KEGG   ORTHOLOGY: K05551
Entry
K05551                      KO                                     

Name
actI1, oxyA, tcmK, snoa1, aknB, mtmP
Definition
minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
Pathway
ko00253  Tetracycline biosynthesis
ko01056  Biosynthesis of type II polyketide backbone
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00778  Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   00253 Tetracycline biosynthesis
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
   01008 Polyketide biosynthesis proteins
    K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.260  tetracycline polyketide synthase
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
    2.3.1.-  
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Component type
   K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type II PKS
   C7-C12 cyclized polyketide type
    Octaketide PKS
     K05551  actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha)
Other DBs
RN: R06635 R06637 R06641 R06643 R06644 R06645 R09258 R09259 R10960 R11516
Genes
DLA: I6G47_07200
MBD: MEBOL_003040
ABF: AMK58_25510
SPAE: E2C16_10950
MSAO: MYCSP_12700
MSAL: DSM43276_02543
NBR: O3I_007445 O3I_015110
NNO: NONO_c10810
NTP: CRH09_08670
NOZ: DMB37_03470
NAH: F5544_10735 F5544_17020 F5544_31065
SCO: SCO5087(actIORF1)
SMA: SAVERM_2376(pks9-4)
SSX: SACTE_5202 SACTE_6346
SFA: Sfla_5318
SBH: SBI_06844
SHY: SHJG_1189
SHO: SHJGH_1024
SVE: SVEN_5977
SDV: BN159_2471 BN159_2515(tcmK)
SALS: SLNWT_5121
STRP: F750_1305(whiE-KS)
SFI: SFUL_4002 SFUL_6285
SCI: B446_13320
SALU: DC74_6590
SALL: SAZ_34270
SLV: SLIV_12950
SGU: SGLAU_26355(tcmK) SGLAU_28980
SVT: SVTN_18780 SVTN_28595
STRE: GZL_p00214
SCW: TU94_31825
SLD: T261_0018 T261_6830
SXI: SXIM_35610
STRC: AA958_14835 AA958_30255
SAMB: SAM23877_0196(alpA) SAM23877_0208(alpR) SAM23877_7465(alpR) SAM23877_7477(alpA)
SPRI: SPRI_0266 SPRI_0280 SPRI_7073 SPRI_7087
SCZ: ABE83_04915 ABE83_16245
SCX: AS200_01095
SRW: TUE45_01297 TUE45_01570
STRF: ASR50_01175 ASR50_34265
SPAV: Spa2297_32720
SGS: AVL59_46045
SLS: SLINC_6895
STRD: NI25_18955
SVU: B1H20_09640
SPUN: BFF78_19350
SLAU: SLA_3074
SALJ: SMD11_0675(actI1) SMD11_6044(actI1)
SLX: SLAV_40245 SLAV_40510
SNZ: DC008_13180
SGE: DWG14_07360
SLK: SLUN_33540
SDX: C4B68_09595
SGD: ELQ87_00815 ELQ87_08170
SCYA: EJ357_29965 EJ357_34780
SNQ: CP978_29750
STIR: DDW44_27780
SKA: CP970_02740 CP970_39675
SGZ: C0216_31850
SNK: CP967_10260
SHAW: CEB94_23570
SRK: FGW37_04255 FGW37_16265
SFIC: EIZ62_03850
SGAL: CP966_29070
SSPO: DDQ41_07350
SVR: CP971_23915
SFY: GFH48_20455
SAQU: EJC51_31355
SGF: HEP81_07943
KAB: B7C62_31265
KAU: B6264_18490
KIT: CFP65_4148
LMOI: VV02_05815
TFU: Tfu_1218
TCU: Tcur_2773
SRO: Sros_4150
NOA: BKM31_22830
FRA: Francci3_4101
FRI: FraEuI1c_1317
SVI: Svir_33690
AMD: AMED_5435(fabF)
AMN: RAM_27705
AMM: AMES_5370(fabF)
AMZ: B737_5370(fabF)
AORI: SD37_09325 SD37_34200
PSEQ: AD006_30020
PECQ: AD017_31230
PHH: AFB00_31125
SESP: BN6_40990 BN6_54860
SSYI: EKG83_16320 EKG83_32220
KAL: KALB_7831
KPHY: AOZ06_32115
LED: BBK82_02455
AHM: TL08_10465
ACTI: UA75_11090
ACAD: UA74_11000
AHG: AHOG_10345
ACTA: C1701_02400
ALO: CRK55091
PMAD: BAY61_07810
STP: Strop_2223
MAU: Micau_4019
MIL: ML5_4402
MICH: FJK98_03840
MSAG: GCM10017556_44990(fabF)
VMA: VAB18032_18175
AMS: AMIS_50430 AMIS_50640
ACTN: L083_3109
PLK: CIK06_11005
VER: HUT12_05340
CAI: Caci_3546 Caci_6485
AG: AAA65206(dpsA) AAF70106(aknB) AAG30189(zhuB) AAZ78325(oxyA) CAA12017(snoa1) CAA61989(mtmP)
 » show all
Reference
PMID:1527048
  Authors
Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F
  Title
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
  Journal
J Biol Chem 267:19278-90 (1992)
  Sequence
[sco:SCO5087]
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:2684656
  Authors
Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR
  Title
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
  Journal
EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x
  Sequence
Reference
PMID:8668120
  Authors
Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P
  Title
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.
  Journal
Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908
  Sequence
Reference
PMID:8654997
  Authors
Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA
  Title
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.
  Journal
Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7
  Sequence
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