KEGG   ORTHOLOGY: K04674
Entry
K04674                      KO                                     

Name
TGFBR1, ALK5
Definition
TGF-beta receptor type-1 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04371  Apelin signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00018  Gastric cancer
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04350 TGF-beta signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04390 Hippo signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04371 Apelin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   04068 FoxO signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09143 Cell growth and death
   04218 Cellular senescence
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05212 Pancreatic cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05225 Hepatocellular carcinoma
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05226 Gastric cancer
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05220 Chronic myeloid leukemia
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
   05161 Hepatitis B
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR1 family [OT]
   K04674  TGFBR1, ALK5; TGF-beta receptor type-1
Other DBs
GO: 0005025
Genes
HSA: 7046(TGFBR1)
PTR: 472992(TGFBR1)
PPS: 100984463(TGFBR1)
GGO: 101128510(TGFBR1)
PON: 100450864(TGFBR1)
NLE: 100592854(TGFBR1)
MCC: 714952(TGFBR1)
MCF: 102115287(TGFBR1)
CSAB: 103219139(TGFBR1)
RRO: 104657765(TGFBR1)
RBB: 108512466(TGFBR1)
CJC: 100389596(TGFBR1)
SBQ: 101030583(TGFBR1)
MMU: 21812(Tgfbr1)
MCAL: 110292408(Tgfbr1)
MPAH: 110322784(Tgfbr1)
RNO: 103690035 29591(Tgfbr1)
MUN: 110551136(Tgfbr1)
CGE: 100772727(Tgfbr1)
NGI: 103744902(Tgfbr1)
HGL: 101718090(Tgfbr1)
CCAN: 109691424(Tgfbr1)
OCU: 100345812(TGFBR1)
TUP: 102476700(TGFBR1)
CFA: 481628(TGFBR1)
VVP: 112930794(TGFBR1)
AML: 100475698(TGFBR1)
UMR: 103678627(TGFBR1)
UAH: 113260405(TGFBR1)
ORO: 101379465(TGFBR1)
ELK: 111146071
FCA: 101094057(TGFBR1)
PTG: 102950020(TGFBR1)
PPAD: 109270084(TGFBR1)
AJU: 106972043(TGFBR1)
BTA: 282382(TGFBR1)
BOM: 102283685(TGFBR1)
BIU: 109563078(TGFBR1)
BBUB: 102396812(TGFBR1)
CHX: 102187767(TGFBR1)
OAS: 554326(TGFBR1)
SSC: 396665(TGFBR1)
CFR: 102522485(TGFBR1)
CDK: 105086891(TGFBR1)
BACU: 102999446(TGFBR1)
LVE: 103071954(TGFBR1)
OOR: 101287555(TGFBR1)
DLE: 111188083(TGFBR1)
PCAD: 102978050(TGFBR1)
ECB: 100034117(TGFBR1)
EPZ: 103555266(TGFBR1)
EAI: 106842924(TGFBR1)
MYB: 102241353(TGFBR1)
MYD: 102765185(TGFBR1)
MNA: 107544970(TGFBR1)
HAI: 109386421(TGFBR1)
DRO: 112304528(TGFBR1)
PALE: 102880759(TGFBR1)
RAY: 107500589(TGFBR1)
MJV: 108394148(TGFBR1)
LAV: 100656286(TGFBR1)
TMU: 101359953
MDO: 100011507(TGFBR1)
SHR: 100913844(TGFBR1)
PCW: 110214564(TGFBR1)
OAA: 100092358(TGFBR1)
GGA: 374094(TGFBR1)
MGP: 100543917(TGFBR1)
CJO: 107309773
NMEL: 110394489(TGFBR1)
APLA: 101805328(TGFBR1)
ACYG: 106038346(TGFBR1)
TGU: 100230911(TGFBR1)
LSR: 110483463(TGFBR1)
SCAN: 103819385(TGFBR1)
GFR: 102037879(TGFBR1)
FAB: 101809241(TGFBR1)
PHI: 102113190(TGFBR1)
PMAJ: 107200568(TGFBR1)
CCAE: 111923709(TGFBR1)
CCW: 104688870(TGFBR1)
ETL: 114063815(TGFBR1)
FPG: 101922518(TGFBR1)
FCH: 102055038(TGFBR1)
CLV: 102095465(TGFBR1)
EGZ: 104125437(TGFBR1)
NNI: 104021869(TGFBR1)
ACUN: 113476683(TGFBR1)
PADL: 103917369(TGFBR1)
AAM: 106491015(TGFBR1)
ASN: 102370778(TGFBR1)
AMJ: 102568992(TGFBR1)
CMY: 102942001(TGFBR1)
CPIC: 101944287(TGFBR1)
ACS: 100566944(tgfbr1)
PVT: 110086076(TGFBR1)
PBI: 103059881
TSR: 106538373(TGFBR1)
PMUA: 114608061(TGFBR1)
GJA: 107109116(TGFBR1)
XLA: 108719029 399295(tgfbr1.S)
XTR: 548715(tgfbr1)
NPR: 108799247(TGFBR1)
DRE: 560578(tgfbr1a) 792928(tgfbr1b)
IPU: 108271704(tgfbr1)
PHYP: 113526975(tgfbr1)
AMEX: 103034175
EEE: 113590741(tgfbr1)
TRU: 101062282
LCO: 104931778
MZE: 101479229
ONL: 100695177
XMA: 102222719
XCO: 114149782
PRET: 103482409
CVG: 107100676
NFU: 107374334
KMR: 108248259
ALIM: 106519000
AOCE: 111569578
CSEM: 103376883
POV: 109638437
LCF: 108898453
SDU: 111220510
SLAL: 111673055
HCQ: 109530275
BPEC: 110165570
MALB: 109965533
LCM: 102350402(TGFBR1)
CMK: 103181552
RTP: 109921531
BFO: 118405617
CIN: 445775(tgfbr-ic)
APLC: 110989541
SKO: 100370253
DME: Dmel_CG8224(babo)
DER: 6540765
DSE: 6608265
DSI: Dsimw501_GD10620(Dsim_GD10620)
DAN: 6495076
DPE: 6592605
DWI: 6646288
DAZ: 108616748
DNV: 108653174
DHE: 111597654
DVI: 6626610
MDE: 101895175
LCQ: 111691242
AAG: 5572069
AALB: 109415848
AME: 550930
BIM: 100740693
BTER: 100643263
CCAL: 108632574
OBB: 114880795
SOC: 105193383
MPHA: 105834262
AEC: 105149442
ACEP: 105627280
PBAR: 105427063
VEM: 105567251
HST: 105191563
DQU: 106742458
CFO: 105256068
LHU: 105676036
PGC: 109857803
OBO: 105287968
PCF: 106793854
NVI: 100114832
CSOL: 105367453
MDL: 103576842
TCA: 659969(babo)
DPA: 109542240
ATD: 109596445
NVL: 108562386
BMOR: 101742113
BMAN: 114250041
PMAC: 106717233
PRAP: 110998149
HAW: 110374498
TNL: 113505189
PXY: 105398137
API: 100164283
DNX: 107173148
AGS: 114125547
RMD: 113550486
BTAB: 109044670
CLEC: 106673837
ZNE: 110839262
FCD: 110842324
DPX: DAPPUDRAFT_347223(BABO)
PVM: 113807067
TUT: 107367555
DPTE: 113797156
BMY: Bm1_44900
PCAN: 112562162
CRG: 105318607
MYI: 110458522
OBI: 106868204
LAK: 106153365
SHX: MS3_01247
EGL: EGR_06011
NVE: 5501225
AMIL: 114966404
PDAM: 113673055
HMG: 100212672
 » show all
Reference
PMID:8242743
  Authors
Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K
  Title
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.
  Journal
Cell 75:681-92 (1993)
DOI:10.1016/0092-8674(93)90489-D
  Sequence
[hsa:7046]
LinkDB

