KEGG   ORTHOLOGY: K05482
Entry
K05482                      KO                                     

Name
IL18, IL1F4
Definition
interleukin 18
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04061  Viral protein interaction with cytokine and cytokine receptor
ko04621  NOD-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05134  Legionellosis
ko05135  Yersinia infection
ko05143  African trypanosomiasis
ko05144  Malaria
ko05152  Tuberculosis
ko05164  Influenza A
ko05321  Inflammatory bowel disease (IBD)
ko05323  Rheumatoid arthritis
Disease
H01360  Allergic rhinitis
H01516  Adult onset Still disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05482  IL18, IL1F4; interleukin 18
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05482  IL18, IL1F4; interleukin 18
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05482  IL18, IL1F4; interleukin 18
   04623 Cytosolic DNA-sensing pathway
    K05482  IL18, IL1F4; interleukin 18
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05482  IL18, IL1F4; interleukin 18
   05321 Inflammatory bowel disease (IBD)
    K05482  IL18, IL1F4; interleukin 18
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05482  IL18, IL1F4; interleukin 18
   05132 Salmonella infection
    K05482  IL18, IL1F4; interleukin 18
   05131 Shigellosis
    K05482  IL18, IL1F4; interleukin 18
   05135 Yersinia infection
    K05482  IL18, IL1F4; interleukin 18
   05134 Legionellosis
    K05482  IL18, IL1F4; interleukin 18
   05152 Tuberculosis
    K05482  IL18, IL1F4; interleukin 18
  09172 Infectious disease: viral
   05164 Influenza A
    K05482  IL18, IL1F4; interleukin 18
  09174 Infectious disease: parasitic
   05144 Malaria
    K05482  IL18, IL1F4; interleukin 18
   05143 African trypanosomiasis
    K05482  IL18, IL1F4; interleukin 18
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05482  IL18, IL1F4; interleukin 18
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Interleukins
   K05482  IL18, IL1F4; interleukin 18
Other DBs
GO: 0045515
Genes
HSA: 3606(IL18)
PTR: 739011(IL18)
PPS: 100971499(IL18)
GGO: 101138403(IL18)
PON: 100433564(IL18)
NLE: 100585066(IL18)
MCC: 574151(IL18)
MCF: 102135101(IL18)
CSAB: 103248464(IL18)
RRO: 104677356(IL18)
RBB: 108536445(IL18)
CJC: 100396804(IL18)
SBQ: 101027404(IL18)
MMU: 16173(Il18)
MCAL: 110301583(Il18)
MPAH: 110328200(Il18)
RNO: 29197(Il18)
MUN: 110562014(Il18)
CGE: 100750469(Il18)
NGI: 103733877(Il18)
HGL: 101702804(Il18)
CCAN: 109699439(Il18)
OCU: 100144338(IL18)
TUP: 102488248(IL18)
CFA: 403796(IL18)
VVP: 112925988(IL18)
AML: 100484109(IL18)
UMR: 103662382(IL18)
UAH: 113260053(IL18)
ORO: 101368106(IL18)
ELK: 111153900
FCA: 493688(IL18)
PTG: 102952004(IL18)
PPAD: 109278654(IL18)
AJU: 106986372(IL18)
BTA: 281249(IL18)
BOM: 102281355(IL18)
BIU: 109569934(IL18)
BBUB: 102401432(IL18)
CHX: 100861190(IL18)
OAS: 443206(IL18)
SSC: 397057(IL18)
CFR: 102520544(IL18)
CDK: 105094167(IL18)
BACU: 103002074(IL18)
LVE: 103087219(IL18)
OOR: 101271274(IL18)
DLE: 111166897(IL18)
PCAD: 102976313(IL18)
ECB: 100034216(IL18)
EPZ: 103565880(IL18)
EAI: 106840220(IL18)
MYB: 102260649(IL18)
MYD: 102761769(IL18)
MNA: 107531295(IL18)
HAI: 109388707(IL18)
DRO: 112314192(IL18)
PALE: 102885001(IL18)
RAY: 107512960(IL18)
MJV: 108401553(IL18)
LAV: 100668369(IL18)
TMU: 101348624
OAA: 100083773(IL18)
GGA: 395312(IL18)
MGP: 100303691(IL18)
CJO: 107324129(IL18)
NMEL: 110387565(IL18)
APLA: 101802715(IL18)
ACYG: 106039774(IL18)
TGU: 100217637(IL18)
LSR: 110470467(IL18)
SCAN: 103822985(IL18)
GFR: 102041240(IL18)
FAB: 101819906(IL18)
PHI: 102105580(IL18)
PMAJ: 107214402
CCAE: 111939282
CCW: 104692079(IL18)
ETL: 114065628(IL18)
FPG: 101910930(IL18)
FCH: 102054449(IL18)
CLV: 102093971(IL18)
EGZ: 104125907(IL18)
NNI: 104019045(IL18)
ACUN: 113488534(IL18)
PADL: 103921543(IL18)
AAM: 106496023(IL18)
ASN: 102369831(IL18)
AMJ: 102569730(IL18)
PSS: 102463679(IL18)
CMY: 102933793(IL18)
CPIC: 101931104(IL18)
ACS: 100567753
PVT: 110079396
PBI: 103051323
PMUR: 107284513
PMUA: 114585328
GJA: 107116145
XTR: 100496716 108648098(il18)
NPR: 108801744
TRU: 445965(il-18)
NCC: 104945633
XMA: 102222709(il18)
PRET: 103474370(il18)
CVG: 107103272
NFU: 107380752
KMR: 108247699(il18)
HCQ: 109510913
SASA: 100196379(il18)
SALP: 111949364
ELS: 105008818
SFM: 108928639
PKI: 111833906
LCM: 102356354(IL18)
RTP: 109919113(il18) 109919115
 » show all
Reference
PMID:8666798
  Authors
Ushio S, Namba M, Okura T, Hattori K, Nukada Y, Akita K, Tanabe F, Konishi K, Micallef M, Fujii M, Torigoe K, Tanimoto T, Fukuda S, Ikeda M, Okamura H, Kurimoto M
  Title
Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein.
  Journal
J Immunol 156:4274-9 (1996)
  Sequence
[hsa:3606]
Reference
  Authors
Gaggero A, De Ambrosis A, Mezzanzanica D, Piazza T, Rubartelli A, Figini M, Canevari S, Ferrini S
  Title
A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing.
  Journal
Oncogene 23:7552-60 (2004)
DOI:10.1038/sj.onc.1208036
  Sequence
[hsa:3606]
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