KEGG   ORTHOLOGY: K04730
Entry
K04730                      KO                                     

Name
IRAK1
Definition
interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04620  Toll-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04722  Neurotrophin signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05133  Pertussis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   04064 NF-kappa B signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   04624 Toll and Imd signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05132 Salmonella infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05135 Yersinia infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05133 Pertussis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05152 Tuberculosis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05162 Measles
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05161 Hepatitis B
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05168 Herpes simplex virus 1 infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05169 Epstein-Barr virus infection
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05140 Leishmaniasis
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
   05142 Chagas disease
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04730  IRAK1; interleukin-1 receptor-associated kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04730  IRAK1; interleukin-1 receptor-associated kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  IRAK family
   K04730  IRAK1; interleukin-1 receptor-associated kinase 1
Genes
HSA: 3654(IRAK1)
PPS: 100981891(IRAK1)
GGO: 101140803(IRAK1)
PON: 100437883(IRAK1)
NLE: 100588136(IRAK1)
MCC: 699919(IRAK1)
MCF: 102134829(IRAK1)
CSAB: 103232815(IRAK1)
RRO: 104662981(IRAK1)
RBB: 108535063(IRAK1)
CJC: 100414273(IRAK1)
SBQ: 101052342(IRAK1)
MMU: 16179(Irak1)
MCAL: 110286819(Irak1)
MPAH: 110313647(Irak1)
RNO: 363520(Irak1)
MUN: 110566945(Irak1)
CGE: 100773909(Irak1)
NGI: 103731212(Irak1)
HGL: 101699021(Irak1)
CCAN: 109690874(Irak1)
OCU: 100354743(IRAK1)
TUP: 102473549(IRAK1)
CFA: 492247(IRAK1)
VVP: 112911496(IRAK1)
AML: 100484977(IRAK1)
UMR: 103679690(IRAK1)
UAH: 113247859(IRAK1)
ORO: 101382179(IRAK1)
ELK: 111139109
FCA: 101090500(IRAK1)
PPAD: 109259848(IRAK1)
AJU: 113597389(IRAK1)
BTA: 533953(IRAK1)
BOM: 102277837(IRAK1)
BIU: 109555285(IRAK1)
BBUB: 102396505(IRAK1)
CHX: 102177432(IRAK1)
OAS: 101121405(IRAK1)
SSC: 396606(IRAK1)
CFR: 102523767(IRAK1)
CDK: 105098727(IRAK1)
BACU: 102998365(IRAK1)
LVE: 103074326(IRAK1)
OOR: 101280639(IRAK1)
DLE: 111170605(IRAK1)
PCAD: 112062410(IRAK1)
ECB: 100059262(IRAK1)
EPZ: 103545279(IRAK1)
EAI: 106825607(IRAK1)
MYB: 102245410(IRAK1)
MYD: 102765985(IRAK1)
MNA: 107538794(IRAK1)
HAI: 109394352(IRAK1)
DRO: 112296346(IRAK1)
PALE: 102894152(IRAK1)
RAY: 107517734(IRAK1)
MJV: 108409511(IRAK1)
LAV: 100676181(IRAK1)
TMU: 101350273
MDO: 100029477(IRAK1)
SHR: 100923900(IRAK1)
PCW: 110201533(IRAK1)
OAA: 100077683(IRAK1)
ASN: 102374837(IRAK1)
AMJ: 102575313(IRAK1)
CPIC: 101937579(IRAK1)
ACS: 100563977(irak1)
PVT: 110078665(IRAK1)
PBI: 103047962(IRAK1)
PMUR: 107284218(IRAK1)
TSR: 106543646(IRAK1)
PMUA: 114587380(IRAK1)
GJA: 107108391(IRAK1)
XTR: 448357(irak1)
NPR: 108790442(IRAK1)
DRE: 569226(irak1)
SRX: 107743109(irak1)
SGH: 107552214(irak1) 107584912
IPU: 108265822(irak1)
PHYP: 113534859(irak1)
AMEX: 103044222(irak1)
EEE: 113575834(irak1)
TRU: 101061773(irak1)
LCO: 104935488
MZE: 101465239(irak1)
ONL: 100703930(irak1)
OLA: 101166698
XMA: 102231075(irak1)
XCO: 114140233
CVG: 107099142(irak1)
NFU: 107391452(irak1)
KMR: 108228236
ALIM: 106511233
AOCE: 111585594(irak1)
CSEM: 103384394(irak1)
POV: 109645801(irak1)
LCF: 108890558(irak1)
SDU: 111235426(irak1)
SLAL: 111654973(irak1)
HCQ: 109529353(irak1)
BPEC: 110154469(irak1)
MALB: 109967881(irak1)
SASA: 106566344
