KEGG   ORTHOLOGY: K04729
Entry
K04729                      KO                                     

Name
MYD88
Definition
myeloid differentiation primary response protein MyD88
Pathway
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05145  Toxoplasmosis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05164  Influenza A
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
Disease
H00721  Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04064 NF-kappa B signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04624 Toll and Imd signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   04621 NOD-like receptor signaling pathway
    K04729  MYD88; myeloid differentiation primary response protein MyD88
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05161 Hepatitis B
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05171 Coronavirus disease - COVID-19
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05164 Influenza A
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05162 Measles
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05168 Herpes simplex virus 1 infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05169 Epstein-Barr virus infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05132 Salmonella infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05131 Shigellosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05135 Yersinia infection
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05133 Pertussis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05134 Legionellosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05152 Tuberculosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09174 Infectious disease: parasitic
   05144 Malaria
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05145 Toxoplasmosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05140 Leishmaniasis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05142 Chagas disease
    K04729  MYD88; myeloid differentiation primary response protein MyD88
   05143 African trypanosomiasis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04729  MYD88; myeloid differentiation primary response protein MyD88
Genes
HSA: 4615(MYD88)
PTR: 460269(MYD88)
PPS: 100996159(MYD88)
GGO: 101141837(MYD88)
PON: 100460593(MYD88)
NLE: 100598173(MYD88)
MCC: 696494(MYD88)
MCF: 101866832(MYD88)
CSAB: 103221064(MYD88)
CATY: 105573904(MYD88)
PANU: 101005327(MYD88)
RRO: 104657448(MYD88)
RBB: 108512239(MYD88)
TFN: 117083885(MYD88)
PTEH: 111523175(MYD88)
CJC: 100413151(MYD88)
SBQ: 101052794(MYD88)
MMUR: 105866806(MYD88)
MMU: 17874(Myd88)
MCAL: 110301084(Myd88)
MPAH: 110327862(Myd88)
RNO: 301059(Myd88)
MCOC: 116073051(Myd88)
MUN: 110555059(Myd88)
CGE: 100775060(Myd88)
PLEU: 114682503(Myd88)
NGI: 103744662(Myd88)
HGL: 101712637(Myd88)
CCAN: 109684529(Myd88)
OCU: 100340811(MYD88)
TUP: 102499350(MYD88)
CFA: 477024(MYD88)
VVP: 112921656(MYD88)
VLG: 121478665(MYD88)
AML: 100479307(MYD88)
UMR: 103680724(MYD88)
UAH: 113253781(MYD88)
ORO: 101363951(MYD88)
ELK: 111159049
MPUF: 101685422(MYD88)
EJU: 114212285(MYD88)
MLX: 118001922(MYD88)
FCA: 101087092(MYD88)
PTG: 102952059(MYD88)
PPAD: 109248749(MYD88)
AJU: 106966692(MYD88)
HHV: 120235110(MYD88)
BTA: 444881(MYD88)
BOM: 102279944(MYD88)
BIU: 109576356(MYD88)
BBUB: 102394532(MYD88)
CHX: 102174883(MYD88)
OAS: 678682(MYD88)
ODA: 120867827(MYD88)
SSC: 396646(MYD88)
CFR: 102506575(MYD88)
CDK: 105090692(MYD88)
BACU: 103011989(MYD88)
LVE: 103088205(MYD88)
OOR: 101278425(MYD88)
DLE: 111164350(MYD88)
PCAD: 102974002(MYD88)
ECB: 100053940(MYD88)
EPZ: 103557961(MYD88)
EAI: 106834265(MYD88)
MYB: 102247438(MYD88)
MYD: 107183283(MYD88)
MMYO: 118668344(MYD88)
MNA: 107524328(MYD88)
HAI: 109393491(MYD88)
DRO: 112309628(MYD88)
AJM: 119051446(MYD88)
MMF: 118633334(MYD88)
PALE: 102890488(MYD88)
RAY: 107499600(MYD88)
MJV: 108401029(MYD88)
TOD: 119258024(MYD88)
LAV: 100659447(MYD88)
TMU: 101341326
SHR: 100927751(MYD88)
PCW: 110197028(MYD88)
OAA: 100077067(MYD88)
GGA: 420420(MYD88)
PCOC: 116238234(MYD88)
MGP: 100541304(MYD88)
CJO: 107308786(MYD88)
NMEL: 110394261(MYD88)
APLA: 101797621(MYD88)
