KEGG   ORTHOLOGY: K05697
Entry
K05697                      KO                                     

Name
PTPN6, SHP-1
Definition
tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
Pathway
ko04520  Adherens junction
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko05130  Pathogenic Escherichia coli infection
ko05140  Leishmaniasis
ko05205  Proteoglycans in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04660 T cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04662 B cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Other DBs
GO: 0005001
Genes
HSA: 5777(PTPN6)
PTR: 748032(PTPN6)
PPS: 100990286(PTPN6)
GGO: 101137792(PTPN6)
PON: 100448471(PTPN6)
NLE: 100599057(PTPN6)
MCC: 714374(PTPN6)
MCF: 102133910(PTPN6)
CSAB: 103218491(PTPN6)
RRO: 104680085(PTPN6)
RBB: 108542024(PTPN6)
CJC: 100410231(PTPN6)
SBQ: 101032306(PTPN6)
MMU: 15170(Ptpn6)
MCAL: 110295792(Ptpn6)
MPAH: 110314992(Ptpn6)
RNO: 116689(Ptpn6)
MUN: 110548584(Ptpn6)
CGE: 100758996(Ptpn6)
NGI: 103727492(Ptpn6)
HGL: 101725029(Ptpn6)
CCAN: 109682813(Ptpn6)
OCU: 100348648(PTPN6)
TUP: 102488290(PTPN6)
CFA: 486717(PTPN6)
VVP: 112917324(PTPN6)
AML: 100473539(PTPN6)
UMR: 103656221(PTPN6)
UAH: 113257950(PTPN6)
ORO: 101374850(PTPN6)
ELK: 111159680
FCA: 101087073(PTPN6)
PTG: 102951517(PTPN6)
PPAD: 109276095(PTPN6)
AJU: 106965341(PTPN6)
BTA: 512312(PTPN6)
BOM: 102283821(PTPN6)
BIU: 109558908(PTPN6)
BBUB: 102390574(PTPN6)
CHX: 102190308(PTPN6)
OAS: 101108643(PTPN6)
SSC: 100171389(PTPN6)
CFR: 102513195(PTPN6)
CDK: 105098192(PTPN6)
BACU: 103005216(PTPN6)
LVE: 103086882(PTPN6)
OOR: 101289268(PTPN6)
DLE: 111176702(PTPN6)
PCAD: 102989908(PTPN6)
ECB: 100052882(PTPN6)
EPZ: 103547027(PTPN6)
EAI: 106847314(PTPN6)
MYB: 102256821(PTPN6)
MYD: 102755999(PTPN6)
MNA: 107544062(PTPN6)
HAI: 109373664(PTPN6)
DRO: 112321823(PTPN6)
PALE: 102895931(PTPN6)
RAY: 107519829(PTPN6)
MJV: 108384835(PTPN6)
LAV: 100676986(PTPN6)
TMU: 101358096
MDO: 100016514(PTPN6)
SHR: 100916661(PTPN6)
PCW: 110213796(PTPN6)
OAA: 100089663(PTPN6)
GGA: 427947(PTPN6)
MGP: 100541130(PTPN6)
CJO: 107318608(PTPN6)
NMEL: 110398321(PTPN6)
APLA: 101791271(PTPN6)
ACYG: 106047839(PTPN6)
TGU: 100222135(PTPN6)
LSR: 110480841(PTPN6)
SCAN: 103827163(PTPN6)
GFR: 102042677(PTPN6)
FAB: 101809704(PTPN6)
PHI: 102110203(PTPN6)
PMAJ: 107208334(PTPN6)
CCAE: 111938183(PTPN6)
CCW: 104687132(PTPN6)
ETL: 114058137(PTPN6)
FPG: 101914570(PTPN6)
FCH: 102049222(PTPN6)
CLV: 102092597(PTPN6)
EGZ: 104126541(PTPN6)
NNI: 104009493(PTPN6)
ACUN: 113477279(PTPN6)
PADL: 103920898(PTPN6)
AAM: 106497267
ASN: 102374529(PTPN6)
AMJ: 106737112(PTPN6)
PSS: 102450493(PTPN6)
CMY: 102932473(PTPN6)
CPIC: 101943173(PTPN6)
ACS: 100560131 100568003(ptpn6)
PVT: 110084628(PTPN6)
PBI: 103066339(PTPN6)
PMUR: 107285777(PTPN6)
TSR: 106552603(PTPN6)
PMUA: 114587712(PTPN6)
GJA: 107116796(PTPN6)
XLA: 100380954(ptpn6.L) 108696044 108697335(ptpn6.S)