OTW: 112238306
SALP: 112072310
ELS: 105028326(irak1)
SFM: 108934844(irak1)
PKI: 111856149(irak1)
LCM: 102359430(IRAK1)
CMK: 103176741
RTP: 109924573
BFO: 118408597
CIN: 100178324
SPU: 577165
APLC: 110983679
SKO: 102804873
DME: Dmel_CG5974(pll)
DER: 6554685
DSE: 6617161
DSI: Dsimw501_GD28088(Dsim_GD28088)
DYA: Dyak_GE10573(Dyak_pll)
DAN: 6501489
DSR: 110177377
DPE: 6587716
DMN: 108156651
DWI: 6649819
DAZ: 108620820
DNV: 115564094
DHE: 111597872
DVI: 6633066
MDE: 101891255
LCQ: 111683854
AGA: AgaP_AGAP002966(PELLE)
AAG: 5568148
AME: 551608
BIM: 100742650
BTER: 100650697
CCAL: 108629985
OBB: 114874825
SOC: 105198406
MPHA: 105837711
AEC: 105145974
ACEP: 105622228
PBAR: 105429360
VEM: 105563659
HST: 105187682
DQU: 106746948
CFO: 105256733
LHU: 105671849
PGC: 109857111
OBO: 105279707
PCF: 106793407
CSOL: 105359643
MDL: 103578198
TCA: 654877(IL-1)
DPA: 109537660
NVL: 108569521
BMOR: 101745667
BMAN: 114248745
PMAC: 106717349
PRAP: 110998947
HAW: 110374306
TNL: 113494818
API: 100169297
DNX: 107168990
AGS: 114127916
RMD: 113548052
BTAB: 109039164
CLEC: 106663343
ZNE: 110829083
FCD: 110858699
PVM: 113827503
TUT: 107362919
DPTE: 113794702
PTEP: 107449997
CEL: CELE_K09B11.1(pik-1)
CBR: CBG01770(Cbr-pik-1)
BMY: Bm1_38375
PCAN: 112571551
CRG: 105339419
MYI: 110461679
OBI: 106870400
AQU: 100640145
 » show all
Reference
  Authors
Jensen LE, Whitehead AS
  Title
IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability.
  Journal
J Biol Chem 276:29037-44 (2001)
DOI:10.1074/jbc.M103815200
  Sequence
[hsa:3654]
LinkDB

KEGG   ORTHOLOGY: K04733
Entry
K04733                      KO                                     

Name
IRAK4
Definition
interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
Pathway
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04722  Neurotrophin signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05133  Pertussis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
Disease
H00096  Defects of toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04064 NF-kappa B signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04624 Toll and Imd signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   04621 NOD-like receptor signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05132 Salmonella infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05135 Yersinia infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05133 Pertussis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05152 Tuberculosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05162 Measles
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05164 Influenza A
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05161 Hepatitis B
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05168 Herpes simplex virus 1 infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05169 Epstein-Barr virus infection
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05140 Leishmaniasis
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
   05142 Chagas disease
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  IRAK family
   K04733  IRAK4; interleukin-1 receptor-associated kinase 4
Genes
HSA: 51135(IRAK4)
PTR: 466962(IRAK4)
PPS: 100968191(IRAK4)
GGO: 101141826(IRAK4)
PON: 100447243(IRAK4)
NLE: 100602648(IRAK4)
MCC: 700568(IRAK4)
MCF: 102140231(IRAK4)
CSAB: 103238180(IRAK4)
RRO: 104677388(IRAK4)
RBB: 108539989(IRAK4)
CJC: 100402978(IRAK4)
SBQ: 101029005(IRAK4)
MMU: 266632(Irak4)
MCAL: 110310638(Irak4)
MPAH: 110334455(Irak4)
RNO: 300177(Irak4)
MUN: 110563636(Irak4)
CGE: 100751891(Irak4)
NGI: 103728592(Irak4)
HGL: 101698190(Irak4)
CCAN: 109684435
OCU: 100341605(IRAK4)
TUP: 102490347(IRAK4)
CFA: 486601(IRAK4)
VVP: 112921061(IRAK4)
AML: 100469127(IRAK4)
UMR: 103675405(IRAK4)
UAH: 113257718(IRAK4)
ORO: 101380365(IRAK4)
ELK: 111157836
FCA: 101100225(IRAK4)
PTG: 102962570(IRAK4)
