KEGG   ORTHOLOGY: K04688Help
Entry
K04688                      KO                                     

Name
RPS6KB
Definition
ribosomal protein S6 kinase beta [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04350  TGF-beta signaling pathway
ko04361  Axon regeneration
ko04371  Apelin signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04931  Insulin resistance
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04350 TGF-beta signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04371 Apelin signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04066 HIF-1 signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04151 PI3K-Akt signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04152 AMPK signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04150 mTOR signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09158 Development and regeneration
   04361 Axon regeneration
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09149 Aging
   04211 Longevity regulating pathway
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04212 Longevity regulating pathway - worm
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   04213 Longevity regulating pathway - multiple species
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09159 Environmental adaptation
   04714 Thermogenesis
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05205 Proteoglycans in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05231 Choline metabolism in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05212 Pancreatic cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05225 Hepatocellular carcinoma
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05226 Gastric cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05221 Acute myeloid leukemia
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05224 Breast cancer
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05163 Human cytomegalovirus infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   05165 Human papillomavirus infection
    K04688  RPS6KB; ribosomal protein S6 kinase beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
   01522 Endocrine resistance
    K04688  RPS6KB; ribosomal protein S6 kinase beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04688  RPS6KB; ribosomal protein S6 kinase beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04688  RPS6KB; ribosomal protein S6 kinase beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   K04688  RPS6KB; ribosomal protein S6 kinase beta
BRITE hierarchy
Other DBs
GO: 0004711
Genes
HSA: 6198(RPS6KB1) 6199(RPS6KB2)
PTR: 468426(RPS6KB1) 746903(RPS6KB2)
PPS: 100986739(RPS6KB2) 100995177(RPS6KB1)
GGO: 101126746(RPS6KB1) 101134525(RPS6KB2)
PON: 100456988(RPS6KB1) 100459428(RPS6KB2) 100462008
NLE: 100593862(RPS6KB1) 100606492(RPS6KB2)
MCC: 711979(RPS6KB1) 721731(RPS6KB2)
MCF: 101925564(RPS6KB1) 102122660 102134845(RPS6KB2)
CSAB: 103218141(RPS6KB2) 103242820(RPS6KB1)