KEGG   ORTHOLOGY: K04388
Entry
K04388                      KO                                     

Name
TGFBR2
Definition
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04068  FoxO signaling pathway
ko04144  Endocytosis
ko04218  Cellular senescence
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04659  Th17 cell differentiation
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05142  Chagas disease
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05220  Chronic myeloid leukemia
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05161 Hepatitis B
    K04388  TGFBR2; TGF-beta receptor type-2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
MCC: 114675335 703088(TGFBR2)
MCF: 102134273(TGFBR2)
CSAB: 103241808(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
MMU: 21813(Tgfbr2)
MCAL: 110301725(Tgfbr2)
MPAH: 110327573(Tgfbr2)
RNO: 81810(Tgfbr2)
MUN: 110547249(Tgfbr2)
CGE: 100773953(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CCAN: 109681522(Tgfbr2)
OCU: 100344335(TGFBR2)
TUP: 102486518(TGFBR2)
CFA: 477039(TGFBR2)
VVP: 112921591(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
UAH: 113253847(TGFBR2)
ORO: 101364575(TGFBR2)
ELK: 111158999
FCA: 101091725(TGFBR2)
PTG: 102958413(TGFBR2)
PPAD: 109251365(TGFBR2)
AJU: 106984570(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
BBUB: 102415303(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CDK: 105087202(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
DLE: 111164342(TGFBR2)
PCAD: 102995949(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
MNA: 107526381(TGFBR2)
HAI: 109394441(TGFBR2)
DRO: 112309970(TGFBR2)
PALE: 102889618(TGFBR2)
RAY: 107508791(TGFBR2)
MJV: 108391859(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
MDO: 100031897(TGFBR2)
SHR: 100913352(TGFBR2)
PCW: 110212998(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
NMEL: 110393465(TGFBR2) 110399236
APLA: 101794795(TGFBR2) 101801641
ACYG: 106029911 106043323(TGFBR2)
TGU: 100220619(TGFBR2) 100224677
LSR: 110468201(TGFBR2) 110468281
SCAN: 103813156(TGFBR2) 103814641
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCAE: 111923501(TGFBR2) 111932269
CCW: 104689295(TGFBR2) 104694032
ETL: 114064578(TGFBR2) 114067323
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
NNI: 104013882(TGFBR2) 104020241
ACUN: 113477102(TGFBR2) 113482298
PADL: 103917105(TGFBR2) 103919595
AAM: 106491249(TGFBR2) 106498480
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
PSS: 102444710(TGFBR2) 102457599
CMY: 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
PBI: 103057562(TGFBR2) 103063579
PMUR: 107284378(TGFBR2) 107290268
TSR: 106543204 106547952(TGFBR2)
PMUA: 114604090 114607243(TGFBR2)
XLA: 108702885 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2.2.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
LCO: 104922506(tgfbr2) 104923102
OLA: 101170689(tgfbr2) 101174785
PRET: 103465886(tgfbr2) 103472661
CVG: 107086189(tgfbr2) 107098322
HCQ: 109516370(tgfbr2) 109530278
SFM: 108918826 108935840(tgfbr2)
PKI: 111857200 111857846(tgfbr2)
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2) 103188937
BFO: 118403077
CIN: 778778(tgfbr-iib)
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
 » show all
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]
LinkDB

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