdr-1)
BMY: Bm1_57385
PCAN: 112565826
CRG: 105335799
MYI: 110463400
LAK: 106166390
SHX: MS3_08427
EGL: EGR_05629
NVE: 5512842
EPA: 110243769
ADF: 107339248
AMIL: 114977498
PDAM: 113682110
SPIS: 111322954
 » show all
Reference
  Authors
Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R
  Title
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.
  Journal
Mol Cell 10:55-67 (2002)
DOI:10.1016/S1097-2765(02)00583-X
  Sequence
[hsa:5071]
Reference
  Authors
Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM
  Title
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.
  Journal
Science 304:1328-31 (2004)
DOI:10.1126/science.1093891
  Sequence
[hsa:5071] [mmu:50873]
Reference
PMID:9560156
  Authors
Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N
  Title
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
  Journal
Nature 392:605-8 (1998)
DOI:10.1038/33416
  Sequence
[hsa:5071]
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