XTR: 100144699(ptpn6) 100486059
NPR: 108784384(PTPN6)
DRE: 335573(ptpn6)
SGH: 107552793 107587794(ptpn6)
IPU: 108263538(PTPN6)
PHYP: 113525151
AMEX: 103022912(ptpn6)
EEE: 113574797
TRU: 101073366(ptpn6)
LCO: 104932546(ptpn6)
NCC: 104967151
MZE: 101478586(ptpn6)
ONL: 100707029(ptpn6)
OLA: 101174216(ptpn6)
XMA: 102235723(ptpn6)
XCO: 114142163(ptpn6)
PRET: 103477996(ptpn6)
CVG: 107082167(ptpn6)
NFU: 107379459(ptpn6)
KMR: 108235407(ptpn6)
ALIM: 106529151(ptpn6)
AOCE: 111585704(ptpn6)
CSEM: 103387950(ptpn6)
POV: 109633267(ptpn6)
LCF: 108880748(ptpn6)
SDU: 111230057(ptpn6)
SLAL: 111669899(ptpn6)
HCQ: 109515280(ptpn6)
BPEC: 110163058(ptpn6)
MALB: 109966237(ptpn6)
SASA: 100195421(ptn6) 106576571(PTN6)
OTW: 112226113
ELS: 105029958(ptpn6)
SFM: 108925851(ptpn6)
PKI: 111835379(ptpn6)
LCM: 102352106
 » show all
Reference
  Authors
Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD
  Title
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
  Journal
J Cell Biol 152:325-34 (2001)
DOI:10.1083/jcb.152.2.325
  Sequence
[hsa:5777]
Reference
PMID:1732748
  Authors
Yi TL, Cleveland JL, Ihle JN
  Title
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
  Journal
Mol Cell Biol 12:836-46 (1992)
DOI:10.1128/MCB.12.2.836
  Sequence
[hsa:5777]
LinkDB

KEGG   ORTHOLOGY: K07293
Entry
K07293                      KO                                     

Name
PTPN11
Definition
tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04931  Insulin resistance
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05168  Herpes simplex virus 1 infection
ko05205  Proteoglycans in cancer
ko05211  Renal cell carcinoma
ko05220  Chronic myeloid leukemia
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00523  Noonan syndrome and related disorders
H01018  Metachondromatosis
H01738  Noonan syndrome
H01984  Leopard syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04014 Ras signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04630 JAK-STAT signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04072 Phospholipase D signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04650 Natural killer cell mediated cytotoxicity
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04670 Leukocyte transendothelial migration
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09158 Development and regeneration
   04360 Axon guidance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05211 Renal cell carcinoma
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05130 Pathogenic Escherichia coli infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Other DBs
GO: 0004726
Genes
HSA: 5781(PTPN11)
PTR: 748225(PTPN11)
PPS: 100970556(PTPN11)
GGO: 101133729(PTPN11)
PON: 100440983(PTPN11)
NLE: 100602671(PTPN11) 100605369
MCC: 712044(PTPN11)
MCF: 102116832 102129572(PTPN11)
CSAB: 103239151(PTPN11)
