KEGG   ORTHOLOGY: K05071Help
Entry
K05071                      KO                                     

Name
IL4R, CD124
Definition
interleukin 4 receptor
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04630  JAK-STAT signaling pathway
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05200  Pathways in cancer
ko05321  Inflammatory bowel disease (IBD)
Disease
H00079  Asthma
H01358  Atopic dermatitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
   04151 PI3K-Akt signaling pathway
    K05071  IL4R, CD124; interleukin 4 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05071  IL4R, CD124; interleukin 4 receptor
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05071  IL4R, CD124; interleukin 4 receptor
   04658 Th1 and Th2 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
   04659 Th17 cell differentiation
    K05071  IL4R, CD124; interleukin 4 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05071  IL4R, CD124; interleukin 4 receptor
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K05071  IL4R, CD124; interleukin 4 receptor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05071  IL4R, CD124; interleukin 4 receptor
   04090 CD molecules
    K05071  IL4R, CD124; interleukin 4 receptor
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05071  IL4R, CD124; interleukin 4 receptor
CD molecules [BR:ko04090]
 Proteins
  K05071  CD124, IL4R; interleukin 4 receptor
BRITE hierarchy
Other DBs
GO: 0004913
Genes
HSA: 3566(IL4R)
PTR: 454005(IL4R)
PPS: 100969808(IL4R)
GGO: 101124934(IL4R)
PON: 100449812(IL4R)
NLE: 100606206(IL4R)
MCC: 705404(IL4R)
MCF: 102133649(IL4R)
CSAB: 103230069(IL4R)
RRO: 104665638(IL4R)
RBB: 108538856(IL4R)
CJC: 100412639(IL4R)
SBQ: 101044733(IL4R)
MMU: 16190(Il4ra)
MCAL: 110299093(Il4r)
MPAH: 110322992(Il4r)
RNO: 25084(Il4r)
MUN: 110564641(Il4r)
CGE: 100762840(Il4r)
NGI: 103741011(Il4r)
HGL: 101704138(Il4r)
CCAN: 109698033(Il4r)
OCU: 100337721(IL4R)
TUP: 102469844(IL4R)
CFA: 489957(IL4R)
VVP: 112929179(IL4R)
AML: 100476095(IL4R)
UMR: 103657902(IL4R)
UAH: 113267608(IL4R)
ORO: 101373228(IL4R)
ELK: 111162191
FCA: 101096277(IL4R)
PTG: 102949893(IL4R)
PPAD: 109256524(IL4R)
AJU: 106966182(IL4R)
BTA: 404154(IL4R)
BOM: 102273764(IL4R)
BIU: 109578521(IL4R)
BBUB: 102394204(IL4R)
CHX: 102176382(IL4R)
OAS: 101109063(IL4R)
SSC: 397614(IL4R)
CFR: 102504937(IL4R)
CDK: 105098257(IL4R)
BACU: 103017383(IL4R)
LVE: 103085500(IL4R)
OOR: 101281237(IL4R)
DLE: 111182213(IL4R)
PCAD: 102979109(IL4R)
ECB: 791252(IL4R)
EPZ: 103556347(IL4R)
EAI: 106829083(IL4R)
MYB: 102243995
MYD: 102752440(IL4R)
HAI: 109385965(IL4R)
DRO: 112304724 112304842(IL4R)
PALE: 102882815(IL4R)
RAY: 107506151(IL4R)
MJV: 108405149(IL4R)
LAV: 100654822(IL4R)
TMU: 101351007
MDO: 103092514(IL4R)
SHR: 100922104(IL4R)
PCW: 110221658(IL4R)
OAA: 103164911(IL4R)
GGA: 416585(IL4R)
MGP: 100541265(IL4R)
CJO: 107320714(IL4R)
NMEL: 110405596(IL4R)
APLA: 101796552(IL4R)
ACYG: 106046042(IL4R)
TGU: 100220266(IL4R)
LSR: 110477758(IL4R)
SCAN: 103817792(IL4R)
