KEGG   ORTHOLOGY: K04824
Entry
K04824                      KO                                     

Name
SCNN1A, ENACA
Definition
amiloride-sensitive sodium channel subunit alpha
Pathway
ko04742  Taste transduction
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00242  Liddle syndrome
H00243  Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00892  Bronchiectasis with or without elevated sweat chloride
H02310  Renal tubular acidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04824  SCNN1A, ENACA; amiloride-sensitive sodium channel subunit alpha
  09157 Sensory system
   04742 Taste transduction
    K04824  SCNN1A, ENACA; amiloride-sensitive sodium channel subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04824  SCNN1A, ENACA; amiloride-sensitive sodium channel subunit alpha
Ion channels [BR:ko04040]
 Ligand-gated channels
  Epithelial sodium channel (ENaC)
   K04824  SCNN1A, ENACA; amiloride-sensitive sodium channel subunit alpha
Other DBs
GO: 0015280
TC: 1.A.6.1.1
Genes
HSA: 6337(SCNN1A)
PTR: 451776(SCNN1A)
PPS: 100981878(SCNN1A)
GGO: 101149563(SCNN1A)
PON: 100442318(SCNN1A)
MCC: 712476(SCNN1A)
MCF: 102137075(SCNN1A)
CSAB: 103218447(SCNN1A)
RRO: 104680125(SCNN1A)
RBB: 108536490(SCNN1A)
CJC: 100401145(SCNN1A)
SBQ: 101042036(SCNN1A)
MMU: 20276(Scnn1a)
MCAL: 110295803(Scnn1a)
MPAH: 110316553(Scnn1a)
RNO: 25122(Scnn1a)
MUN: 110548570(Scnn1a)
CGE: 100765305(Scnn1a)
NGI: 103727529(Scnn1a)
HGL: 101700410(Scnn1a)
CCAN: 109682794(Scnn1a)
OCU: 100009488(SCNN1A)
TUP: 102493278(SCNN1A)
CFA: 403650(SCNN1A)
VVP: 112917361(SCNN1A)
AML: 100484947(SCNN1A)
UMR: 103656233(SCNN1A)
UAH: 113257984(SCNN1A)
ORO: 101376480(SCNN1A)
ELK: 111159777
FCA: 101091122(SCNN1A)
PTG: 102956497(SCNN1A)
PPAD: 109276140(SCNN1A)
AJU: 106965449(SCNN1A)
BTA: 282348(SCNN1A)
BOM: 102286150(SCNN1A)
BIU: 109558605(SCNN1A)
BBUB: 102399278(SCNN1A)
CHX: 102190031(SCNN1A)
OAS: 443488(SCNN1A)
SSC: 396608(SCNN1A)
BACU: 103016202(SCNN1A)
LVE: 103074664(SCNN1A)
OOR: 101278430(SCNN1A)
DLE: 111176659(SCNN1A)
PCAD: 102992445(SCNN1A)
ECB: 100059623(SCNN1A)
EPZ: 103546994(SCNN1A)
EAI: 106831479(SCNN1A)
MYB: 102250747(SCNN1A)
MYD: 102756644(SCNN1A)
MNA: 107544037(SCNN1A)
HAI: 109373671(SCNN1A)
DRO: 112321954(SCNN1A)
PALE: 102886174(SCNN1A)
RAY: 107519787(SCNN1A)
MJV: 108387606(SCNN1A)
LAV: 100672430(SCNN1A)
TMU: 101342126
MDO: 100014763(SCNN1A)
SHR: 100920053(SCNN1A)
PCW: 110213831(SCNN1A)
OAA: 100081848(SCNN1A)
GGA: 396050(SCNN1A)
MGP: 100546783(SCNN1A)
CJO: 107318980(SCNN1A)
NMEL: 110398699(SCNN1A)
APLA: 101792707(SCNN1A)
ACYG: 106047836(SCNN1A)
TGU: 100222046(SCNN1A)
LSR: 110480775(SCNN1A)
SCAN: 103827159(SCNN1A)
GFR: 102040434(SCNN1A)
FAB: 101815570(SCNN1A)
PHI: 102099949(SCNN1A)
PMAJ: 107203681(SCNN1A)
CCAE: 111938492(SCNN1A)
CCW: 104687113(SCNN1A)
ETL: 114058175(SCNN1A)
FPG: 101912098(SCNN1A)
FCH: 102051522(SCNN1A)
CLV: 102089256(SCNN1A)
EGZ: 104126525(SCNN1A)
NNI: 104009449(SCNN1A)
ACUN: 113486700(SCNN1A)
