KEGG   ORTHOLOGY: K05718
Entry
K05718                      KO                                     

Name
ITGAL, CD11a
Definition
integrin alpha L
Pathway
ko04015  Rap1 signaling pathway
ko04514  Cell adhesion molecules
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05144  Malaria
ko05150  Staphylococcus aureus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05323  Rheumatoid arthritis
ko05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05718  ITGAL, CD11a; integrin alpha L
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05718  ITGAL, CD11a; integrin alpha L
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05718  ITGAL, CD11a; integrin alpha L
   04670 Leukocyte transendothelial migration
    K05718  ITGAL, CD11a; integrin alpha L
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05718  ITGAL, CD11a; integrin alpha L
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05718  ITGAL, CD11a; integrin alpha L
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05718  ITGAL, CD11a; integrin alpha L
   05169 Epstein-Barr virus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09174 Infectious disease: parasitic
   05144 Malaria
    K05718  ITGAL, CD11a; integrin alpha L
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05718  ITGAL, CD11a; integrin alpha L
   04515 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
   04090 CD molecules
    K05718  ITGAL, CD11a; integrin alpha L
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K05718  ITGAL, CD11a; integrin alpha L
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K05718  ITGAL, CD11a; integrin alpha L
CD molecules [BR:ko04090]
 Proteins
  K05718  CD11a, ITGAL; integrin, alpha L
Genes
HSA: 3683(ITGAL)
PTR: 454045(ITGAL)
PPS: 100968171(ITGAL)
GGO: 101139540(ITGAL)
PON: 100451665(ITGAL)
NLE: 100600240(ITGAL)
MCC: 711945(ITGAL)
MCF: 102117706(ITGAL)
CSAB: 103231906(ITGAL)
RRO: 104681602(ITGAL)
RBB: 108535405(ITGAL)
CJC: 100390790(ITGAL)
SBQ: 101049788(ITGAL)
MMU: 16408(Itgal)
MCAL: 110299482(Itgal)
MPAH: 110338926(Itgal)
RNO: 308995(Itgal)
MUN: 110548001(Itgal)
CGE: 100770691(Itgal)
NGI: 103726419(Itgal)
HGL: 101723643(Itgal)
CCAN: 109683028(Itgal)
OCU: 100356927(ITGAL)
TUP: 102469543(ITGAL)
CFA: 489905(ITGAL)
VVP: 112929237(ITGAL)
AML: 100464009(ITGAL)
UMR: 103657863(ITGAL)
UAH: 113267681(ITGAL)
ORO: 101370679(ITGAL)
ELK: 111162178
FCA: 101085940(ITGAL)
PTG: 102951540(ITGAL)
PPAD: 109259024(ITGAL)
AJU: 106979092(ITGAL)
BTA: 281874(ITGAL)
BOM: 102281951(ITGAL)
BIU: 109578145(ITGAL)
BBUB: 102412430(ITGAL)
CHX: 102172115(ITGAL)
OAS: 641296(ITGAL)
SSC: 733681(ITGAL)
CFR: 102519794(ITGAL)
CDK: 105102736(ITGAL)
BACU: 103015686(ITGAL)
LVE: 103086254(ITGAL)
OOR: 101278885(ITGAL)
DLE: 111182142(ITGAL)
PCAD: 102973622
ECB: 100065508(ITGAL)
EPZ: 103547219(ITGAL)
EAI: 106831918(ITGAL)
MYB: 102245292(ITGAL)
MYD: 102754113(ITGAL)
MNA: 107541988(ITGAL)
HAI: 109374220(ITGAL)
DRO: 112304654(ITGAL)
PALE: 102879417(ITGAL)
RAY: 107515868(ITGAL)
MJV: 108399261(ITGAL)
LAV: 100658239(ITGAL)
TMU: 101355641
MDO: 100017790(ITGAL)
SHR: 100932849(ITGAL)
PCW: 110223126(ITGAL)
OAA: 100090742(ITGAL)
ASN: 102379989
AMJ: 102574904(ITGAL)
PSS: 102448841(ITGAL)
CMY: 102935120(ITGAL)
CPIC: 101951426
ACS: 103280821(itgal)
PVT: 110090083(ITGAL)
PBI: 103063786
TSR: 106549614(ITGAL)
PMUA: 114581671(ITGAL)
GJA: 107111209(ITGAL)
XLA: 108701717
XTR: 100495488(itgal)
DRE: 557935(zmp:0000001082)
SRX: 107755319
SANH: 107690075
SGH: 107572597
CCAR: 109082665
IPU: 108258823
PHYP: 113524847
EEE: 113568533
NCC: 104956319
XMA: 102232813
XCO: 114143997
PRET: 103463430
CVG: 107085482
NFU: 107397049
KMR: 108251354
ALIM: 106526910
AOCE: 111575069
CSEM: 103384365
POV: 109627556
SLAL: 111660400
HCQ: 109521850(itgal)
MALB: 109956782
ELS: 105021449
SFM: 108933547
PKI: 111850807
 » show all
Reference
PMID:2537322
  Authors
Larson RS, Corbi AL, Berman L, Springer T
  Title
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
  Journal
J Cell Biol 108:703-12 (1989)
DOI:10.1083/jcb.108.2.703
  Sequence
[hsa:3683]
Reference
  Authors
Knight JM, Lee SH, Roberts L, Smith CW, Weiss ST, Kheradmand F, Corry DB
  Title
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease.
  Journal
J Allergy Clin Immunol 133:189-97.e1-8 (2014)
DOI:10.1016/j.jaci.2013.03.049
LinkDB

