KEGG   ORTHOLOGY: K04741
Entry
K04741                      KO                                     

Name
CASP12
Definition
caspase 12 [EC:3.4.22.-]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04621  NOD-like receptor signaling pathway
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05161  Hepatitis B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04741  CASP12; caspase 12
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04741  CASP12; caspase 12
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04741  CASP12; caspase 12
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04741  CASP12; caspase 12
   05014 Amyotrophic lateral sclerosis
    K04741  CASP12; caspase 12
   05020 Prion disease
    K04741  CASP12; caspase 12
   05022 Pathways of neurodegeneration - multiple diseases
    K04741  CASP12; caspase 12
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04741  CASP12; caspase 12
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04741  CASP12; caspase 12
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.-  
     K04741  CASP12; caspase 12
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K04741  CASP12; caspase 12
Genes
HSA: 100506742(CASP12)
PTR: 466766(CASP12)
PPS: 100991705(CASP12)
GGO: 101137790
PON: 100436165 100938140
NLE: 100587073
MCC: 724039(CASP12)
MCF: 102115795
CSAB: 103248368
RRO: 104665278
RBB: 108513174
MMU: 12364(Casp12)
MCAL: 110302047
MPAH: 110327565
RNO: 156117(Casp12)
MUN: 110552937
CGE: 100759746(Casp4)
HGL: 101725565
OCU: 103350677
TUP: 102489486
CFA: 479458(CASP12)
VVP: 112925944
AML: 100465168
UMR: 103662441
UAH: 113259719
ORO: 101382304
ELK: 111153889
FCA: 100135767(CASP12)
PTG: 102968230
PPAD: 109258466
AJU: 106976502
BACU: 103011794(CASP12)
LVE: 103079424
OOR: 101272972
ECB: 100069290
EPZ: 103559836
EAI: 106837654
MYB: 102240773
MYD: 102773959
MNA: 107532383
HAI: 109377699
DRO: 112314270
PALE: 102894880
RAY: 107504291
MJV: 108385985
TMU: 101352646
SHR: 100913862
PCW: 110214950
 » show all
Reference
  Authors
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J
  Title
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.
  Journal
Nature 403:98-103 (2000)
DOI:10.1038/47513
Reference
  Authors
Fischer H, Koenig U, Eckhart L, Tschachler E
  Title
Human caspase 12 has acquired deleterious mutations.
  Journal
Biochem Biophys Res Commun 293:722-6 (2002)
DOI:10.1016/S0006-291X(02)00289-9
  Sequence
[hsa:100506742]
LinkDB

DBGET integrated database retrieval system