GFR: 102032458(IL4R)
FAB: 101812385(IL4R)
PHI: 102114232(IL4R)
PMAJ: 107211179(IL4R)
CCAE: 111936216(IL4R)
CCW: 104684903(IL4R)
ETL: 114061435(IL4R)
FPG: 101913747(IL4R)
FCH: 102059925(IL4R)
CLV: 102092650(IL4R)
EGZ: 104131347(IL4R)
NNI: 104015288(IL4R)
ACUN: 113485935(IL4R)
PADL: 103913920(IL4R)
AAM: 106486134(IL4R)
ASN: 102384900
AMJ: 102563749(IL4R)
PSS: 102459395(IL4R)
CMY: 102929479(IL4R)
CPIC: 101942260(IL4R)
ACS: 103281083(il4r)
PVT: 110085007
PBI: 103065038(IL4R)
TSR: 106546610(IL4R)
PMUA: 114584165(IL4R)
XTR: 101732450(il4r) 105948365
DRE: 563674(il4r.2)
SRX: 107745579
IPU: 108257347(il4r) 108280483
PHYP: 113535949(il4r) 113546473
AMEX: 111195543
EEE: 113575903(il4r)
ONL: 100705710
XMA: 111608325
CVG: 107086945
AOCE: 111587969
CSEM: 103398546
POV: 109624836
LCF: 108877014
SDU: 111219228
BPEC: 110175441
SASA: 100195064(il4ra) 106601108
SALP: 111979922
SFM: 108932964
PKI: 111846440(il4r)
LCM: 102349939
CMK: 103186635(il4r)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2307934
  Authors
Idzerda RL, March CJ, Mosley B, Lyman SD, Vanden Bos T, Gimpel SD, Din WS, Grabstein KH, Widmer MB, Park LS, et al.
  Title
Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.
  Journal
J Exp Med 171:861-73 (1990)
DOI:10.1084/jem.171.3.861
  Sequence
[hsa:3566]
Reference
PMID:8124718
  Authors
Keegan AD, Nelms K, White M, Wang LM, Pierce JH, Paul WE
  Title
An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth.
  Journal
Cell 76:811-20 (1994)
DOI:10.1016/0092-8674(94)90356-5
LinkDB All DBs

KEGG   ORTHOLOGY: K05070Help
Entry
K05070                      KO                                     

Name
IL2RG, CD132
Definition
interleukin 2 receptor gamma
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04630  JAK-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04151 PI3K-Akt signaling pathway
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04659 Th17 cell differentiation
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09163 Immune disease
   05321 Inflammatory bowel disease (IBD)
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05340 Primary immunodeficiency
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   05162 Measles
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
   04090 CD molecules
    K05070  IL2RG, CD132; interleukin 2 receptor gamma
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05070  IL2RG, CD132; interleukin 2 receptor gamma
CD molecules [BR:ko04090]
 Proteins
  K05070  CD132, IL2RG; interleukin 2 receptor, gamma (severe combined immunodeficiency)
BRITE hierarchy
Other DBs
GO: 0004911
Genes
HSA: 3561(IL2RG)
PTR: 101059843(IL2RG)
PPS: 100986679(IL2RG)
PON: 100454903(IL2RG)
NLE: 100585758(IL2RG)
MCC: 641338(IL2RG)
MCF: 102144912(IL2RG)
CSAB: 103232148(IL2RG)
RRO: 104656782(IL2RG)
RBB: 108532108(IL2RG)
CJC: 100388189(IL2RG)
SBQ: 101047979(IL2RG)
MMU: 16186(Il2rg)
MCAL: 110286942(Il2rg)
MPAH: 110313918(Il2rg)
RNO: 140924(Il2rg)
MUN: 110564656(Il2rg)
CGE: 100756284(Il2rg)
NGI: 103751955(Il2rg)
