KEGG   ORTHOLOGY: K05069
Entry
K05069                      KO                                     

Name
IL2RB, CD122
Definition
interleukin 2 receptor beta
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04151 PI3K-Akt signaling pathway
    K05069  IL2RB, CD122; interleukin 2 receptor beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05069  IL2RB, CD122; interleukin 2 receptor beta
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05069  IL2RB, CD122; interleukin 2 receptor beta
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04659 Th17 cell differentiation
    K05069  IL2RB, CD122; interleukin 2 receptor beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   05202 Transcriptional misregulation in cancer
    K05069  IL2RB, CD122; interleukin 2 receptor beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   05162 Measles
    K05069  IL2RB, CD122; interleukin 2 receptor beta
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04090 CD molecules
    K05069  IL2RB, CD122; interleukin 2 receptor beta
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05069  IL2RB, CD122; interleukin 2 receptor beta
CD molecules [BR:ko04090]
 Proteins
  K05069  CD122, IL2RB; interleukin 2 receptor, beta
Other DBs
GO: 0004911
Genes
HSA: 3560(IL2RB)
PTR: 470203(IL2RB)
PPS: 100992438(IL2RB)
GGO: 101139583(IL2RB)
PON: 100460977(IL2RB)
NLE: 100581366(IL2RB)
MCC: 696331(IL2RB)
MCF: 102138714(IL2RB)
CSAB: 103223268(IL2RB)
RRO: 104682498(IL2RB)
RBB: 108512733(IL2RB)
CJC: 100394910(IL2RB)
SBQ: 101030332(IL2RB)
MMU: 16185(Il2rb)
MCAL: 110310694(Il2rb)
MPAH: 110335025(Il2rb)
RNO: 25746(Il2rb)
MUN: 110548465(Il2rb)
NGI: 103748643(Il2rb)
HGL: 101726369(Il2rb)
CCAN: 109698250(Il2rb)
TUP: 102467660(IL2RB)
CFA: 403439(IL2RB)
VVP: 112929101(IL2RB)
AML: 100478292(IL2RB)
UMR: 103676409(IL2RB)
ORO: 101366322(IL2RB)
ELK: 111157559
FCA: 101092622(IL2RB)
PTG: 102965369(IL2RB)
PPAD: 109265527(IL2RB)
AJU: 106981084(IL2RB)
BTA: 104968644(IL2RB) 510185
BOM: 102284639(IL2RB) 106700824
BIU: 109559534(IL2RB)
BBUB: 102391873 102392192(IL2RB)
OAS: 101107088(IL2RB)
SSC: 100621776(IL2RB)
CFR: 102524470(IL2RB)
CDK: 105101578(IL2RB)
BACU: 103006990(IL2RB)
LVE: 103071005(IL2RB)
OOR: 101271954(IL2RB)
DLE: 111186349(IL2RB)
PCAD: 102995923(IL2RB)
ECB: 100069676(IL2RB)
EPZ: 103564462(IL2RB)
EAI: 106837581(IL2RB)
MYB: 102241115(IL2RB)
MYD: 102768408(IL2RB)
MNA: 107545294(IL2RB)
HAI: 109394467(IL2RB)
DRO: 112321925(IL2RB)
PALE: 102883396(IL2RB)
RAY: 107519288(IL2RB)
MJV: 108392662(IL2RB)
LAV: 100669139(IL2RB)
TMU: 101344371
MDO: 100025393(IL2RB)
SHR: 100913275(IL2RB)
PCW: 110205742(IL2RB)
OAA: 100092851(IL2RB)
GGA: 100859707(IL2RB)
MGP: 104911125(IL2RB)
CJO: 107313789(IL2RB)
NMEL: 110393218(IL2RB)
APLA: 101791719(IL2RB)
ACYG: 106035899(IL2RB)
TGU: 101232975(IL2RB)
LSR: 110483875(IL2RB)
SCAN: 103813230(IL2RB)
GFR: 102031500(IL2RB)
FAB: 101809303(IL2RB)
PHI: 102106386(IL2RB)
PMAJ: 107204849(IL2RB)
CCAE: 111935345(IL2RB)
CCW: 104696293(IL2RB)
