KEGG   ORTHOLOGY: K05356
Entry
K05356                      KO                                     

Name
SPS, sds
Definition
all-trans-nonaprenyl-diphosphate synthase [EC:2.5.1.84 2.5.1.85]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K05356  SPS, sds; all-trans-nonaprenyl-diphosphate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K05356  SPS, sds; all-trans-nonaprenyl-diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.84  all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]
     K05356  SPS, sds; all-trans-nonaprenyl-diphosphate synthase
    2.5.1.85  all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
     K05356  SPS, sds; all-trans-nonaprenyl-diphosphate synthase
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K05356  SPS, sds; all-trans-nonaprenyl-diphosphate synthase
Other DBs
RN: R07267 R09250 R09251
COG: COG0142
GO: 0050347
Genes
ATH: AT1G17050(SPS2) AT1G78510(SPS1)
ALY: 110225373 9304798 9323808
CRB: 17894671 17896965
CSAT: 104702634 104713531 104740392 104751747 104756029 104775809
EUS: EUTSA_v10007715mg EUTSA_v10018616mg
BRP: 103832329 103872491
BNA: 106346730 106354554 106354696 106365558
BOE: 106301071 106343305
RSZ: 108825091 108828623
THJ: 104810419 104812299 104813987 104822586
CPAP: 110811666
CIT: 102612772
TCC: 18594463
GAB: 108464212
DZI: 111298875
VRA: 106762491
VAR: 108334430
VUN: 114186101
CCAJ: 109790225
CAM: 101502183
LJA: Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
ADU: 107459857
AIP: 107613812
FVE: 101297041
RCN: 112202839
PPER: 18778932
PMUM: 103325805
PAVI: 110772576
ZJU: 107414345
CSV: 101214140
CMO: 103492962
MCHA: 111012845
RCU: 8258714
JCU: 105641085
MESC: 110601874
POP: 7459128
PEU: 105140437
JRE: 108994345
QSU: 111989322
VVI: 100246988
SLY: 101253007(SppS)
SPEN: 107026209
SOT: 102593674
CANN: 107878554
NSY: 104243529
NTO: 104101158
NAU: 109243898
LSV: 111904475
CCAV: 112516899
BVG: 104899063
SOE: 110783766
DOSA: Os05t0582300-01(Os05g0582300)
ATS: 109748254(LOC109748254)
SBI: 8155346
PDA: 103712684
MUS: 103989203
DCT: 110112294
PEQ: 110032238
AOF: 109842749
ATR: 18430924
APRO: F751_0189
OLU: OSTLU_51700(clpR2)
SMIN: v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: slr0611(sds)
SYZ: MYO_110(sds)
SYY: SYNGTS_0001(sds)
SYT: SYNGTI_0001(sds)
SYS: SYNPCCN_0001(sds)
SYQ: SYNPCCP_0001(sds)
SYJ: D082_04480(sds)
SYO: C7I86_00005(sds)
SYC: syc1741_c(sds)
SYW: SYNW1011(sds)
SYG: sync_1551
SYR: SynRCC307_1159(preA)
SYX: SynWH7803_1038(preA)
SYP: SYNPCC7002_A0580(sdsA)
CYA: CYA_2276(sds)
CYB: CYB_0451(sds)
SYNR: KR49_03240
SYND: KR52_10950
SYNW: SynWH8103_01143(sds)
SYNC: CB0101_03630(sds)
TEL: tlr1757(sds)
THN: NK55_05445(sdsA)
TVN: NIES2134_116780(sds)
THEC: FFX45_07305(sds)
CYI: CBM981_0715(preA)
LET: O77CONTIG1_01361(hepT)
HHG: XM38_031750(preA)
PMA: Pro_1042(crtE)
PMM: PMM0618(sds)
PMT: PMT_0392
PMB: A9601_06741(sds)
PMC: P9515_06831(sds)
PMF: P9303_18951(sds)
PMG: P9301_06441(sds)
PMH: P9215_07001(sds)
PMJ: P9211_10311(sds)
PME: NATL1_06761(sds)
PRC: EW14_0663
PRM: EW15_0718
AMR: AM1_4909(sds)
THEU: HPC62_12685(sds)
MAR: MAE_00010(sds)
MPK: VL20_2046
MVZ: myaer102_35090(sds)
CYL: AA637_04100(sds)
ENN: FRE64_00290(sds)
CYT: cce_2465(sds)
TER: Tery_0157
ARP: NIES39_N00440(sds)
PAGH: NIES204_34370(sds)
OXY: HCG48_21390(sds)
LFS: HFV01_14595(sds)
GVI: gvip084(sds)
GLJ: GKIL_2127(sds)
ANA: alr0096(sds)
NOE: CLI64_12930(sds)
NSH: GXM_01052
AVA: Ava_1469
NAZ: Aazo_0858
ANB: ANA_C12807(sds)
ANN: EH233_05145(sds)
CALH: IJ00_17620
NSP: BMF81_03890(hepT)
DOU: BMF77_03530(hepT)
DFS: HGD76_22675(sds)
CCUR: IAR63_04880(sds)
TOQ: HCG51_11960(sds)
CTHE: Chro_0646
CEO: ETSB_0422(sds)
CER: RGRSB_0382(sds)
 » show all
Reference
  Authors
Hirooka K, Bamba T, Fukusaki E, Kobayashi A
  Title
Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase.
  Journal
Biochem J 370:679-86 (2003)
DOI:10.1042/BJ20021311
  Sequence
[ath:AT1G78510]
Reference
  Authors
Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A
  Title
Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana.
  Journal
Biosci Biotechnol Biochem 69:592-601 (2005)
DOI:10.1271/bbb.69.592
  Sequence
[ath:AT1G17050]
LinkDB