HGL: 101715243(Il2rg)
CCAN: 109673990(Il2rg)
OCU: 103351862(IL2RG)
TUP: 102476004(IL2RG)
CFA: 403851(IL2RG)
VVP: 112907637(IL2RG)
AML: 100468126(IL2RG)
UMR: 103682591(IL2RG)
UAH: 113245610(IL2RG)
ORO: 101374379(IL2RG)
ELK: 111161041
FCA: 101090239(IL2RG)
PTG: 102966580(IL2RG)
PPAD: 109254610(IL2RG)
AJU: 106982399(IL2RG)
BTA: 281862(IL2RG)
BOM: 102266681(IL2RG)
BIU: 109555190(IL2RG)
BBUB: 102402566(IL2RG)
CHX: 102169656(IL2RG)
OAS: 101103538(IL2RG)
SSC: 397156(IL2RG)
CDK: 105087982(IL2RG)
BACU: 103016442(IL2RG)
LVE: 103087530(IL2RG)
OOR: 101286718(IL2RG)
DLE: 111167807(IL2RG)
PCAD: 102979617(IL2RG)
ECB: 100055911(IL2RG)
EPZ: 103544610(IL2RG)
EAI: 106828880(IL2RG)
MYB: 102241164(IL2RG)
MYD: 102757155(IL2RG)
MNA: 107532895(IL2RG)
HAI: 109385585(IL2RG)
DRO: 112300079(IL2RG)
PALE: 102888070(IL2RG)
RAY: 107513773(IL2RG)
MJV: 108403309(IL2RG)
LAV: 100664834(IL2RG)
TMU: 101359472
MDO: 100619507(IL2RG)
SHR: 100929781(IL2RG)
PCW: 110201024(IL2RG)
OAA: 114812802(IL2RG)
GGA: 395199(IL2RG)
MGP: 104912104(IL2RG)
CJO: 107312576(IL2RG)
NMEL: 110403135(IL2RG)
APLA: 101794194(IL2RG)
ACYG: 106037383(IL2RG)
TGU: 100226174(IL2RG)
LSR: 110472683(IL2RG)
SCAN: 103824248(IL2RG)
GFR: 102043888(IL2RG)
FAB: 107603321(IL2RG)
PHI: 102112500(IL2RG)
PMAJ: 107203656(IL2RG)
CCAE: 111929372(IL2RG)
CCW: 104691748(IL2RG)
ETL: 114067449(IL2RG)
FPG: 101923008(IL2RG)
FCH: 102052025(IL2RG)
CLV: 102094834(IL2RG)
EGZ: 104124289(IL2RG)
NNI: 104012899(IL2RG)
ACUN: 113479902(IL2RG)
PADL: 103923348(IL2RG)
ASN: 102379602(IL2RG)
AMJ: 102575498(IL2RG)
PSS: 102443813(IL2RG)
CMY: 102933244(IL2RG)
CPIC: 101931356(IL2RG)
ACS: 103281066(il2rg)
PVT: 110080214(IL2RG)
PBI: 103061889(IL2RG)
PMUR: 107303211(IL2RG)
PMUA: 114589433(IL2RG)
GJA: 107108490(IL2RG)
XLA: 100036958(il2rg.L)
XTR: 100492995(il2rg)
NPR: 108800627(IL2RG)
DRE: 100144554(il2rgb) 796604(il2rga)
IPU: 108269358(il2rg) 108276805
TRU: 100190946(il2rg)
LCO: 104938889
NCC: 104967331
OLA: 101156347
XMA: 102230559
XCO: 114152754
PRET: 103475386
CVG: 107084171
NFU: 107386732
AOCE: 111573091
CSEM: 103395485(il2rg)
POV: 109635689
SDU: 111217233(il2rg)
SLAL: 111672069
HCQ: 109512452
MALB: 109960011
SALP: 111964368
LCM: 102356230(IL2RG)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1631559
  Authors
Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K
  Title
Cloning of the gamma chain of the human IL-2 receptor.
  Journal
Science 257:379-82 (1992)
DOI:10.1126/science.1631559
  Sequence
[hsa:3561]
Reference
PMID:8476561
  Authors
Minami Y, Kono T, Miyazaki T, Taniguchi T
  Title
The IL-2 receptor complex: its structure, function, and target genes.
  Journal
Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333
Reference
  Authors
Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M
  Title
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.
  Journal
Proc Natl Acad Sci U S A 108:11977-82 (2011)
DOI:10.1073/pnas.1100319108
  Sequence
[hsa:3561]
LinkDB All DBs

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