KEGG   ORTHOLOGY: K05551Help
Entry
K05551                      KO                                     

Name
actI1, oxyA, tcmK, snoa1, aknB, mtmP
Definition
minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   00253 Tetracycline biosynthesis
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   01008 Polyketide biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.260  tetracycline polyketide synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.-  
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
BRITE hierarchy
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
MBD: MEBOL_003040
ABF: AMK58_25510
SPAE: E2C16_10950
MSAO: MYCSP_12700
MSAL: DSM43276_02543
NBR: O3I_007445 O3I_015110
NNO: NONO_c10810
NTP: CRH09_08670
NOZ: DMB37_03470
SCO: SCO5087(actIORF1)
SMA: SAVERM_2376(pks9-4)
SFA: Sfla_5318
SBH: SBI_06844
SHY: SHJG_1189
SVE: SVEN_5977
SALS: SLNWT_5121
STRP: F750_1305(whiE-KS)
SALU: DC74_6590
SALL: SAZ_34270
STRE: GZL_p00214
STRD: NI25_18955
SLAU: SLA_3074
SALJ: SMD11_0675(actI1) SMD11_6044(actI1)
LMOI: VV02_05815
TFU: Tfu_1218
TCU: Tcur_2773
SRO: Sros_4150
AMD: AMED_5435(fabF)
AMN: RAM_27705
AMM: AMES_5370(fabF)
AMZ: B737_5370(fabF)
KAL: KALB_7831
ACTI: UA75_11090
ACAD: UA74_11000
ALO: CRK55091
MIL: ML5_4402
ACTN: L083_3109
AG: AAA65206(dpsA) AAF70106(aknB) AAG30189(zhuB) AAZ78325(oxyA) CAA12017(snoa1) CAA61989(mtmP)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5087]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence
LinkDB All DBs

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