KEGG ORTHOLOGY: K05634

ORTHOLOGY: K05634

Entry

K05634                      KO

Symbol

PRNP, PrP, CD230

Name

prion protein

Pathway

map04216

Ferroptosis

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00061

Prion disease

H01243

Huntington disease-like syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K05634  PRNP, PrP, CD230; prion protein
09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    K05634  PRNP, PrP, CD230; prion protein
   05022 Pathways of neurodegeneration - multiple diseases
    K05634  PRNP, PrP, CD230; prion protein
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05634  PRNP, PrP, CD230; prion protein
   04090 CD molecules
    K05634  PRNP, PrP, CD230; prion protein
   00536 Glycosaminoglycan binding proteins
    K05634  PRNP, PrP, CD230; prion protein
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K05634  PRNP, PrP, CD230; prion protein
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05634  PRNP, PrP, CD230; prion protein
CD molecules [BR:ko04090]
Proteins
  K05634  CD230, PRNP; prion protein
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Others
   K05634  PRNP, PrP, CD230; prion protein
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
Others
  K05634  PRNP, PrP, CD230; prion protein

Other DBs

TC:	1.C.48.1.1 1.C.48.1.2

Genes

HSA:	5621(PRNP)

PTR:	458076(PRNP)

PPS:	100984581(PRNP) 117979204

GGO:	101135304(PRNP)

PON:	100173712(PRNP)

NLE:	100587690(PRNP)

HMH:	116461416(PRNP)

MCC:	717859(PRNP)

MCF:

102127229

MTHB:

126929129

MNI:	105481568(PRNP)

CSAB:

103247014(PRNP)

CATY:

105582120(PRNP)

PANU:

101012637(PRNP)

TGE:	112633266(PRNP)

MLEU:

105535948(PRNP)

RRO:	104674584(PRNP)

RBB:	108533419(PRNP)

TFN:	117068501(PRNP)

PTEH:

111546477(PRNP)

CANG:

105511027(PRNP)

CJC:	100398566(PRNP)

SBQ:	101039770(PRNP)

CIMI:

108301007

CSYR:

103255549(PRNP)

MMUR:

105866025(PRNP)

LCAT:

123622563

PCOQ:

105806197(PRNP)

OGA:	100959325(PRNP)

MMU:	19122(Prnp)

MCAL:

110312291(Prnp)

MPAH:

110318145(Prnp)

RNO:	24686(Prnp)

MCOC:

116090968(Prnp)

ANU:	117702739(Prnp)

MUN:	110556990(Prnp)

CGE:	100762792(Prnp)

MAUA:

101829062

PROB:

127221413(Prnp)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103736406(Prnp)

HGL:	101710391(Prnp)

CPOC:

100714701(Prnp)

CCAN:

109699373(Prnp)

DORD:

105981691(Prnp)

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100008658(PRNP)

OPI:	101521014(PRNP)

TUP:	102478560(PRNP)

GVR:	103595532(PRNP)

CFA:	485783(PRNP)

CLUD:

112673643

VVP:	112930073(PRNP)

VLG:

121478271

NPO:	129495768(PRNP)

AML:	100473044(PRNP)

UMR:

103674536

UAH:	113258373(PRNP)

UAR:

123799460

ELK:

111141608

LLV:

125109125

MPUF:

101677643(PRNP)

MNP:	132008110 132021751

MLK:	131808010(PRNP)

NVS:

122916237

ORO:	101370976(PRNP)

EJU:	114220784(PRNP)

ZCA:

113938055

MLX:	118011275(PRNP)

NSU:

110579492

LWW:	102729876(PRNP)

FCA:	101087310(PRNP)

PYU:

121012448

PCOO:

112869718(PRNP)

PBG:

122496539

PVIV:

125162799(PRNP)

LRUF:

124503531

PTG:	102964375(PRNP)

PPAD:

109274743(PRNP)

PUC:

125936780

AJU:

106980154

HHV:

120226386

BTA:	281427(PRNP)

BOM:	102278930(PRNP)

BIU:	109568114(PRNP)

BBUB:

102412748

BBIS:

104986021(PRNP)

CHX:	102169975(PRNP)

OAS:	493887(PRNP)

BTAX:

128058006(PRNP)

ODA:

120868932

CCAD:

122448236

MBEZ:

129559932(PRNP)

SSC:	494014(PRNP)

CFR:	102518771(PRNP)

CBAI:

105083017(PRNP)

CDK:	105101461(PRNP)

VPC:	102545967(PRNP)

BACU:

103021028(PRNP)

BMUS:

118881038

LVE:	103078120(PRNP)

OOR:	101286552(PRNP)

DLE:	111165622(PRNP)

PCAD:

102990340(PRNP)

PSIU:

116740149(PRNP)

NASI:

112412520(PRNP)

ECB:	100065904(PRNP)

EPZ:	103550738(PRNP)