KEGG   ENZYME: 2.5.1.84
Entry
EC 2.5.1.84                 Enzyme                                 

Name
all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG)
R09250 > R07267
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: AT1G17050(SPS2) AT1G78510(SPS1)
ALY: 110225373 9304798 9323808
CRB: 17894671 17896965
CSAT: 104702634 104713531 104740392 104751747 104756029 104775809
EUS: EUTSA_v10007715mg EUTSA_v10018616mg
BRP: 103832329 103872491
BNA: 106346730 106354554 106354696 106365558
BOE: 106301071 106343305
RSZ: 108825091 108828623
THJ: 104810419 104812299 104813987 104822586
CPAP: 110811666
CIT: 102612772
TCC: 18594463
GAB: 108464212
DZI: 111298875
VRA: 106762491
VAR: 108334430
VUN: 114186101
CCAJ: 109790225
CAM: 101502183
LJA: Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
ADU: 107459857
AIP: 107613812
FVE: 101297041
RCN: 112202839
PPER: 18778932
PMUM: 103325805
PAVI: 110772576
ZJU: 107414345
CSV: 101214140
CMO: 103492962
MCHA: 111012845
RCU: 8258714
JCU: 105641085
MESC: 110601874
POP: 7459128
PEU: 105140437
JRE: 108994345
QSU: 111989322
VVI: 100246988
SLY: 101253007(SppS)
SPEN: 107026209
SOT: 102593674
CANN: 107878554
NSY: 104243529
NTO: 104101158
NAU: 109243898
LSV: 111904475
CCAV: 112516899
BVG: 104899063
SOE: 110783766
DOSA: Os05t0582300-01(Os05g0582300)
ATS: 109748254(LOC109748254)
SBI: 8155346
PDA: 103712684
MUS: 103989203
DCT: 110112294
PEQ: 110032238
AOF: 109842749
ATR: 18430924
APRO: F751_0189
OLU: OSTLU_51700(clpR2)
SMIN: v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: slr0611(sds)
SYZ: MYO_110(sds)
SYY: SYNGTS_0001(sds)
SYT: SYNGTI_0001(sds)
SYS: SYNPCCN_0001(sds)
SYQ: SYNPCCP_0001(sds)
SYJ: D082_04480(sds)
SYO: C7I86_00005(sds)
SYC: syc1741_c(sds)
SYW: SYNW1011(sds)
SYG: sync_1551
SYR: SynRCC307_1159(preA)
SYX: SynWH7803_1038(preA)
SYP: SYNPCC7002_A0580(sdsA)
CYA: CYA_2276(sds)
CYB: CYB_0451(sds)
SYNR: KR49_03240
SYND: KR52_10950
SYNW: SynWH8103_01143(sds)
SYNC: CB0101_03630(sds)
TEL: tlr1757(sds)
THN: NK55_05445(sdsA)
TVN: NIES2134_116780(sds)
THEC: FFX45_07305(sds)
CYI: CBM981_0715(preA)
LET: O77CONTIG1_01361(hepT)
HHG: XM38_031750(preA)
PMA: Pro_1042(crtE)
PMM: PMM0618(sds)
PMT: PMT_0392
PMB: A9601_06741(sds)
PMC: P9515_06831(sds)
PMF: P9303_18951(sds)
PMG: P9301_06441(sds)
PMH: P9215_07001(sds)
PMJ: P9211_10311(sds)
PME: NATL1_06761(sds)
PRC: EW14_0663
PRM: EW15_0718
AMR: AM1_4909(sds)
THEU: HPC62_12685(sds)
MAR: MAE_00010(sds)
MPK: VL20_2046
MVZ: myaer102_35090(sds)