ETL: 114055414(IL2RB)
FPG: 101915263(IL2RB)
FCH: 102058748(IL2RB)
CLV: 102091469(IL2RB)
EGZ: 104134213(IL2RB)
NNI: 104021675(IL2RB)
ACUN: 113475953(IL2RB)
PADL: 103924145(IL2RB)
AAM: 106488409(IL2RB)
ASN: 102376875(IL2RB)
AMJ: 102571730(IL2RB)
PSS: 102449512(IL2RB)
CMY: 102936500(IL2RB)
CPIC: 101932173(IL2RB)
ACS: 103278848(il2rb)
PVT: 110075925(IL2RB)
PBI: 112541087(IL2RB)
PMUR: 107302587(IL2RB)
TSR: 106555941(IL2RB)
PMUA: 114605576(IL2RB)
GJA: 107120056(IL2RB)
XTR: 101731938(il2rb)
DRE: 793920(il2rb)
IPU: 108272990 108273212(il2rb)
TRU: 101076872
LCO: 104936154(il2rb)
NCC: 104964346
OLA: 101165891 105354598(csf2rb)
PRET: 103468486
ALIM: 106520638 106522494(csf2rb)
AOCE: 111579444 111579883(csf2rb)
LCF: 108877635(il2rb)
HCQ: 109520288
MALB: 109972408(il2rb)
ELS: 105009012(il2rb) 105029657
LCM: 102367350
CMK: 103189779(il2rb)
RTP: 109914787(il2rb)
 » show all
Reference
PMID:2785715
  Authors
Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T
  Title
Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
  Journal
Science 244:551-6 (1989)
DOI:10.1126/science.2785715
  Sequence
[hsa:3560]
Reference
PMID:8476561
  Authors
Minami Y, Kono T, Miyazaki T, Taniguchi T
  Title
The IL-2 receptor complex: its structure, function, and target genes.
  Journal
Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333
Reference
  Authors
Bucheton B, Argiro L, Chevillard C, Marquet S, Kheir MM, Mergani A, El-Safi SH, Dessein AJ
  Title
Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.
  Journal
Genes Immun 8:79-83 (2007)
DOI:10.1038/sj.gene.6364355
  Sequence
[hsa:3560]
LinkDB

KEGG   ORTHOLOGY: K05070
Entry
K05070                      KO                                     

Name
IL2RG, CD132
Definition
interleukin 2 receptor gamma
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05321  Inflammatory bowel disease
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04151 PI3K-Akt signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04659 Th17 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09163 Immune disease
   05321 Inflammatory bowel disease
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05340 Primary immunodeficiency
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05162 Measles
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04090 CD molecules
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05070  IL2RG, CD132; interleukin 2 receptor gamma
CD molecules [BR:ko04090]
 Proteins
  K05070  CD132, IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency)
Other DBs
GO: 0004911
Genes
HSA: 3561(IL2RG)
PTR: 101059843(IL2RG)
PPS: 100986679(IL2RG)
PON: 100454903(IL2RG)
NLE: 100585758(IL2RG)
MCC: 641338(IL2RG)
MCF: 102144912(IL2RG)
CSAB: 103232148(IL2RG)
RRO: 104656782(IL2RG)
RBB: 108532108(IL2RG)
CJC: 100388189(IL2RG)
SBQ: 101047979(IL2RG)
MMU: 16186(Il2rg)
MCAL: 110286942(Il2rg)
MPAH: 110313918(Il2rg)
RNO: 140924(Il2rg)
MUN: 110564656(Il2rg)
CGE: 100756284(Il2rg)
NGI: 103751955(Il2rg)
