KEGG   ORTHOLOGY: K05699Help
Entry
K05699                      KO                                     

Name
ACTN1_4
Definition
actinin alpha 1/4
Pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05131  Shigellosis
ko05146  Amoebiasis
ko05203  Viral carcinogenesis
ko05322  Systemic lupus erythematosus
Disease
H00626  Focal segmental glomerulosclerosis
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05699  ACTN1_4; actinin alpha 1/4
   04520 Adherens junction
    K05699  ACTN1_4; actinin alpha 1/4
   04530 Tight junction
    K05699  ACTN1_4; actinin alpha 1/4
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05699  ACTN1_4; actinin alpha 1/4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K05699  ACTN1_4; actinin alpha 1/4
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05699  ACTN1_4; actinin alpha 1/4
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K05699  ACTN1_4; actinin alpha 1/4
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05699  ACTN1_4; actinin alpha 1/4
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05699  ACTN1_4; actinin alpha 1/4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05699  ACTN1_4; actinin alpha 1/4
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05699  ACTN1_4; actinin alpha 1/4
   04147 Exosome
    K05699  ACTN1_4; actinin alpha 1/4
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K05699  ACTN1_4; actinin alpha 1/4
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K05699  ACTN1_4; actinin alpha 1/4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of colorectal cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of bladder cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
BRITE hierarchy
Genes
HSA: 81(ACTN4) 87(ACTN1)
PTR: 452993(ACTN1) 456010(ACTN4)
PPS: 100979183(ACTN1) 100981951(ACTN4)
GGO: 101138551(ACTN1) 101144840(ACTN4)
PON: 100174343(ACTN4) 100460195(ACTN1)
NLE: 100588862(ACTN4) 100596303(ACTN1)
MCC: 693666(ACTN4) 711994(ACTN1)
MCF: 102125329(ACTN4) 102127552(ACTN1)
CSAB: 103229232(ACTN1) 103234638(ACTN4)
RRO: 104659630(ACTN1) 104679965(ACTN4)
RBB: 108533731(ACTN1) 108539029(ACTN4)
CJC: 100392168(ACTN4) 100406377(ACTN1)
SBQ: 101039348(ACTN1) 101050047(ACTN4)
MMU: 109711(Actn1) 60595(Actn4)
MCAL: 110298906(Actn4) 110306555(Actn1)
MPAH: 110324934(Actn1) 110338744(Actn4)
RNO: 63836(Actn4) 81634(Actn1)
MUN: 110546596(Actn1) 110552530(Actn4)
CGE: 100755831(Actn1) 100766890(Actn4)
NGI: 103749304(Actn1) 103750716(Actn4)
HGL: 101710271(Actn4) 101711839(Actn1)
CCAN: 109685991 109685993 109695844(Actn4)
OCU: 100341378(ACTN1) 100351066(ACTN4)
TUP: 102493901(ACTN4) 102494430(ACTN1)
CFA: 480369(ACTN1) 484526(ACTN4)
VVP: 112927202(ACTN1) 112928413(ACTN4)
AML: 100467263(ACTN4) 100472341(ACTN1)
UMR: 103661071(ACTN4) 103674291(ACTN1)
UAH: 113243609(ACTN4) 113270401(ACTN1)
ORO: 101363974(ACTN4) 101368696(ACTN1)
ELK: 111148595 111161418
FCA: 101093978(ACTN4) 101097986(ACTN1)
PTG: 102963733(ACTN4) 102965456(ACTN1)
PPAD: 109256593(ACTN4) 109268265(ACTN1)
AJU: 106971540(ACTN1) 106980245(ACTN4)
BTA: 522269(ACTN4) 524770(ACTN1)
BOM: 102275865(ACTN4) 102287647(ACTN1)