RRO: 104662932(RPS6KB1) 104664740(RPS6KB2)
RBB: 108518621(RPS6KB2) 108533071(RPS6KB1)
CJC: 100397180(RPS6KB2) 100409247(RPS6KB1)
SBQ: 101033758(RPS6KB2) 101038541(RPS6KB1)
MMU: 58988(Rps6kb2) 72508(Rps6kb1)
MCAL: 110285417(Rps6kb2) 110304919(Rps6kb1)
MPAH: 110315992(Rps6kb2) 110331448(Rps6kb1)
RNO: 361696(Rps6kb2) 83840(Rps6kb1)
MUN: 110553742(Rps6kb1) 110560360(Rps6kb2)
CGE: 100757513(Rps6kb1) 100760227(Rps6kb2)
NGI: 103725586(Rps6kb2) 103741760(Rps6kb1)
HGL: 101702911(Rps6kb2) 101724077(Rps6kb1)
CCAN: 109685124(Rps6kb1) 109688624(Rps6kb2)
OCU: 100009260(RPS6KB1)
TUP: 102475423(RPS6KB2) 102493152(RPS6KB1)
CFA: 480580(RPS6KB1) 610499(RPS6KB2)
VVP: 112917940(RPS6KB1) 112924182(RPS6KB2)
AML: 100464998(RPS6KB2) 100484786(RPS6KB1)
UMR: 103667329(RPS6KB1) 103679516(RPS6KB2)
UAH: 113244028(RPS6KB2) 113268897(RPS6KB1)
ORO: 101365998(RPS6KB1) 101381996(RPS6KB2)
FCA: 101091812(RPS6KB2) 101092561(RPS6KB1)
PTG: 102950850(RPS6KB2) 102960736(RPS6KB1)
AJU: 106971103(RPS6KB2) 106972702(RPS6KB1)
BTA: 404181(RPS6KB1) 506083(RPS6KB2)
BOM: 102271079(RPS6KB2) 102285710(RPS6KB1)
BIU: 109554358(RPS6KB2) 109573726(RPS6KB1)
BBUB: 102402840(RPS6KB1) 102413442(RPS6KB2)
PHD: 102327841(RPS6KB1) 102336092(RPS6KB2)
CHX: 100861297(RPS6KB1) 102169319 102182675(RPS6KB2)
OAS: 101107371(RPS6KB1) 101109574(RPS6KB2)
SSC: 100127158(RPS6KB1) 100512153(RPS6KB2)
CFR: 102511731(RPS6KB1) 102518322(RPS6KB2)
CDK: 105097829(RPS6KB1) 105104425(RPS6KB2)
BACU: 102998750(RPS6KB2) 103019799(RPS6KB1)
LVE: 103073645(RPS6KB2) 103090358(RPS6KB1)
OOR: 101283084(RPS6KB1) 101286642(RPS6KB2)
DLE: 111163760(RPS6KB1) 111183673(RPS6KB2)
PCAD: 102976885(RPS6KB2) 102990399(RPS6KB1)
ECB: 100053005(RPS6KB2) 100057481(RPS6KB1)
EPZ: 103559935(RPS6KB2) 103565282(RPS6KB1)
EAI: 106833496(RPS6KB2) 106841135(RPS6KB1)
MYB: 102245108(RPS6KB2) 102253735(RPS6KB1)
MYD: 102763828(RPS6KB2) 102775361(RPS6KB1)
MNA: 107530082(RPS6KB1) 107537414(RPS6KB2)
HAI: 109379764(RPS6KB1) 109384219(RPS6KB2)
RSS: 109449767(RPS6KB1) 109450432(RPS6KB2)
DRO: 112316527(RPS6KB1) 112317229(RPS6KB2)
PALE: 102889369(RPS6KB1) 102891214(RPS6KB2)
RAY: 107503682(RPS6KB2) 107510136(RPS6KB1)
LAV: 100653946(RPS6KB1) 100671034(RPS6KB2)
MDO: 100010269(RPS6KB1) 100014573(RPS6KB2)
SHR: 100930707(RPS6KB1) 100935081(RPS6KB2)
PCW: 110195494(RPS6KB2) 110212045(RPS6KB1)
OAA: 100078852(RPS6KB1) 100087780(RPS6KB2)
GGA: 417637(RPS6KB1) 429557(RPS6KB2)
MGP: 100548374(RPS6KB2) 100551178(RPS6KB1)
CJO: 107314239(RPS6KB2) 107322434(RPS6KB1)
NMEL: 110407933(RPS6KB1)
APLA: 101792883(RPS6KB1)
ACYG: 106046854(RPS6KB1)
TGU: 100226155(RPS6KB1) 100232065
LSR: 110467654(RPS6KB1) 110485073(RPS6KB2)
SCAN: 103820173(RPS6KB1) 103822256(RPS6KB2)
GFR: 102036821(RPS6KB1)
FAB: 101810135(RPS6KB1) 101817600(RPS6KB2)
PHI: 102100544(RPS6KB1) 102108348(RPS6KB2)
PMAJ: 107206395(RPS6KB2) 107212783(RPS6KB1)
CCAE: 111937833(RPS6KB1) 111944245
CCW: 104691002(RPS6KB1)
ETL: 114063332(RPS6KB2) 114067697(RPS6KB1)