PADL: 103921111(SCNN1A)
AAM: 106497208(SCNN1A)
ASN: 102382829(SCNN1A)
AMJ: 102566743(SCNN1A)
PSS: 102458615(SCNN1A)
CMY: 102943993
CPIC: 101941378(SCNN1A)
ACS: 100565527(scnn1a)
PVT: 110084639(SCNN1A)
PBI: 103050561(SCNN1A)
PMUR: 107285807(SCNN1A)
TSR: 106549840(SCNN1A)
PMUA: 114587910(SCNN1A)
GJA: 107118400(SCNN1A)
XLA: 108697352(scnn1a.S) 397811(scnn1a.L)
XTR: 395013(scnn1a)
NPR: 108796007(SCNN1A)
LCM: 102356070(SCNN1A)
SPU: 100889460 100889526 100891272 100891438 594671
APLC: 110973738
CSCU: 111627554
MYI: 110457895
LAK: 106164625
SMM: Smp_052630 Smp_180260
OVI: T265_10302
NVE: 5502628 5509155
EPA: 110252035
AMIL: 114953830
PDAM: 113672659 113672730 113682091
SPIS: 111329881 111335607 111344901
DGT: 114530712 114530715 114530716 114533819 114533820 114543512 114543514
 » show all
Reference
PMID:8023962
  Authors
McDonald FJ, Snyder PM, McCray PB Jr, Welsh MJ
  Title
Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.
  Journal
Am J Physiol 266:L728-34 (1994)
DOI:10.1152/ajplung.1994.266.6.L728
  Sequence
[hsa:6337]
LinkDB

KEGG   ORTHOLOGY: K04825
Entry
K04825                      KO                                     

Name
SCNN1B, ENACB
Definition
amiloride-sensitive sodium channel subunit beta
Pathway
ko04742  Taste transduction
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00242  Liddle syndrome
H00243  Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00892  Bronchiectasis with or without elevated sweat chloride
H01633  High blood pressure
H02310  Renal tubular acidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04825  SCNN1B, ENACB; amiloride-sensitive sodium channel subunit beta
  09157 Sensory system
   04742 Taste transduction
    K04825  SCNN1B, ENACB; amiloride-sensitive sodium channel subunit beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04825  SCNN1B, ENACB; amiloride-sensitive sodium channel subunit beta
Ion channels [BR:ko04040]
 Ligand-gated channels
  Epithelial sodium channel (ENaC)
   K04825  SCNN1B, ENACB; amiloride-sensitive sodium channel subunit beta
Other DBs
GO: 0015280
TC: 1.A.6.1.1
Genes
HSA: 6338(SCNN1B)
PTR: 453984(SCNN1B)
PPS: 100967758(SCNN1B)
GGO: 101139786(SCNN1B)
NLE: 100590266(SCNN1B)
MCC: 700093(SCNN1B)
MCF: 102144896(SCNN1B)
CSAB: 103229709(SCNN1B)
RRO: 104658244(SCNN1B)
RBB: 108538845(SCNN1B)
CJC: 100400682(SCNN1B)
SBQ: 101034739(SCNN1B)
MMU: 20277(Scnn1b)
MCAL: 110298060(Scnn1b)
MPAH: 110332363(Scnn1b)
RNO: 24767(Scnn1b)
MUN: 110550638(Scnn1b)
CGE: 100754564(Scnn1b)
NGI: 103742738(Scnn1b)
HGL: 101717352(Scnn1b)
CCAN: 109678009
OCU: 100009564(SCNN1B)
TUP: 102499999(SCNN1B)
CFA: 489972(SCNN1B)
VVP: 112908303(SCNN1B)
AML: 100476005(SCNN1B)
UMR: 103668861(SCNN1B)
UAH: 113267571(SCNN1B)
ORO: 101383943(SCNN1B)
ELK: 111162305
FCA: 101099767(SCNN1B)
PTG: 102958824(SCNN1B)
PPAD: 109255567(SCNN1B)
AJU: 106970457(SCNN1B)
BTA: 533355(SCNN1B)
BOM: 102287562(SCNN1B)
BIU: 109578236(SCNN1B)
BBUB: 102411235(SCNN1B)
CHX: 100861026(SCNN1B)
