KEGG   ORTHOLOGY: K04962
Entry
K04962                      KO                                     

Name
RYR2
Definition
ryanodine receptor 2
Pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04260  Cardiac muscle contraction
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04713  Circadian entrainment
ko04911  Insulin secretion
ko04921  Oxytocin signaling pathway
ko04972  Pancreatic secretion
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Disease
H00293  Arrhythmogenic right ventricular cardiomyopathy
H01019  Catecholaminergic polymorphic ventricular tachycardia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04962  RYR2; ryanodine receptor 2
   04020 Calcium signaling pathway
    K04962  RYR2; ryanodine receptor 2
   04024 cAMP signaling pathway
    K04962  RYR2; ryanodine receptor 2
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04962  RYR2; ryanodine receptor 2
   04921 Oxytocin signaling pathway
    K04962  RYR2; ryanodine receptor 2
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04962  RYR2; ryanodine receptor 2
   04261 Adrenergic signaling in cardiomyocytes
    K04962  RYR2; ryanodine receptor 2
  09154 Digestive system
   04972 Pancreatic secretion
    K04962  RYR2; ryanodine receptor 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04962  RYR2; ryanodine receptor 2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    K04962  RYR2; ryanodine receptor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04962  RYR2; ryanodine receptor 2
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04962  RYR2; ryanodine receptor 2
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04962  RYR2; ryanodine receptor 2
   05414 Dilated cardiomyopathy
    K04962  RYR2; ryanodine receptor 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04962  RYR2; ryanodine receptor 2
   04990 Domain-containing proteins not elsewhere classified
    K04962  RYR2; ryanodine receptor 2
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Ryanodine receptor
   K04962  RYR2; ryanodine receptor 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K04962  RYR2; ryanodine receptor 2
Other DBs
GO: 0005219
TC: 1.A.3.1
Genes
HSA: 6262(RYR2)
PTR: 457846(RYR2)
PPS: 100974705(RYR2)
GGO: 101152456(RYR2)
PON: 100173051(RYR2)
NLE: 100598810(RYR2)
MCC: 717179(RYR2)
MCF: 102132307(RYR2)
CSAB: 103230821(RYR2)
RRO: 104679189(RYR2)
RBB: 108522194(RYR2)
CJC: 100406916(RYR2)
SBQ: 101044099(RYR2)
MMU: 20191(Ryr2)
MCAL: 110308440(Ryr2)
MPAH: 110334252(Ryr2)
RNO: 689560(Ryr2)
CGE: 100774683(Ryr2)
NGI: 103743548
HGL: 101703865(Ryr2)
CCAN: 109682314(Ryr2)
OCU: 100009536(RYR2)
TUP: 102473653(RYR2)
CFA: 403615(RYR2)
VVP: 112927407(RYR2)
AML: 100476576(RYR2)
UMR: 103662005(RYR2)
UAH: 113258943(RYR2)
ORO: 101368222 101372904(RYR2)
ELK: 111144745
FCA: 101084482(RYR2)
PTG: 102963018(RYR2)
PPAD: 109248970(RYR2)
AJU: 106987226(RYR2)
BTA: 537376(RYR2)
BOM: 102280999(RYR2)
BIU: 109553606(RYR2)
BBUB: 102409584(RYR2)
CHX: 102180565(RYR2)
OAS: 101118500(RYR2)
SSC: 396856(RYR2)
CFR: 102523222(RYR2)
CDK: 105088820
BACU: 103000050(RYR2)
LVE: 103085414(RYR2)
OOR: 101289369(RYR2)
DLE: 111163908(RYR2)
PCAD: 102974889(RYR2)
ECB: 100057437(RYR2)
EPZ: 103554178(RYR2)
EAI: 106834687(RYR2)
MYB: 102263572(RYR2)