EAI:

106847681

MYB:	102247570(PRNP)

MYD:	102769375(PRNP)

MMYO:

118662646

MLF:	102442584(PRNP)

PKL:

118707523

EFUS:

103285647(PRNP)

MNA:	107536389(PRNP)

DRO:	112304028(PRNP)

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

129070831(PRNP)

HAI:	109383849(PRNP)

RFQ:	117015917(PRNP)

PALE:

102891407(PRNP)

PGIG:

120603429

PVP:	105298580(PRNP)

RAY:	107505150(PRNP)

MJV:

108399245

TOD:	119235355(PRNP)

SARA:

101550687(PRNP)

SETR:

126017426(PRNP)

LAV:	100671000(PRNP)

TMU:

101348533

ETF:

101653719

DNM:	101436201(PRNP)

MDO:	554189(PRNP)

GAS:

123234886

SHR:	100927381(PRNP)

AFZ:

127548190

PCW:	110207628(PRNP)

OAA:

100086593

GGA:	396452(PRNP)

PCOC:

116238382(PRNP)

MGP:	100538706(PRNP)

CJO:	107323677(PRNP)

TPAI:

128090067(PRNP)

LMUT:

125685299

NMEL:

110387172(PRNP)

APLA:

119713510

ACYG:

106047656

CATA:

118259349(PRNP)

AFUL:

116499357(PRNP)

TGU:	115498155(PRNP)

LSR:	110480188(PRNP)

SCAN:

103822732(PRNP)

PMOA:

120499134

OTC:

121336273

PRUF:

121357296

FAB:	101814306(PRNP)

OMA:	130261903(PRNP)

PHI:	102101927(PRNP)

PMAJ:

107213897(PRNP)

CCW:

120411164

ETL:	114070395(PRNP)

ACHL:

103807137(PRNP)

SVG:	106862887(PRNP)

MMEA:

130584208(PRNP)

HRT:	120764027(PRNP)

FPG:	101921898(PRNP)

FCH:	102055080(PRNP)

CLV:	102088986(PRNP)

EGZ:	104130355(PRNP)

PCRI:

104036354(PRNP)

EHS:	104516205(PRNP)

ACUN:

113488134(PRNP)

TALA:

116959722

AFOR:

103894428(PRNP)

ACHC:

115350194

HLE:	104828882(PRNP)

AGEN:

126051612

GCL:

127025299

CSTI:

104560849(PRNP)

CMAC:

104482629(PRNP)

MUI:	104547793(PRNP)

BREG:

104643936(PRNP)

FGA:	104077877(PRNP)

LDI:	104352493(PRNP)

OHA:	104331273(PRNP)

NNT:	104401600(PRNP)

SHAB:

115618492(PRNP)

PGUU:

104463468(PRNP)

CPEA:

104394342(PRNP)

CVF:	104282033(PRNP)

RTD:	128900126(PRNP)

CUCA:

104065361(PRNP)

TEO:	104377275(PRNP)

BRHI:

104499804(PRNP)

AROW:

112973673(PRNP)

NPD:	112950853(PRNP)

TGT:	104568469(PRNP)

DNE:	112990023(PRNP)

SCAM:

104140541(PRNP)

ASN:	102374683(PRNP)

AMJ:	102561492(PRNP)

CPOO:

109317341(PRNP)

GGN:	109295485(PRNP)

PSS:	102460857(PRNP)

CMY:

CCAY:

DCC:

CPIC:

TST:	117872934(PRNP)

CABI:

116828499(PRNP)

MRV:

120398820

ACS:

100555750

ASAO:

132763089 132763174 132782688 132782740

PVT:	110071631 110075183 110075186

SUND:

121933293 121935084 121935687

PBI:	103064789(PRNP)

PMUR:

107299295

CTIG:

120303423

TSR:	106543634(PRNP)

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:	128333741(PRNP)

GJA:	107108354(PRNP)

STOW:

125441836

EMC:	129342663(PRNP)

XLA:	398272(prnp.L) 444620(prnp.S)

XTR:	100158502(prnp)

NPR:	108797150(PRNP)

RTEM:

120932994

BBUF:

120986111

BGAR:

122927427 122927429

MUO:	115469328(PRNP)

GSH:	117361889(PRNP)

LCM:	102348289(PRNP)

DMK:

HAME:

OSN:

Reference

PMID:3755672

Authors

Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ

Title

Molecular cloning of a human prion protein cDNA.

Journal

DNA 5:315-24 (1986)
DOI:10.1089/dna.1986.5.315

Sequence

[hsa:5621]

Reference

PMID:12732622

Authors

Mani K, Cheng F, Havsmark B, Jonsson M, Belting M, Fransson LA

Title

Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

Journal

J Biol Chem 278:38956-65 (2003)
DOI:10.1074/jbc.M300394200

Sequence

[hsa:5621] [mmu:19122]

LinkDB

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