FPG: 101910744(RPS6KB1)
FCH: 102057985(RPS6KB1)
CLV: 102090789(RPS6KB2) 102091507(RPS6KB1)
EGZ: 104121880(RPS6KB1)
NNI: 104016535(RPS6KB1)
ACUN: 113487063(RPS6KB1)
PADL: 103916836(RPS6KB1)
AAM: 106492594 106500339(RPS6KB1)
ASN: 102370189(RPS6KB2) 102387892(RPS6KB1)
AMJ: 102571014(RPS6KB2) 106736874(RPS6KB1)
PSS: 102458972(RPS6KB1) 102460281(RPS6KB2)
CMY: 102932417(RPS6KB2) 102948337(RPS6KB1)
CPIC: 101938925(RPS6KB1) 101949346(RPS6KB2)
ACS: 100557539(rps6kb2) 100565927(rps6kb1)
PVT: 110075522(RPS6KB1) 110085635(RPS6KB2)
PBI: 103054324(RPS6KB1) 103056543(RPS6KB2)
PMUR: 107293632(RPS6KB2) 107298703(RPS6KB1)
XLA: 394276(rps6kb1.S) 394347(rps6kb1.L)
XTR: 394938(rps6kb1)
NPR: 108796234 108798072(RPS6KB1)
DRE: 406349(rps6kb1b) 562242(rps6kb1a)
IPU: 108260512 108278249(rps6kb1)
PHYP: 113532841(rps6kb1)
AMEX: 103031203(rps6kb2) 103035647(rps6kb1)
EEE: 113568160 113584368(rps6kb1)
LCO: 104930044 104933515(rps6kb1)
NCC: 104949480(rps6kb1) 104965260
NFU: 107380537(rps6kb1) 107396767
AOCE: 111566696(rps6kb1) 111579842 111588930
CSEM: 103377585(rps6kb1) 103383966 103395203
PKI: 111839121 111854744(rps6kb1)
LCM: 102353676(RPS6KB1) 102361574
CMK: 103186905(rps6kb1)
CIN: 100178579
SPU: 575764
APLC: 110990034
DME: Dmel_CG10539(S6k)
DER: 6544636
DSI: Dsimw501_GD13174(Dsim_GD13174)
DPE: 6602941
DWI: 6638935
DAZ: 108614230
DNV: 108651078
DHE: 111594833
MDE: 101896302
LCQ: 111684608
AAG: 5566289
AME: 552549
TCA: 661481
DPA: 109545103
NVL: 108561831
BMOR: 100174852(P70S6K)
PMAC: 106710712
PRAP: 110996455
HAW: 110369906
TNL: 113504422
PXY: 105380575
API: 100162508
DNX: 107172741
BTAB: 109037417
CLEC: 106664197
ZNE: 110838355
TUT: 107361083
DPTE: 113797177
CEL: CELE_R04A9.7(R04A9.7) CELE_Y47D3A.16(rsks-1)
CBR: CBG13216(Cbr-rsks-1)
BMY: Bm1_44635
TSP: Tsp_06286
CRG: 105324844
MYI: 110457708
OBI: 106872574
LAK: 106160338
SHX: MS3_07747
EGL: EGR_03446
EPA: 110232607
ADF: 107339103
PDAM: 113665493
SPIS: 111345005
HMG: 100209609
AQU: 100638046
ATH: AT3G08720(S6K2) AT3G08730(PK1)
CPAP: 110811621
LJA: Lj0g3v0157689.1(Lj0g3v0157689.1) Lj2g3v2172980.1(Lj2g3v2172980.1)
CSV: 101214867(CsPK5)
CMO: 103493951
CMOS: 111440587
RCU: 8267116
DOSA: Os03t0334000-02(Os03g0334000) Os07t0680900-01(Os07g0680900)
ATS: 109732797(LOC109732797) 109771848(LOC109771848)
ZMA: 100273759 100281573(IDP300) 542142(S6K)
MUS: 103986206
CRE: CHLREDRAFT_39110(S6K1)
APRO: F751_2597
DFA: DFA_08678
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1922062
  Authors
Grove JR, Banerjee P, Balasubramanyam A, Coffer PJ, Price DJ, Avruch J, Woodgett JR
  Title
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.
  Journal
Mol Cell Biol 11:5541-50 (1991)
DOI:10.1128/MCB.11.11.5541
Reference
  Authors
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG
  Title
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
  Journal
EMBO J 20:4370-9 (2001)
DOI:10.1093/emboj/20.16.4370
  Sequence
[hsa:6198]
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