KEGG   ORTHOLOGY: K05090
Entry
K05090                      KO                                     

Name
CSF1R, FMS, CD115
Definition
macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
Pathway
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04151  PI3K-Akt signaling pathway
ko04380  Osteoclast differentiation
ko04640  Hematopoietic cell lineage
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Disease
H00028  Choriocarcinoma
H01807  Hereditary diffuse leukoencephalopathy with spheroids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04015 Rap1 signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04010 MAPK signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04151 PI3K-Akt signaling pathway
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
   05202 Transcriptional misregulation in cancer
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor
CD molecules [BR:ko04090]
 Proteins
  K05090  CD115, CSF1R; colony stimulating factor 1 receptor
Genes
HSA: 1436(CSF1R)
PTR: 462187(CSF1R)
PPS: 100974967(CSF1R)
GGO: 101151662(CSF1R)
PON: 100433386(CSF1R)
NLE: 100598906(CSF1R)
MCC: 711512(CSF1R)
MCF: 102124214(CSF1R)
CSAB: 103244788(CSF1R)
RRO: 104670407(CSF1R)
RBB: 108532049(CSF1R)
CJC: 100406047(CSF1R)
SBQ: 101043573(CSF1R)
MMU: 12978(Csf1r)
MCAL: 110285184(Csf1r)
MPAH: 110333327(Csf1r)
RNO: 307403(Csf1r)
MUN: 110546688(Csf1r)
CGE: 100763221(Csf1r)
NGI: 103747075(Csf1r)
HGL: 101719513(Csf1r)
CCAN: 109683164(Csf1r)
OCU: 100340992(CSF1R)
TUP: 102491581(CSF1R)
CFA: 489188(CSF1R)
VVP: 112927384(CSF1R)
AML: 100472252(CSF1R)
UMR: 103664603(CSF1R)
UAH: 113263940(CSF1R)
ORO: 101374504(CSF1R)
ELK: 111140850
FCA: 493706(CSF1R)
PTG: 102953056(CSF1R)
PPAD: 109275945(CSF1R)
AJU: 106985394(CSF1R)
BTA: 509418(CSF1R)
BOM: 102272280(CSF1R)
BIU: 109562194(CSF1R)
BBUB: 102414145(CSF1R)
CHX: 100861303(CSF1R)
OAS: 101109969(CSF1R)
SSC: 100517086(CSF1R)
CFR: 102513202(CSF1R)
CDK: 105098488(CSF1R)
BACU: 102999126(CSF1R)
OOR: 101273049(CSF1R)
DLE: 111183085(CSF1R)
PCAD: 102996862
ECB: 100060422(CSF1R)
EPZ: 103560147
EAI: 106838490(CSF1R)
MYB: 102256301(CSF1R)
MYD: 102763897(CSF1R)
MNA: 107535231(CSF1R)
HAI: 109374995(CSF1R)
DRO: 112319552(CSF1R)
PALE: 102886964(CSF1R)
RAY: 107513557(CSF1R)
MJV: 108385396(CSF1R)
LAV: 100670956(CSF1R)
TMU: 101360266
MDO: 100028926(CSF1R)
SHR: 100916950(CSF1R)
PCW: 110192877(CSF1R)
OAA: 100079755(CSF1R)
GGA: 396406(CSF1R)
MGP: 100549842(CSF1R)
CJO: 107320150(CSF1R)
NMEL: 110405187(CSF1R)
APLA: 101802224(CSF1R)
ACYG: 106032822(CSF1R)
TGU: 100220482(CSF1R)
LSR: 110482754(CSF1R)
SCAN: 103817300(CSF1R)
GFR: 102045177(CSF1R)
FAB: 101809748(CSF1R)
PHI: 102111338(CSF1R)
PMAJ: 107210711(CSF1R)
CCAE: 111935546(CSF1R)
CCW: 104689582(CSF1R)
ETL: 114063183(CSF1R)
FPG: 101918260(CSF1R)
FCH: 102052893(CSF1R)
CLV: 102090039(CSF1R)
EGZ: 104123541(CSF1R)
NNI: 104014195(CSF1R)
ACUN: 113485362(CSF1R)
PADL: 103915746(CSF1R)
AAM: 106493440(CSF1R)
ASN: 102373216(CSF1R)
AMJ: 102565932(CSF1R)
PSS: 102460494(CSF1R)
CMY: 102937993(CSF1R)
CPIC: 101940831(CSF1R)
ACS: 100555979(csf1r)
PVT: 110086091(CSF1R)
PBI: 103051818(CSF1R)
PMUR: 107298558(CSF1R) 107300232
TSR: 106547767(CSF1R)
PMUA: 114591344(CSF1R)
GJA: 107116323(CSF1R)
XLA: 101243554(csf1r)
XTR: 493543(csf1r)
NPR: 108785796(CSF1R)
DRE: 568405(csf1rb) 64274(csf1ra)
CCAR: 109046330 109085854(csf1r)
IPU: 100526732(csf1r) 108278893
PHYP: 113524593 113529571(csf1r)
AMEX: 103039626(csf1r) 103043165
EEE: 113575551(csf1r) 113587446
TRU: 101069994(csf1r) 101080143
NCC: 104965699(csf1r)
MZE: 101466356 101484032(csf1r)
ONL: 100709907(csf1r) 100710555
PRET: 103459904(csf1r) 103471278(csf1r)
NFU: 107375663 107387189(csf1r)
KMR: 108228290 108240545(csf1r)
ALIM: 106517374(csf1r) 106532555
AOCE: 111569513(csf1r) 111575718
CSEM: 103391009(csf1r) 103395736
POV: 109626445(csf1r) 109642209
LCF: 108873645 108899187(csf1r)
SDU: 111226429(csf1r) 111239498
SLAL: 111646667(csf1r) 111671143
HCQ: 109518749(csf1r) 109528889
SFM: 108934464 108936825(csf1r)
LCM: 102349790(CSF1R)
CMK: 103188221
FCD: 110847679
 » show all
Reference
PMID:2421165
  Authors
Coussens L, Van Beveren C, Smith D, Chen E, Mitchell RL, Isacke CM, Verma IM, Ullrich A
  Title
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.
  Journal
Nature 320:277-80 (1986)
DOI:10.1038/320277a0
  Sequence
[hsa:1436]
Reference
PMID:9262961
  Authors
Fixe P, Praloran V
  Title
Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships.
  Journal
Eur Cytokine Netw 8:125-36 (1997)
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