BIU: 109565282(ACTN1) 109572506(ACTN4)
BBUB: 102402259(ACTN1) 102409224(ACTN4)
CHX: 102176966(ACTN1) 102179802(ACTN4)
OAS: 101111737(ACTN4) 101122194(ACTN1)
SSC: 100513412(ACTN1) 100517284(ACTN4)
CFR: 102511098(ACTN4) 102515180(ACTN1)
CDK: 105086159(ACTN1) 105101782(ACTN4)
BACU: 103010879(ACTN1) 103018854(ACTN4)
LVE: 103070717(ACTN4) 103088628(ACTN1)
OOR: 101278864(ACTN4) 101284859(ACTN1)
DLE: 111173031(ACTN1) 111180889(ACTN4)
PCAD: 102973544(ACTN1) 102994912(ACTN4)
ECB: 100053070(ACTN1) 100066343(ACTN4)
EPZ: 103540812(ACTN4) 103547163(ACTN1)
EAI: 106836069(ACTN4) 106843321(ACTN1)
MYB: 102247194(ACTN1) 102250785(ACTN4)
MYD: 102762055(ACTN4) 102773341(ACTN1)
MNA: 107532204(ACTN4) 107545701(ACTN1)
HAI: 109382080(ACTN1) 109395369(ACTN4)
DRO: 112311182(ACTN1) 112320200(ACTN4)
PALE: 102884236(ACTN4) 102887929(ACTN1)
RAY: 107503261(ACTN1) 107520952(ACTN4)
MJV: 108391826(ACTN1) 108399501(ACTN4)
LAV: 100655307(ACTN4) 100661051(ACTN1)
TMU: 101351810 101359687
MDO: 100010983(ACTN4) 100023431(ACTN1)
SHR: 100917501(ACTN4) 100924961(ACTN1)
PCW: 110202355(ACTN4) 110220704(ACTN1)
OAA: 100089387(ACTN1) 103165750(ACTN4)
GGA: 373918(ACTN1) 396024(ACTN4)
MGP: 100539916(ACTN1) 100547916
CJO: 107307545 107314914
NMEL: 110389118(ACTN4) 110402069(ACTN1)
APLA: 101795217(ACTN1)
ACYG: 106031661(ACTN1)
TGU: 100221879(ACTN1) 105759663 115493150
LSR: 110474004(ACTN1) 110478799
SCAN: 103825050 103826606(ACTN1)
GFR: 102033981 102042336(ACTN1)
FAB: 101814028(ACTN1)
PHI: 102100036(ACTN4) 102100480(ACTN1)
PMAJ: 107206008(ACTN1)
CCAE: 111930279(ACTN1) 111942417
CCW: 104683694(ACTN1)
ETL: 114061337(ACTN1)
FPG: 101912082(ACTN1)
FCH: 102048669(ACTN1) 102059725
CLV: 102088244(ACTN1) 102090066
EGZ: 104122105(ACTN1)
NNI: 104017281(ACTN4) 104020309(ACTN1)
ACUN: 113480355(ACTN1)
PADL: 103918284(ACTN1)
AAM: 106496060 106498254(ACTN1)
ASN: 102378883(ACTN4) 102381557(ACTN1)
AMJ: 102573872(ACTN4) 106736747(ACTN1)
PSS: 102451042(ACTN4) 102453609(ACTN1)
CMY: 102929632(ACTN4) 102932714(ACTN1)
CPIC: 101932600(ACTN4) 101945411(ACTN1)
ACS: 100553987(actn1) 100566396(actn4)
PVT: 110075766(ACTN4) 110076389(ACTN1)
PBI: 103053907(ACTN1) 103054269(ACTN4)
PMUR: 107285832(ACTN1) 107295483(ACTN4)
TSR: 106539595(ACTN1) 106547454 106555707
PMUA: 114595039(ACTN1) 114603224(ACTN4)
GJA: 107106834(ACTN4) 107112209(ACTN1)
XLA: 399422(actn1.L) 431885 446865(actn4.S) 734930
XTR: 448522(actn4) 780123(actn1)
NPR: 108794113(ACTN1) 108804987(ACTN4)
DRE: 322221(actn4) 560400(actn1)
SRX: 107705429 107731818 107737420 107739883
SANH: 107654957 107669904 107680897
SGH: 107553176 107558830 107570110 107602958
CCAR: 109092183 109100417 109103447 109104020
IPU: 108261236 108280413(actn4)
PHYP: 113525174
AMEX: 103022122(actn4) 103031817(actn1)
EEE: 113574674 113589928
TRU: 101075286 101078391(actn4)
TNG: GSTEN00012749G001 GSTEN00026683G001
LCO: 104927498 104929780(actn1)
NCC: 104948803 104961894
MZE: 101467576 101469024
ONL: 100696265 100708272
OLA: 101155449 101169077(actn1)
XMA: 102222656(actn4) 102233488
XCO: 114133482(actn4) 114133746
PRET: 103458304(actn1) 103475218(actn4)
CVG: 107091414(actn1) 107092502(actn4)
