KEGG   ORTHOLOGY: K05119Help
Entry
K05119                      KO                                     

Name
ALK, CD246
Definition
anaplastic lymphoma kinase [EC:2.7.10.1]
Pathway
ko05200  Pathways in cancer
ko05223  Non-small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00014  Non-small cell lung cancer
H01601  Anaplastic large-cell lymphoma
H01892  Peripheral T cell lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K05119  ALK, CD246; anaplastic lymphoma kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05119  ALK, CD246; anaplastic lymphoma kinase
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05119  ALK, CD246; anaplastic lymphoma kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05119  ALK, CD246; anaplastic lymphoma kinase
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  ALK family
   K05119  ALK, CD246; anaplastic lymphoma kinase
CD molecules [BR:ko04090]
 Proteins
  K05119  CD246, ALK; anaplastic lymphoma kinase (Ki-1)
BRITE hierarchy
Genes
HSA: 238(ALK)
PTR: 459127(ALK)
PPS: 100981152(ALK)
GGO: 101141580(ALK)
PON: 100458012(ALK)
NLE: 100593886(ALK)
MCC: 704823(ALK)
MCF: 102128455(ALK)
CSAB: 103220559(ALK)
RRO: 104663931
RBB: 108532772(ALK)
CJC: 100399252(ALK)
SBQ: 101044905(ALK)
MMU: 11682(Alk)
MCAL: 110312131(Alk)
MPAH: 110335467(Alk)
RNO: 266802(Alk)
MUN: 110554521(Alk)
CGE: 100760366(Alk)
NGI: 103744649(Alk)
HGL: 101703312(Alk)
CCAN: 109679287(Alk)
OCU: 100347722(ALK)
TUP: 102492665(ALK)
CFA: 483021(ALK)
VVP: 112932997(ALK)
AML: 100473389(ALK)
UMR: 103671905(ALK)
UAH: 113268019(ALK)
ORO: 101373502(ALK)
FCA: 101091689(ALK)
PTG: 102970257(ALK)
AJU: 106967924(ALK)
BTA: 536642(ALK)
BOM: 106701242(ALK)
BIU: 109565582(ALK)
BBUB: 102394478(ALK)
PHD: 102331518(ALK)
CHX: 106502631(ALK)
OAS: 101114094(ALK)
SSC: 100518423(ALK)
CFR: 102504436(ALK)
CDK: 105098577
BACU: 103020848(ALK)
LVE: 103082654(ALK)
OOR: 101281727(ALK)
DLE: 111174732(ALK)
ECB: 100070891
EPZ: 103549200(ALK)
EAI: 106837084(ALK)
MYD: 102759675(ALK)
MNA: 107534860(ALK)
HAI: 109390951(ALK)
RSS: 109449229(ALK)
DRO: 112298036(ALK)
PALE: 102884662(ALK)
LAV: 100661350(ALK)
TMU: 101346489
MDO: 100031373(ALK)
SHR: 100931895(ALK)
PCW: 110206438(ALK)
OAA: 100078902(ALK)
GGA: 421297(ALK) 423216(LTK)
MGP: 100542012(LTK) 100543352(ALK)
CJO: 107310876(ALK) 107314725(LTK)
APLA: 101789875(LTK) 101797885(ALK)
ACYG: 106043115(LTK) 106043136(ALK)
TGU: 100221054(LTK) 100221929(ALK)
LSR: 110472103(LTK) 110472832(ALK)
SCAN: 103821381(ALK) 103826985(LTK)
GFR: 102034482(ALK) 102036797(LTK)
FAB: 101817862(LTK) 101819549(ALK)
PHI: 102108510(LTK) 102112738(ALK)
PMAJ: 107202471(ALK) 107205794(LTK)
CCAE: 111926304(ALK) 111930075(LTK)
CCW: 104685582(ALK) 104698444(LTK)
ETL: 114059427(LTK) 114060910(ALK)
FPG: 101923162(LTK) 101924804(ALK)
FCH: 102055199(LTK) 102059446(ALK)
CLV: 102096456 102097986(LTK)
EGZ: 104127545(LTK) 104134596(ALK)
NNI: 104018112(ALK) 104020450(LTK)
ACUN: 113478473(ALK) 113480533(LTK)
AAM: 106490437(ALK) 106498243(LTK)
ASN: 102383997(ALK) 102386513(LTK)
AMJ: 102572248(LTK) 102573864(ALK)
PSS: 102449858(LTK) 102462403(ALK)
CMY: 102944568(ALK)
CPIC: 101947911(ALK) 101951471(LTK)
ACS: 100553426(alk) 100563969(ltk) 103283044
PVT: 110078686(ALK) 110079037(LTK)
PBI: 103054608 103060733(ALK)
PMUR: 107295457 107296234(ALK)
GJA: 107113542(ALK) 107126012(LTK)
XTR: 100495071(alk) 100498306(ltk)
NPR: 108789911(LTK) 108796594(ALK)
DRE: 563509(alk) 564470(ltk)
IPU: 108270425 108270462(ltk)
PHYP: 113539006(ltk) 113545033(alk)
TRU: 101062160(ltk) 101068218(alk)
LCO: 104922171 104924780(alk)
MZE: 101473442(alk) 101473463
OLA: 101156784 105357017(alk)
XMA: 102218265(alk) 102223978
XCO: 114133996 114134142(alk)
PRET: 103458724(alk) 103458875
NFU: 107392283 107395952(alk)
KMR: 108237218 108241771(alk)
CSEM: 103377486(ltk) 103383830(alk)
LCF: 108888127 108896151(alk)
SDU: 111225567 111226063(alk)
BPEC: 110155417
MALB: 109955116(ltk) 109972827
ELS: 105015742 105029147(alk)
PKI: 111833981(alk) 111852371(ltk)
LCM: 102363060 102363661(ALK)
CMK: 103176144 103180837(alk)
SPU: 753560
APLC: 110975206
SKO: 100368524
DME: Dmel_CG8250(Alk)
DER: 6548537
DPE: 6601606
DSI: Dsimw501_GD25528(Dsim_GD25528)
DWI: 6637928
DAZ: 108617073
DNV: 108653643
DHE: 111593842
MDE: 101891328
AAG: 5579652
AME: 408718
BIM: 100744065
BTER: 100646372
SOC: 105197862
MPHA: 105828354
AEC: 105145518
ACEP: 105626376
PBAR: 105422090
HST: 105191722
DQU: 106752358
CFO: 105251192
LHU: 105679911
PGC: 109854323
OBO: 105276946
PCF: 106791608
NVI: 100119087
MDL: 103571904
TCA: 657445
DPA: 109534510
NVL: 108557067
BMOR: 101735728
PMAC: 106707912
PRAP: 110999387
TNL: 113505045
API: 100169221
DNX: 107167771
AGS: 114126210
CLEC: 106665745
ZNE: 110837757
FCD: 110843553
TUT: 107365132
DPTE: 113791595
CEL: CELE_T10H9.2(scd-2)
CBR: CBG18982(Cbr-scd-2)
BMY: Bm1_52030
TSP: Tsp_02986
PCAN: 112569873
EGL: EGR_02729
AQU: 105316836
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9174053
  Authors
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP
  Title
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
  Journal
Oncogene 14:2175-88 (1997)
DOI:10.1038/sj.onc.1201062
  Sequence
[hsa:238]
Reference
  Authors
Palmer RH, Vernersson E, Grabbe C, Hallberg B
  Title
Anaplastic lymphoma kinase: signalling in development and disease.
  Journal
Biochem J 420:345-61 (2009)
DOI:10.1042/BJ20090387
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