RRO: 104674419(PTPN11)
RBB: 108540455(PTPN11)
CJC: 100414905(PTPN11)
SBQ: 101031381(PTPN11) 101033019
MMU: 19247(Ptpn11)
MCAL: 110294055(Ptpn11)
MPAH: 110339175(Ptpn11)
RNO: 25622(Ptpn11)
MUN: 110546380(Ptpn11)
CGE: 100771077(Ptpn11)
NGI: 103745559(Ptpn11)
HGL: 101701336(Ptpn11)
CCAN: 109696291(Ptpn11)
OCU: 100339517(PTPN11)
TUP: 102485136(PTPN11) 102498455
CFA: 477488(PTPN11)
VVP: 112926139 112935165(PTPN11)
AML: 100468867(PTPN11) 100471152
UMR: 103661289(PTPN11)
UAH: 113266983(PTPN11) 113270688
ORO: 101368461(PTPN11) 101374328
FCA: 101085500(PTPN11)
PTG: 102951653(PTPN11) 102954137
PPAD: 109273906 109277629(PTPN11)
AJU: 106982085(PTPN11) 106988776
BTA: 533590(PTPN11)
BOM: 102276389(PTPN11)
BIU: 109570168 109570927(PTPN11)
BBUB: 102401129 102405817(PTPN11)
CHX: 102177271(PTPN11)
OAS: 101114308(PTPN11)
SSC: 100170851(PTPN11) 100620540
CFR: 102523889(PTPN11)
CDK: 105102551(PTPN11) 105105612
BACU: 103004467(PTPN11)
LVE: 103088783(PTPN11)
OOR: 101275685 101288182(PTPN11)
DLE: 111187198 111188123(PTPN11)
PCAD: 102979922(PTPN11) 102987506
ECB: 100056857(PTPN11) 100146191
EPZ: 103557133(PTPN11) 103558567
EAI: 106842252(PTPN11) 106845198
MYB: 102251345(PTPN11)
MYD: 102755861(PTPN11)
MNA: 107529574(PTPN11)
HAI: 109382264(PTPN11) 109391216
DRO: 112310448(PTPN11)
PALE: 102889219(PTPN11)
RAY: 107510717 107513271(PTPN11)
MJV: 108405695
LAV: 100674758(PTPN11)
TMU: 101348102
MDO: 100023824 100028991(PTPN11)
SHR: 100930062(PTPN11)
PCW: 110201173 110203391(PTPN11)
OAA: 100086381 100089978(PTPN11)
GGA: 395815(PTPN11) 419429
MGP: 100541480 100550508(PTPN11)
CJO: 107321154(PTPN11) 107323557
NMEL: 110406211(PTPN11) 110408529
APLA: 101789439
ACYG: 106031098(PTPN11) 106044308
TGU: 100218949(PTPN11)
LSR: 110478178(PTPN11)
SCAN: 103818137(PTPN11)
GFR: 102033785(PTPN11)
FAB: 101811730(PTPN11)
PHI: 102103197(PTPN11)
PMAJ: 107211728(PTPN11)
CCAE: 111936431(PTPN11)
CCW: 104688668(PTPN11) 104693326
ETL: 114062648(PTPN11) 114071019
FPG: 101914986(PTPN11) 101915334
FCH: 102054041 102058357(PTPN11)
CLV: 102084071(PTPN11) 102097440
EGZ: 104123916(PTPN11) 104133393
NNI: 104009062 104020567(PTPN11)
ACUN: 113485966(PTPN11) 113487880
PADL: 103917957 103925702(PTPN11)
AAM: 106492969(PTPN11) 106495554
ASN: 102371778(PTPN11) 102386995
AMJ: 102562607 102570430(PTPN11)
PSS: 102443910 102453333(PTPN11)
CMY: 102934329(PTPN11) 102934807
CPIC: 101941295 101949667(PTPN11)
ACS: 100559345(ptpn11) 100564881
PVT: 110073274 110083443(PTPN11)
PBI: 103048752 103055536(PTPN11)
PMUR: 107286989(PTPN11) 107297989
TSR: 106539364(PTPN11) 106556002
PMUA: 114602500 114602756(PTPN11)
GJA: 107110836 107112180(PTPN11)
XLA: 108697240 108716965 399291(ptpn11.S) 444193(ptpn11.L)
XTR: 548434(ptpn11b) 549586(ptpn11)
NPR: 108790634 108798021(PTPN11)
DRE: 333979(ptpn11a) 393426(ptpn11b)
IPU: 108276278(PTPN11) 108277290(ptpn11)