MYD: 102765493(RYR2)
DRO: 112306096(RYR2)
PALE: 102877858(RYR2)
RAY: 107520024(RYR2)
LAV: 100676989
TMU: 101346209
MDO: 100028207(RYR2)
SHR: 100916914(RYR2)
PCW: 110217820(RYR2)
OAA: 100084273(RYR2)
GGA: 421508(RYR2)
MGP: 100551096(RYR2)
CJO: 107311396(RYR2)
NMEL: 110395962(RYR2)
APLA: 101793907(RYR2)
ACYG: 106048956(RYR2)
TGU: 100225109(RYR2)
LSR: 110468857(RYR2)
SCAN: 103818574(RYR2)
GFR: 102039305(RYR2)
FAB: 101815198(RYR2)
PHI: 102105661(RYR2)
PMAJ: 107201934(RYR2)
CCAE: 111927063(RYR2)
CCW: 104684437(RYR2)
ETL: 114067667
FPG: 101913442(RYR2)
FCH: 102053979(RYR2)
CLV: 102091036(RYR2)
NNI: 104011583(RYR2)
ACUN: 113478912(RYR2)
PADL: 103921270(RYR2)
AAM: 106485406(RYR2)
ASN: 102379736(RYR2)
AMJ: 102572051(RYR2)
PSS: 102449862(RYR2)
CMY: 102931487(RYR2)
CPIC: 101950679(RYR2)
ACS: 100555710(ryr2)
PVT: 110076303(RYR2)
PBI: 103059179(RYR2)
PMUR: 107290170(RYR2)
PMUA: 114594427(RYR2)
GJA: 107120023
DRE: 100126126(ryr2a) 568463(ryr2b)
SRX: 107715498(ryr2) 107750874
SANH: 107668588 107674386(ryr2)
IPU: 108269589 108274087(ryr2)
PHYP: 113527372(ryr2) 113544964
AMEX: 103025966(ryr2) 103027186
TRU: 101062804(ryr2) 101066256
LCO: 104919544 104924325(ryr2)
NCC: 104957116 104964697(ryr2)
MZE: 101465081 101474189(ryr2)
ONL: 100693556(ryr2) 100710196
XMA: 102235428(ryr2) 102238415
XCO: 114137831 114150588(ryr2)
PRET: 103476718 103482120(ryr2)
CVG: 107084672 107087628(ryr2)
ALIM: 106512392
AOCE: 111564972(ryr2) 111581551
CSEM: 103382205(ryr2) 103387261
POV: 109627002(ryr2) 109632650
LCF: 108876764(ryr2) 108897382
SDU: 111235207 111237061(ryr2)
SLAL: 111663756 111664302(ryr2)
HCQ: 109509992 109529278(ryr2)
MALB: 109960630 109966672(ryr2)
SASA: 106577062
OTW: 112253542
SALP: 111951725
ELS: 105010552 105025293(ryr2)
SFM: 108939633(ryr2)
PKI: 111853670(ryr2)
LCM: 102353265(RYR2)
CMK: 103178965(ryr2)
BFO: 118419221
CIN: 100178148
SPU: 580223
APLC: 110986867
SKO: 100328999(RYR)
DME: Dmel_CG10844(RyR)
DER: 6542186
DSE: 6608238
DSI: Dsimw501_GD10606(Dsim_GD10606)
DAN: 6495234
DSR: 110189240
DPE: 6592470
DWI: 6638476
DAZ: 108616347
DNV: 108653384
DHE: 111598039
DVI: 6625935
MDE: 101888405
LCQ: 111677492
AAG: 5579122
AALB: 109399084
AME: 408680
BIM: 100749661
BTER: 100643070
CCAL: 108623053
OBB: 114882194
SOC: 105195231
AEC: 105146428
ACEP: 105626523
PBAR: 105431823
VEM: 105568800
HST: 105188290
DQU: 106745598
CFO: 105252243
LHU: 105669060
PGC: 109853394
OBO: 105282237
PCF: 106787111
NVI: 100118800
CSOL: 105361468
MDL: 103571418
TCA: 655265
DPA: 109544790
ATD: 109600215
NVL: 108563731
BMOR: 101739070
BMAN: 114250644
PMAC: 106707973
TNL: 113505095
PXY: 105388065(Ryr)
API: 100167965
DNX: 107164288
AGS: 114127583
RMD: 113558741
BTAB: 109033133
CLEC: 106666716
ZNE: 110838949
FCD: 110843639
PVM: 113815056
TUT: 107361086
DPTE: 113798297
PTEP: 107450496
CEL: CELE_K11C4.5(unc-68)
CBR: CBG19042(Cbr-unc-68)
BMY: Bm1_45145
TSP: Tsp_02477
PCAN: 112569989
CRG: 105333338
MYI: 110461458
OBI: 106881762
EGL: EGR_09047
AQU: 100637092
 » show all
Reference
PMID:8809036
  Authors
Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA
  Title
The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis.
  Journal
Biochem J 318 ( Pt 2):477-87 (1996)
DOI:10.1042/bj3180477
  Sequence
[hsa:6262]
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