OAS: 100170325(SCNN1B)
SSC: 100627971(SCNN1B)
CFR: 102513946(SCNN1B)
CDK: 105094823(SCNN1B)
BACU: 103004408(SCNN1B)
LVE: 103087608(SCNN1B)
OOR: 101274016(SCNN1B)
DLE: 111182245(SCNN1B)
PCAD: 102978342(SCNN1B)
ECB: 100069008(SCNN1B)
EPZ: 103540201(SCNN1B)
EAI: 106846153(SCNN1B)
MYB: 102261552(SCNN1B)
MYD: 102759519(SCNN1B)
MNA: 107544753(SCNN1B)
DRO: 112304784(SCNN1B)
PALE: 102896528(SCNN1B)
RAY: 107516104(SCNN1B)
MJV: 108404704(SCNN1B)
LAV: 100673712(SCNN1B)
TMU: 101354417
MDO: 100027536(SCNN1B)
SHR: 100929720(SCNN1B)
PCW: 110202460(SCNN1B)
OAA: 100079130(SCNN1B)
GGA: 427673(SCNN1B)
MGP: 100543688(SCNN1B)
CJO: 107320790(SCNN1B)
NMEL: 110405603(SCNN1B)
APLA: 101795138(SCNN1B)
ACYG: 106046021(SCNN1B)
TGU: 100226405(SCNN1B)
LSR: 110479552(SCNN1B)
SCAN: 103817558(SCNN1B)
GFR: 102043750(SCNN1B)
FAB: 101810758(SCNN1B)
PHI: 102113494(SCNN1B)
PMAJ: 107211392(SCNN1B)
CCAE: 111936208(SCNN1B)
CCW: 104684728(SCNN1B)
ETL: 114061448(SCNN1B)
FPG: 101921771(SCNN1B)
FCH: 102054757(SCNN1B)
CLV: 102088625(SCNN1B)
EGZ: 104134531(SCNN1B)
NNI: 104015154(SCNN1B)
ACUN: 113485903(SCNN1B)
PADL: 103913932(SCNN1B)
AAM: 106486203(SCNN1B)
ASN: 102386268(SCNN1B)
AMJ: 102575151(SCNN1B)
PSS: 102448819(SCNN1B)
CMY: 102932510(SCNN1B)
CPIC: 101947270(SCNN1B)
ACS: 100567232(scnn1b)
PVT: 110085048(SCNN1B)
PBI: 103063383(SCNN1B)
PMUR: 107302602(SCNN1B)
TSR: 106553453(SCNN1B)
PMUA: 114584788(SCNN1B)
GJA: 107126206(SCNN1B)
XLA: 378536(scnn1b.L) 397893(scnn1b.S)
XTR: 779891(scnn1b)
NPR: 108783710(SCNN1B)
LCM: 102355590(SCNN1B)
CMK: 103186630(scnn1b)
RTP: 109916143
SPU: 105441174
APLC: 110987987
TUT: 107363008
PTEP: 107437732
MYI: 110441792
LAK: 106152772 106181584
NVE: 5505650 5508958 5508959
SPIS: 111325715
DGT: 114530713
 » show all
Reference
PMID:7490094
  Authors
Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M, Barbry P
  Title
Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.
  Journal
Genomics 28:560-5 (1995)
DOI:10.1006/geno.1995.1188
  Sequence
[hsa:6338]
LinkDB

KEGG   ORTHOLOGY: K04827
Entry
K04827                      KO                                     

Name
SCNN1G, ENACG
Definition
amiloride-sensitive sodium channel subunit gamma
Pathway
ko04742  Taste transduction
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00242  Liddle syndrome
H00243  Hyperkalemic distal renal tubular acidosis (RTA type 4)
H00892  Bronchiectasis with or without elevated sweat chloride
H01633  High blood pressure
H02310  Renal tubular acidosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K04827  SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma
  09157 Sensory system
   04742 Taste transduction
    K04827  SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04827  SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma
Ion channels [BR:ko04040]
 Ligand-gated channels
  Epithelial sodium channel (ENaC)
   K04827  SCNN1G, ENACG; amiloride-sensitive sodium channel subunit gamma
Other DBs
