KEGG   ORTHOLOGY: K05355
Entry
K05355                      KO                                     

Name
hexPS, COQ1
Definition
hexaprenyl-diphosphate synthase [EC:2.5.1.82 2.5.1.83]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K05355  hexPS, COQ1; hexaprenyl-diphosphate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K05355  hexPS, COQ1; hexaprenyl-diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.82  hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
     K05355  hexPS, COQ1; hexaprenyl-diphosphate synthase
    2.5.1.83  hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
     K05355  hexPS, COQ1; hexaprenyl-diphosphate synthase
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K05355  hexPS, COQ1; hexaprenyl-diphosphate synthase
Other DBs
RN: R09245 R09246
COG: COG0142
Genes
QSU: 111992756 112011202
CME: CYME_CMJ246C
SCE: YBR003W(COQ1)
AGO: AGOS_AER004W
ERC: Ecym_5300
KLA: KLLA0_E17183g
KMX: KLMA_60114(COQ1)
LTH: KLTH0G16368g
VPO: Kpol_1036p41
ZRO: ZYRO0A04620g
NCS: NCAS_0I01970(NCAS0I01970)
NDI: NDAI_0A06570(NDAI0A06570)
TPF: TPHA_0A04460(TPHA0A04460)
TBL: TBLA_0F00560(TBLA0F00560)
TDL: TDEL_0D04200(TDEL0D04200)
KAF: KAFR_0F02550(KAFR0F02550)
PIC: PICST_86778(COQ1)
CAL: CAALFM_CR00570WA(CaO19.7478)
SLB: AWJ20_394(COQ1)
NCR: NCU02305
NTE: NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
MGR: MGG_03343
SSCK: SPSK_04068
MAW: MAC_09061
MAJ: MAA_03330
CMT: CCM_00496
BFU: BCIN_02g05540(Bccoq1)
MBE: MBM_07123
ANG: ANI_1_1348094(An11g10370)
ABE: ARB_07252
TVE: TRV_03960
PTE: PTT_13690
ZTR: MYCGRDRAFT_73426(COQ1)
SPO: SPBPJ4664.01(dps1)
CNE: CNI01740
CNB: CNBH1650
ABP: AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
MGL: MGL_1241
MRT: MRET_2902
DFA: DFA_03641(coq1)
PCB: PCHAS_030300(PC000612.04.0)
 » show all
Reference
PMID:2198286
  Authors
Ashby MN, Edwards PA
  Title
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
  Journal
J Biol Chem 265:13157-64 (1990)
  Sequence
[sce:YBR003W]
LinkDB

KEGG   ORTHOLOGY: K21268
Entry
K21268                      KO                                     

Name
gdS-2
Definition
hexaprenyl diphosphate synthase [EC:2.5.1.82]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K21268  gdS-2; hexaprenyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.82  hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
     K21268  gdS-2; hexaprenyl diphosphate synthase
Other DBs
RN: R09246
COG: COG0142
GO: 0052922
Genes
STO: STK_04870
SSO: SSO2345(gdS-2)
SOL: Ssol_0157
SSOA: SULA_0149
SSOL: SULB_0150
SSOF: SULC_0149
SAI: Saci_0995
SACN: SacN8_04825
SACR: SacRon12I_04815
SACS: SUSAZ_04575
SID: M164_0161
SII: LD85_0146
SIH: SiH_0146
SIR: SiRe_0142
SIC: SiL_0133
MSE: Msed_0691
MCN: Mcup_1409
AHO: Ahos_2145
 » show all
Reference
  Authors
Hemmi H, Ikejiri S, Yamashita S, Nishino T
  Title
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
  Journal
J Bacteriol 184:615-20 (2002)
DOI:10.1128/JB.184.3.615-620.2002
  Sequence
[sso:SSO2345]
LinkDB