PHYP: 113530358 113544720(ptpn11)
AMEX: 103022363(ptpn11) 103032744
EEE: 113580163 113591662(ptpn11)
TRU: 101068465(ptpn11) 101076633
LCO: 104919515 104934925(ptpn11)
NCC: 104956326 104967981(ptpn11)
MZE: 101469361 101475609(ptpn11)
ONL: 100697902(ptpn11) 100700918
OLA: 101156835(ptpn11) 101172160
XMA: 102223330 102232688(ptpn11)
XCO: 114147980 114149733(ptpn11)
PRET: 103467098 103473239(ptpn11)
CVG: 107086071(ptpn11) 107086704
NFU: 107396142(ptpn11) 107397076
KMR: 108233149 108247149(ptpn11)
ALIM: 106518899 106527575(ptpn11)
AOCE: 111567360 111572898(ptpn11)
CSEM: 103384897 103389968(ptpn11)
POV: 109626354(ptpn11) 109630583
LCF: 108882629 108897434(ptpn11)
SDU: 111217827(ptpn11) 111227612
SLAL: 111656118 111666017(ptpn11)
HCQ: 109507188(ptpn11) 109511800
BPEC: 110157366(ptpn11) 110157943
MALB: 109952842(ptpn11) 109967179
ELS: 105007638(ptpn11) 105013921
LCM: 102352712 102357168(PTPN11)
CMK: 103184045(ptpn11) 103187442
RTP: 109926577 109932773(ptpn11)
BFO: 118430024
CIN: 100184658
APLC: 110984574
SKO: 102803939
DME: Dmel_CG3954(csw)
DER: 6555622
DSE: 6616088
DSI: Dsimw501_GD24731(Dsim_GD24731)
DAN: 6504142
DSR: 110180159
DPE: 6600767
DMN: 108162535
DWI: 6648549
DAZ: 108619678
DNV: 108656917
DVI: 6633324
MDE: 101887567
LCQ: 111685385
AAG: 5570773
AME: 412529
BIM: 100746379
BTER: 100644829
CCAL: 108623268
OBB: 114875774
SOC: 105194971
MPHA: 105836746
AEC: 105154855
ACEP: 105620789
PBAR: 105429975
VEM: 105561475
HST: 105186698
DQU: 106749128
CFO: 105254344
LHU: 105677799
PGC: 109861190
OBO: 105283745
PCF: 106786660
NVI: 100115335
CSOL: 105359860
MDL: 103573389
TCA: 660085
DPA: 109536044
ATD: 109594310
NVL: 108560697
PXY: 105384127
API: 100163524
DNX: 107163725
AGS: 114125542
RMD: 113550141
BTAB: 109040742
CLEC: 106671929
ZNE: 110838312
FCD: 110853883
PVM: 113817688
TUT: 107367026
DPTE: 113794101
PTEP: 107456622
CEL: CELE_F59G1.5(ptp-2)
CBR: CBG02539(Cbr-ptp-2)
BMY: Bm1_43090
TSP: Tsp_10590
PCAN: 112556534
CRG: 105321845
MYI: 110455301
OBI: 106868673
SHX: MS3_05455
NVE: 116617638
EPA: 110237259
ADF: 107346465
AMIL: 114975988
PDAM: 113672176
SPIS: 111329394
DGT: 114518227
 » show all
Reference
  Authors
Jakob S, Schroeder P, Lukosz M, Buchner N, Spyridopoulos I, Altschmied J, Haendeler J
  Title
Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.
  Journal
J Biol Chem 283:33155-61 (2008)
DOI:10.1074/jbc.M805138200
Reference
  Authors
Lee HH, Chang ZF
  Title
Regulation of RhoA-dependent ROCKII activation by Shp2.
  Journal
J Cell Biol 181:999-1012 (2008)
DOI:10.1083/jcb.200710187
Reference
PMID:1281790
  Authors
Adachi M, Sekiya M, Miyachi T, Matsuno K, Hinoda Y, Imai K, Yachi A
  Title
Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
  Journal
FEBS Lett 314:335-9 (1992)
DOI:10.1016/0014-5793(92)81500-L
  Sequence
[hsa:5781]
LinkDB

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