HGL: 101715243(Il2rg)
CCAN: 109673990(Il2rg)
OCU: 103351862(IL2RG)
TUP: 102476004(IL2RG)
CFA: 403851(IL2RG)
VVP: 112907637(IL2RG)
AML: 100468126(IL2RG)
UMR: 103682591(IL2RG)
UAH: 113245610(IL2RG)
ORO: 101374379(IL2RG)
ELK: 111161041
FCA: 101090239(IL2RG)
PTG: 102966580(IL2RG)
PPAD: 109254610(IL2RG)
AJU: 106982399(IL2RG)
BTA: 281862(IL2RG)
BOM: 102266681(IL2RG)
BIU: 109555190(IL2RG)
BBUB: 102402566(IL2RG)
CHX: 102169656(IL2RG)
OAS: 101103538(IL2RG)
SSC: 397156(IL2RG)
CDK: 105087982(IL2RG)
BACU: 103016442(IL2RG)
LVE: 103087530(IL2RG)
OOR: 101286718(IL2RG)
DLE: 111167807(IL2RG)
PCAD: 102979617(IL2RG)
ECB: 100055911(IL2RG)
EPZ: 103544610(IL2RG)
EAI: 106828880(IL2RG)
MYB: 102241164(IL2RG)
MYD: 102757155(IL2RG)
MNA: 107532895(IL2RG)
HAI: 109385585(IL2RG)
DRO: 112300079(IL2RG)
PALE: 102888070(IL2RG)
RAY: 107513773(IL2RG)
MJV: 108403309(IL2RG)
LAV: 100664834(IL2RG)
TMU: 101359472
MDO: 100619507(IL2RG)
SHR: 100929781(IL2RG)
PCW: 110201024(IL2RG)
OAA: 114812802(IL2RG)
GGA: 395199(IL2RG)
MGP: 104912104(IL2RG)
CJO: 107312576(IL2RG)
NMEL: 110403135(IL2RG)
APLA: 101794194(IL2RG)
ACYG: 106037383(IL2RG)
TGU: 100226174(IL2RG)
LSR: 110472683(IL2RG)
SCAN: 103824248(IL2RG)
GFR: 102043888(IL2RG)
FAB: 107603321(IL2RG)
PHI: 102112500(IL2RG)
PMAJ: 107203656(IL2RG)
CCAE: 111929372(IL2RG)
CCW: 104691748(IL2RG)
ETL: 114067449(IL2RG)
FPG: 101923008(IL2RG)
FCH: 102052025(IL2RG)
CLV: 102094834(IL2RG)
EGZ: 104124289(IL2RG)
NNI: 104012899(IL2RG)
ACUN: 113479902(IL2RG)
PADL: 103923348(IL2RG)
ASN: 102379602(IL2RG)
AMJ: 102575498(IL2RG)
PSS: 102443813(IL2RG)
CMY: 102933244(IL2RG)
CPIC: 101931356(IL2RG)
ACS: 103281066(il2rg)
PVT: 110080214(IL2RG)
PBI: 103061889(IL2RG)
PMUR: 107303211(IL2RG)
PMUA: 114589433(IL2RG)
GJA: 107108490(IL2RG)
XLA: 100036958(il2rg.L)
XTR: 100492995(il2rg)
NPR: 108800627(IL2RG)
DRE: 100144554(il2rgb) 796604(il2rga)
IPU: 108269358(il2rg) 108276805
TRU: 100190946(il2rg)
LCO: 104938889
NCC: 104967331
OLA: 101156347
XMA: 102230559
XCO: 114152754
PRET: 103475386
CVG: 107084171
NFU: 107386732
AOCE: 111573091
CSEM: 103395485(il2rg)
POV: 109635689
SDU: 111217233(il2rg)
SLAL: 111672069
HCQ: 109512452
MALB: 109960011
SALP: 111964368
LCM: 102356230(IL2RG)
 » show all
Reference
PMID:1631559
  Authors
Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K
  Title
Cloning of the gamma chain of the human IL-2 receptor.
  Journal
Science 257:379-82 (1992)
DOI:10.1126/science.1631559
  Sequence
[hsa:3561]
Reference
PMID:8476561
  Authors
Minami Y, Kono T, Miyazaki T, Taniguchi T
  Title
The IL-2 receptor complex: its structure, function, and target genes.
  Journal
Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333
Reference
  Authors
Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M
  Title
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
  Journal
Proc Natl Acad Sci U S A 108:11977-82 (2011)
DOI:10.1073/pnas.1100319108
  Sequence
[hsa:3561]
LinkDB

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