KEGG   ENZYME: 2.5.1.82
Entry
EC 2.5.1.82                 Enzyme                                 

Name
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09246]
Reaction(KEGG)
R09246
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].
History
EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl-diphosphate synthase
K21268  hexaprenyl diphosphate synthase
Genes
QSU: 111992756 112011202
CME: CYME_CMJ246C
SCE: YBR003W(COQ1)
AGO: AGOS_AER004W
ERC: Ecym_5300
KLA: KLLA0_E17183g
KMX: KLMA_60114(COQ1)
LTH: KLTH0G16368g
VPO: Kpol_1036p41
ZRO: ZYRO0A04620g
NCS: NCAS_0I01970(NCAS0I01970)
NDI: NDAI_0A06570(NDAI0A06570)
TPF: TPHA_0A04460(TPHA0A04460)
TBL: TBLA_0F00560(TBLA0F00560)
TDL: TDEL_0D04200(TDEL0D04200)
KAF: KAFR_0F02550(KAFR0F02550)
PIC: PICST_86778(COQ1)
CAL: CAALFM_CR00570WA(CaO19.7478)
SLB: AWJ20_394(COQ1)
NCR: NCU02305
NTE: NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
MGR: MGG_03343
SSCK: SPSK_04068
MAW: MAC_09061
MAJ: MAA_03330
CMT: CCM_00496
BFU: BCIN_02g05540(Bccoq1)
MBE: MBM_07123
ANG: ANI_1_1348094(An11g10370)
ABE: ARB_07252
TVE: TRV_03960
PTE: PTT_13690
ZTR: MYCGRDRAFT_73426(COQ1)
SPO: SPBPJ4664.01(dps1)
CNE: CNI01740
CNB: CNBH1650
ABP: AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
MGL: MGL_1241
MRT: MRET_2902
DFA: DFA_03641(coq1)
PCB: PCHAS_030300(PC000612.04.0)
STO: STK_04870
SSO: SSO2345(gdS-2)
SOL: Ssol_0157
SSOA: SULA_0149
SSOL: SULB_0150
SSOF: SULC_0149
SAI: Saci_0995
SID: M164_0161
SII: LD85_0146
SIH: SiH_0146
SIR: SiRe_0142
SIC: SiL_0133
MSE: Msed_0691
MCN: Mcup_1409
AHO: Ahos_2145
 » show all
Reference
1  [PMID:11790729]
  Authors
Hemmi H, Ikejiri S, Yamashita S, Nishino T
  Title
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus.
  Journal
J Bacteriol 184:615-20 (2002)
DOI:10.1128/JB.184.3.615-620.2002
  Sequence
[sso:SSO2345]
Reference
2  [PMID:12372398]
  Authors
Hemmi H, Noike M, Nakayama T, Nishino T
  Title
Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus  solfataricus by introducing mimetic mutations.
  Journal
Biochem Biophys Res Commun 297:1096-101 (2002)
DOI:10.1016/S0006-291X(02)02348-3
Reference
3  [PMID:16291686]
  Authors
Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH
  Title
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures.
  Journal
J Bacteriol 187:8137-48 (2005)
DOI:10.1128/JB.187.23.8137-8148.2005
  Sequence
[sso:SSO2345]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.82
IUBMB Enzyme Nomenclature: 2.5.1.82
ExPASy - ENZYME nomenclature database: 2.5.1.82
BRENDA, the Enzyme Database: 2.5.1.82
LinkDB

KEGG   REACTION: R09246
Entry
R09246                      Reaction                               

Name
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Definition
Geranylgeranyl diphosphate + 2 Isopentenyl diphosphate <=> all-trans-Hexaprenyl diphosphate + 2 Diphosphate
Equation
C00353 + 2 C00129 <=> C01230 + 2 C00013
Comment
2-step reaction
see R07475+R05613
Reaction class
RC00279  C00129_C01230
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl-diphosphate synthase [EC:2.5.1.82 2.5.1.83]
K21268  hexaprenyl diphosphate synthase [EC:2.5.1.82]
Other DBs
RHEA: 27558
LinkDB

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