GO: 0015280
TC: 1.A.6.1.1
Genes
HSA: 6340(SCNN1G)
PTR: 467925(SCNN1G)
PPS: 100968574(SCNN1G)
GGO: 101138685(SCNN1G)
PON: 100460323(SCNN1G)
NLE: 115837449(SCNN1G)
MCC: 699971(SCNN1G)
MCF: 102144269(SCNN1G)
CSAB: 103229693(SCNN1G)
RRO: 104658243(SCNN1G)
RBB: 108538877(SCNN1G)
CJC: 100405534(SCNN1G)
SBQ: 101034426(SCNN1G)
MMU: 20278(Scnn1g)
MCAL: 110299034(Scnn1g)
MPAH: 110335302(Scnn1g)
RNO: 24768(Scnn1g)
MUN: 110550645(Scnn1g)
CGE: 100764998(Scnn1g)
NGI: 103742739(Scnn1g)
HGL: 101716529(Scnn1g)
CCAN: 109678013(Scnn1g)
OCU: 100008850(SCNN1G)
TUP: 102500817(SCNN1G)
CFA: 489973(SCNN1G)
VVP: 112908316(SCNN1G)
AML: 100476758(SCNN1G)
UMR: 103668864(SCNN1G)
UAH: 113267570(SCNN1G)
ORO: 101384225(SCNN1G)
ELK: 111162316
FCA: 101100020(SCNN1G)
PTG: 102955126(SCNN1G)
PPAD: 109255566(SCNN1G)
AJU: 106970498(SCNN1G)
BTA: 617802(SCNN1G)
BOM: 102288125(SCNN1G)
BIU: 109578880(SCNN1G)
BBUB: 102411793(SCNN1G)
CHX: 102169542(SCNN1G)
OAS: 100170326(SCNN1G)
SSC: 100522244(SCNN1G)
CFR: 102514195(SCNN1G)
CDK: 105094822(SCNN1G)
BACU: 103004693(SCNN1G)
LVE: 103087150(SCNN1G)
OOR: 101273526(SCNN1G)
DLE: 111182247(SCNN1G)
PCAD: 102984040(SCNN1G)
ECB: 102147597(SCNN1G)
EPZ: 103561574(SCNN1G)
EAI: 106846154(SCNN1G)
MYB: 102258193(SCNN1G)
MYD: 102752885(SCNN1G)
MNA: 107544758(SCNN1G)
HAI: 109386593(SCNN1G)
DRO: 112304799(SCNN1G)
PALE: 102882214(SCNN1G)
RAY: 107516103(SCNN1G)
MJV: 108404705(SCNN1G)
LAV: 100673417(SCNN1G)
TMU: 101345781
MDO: 100019886(SCNN1G)
SHR: 100931556(SCNN1G)
PCW: 110202462(SCNN1G)
OAA: 100078674(SCNN1G)
GGA: 416579(SCNN1G)
MGP: 100540499(SCNN1G)
CJO: 107320778(SCNN1G)
NMEL: 110405875(SCNN1G)
APLA: 101795334(SCNN1G)
ACYG: 106046058(SCNN1G)
TGU: 100232159(SCNN1G)
LSR: 110477767(SCNN1G)
SCAN: 103817794(SCNN1G)
GFR: 102043908(SCNN1G)
FAB: 101808808(SCNN1G)
PHI: 102113676(SCNN1G)
PMAJ: 107211376(SCNN1G)
CCAE: 111936303(SCNN1G)
CCW: 104684981(SCNN1G)
ETL: 114061456(SCNN1G)
FPG: 101913065(SCNN1G)
CLV: 102093206(SCNN1G)
EGZ: 104134550(SCNN1G)
NNI: 104015155(SCNN1G)
ACUN: 113485941(SCNN1G)
PADL: 103913934(SCNN1G)
AAM: 106486201(SCNN1G)
ASN: 102371138(SCNN1G)
AMJ: 102575387(SCNN1G)
PSS: 102447008(SCNN1G)
CMY: 102942896(SCNN1G)
CPIC: 101946998(SCNN1G)
ACS: 103282494
PVT: 110085000(SCNN1G)
PBI: 103064381(SCNN1G)
PMUR: 107302631(SCNN1G)
TSR: 106553452(SCNN1G)
PMUA: 114584679 114584790
GJA: 107126201(SCNN1G)
XLA: 373658(scnn1g.L) 373668(scnn1g.S) 779366(scnn1g)
XTR: 100487822(scnn1g) 101731449
NPR: 108783713(SCNN1G)
LCM: 102355323(SCNN1G)
CMK: 103186631(scnn1g)
RTP: 109916140(scnn1g)
PCAN: 112554349
MYI: 110443677 110443705
OVI: T265_01690
EPA: 110231423
PDAM: 113683456
 » show all
Reference
PMID:7490094
  Authors
Voilley N, Bassilana F, Mignon C, Merscher S, Mattei MG, Carle GF, Lazdunski M, Barbry P
  Title
Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel.
  Journal
Genomics 28:560-5 (1995)
DOI:10.1006/geno.1995.1188
  Sequence
[hsa:6340]
LinkDB

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