ACYG: 106036798(MYD88)
TGU: 100223638(MYD88)
LSR: 110484551(MYD88)
SCAN: 103813055(MYD88)
PMOA: 120510590(MYD88)
GFR: 102044578(MYD88)
FAB: 101805645(MYD88)
PHI: 102100550(MYD88)
PMAJ: 107200823(MYD88)
CCAE: 111925454(MYD88)
CCW: 104686502(MYD88)
ETL: 114065146(MYD88)
FPG: 101922907(MYD88)
FCH: 102049997(MYD88)
CLV: 102087774(MYD88)
EGZ: 104130985(MYD88)
NNI: 104021773(MYD88)
ACUN: 113476914(MYD88)
PADL: 103924746(MYD88)
AAM: 106490262
ASN: 102372553(MYD88)
AMJ: 102560312(MYD88)
CPOO: 109320185(MYD88)
GGN: 109291074(MYD88)
PSS: 102454616(MYD88)
CMY: 102935478(MYD88)
CPIC: 101944305(MYD88)
TST: 117871992(MYD88)
CABI: 116826962(MYD88)
ACS: 100561767(myd88)
PVT: 110085835(MYD88)
PBI: 103066844(MYD88)
PMUR: 107303333(MYD88)
TSR: 106539892(MYD88)
PGUT: 117654762(MYD88)
PMUA: 114607585(MYD88)
ZVI: 118092232(MYD88)
XLA: 394321(myd88.L) 734302(myd88.S)
XTR: 549591(myd88)
NPR: 108784626(MYD88)
DRE: 403145(myd88)
SANH: 107678069(myd88) 107701636
SGH: 107584943 107591285(myd88)
CCAR: 109049860(myd88)
IPU: 100305041(myd88)
PHYP: 113541356(myd88)
AMEX: 103044166(myd88)
EEE: 113585082(myd88)
TRU: 100134853(myd88)
LCO: 104937116(myd88)
ELY: 117264724(myd88)
PLEP: 121960534(myd88)
SLUC: 116037895(myd88)
ECRA: 117937605(myd88)
PFLV: 114549018(myd88)
GAT: 120811549 120811921(myd88)
MSAM: 119910303(myd88)
CUD: 121527123(myd88)
MZE: 101476408(myd88)
ONL: 100700534(myd88)
OAU: 116314457(myd88)
OLA: 101168580(myd88)
OML: 112151085(myd88)
XMA: 102234764(myd88)
XCO: 114136895(myd88)
XHE: 116712350(myd88)
PRET: 103456564(myd88)
CVG: 107100961(myd88)
CTUL: 119789066(myd88)
NFU: 107382819(myd88)
KMR: 108230293(myd88)
ALIM: 106513380(myd88)
AOCE: 111565947(myd88)
CSEM: 103377208(myd88)
POV: 109629696(myd88)
LCF: 108881704(myd88)
SDU: 111220968
SLAL: 111656280
XGL: 120789782
HCQ: 109514064(myd88)
BPEC: 110160924(myd88)
MALB: 109961464(myd88)
SASA: 100169859(myd88)
OTW: 112227606(myd88)
OMY: 100136123(myd88)
SALP: 112079159(myd88)
ELS: 105007691(myd88)
SFM: 108934019(myd88)
PKI: 111837820(myd88)
LOC: 102684939(myd88)
ARUT: 117399595 117435484(myd88)
LCM: 102348650(MYD88)
CMK: 103189851(myd88)
RTP: 109927021(myd88)
SCLV: 120344932
SPU: 575081
APLC: 110974581
SKO: 100373041(myd88)
DME: Dmel_CG2078(Myd88)
DER: 6540756
DSE: 6608336
DSI: Dsimw501_GD10085(Dsim_GD10085)
DAN: 6495929
DSR: 110176999
DPE: 6592675
DWI: 6639863
DAZ: 108616650
DNV: 108653970
DHE: 111593904
DVI: 6625696
MDE: 101901307
LCQ: 111686209
AGA: AgaP_AGAP005252(MYD)
ACOZ: 120948777
AARA: 120908746
AAG: 5569574
CPII: 120414968
AME: 413194
ACER: 107997261
BIM: 100748729
BTER: 100631094
CCAL: 108621994
OBB: 114873221
NMEA: 116432162
CGIG: 122398262
SOC: 105201138
MPHA: 105833799
AEC: 105146388
ACEP: 105627791
PBAR: 105433443
VEM: 105557765
HST: 105184911
DQU: 106741300
CFO: 105256115
FEX: 115245451
PGC: 109859222
OBO: 105286460
PCF: 106786257
NVI: 100118553
CSOL: 105368413
MDL: 103571646
TCA: 662213(Kra)
DPA: 109539329
ATD: 109604347
AGB: 108914167
NVL: 108565220
APLN: 108732216
PPYR: 116176027
OTU: 111415135
BMOR: 101735950
BMAN: 114251951
MSEX: 115451464
BANY: 112052730
PMAC: 106718991
PPOT: 106105140
PXU: 106128536
PRAP: 110999561
ZCE: 119835194
HAW: 110374863
TNL: 113504445
PXY: 105382914
API: 100160335
DNX: 107169682
AGS: 114119074
RMD: 113547771
BTAB: 109038841
DCI: 103524770
CLEC: 106662592
NLU: 111046615
ZNE: 110832274
CSEC: 111874102
FCD: 110851565
PVM: 113813740
HAME: 121858262
EAF: 111701169
DSV: 119446655
RSAN: 119389543
RMP: 119181425
VDE: 111251750
VJA: 111268891
TUT: 107363907
DPTE: 113792353
PTEP: 107443819
PCAN: 112556147
CRG: 105337632 105342664(Myd88-2) 105342670(Myd88)
OBI: 106879143
LAK: 106177828
NVE: 5521208
ADF: 107335471
AMIL: 114964902
PDAM: 113672565
SPIS: 111337079
DGT: 114516060
HMG: 105846374
AQU: 100616081(Myd88)
 » show all
Reference
PMID:9013863
  Authors
Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE
  Title
The cloning and characterization of human MyD88: a member of an IL-1 receptor related family.
  Journal
FEBS Lett 402:81-4 (1997)
DOI:10.1016/S0014-5793(96)01506-2
  Sequence
[hsa:4615]
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