PPAD: 109248991(IRAK4)
AJU: 106978292(IRAK4)
BTA: 533692(IRAK4)
BOM: 102284148(IRAK4)
BIU: 109559201(IRAK4)
BBUB: 102402933(IRAK4)
CHX: 102171575(IRAK4)
OAS: 100216438(IRAK4)
SSC: 100127166(IRAK4)
CFR: 102518467(IRAK4)
CDK: 105097094(IRAK4)
BACU: 103013107(IRAK4)
LVE: 103080704(IRAK4)
OOR: 101283238(IRAK4)
DLE: 111174096(IRAK4)
PCAD: 102982312(IRAK4)
ECB: 100054848(IRAK4)
EPZ: 103547487(IRAK4)
EAI: 106828056(IRAK4)
MYB: 102262455(IRAK4)
MYD: 102754676(IRAK4)
MNA: 107528202(IRAK4)
HAI: 109388403(IRAK4)
DRO: 112318391(IRAK4)
PALE: 102880867(IRAK4)
RAY: 107511752(IRAK4)
MJV: 108396677(IRAK4)
LAV: 100653528(IRAK4)
TMU: 101349224
MDO: 100019202(IRAK4)
SHR: 100934112(IRAK4)
PCW: 110199045(IRAK4)
OAA: 100093279(IRAK4)
GGA: 417796(IRAK4)
MGP: 100538968(IRAK4)
CJO: 107309789(IRAK4)
NMEL: 110392685(IRAK4)
APLA: 101794110(IRAK4)
ACYG: 106047628(IRAK4)
TGU: 100227974(IRAK4)
LSR: 110478580(IRAK4)
SCAN: 103820377(IRAK4)
GFR: 102032992(IRAK4)
FAB: 101816877(IRAK4)
PHI: 102100592(IRAK4)
PMAJ: 107204545(IRAK4)
CCAE: 111932046(IRAK4)
CCW: 104698327(IRAK4)
ETL: 114061965(IRAK4)
FPG: 101914647(IRAK4)
FCH: 102057320(IRAK4)
CLV: 102092630(IRAK4)
EGZ: 104129331(IRAK4)
NNI: 104013612(IRAK4)
ACUN: 113475900(IRAK4)
PADL: 103919991(IRAK4)
AAM: 106488895(IRAK4)
ASN: 102375747(IRAK4)
AMJ: 102560034(IRAK4)
PSS: 102445433(IRAK4)
CMY: 102940314(IRAK4)
CPIC: 101931311(IRAK4)
ACS: 100556834(irak4)
PVT: 110079982(IRAK4)
PBI: 103053361(IRAK4)
PMUR: 107284404(IRAK3)
TSR: 106556721
PMUA: 114605640(IRAK4)
GJA: 107125917(IRAK4)
XLA: 108711122(irak4.L)
XTR: 733738(irak4)
NPR: 108789468(IRAK4)
DRE: 393132(irak4)
SRX: 107710863(irak4)
SANH: 107695004(irak4)
SGH: 107564744(irak4)
IPU: 100528915(irak4)
PHYP: 113529752(irak4)
AMEX: 103046249(irak4)
EEE: 113571874(irak4)
TRU: 101066430(irak4)
LCO: 104933859(irak4)
NCC: 104950347(irak4)
MZE: 101482950(irak4)
ONL: 100707440(irak4)
OLA: 101158603(irak4)
XMA: 102235789(irak4)
XCO: 114158068(irak4)
PRET: 103465840(irak4)
CVG: 107089506(irak4)
NFU: 107388500(irak4)
KMR: 108246966(irak4)
ALIM: 106526262(irak4)
AOCE: 111569910(irak4)
CSEM: 103380353(irak4)
POV: 109624486(irak4)
LCF: 108888551(irak4)
SDU: 111229598(irak4)
SLAL: 111650410(irak4)
HCQ: 109529881(irak4)
BPEC: 110168058(irak4)
MALB: 109973145(irak4)
SASA: 100196744(irak4)
OTW: 112218414(irak4)
SALP: 111962246(irak4)
ELS: 105026619(irak4)
SFM: 108931599(irak4)
PKI: 111833297(irak4)
LCM: 102365908(IRAK4)
CMK: 103186122(irak4)
RTP: 109935969(irak4)
BFO: 118415803
CIN: 100179860
SPU: 579511
APLC: 110983878
SKO: 100371791
DME: Dmel_CG10520(tub)
DER: 6552132
DSE: 6613818
DSI: Dsimw501_GD19725(Dsim_tub)
DYA: Dyak_GE25413(Dyak_tub)
DAN: 6500989
DSR: 110176403
DPE: 6591319
DMN: 108156569
DWI: 6650039
DAZ: 108619657
DNV: 108652303
DHE: 111602009
MDE: 101888716
LCQ: 111681529
AGA: AgaP_AGAP003062(TUBE)
AAG: 5569460
AALB: 109412409
AME: 725368
BIM: 100744966
BTER: 100643452
CCAL: 108629527
OBB: 114880216
SOC: 105197305
MPHA: 105831492
AEC: 105147253
ACEP: 105625035
VEM: 105558553
HST: 105180475
DQU: 106741442
CFO: 105259295
LHU: 105667498
PGC: 109858712
OBO: 105278893
PCF: 106789276
NVI: 100122761
CSOL: 105361279
MDL: 103573816
TCA: 663280
DPA: 109545504
ATD: 109603470
NVL: 108563060
BMOR: 101746674
BMAN: 114242113
PMAC: 106720650
PRAP: 110995204
HAW: 110383958
TNL: 113500756
PXY: 105383258
API: 100165647
DNX: 107161307
AGS: 114131683
RMD: 113558107
BTAB: 109033636
CLEC: 106672583
ZNE: 110831970
FCD: 110862708
PVM: 113829427
TUT: 107372022
PTEP: 107439900
PCAN: 112555277
CRG: 105329202
MYI: 110451150
AQU: 100631706
 » show all
Reference
  Authors
Li S, Strelow A, Fontana EJ, Wesche H
  Title
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
  Journal
Proc Natl Acad Sci U S A 99:5567-72 (2002)
DOI:10.1073/pnas.082100399
  Sequence
[hsa:51135]
LinkDB

DBGET integrated database retrieval system