CYL: AA637_04100(sds)
ENN: FRE64_00290(sds)
CYT: cce_2465(sds)
TER: Tery_0157
ARP: NIES39_N00440(sds)
PAGH: NIES204_34370(sds)
OXY: HCG48_21390(sds)
LFS: HFV01_14595(sds)
GVI: gvip084(sds)
GLJ: GKIL_2127(sds)
ANA: alr0096(sds)
NOE: CLI64_12930(sds)
NSH: GXM_01052
AVA: Ava_1469
NAZ: Aazo_0858
ANB: ANA_C12807(sds)
ANN: EH233_05145(sds)
CALH: IJ00_17620
NSP: BMF81_03890(hepT)
DOU: BMF77_03530(hepT)
DFS: HGD76_22675(sds)
CCUR: IAR63_04880(sds)
TOQ: HCG51_11960(sds)
CTHE: Chro_0646
CEO: ETSB_0422(sds)
CER: RGRSB_0382(sds)
 » show all
Reference
1  [PMID:911777]
  Authors
Sagami H, Ogura K, Seto S
  Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
  Journal
Biochemistry 16:4616-22 (1977)
DOI:10.1021/bi00640a014
Reference
2  [PMID:7447947]
  Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
  Title
Variable product specificity of solanesyl pyrophosphate synthetase.
  Journal
Biochem Biophys Res Commun 96:1648-53 (1980)
DOI:10.1016/0006-291X(80)91363-7
Reference
3  [PMID:20421194]
  Authors
Ohara K, Sasaki K, Yazaki K
  Title
Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.
  Journal
J Exp Bot 61:2683-92 (2010)
DOI:10.1093/jxb/erq103
  Sequence
[osa:4341844]
Reference
4  [PMID:1748647]
  Authors
Ohnuma S, Koyama T, Ogura K
  Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
  Journal
J Biol Chem 266:23706-13 (1991)
Reference
5  [PMID:1429508]
  Authors
Gotoh T, Koyama T, Ogura K
  Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
  Journal
J Biochem 112:20-7 (1992)
DOI:10.1093/oxfordjournals.jbchem.a123859
Reference
6  [PMID:8226825]
  Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
  Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
  Journal
J Biol Chem 268:23081-6 (1993)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.84
IUBMB Enzyme Nomenclature: 2.5.1.84
ExPASy - ENZYME nomenclature database: 2.5.1.84
BRENDA, the Enzyme Database: 2.5.1.84
LinkDB

KEGG   REACTION: R09250
Entry
R09250                      Reaction                               

Name
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Definition
Geranyl diphosphate + 7 Isopentenyl diphosphate <=> all-trans-Nonaprenyl diphosphate + 7 Diphosphate
Equation
C00341 + 7 C00129 <=> C04145 + 7 C00013
Comment
Reaction class
RC00279  C00129_C04145
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase [EC:2.5.1.84 2.5.1.85]
Other DBs
RHEA: 27566
LinkDB

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