NFU: 107380143(actn4) 107391737
KMR: 108235645(actn1) 108248547
ALIM: 106530135 106536526
AOCE: 111579397(actn1) 111582786
CSEM: 103377927(actn4) 103381068(actn1)
POV: 109640131 109643766
LCF: 108872698 108886695
SDU: 111216823(actn4) 111225279
SLAL: 111657978(actn4) 111665914(actn1)
HCQ: 109517259 109529370(actn4)
BPEC: 110157588(actn1) 110165853
MALB: 109953247 109973383
SASA: 100380299(actn1) 106580854(actn4) 106600942 106612603
OTW: 112265290 112266874
SALP: 111982509 111982854
ELS: 105025529(actn1) 105026813(actn4)
SFM: 108919448(actn1) 108924087 108928746(actn4)
PKI: 111844015(actn4) 111856226 111859957
LCM: 102356889(ACTN4) 102358724(ACTN1)
CMK: 103175234(actn1) 103190613
RTP: 109911376
BFO: BRAFLDRAFT_275861
SPU: 592971
APLC: 110981963
SKO: 100374060
DME: Dmel_CG4376(Actn)
DER: 6555557
DSI: Dsimw501_GD28856(Dsim_GD28856)
DYA: Dyak_GE16989
DSR: 110180448
DPO: Dpse_GA18143
DPE: 6600445
DMN: 108164112
DWI: 6648530
DGR: Dgri_GH24410
DMO: Dmoj_GI15429
DAZ: 108618265
DNV: 115564074
DHE: 111604068
MDE: 101887563
LCQ: 111676579
AGA: AgaP_AGAP001497(ACTN_ANOGA)
AAG: 5568986
CQU: CpipJ_CPIJ019577
AME: 725782
BIM: 100749119
BTER: 100652204
CCAL: 108623541
OBB: 114875769
SOC: 105201176
MPHA: 105832851
AEC: 105146320
ACEP: 105620710
PBAR: 105426241
VEM: 105561541
HST: 105189773
DQU: 106747552
CFO: 105250976
LHU: 105673416
PGC: 109863707
OBO: 105279188
PCF: 106793025
NVI: 100118107
CSOL: 105367848
MDL: 103571495
TCA: 661042
DPA: 109535688
ATD: 109598117
NVL: 108556321
BMOR: 101742794
BMAN: 114240872
DPL: KGM_206602
PMAC: 106710704
PRAP: 111004138
HAW: 110384521
TNL: 113495698
PXY: 105380431 105397193
API: 100159279
DNX: 107170710
AGS: 114125111
RMD: 113554459
BTAB: 109033273
CLEC: 106668995
PHU: Phum_PHUM299510
ZNE: 110832782
FCD: 110844414
DPX: DAPPUDRAFT_99081
PVM: 113805466 113805468
ISC: IscW_ISCW013566
TUT: 107360403
DPTE: 113796470
CSCU: 111628253
PTEP: 107438082
CEL: CELE_W04D2.1(atn-1)
CBR: CBG23504(Cbr-atn-1)
BMY: Bm1_51465
LOA: LOAG_17738
NAI: NECAME_05472
TSP: Tsp_06092
HRO: HELRODRAFT_187038 HELRODRAFT_93275 HELRODRAFT_97639
LGI: LOTGIDRAFT_189716
PCAN: 112569731
CRG: 105326760
MYI: 110459175
OBI: 106875711
LAK: 106156043
SMM: Smp_014780.1 Smp_034550
SHX: MS3_00361 MS3_04427
OVI: T265_02869 T265_07209
EGL: EGR_01584 EGR_05954
NVE: NEMVE_v1g206855
EPA: 110233331
AMIL: 114967726
PDAM: 113667159
SPIS: 111330358
DGT: 114539344 114540197
HMG: 100215556
TAD: TRIADDRAFT_37811
AQU: 100633045
EIN: Eint_090280
EHE: EHEL_090270
ERO: EROM_090280
NCE: NCER_101064
SRE: PTSG_01737
DFA: DFA_04278(abpA)
ACAN: ACA1_353650
NGR: NAEGRDRAFT_56285
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2349951
  Authors
Youssoufian H, McAfee M, Kwiatkowski DJ
  Title
Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.
  Journal
Am J Hum Genet 47:62-72 (1990)
  Sequence
[hsa:87]
Reference
  Authors
Nikolopoulos SN, Spengler BA, Kisselbach K, Evans AE, Biedler JL, Ross RA
  Title
The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.
  Journal
Oncogene 19:380-6 (2000)
DOI:10.1038/sj.onc.1203310
  Sequence
[hsa:81]
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