KEGG   ORTHOLOGY: K05099
Entry
K05099                      KO                                     

Name
MET, HGFR
Definition
proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04360  Axon guidance
map04361  Axon regeneration
map04510  Focal adhesion
map04520  Adherens junction
map05100  Bacterial invasion of epithelial cells
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05144  Malaria
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05211  Renal cell carcinoma
map05218  Melanoma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
Disease
H00014  Non-small cell lung cancer
H00018  Gastric cancer
H00021  Renal cell carcinoma
H00046  Cholangiocarcinoma
H00048  Hepatocellular carcinoma
H00605  Deafness, autosomal recessive
H01985  Desmoplastic small round cell tumor
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04014 Ras signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04015 Rap1 signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04020 Calcium signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04151 PI3K-Akt signaling pathway
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04520 Adherens junction
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   04361 Axon regeneration
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05202 Transcriptional misregulation in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05206 MicroRNAs in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05205 Proteoglycans in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05208 Chemical carcinogenesis - reactive oxygen species
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05230 Central carbon metabolism in cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05226 Gastric cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05218 Melanoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05211 Renal cell carcinoma
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05223 Non-small cell lung cancer
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
   05100 Bacterial invasion of epithelial cells
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09174 Infectious disease: parasitic
   05144 Malaria
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  MET family
   K05099  MET, HGFR; proto-oncogene tyrosine-protein kinase Met
Genes
HSA: 4233(MET)
PTR: 463671(MET)
PPS: 100991777(MET)
GGO: 101127399(MET)
PON: 100137030(MET)
NLE: 100597172(MET)
MCC: 704562(MET)
MCF: 102123512(MET)
CSAB: 103226771(MET)
CATY: 105598476(MET)
PANU: 100126669(MET)
RRO: 104682633(MET)
RBB: 108528695(MET)
TFN: 117073436(MET)
PTEH: 111553422(MET)
CJC: 100408551(MET)
SBQ: 101038696(MET)
MMUR: 105869368(MET)
MMU: 17295(Met)
MCAL: 110295947(Met)
MPAH: 110316104(Met)
RNO: 24553(Met)
MCOC: 116098601(Met)
MUN: 110558703(Met)
CGE: 100751933(Met)
PLEU: 114694721(Met)
NGI: 103737431(Met)
HGL: 101725772(Met)
CCAN: 109689877(Met)
OCU: 100126565(MET)
TUP: 102485847(MET)
CFA: 403438(MET)
VVP: 112929871(MET)
VLG: 121474658(MET)
AML: 100480742(MET)
UMR: 103676585(MET)
UAH: 113263211(MET)
ORO: 101365730(MET)
ELK: 111151956
MPUF: 101675655(MET)
EJU: 114210625(MET)
MLX: 118021010(MET)
FCA: 493669(MET)
PTG: 102953616(MET)
PPAD: 109248389(MET)
AJU: 106970667(MET)
HHV: 120223826(MET)
BTA: 280855(MET)
BOM: 102285634(MET)
BIU: 109557411(MET)
BBUB: 102393442(MET)
CHX: 102181186(MET)
OAS: 443076(MET)
ODA: 120878210(MET)
SSC: 654328(MET)
CFR: 102504138
CDK: 105085321
BACU: 103002086(MET)
LVE: 103090984(MET)
OOR: 101280136(MET)
DLE: 111179292(MET)
PCAD: 102987522(MET)
ECB: 100056013(MET)
EPZ: 103562070(MET)
EAI: 106829287(MET)
MYB: 102263347(MET)
MYD: 102753524
MMYO: 118666481(MET)
MNA: 107528536(MET)
HAI: 109389346(MET)
DRO: 112300421(MET)
AJM: 119038260(MET)
MMF: 118619859(MET)
PALE: 102885990(MET)
RAY: 107497465(MET)
MJV: 108399322(MET)
TOD: 119245963(MET)
LAV: 100656285(MET)
TMU: 101345595
MDO: 100013788(MET)
SHR: 100917007(MET)
PCW: 110202946(MET)
OAA: 100079345(MET)
GGA: 396134(MET)
PCOC: 116243979(MET)
MGP: 100544894(MET)
CJO: 107309125(MET)
NMEL: 110392601(MET)
APLA: 101801559(MET)
ACYG: 106042077(MET)
TGU: 100227998(MET)
LSR: 110477141(MET)
SCAN: 103813465(MET)
PMOA: 120510753(MET)
GFR: 102035281(MET)
FAB: 101822032(MET)
PHI: 102099870(MET)
PMAJ: 107204940(MET)
CCAE: 111931552(MET) 111943846
CCW: 104698290(MET)
ETL: 114062356(MET)
FPG: 101921590(MET)
FCH: 102046148(MET)
CLV: 102091194(MET)
EGZ: 104133409(MET)
NNI: 104013588(MET)
ACUN: 113491414(MET)
PADL: 103916977(MET)
AAM: 106488808(MET)
ASN: 102387009(MET)
AMJ: 102568767(MET)
CPOO: 109315620(MET)
GGN: 109295605(MET)
PSS: 102447079(MET)
CMY: 102936928(MET)
CPIC: 101931256(MET)
TST: 117876645(MET)
CABI: 116830742
ACS: 100561443(met)
PVT: 110077032(MET)
PBI: 103067929(MET)
PMUR: 107285371(MET)
TSR: 106557423(MET)
PGUT: 117673589(MET)
PMUA: 114605269(MET)
ZVI: 118090716(MET)
GJA: 107114504(MET)
XLA: 108712362(met.S) 373551(met.L)
XTR: 100485823(met)
NPR: 108788984(MET)
DRE: 100150664(met)
SRX: 107716667
IPU: 108268944(met)
PHYP: 113546663(met)
AMEX: 103023930
EEE: 113581523(met) 113584980
TRU: 100137507(met)
LCO: 104931751(met)
ELY: 117262484(met)
PLEP: 121950165(met)
SLUC: 116036253(met)
ECRA: 117949070(met)
PFLV: 114560667(met)
GAT: 120809534(met)
MSAM: 119894195(met)
CUD: 121515323(met)
MZE: 101465566(met)
ONL: 100709985(met)
OAU: 116317475(met)
OLA: 101174570(met)
OML: 112139178(met)
XMA: 102219516(met)
XCO: 114142761(met)
XHE: 116709506(met)
PRET: 103465633(met)
CVG: 107083224(met)
CTUL: 119780439(met)
NFU: 107388350(met)
KMR: 108248206(met)
ALIM: 106511318 106518848(met)
AOCE: 111572785(met)
CSEM: 103379587(met)
POV: 109624638(met)
LCF: 108893984(met)
SDU: 111220524(met)
SLAL: 111672169(met)
XGL: 120793161(met)
HCQ: 109530899(met)
BPEC: 110155115(met)
MALB: 109956390(met)
OMY: 110502318(met) 110532382
ELS: 105029522(met)
PKI: 111836018 111842454(met)
LOC: 102696260(met)
LCM: 102366006(MET)
CMK: 103179355(met)
CIN: 445767
SPU: 589012
APLC: 110983946
SKO: 100366742
TUT: 107359841
DPTE: 113794711
CSCU: 111618069
PTEP: 107436100
SDM: 118193963
CEL: CELE_T14E8.1(svh-2)
CBR: CBG10839
BGT: 106052215
GAE: 121369173
OBI: 106879211
 » show all
Reference
PMID:2819873
  Authors
Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude G
  Title
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.
  Journal
Proc Natl Acad Sci U S A 84:6379-83 (1987)
DOI:10.1073/pnas.84.18.6379
  Sequence
[hsa:4233]
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