KEGG   ORTHOLOGY: K06464
Entry
K06464                      KO                                     

Name
ITGB2, CD18
Definition
integrin beta 2
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04390  Hippo signaling pathway
ko04514  Cell adhesion molecules
ko04610  Complement and coagulation cascades
ko04650  Natural killer cell mediated cytotoxicity
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05144  Malaria
ko05146  Amoebiasis
ko05150  Staphylococcus aureus infection
ko05152  Tuberculosis
ko05166  Human T-cell leukemia virus 1 infection
ko05323  Rheumatoid arthritis
ko05416  Viral myocarditis
Disease
H00099  Leukocyte adhesion deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K06464  ITGB2, CD18; integrin beta 2
   04390 Hippo signaling pathway
    K06464  ITGB2, CD18; integrin beta 2
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K06464  ITGB2, CD18; integrin beta 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06464  ITGB2, CD18; integrin beta 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06464  ITGB2, CD18; integrin beta 2
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K06464  ITGB2, CD18; integrin beta 2
   04650 Natural killer cell mediated cytotoxicity
    K06464  ITGB2, CD18; integrin beta 2
   04670 Leukocyte transendothelial migration
    K06464  ITGB2, CD18; integrin beta 2
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K06464  ITGB2, CD18; integrin beta 2
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K06464  ITGB2, CD18; integrin beta 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K06464  ITGB2, CD18; integrin beta 2
   05134 Legionellosis
    K06464  ITGB2, CD18; integrin beta 2
   05150 Staphylococcus aureus infection
    K06464  ITGB2, CD18; integrin beta 2
   05152 Tuberculosis
    K06464  ITGB2, CD18; integrin beta 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06464  ITGB2, CD18; integrin beta 2
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K06464  ITGB2, CD18; integrin beta 2
   05144 Malaria
    K06464  ITGB2, CD18; integrin beta 2
   05140 Leishmaniasis
    K06464  ITGB2, CD18; integrin beta 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06464  ITGB2, CD18; integrin beta 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06464  ITGB2, CD18; integrin beta 2
   04515 Cell adhesion molecules
    K06464  ITGB2, CD18; integrin beta 2
   04090 CD molecules
    K06464  ITGB2, CD18; integrin beta 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06464  ITGB2, CD18; integrin beta 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06464  ITGB2, CD18; integrin beta 2
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin beta subunits
   K06464  ITGB2, CD18; integrin beta 2
CD molecules [BR:ko04090]
 Proteins
  K06464  CD18, ITGB2; integrin, beta 2
Other DBs
GO: 0030369
Genes
HSA: 3689(ITGB2)
PTR: 458607(ITGB2)
PPS: 100985940(ITGB2)
GGO: 101142773(ITGB2)
PON: 100451938(ITGB2)
NLE: 100600337(ITGB2)
MCC: 710577(ITGB2)
MCF: 101925124(ITGB2)
CSAB: 103220048(ITGB2)
RRO: 104659958(ITGB2)
RBB: 108539787(ITGB2)
CJC: 100402685(ITGB2)
SBQ: 101053620(ITGB2)
MMU: 16414(Itgb2) 16415(Itgb2l)
MCAL: 110303281(Itgb2) 110311769
MPAH: 110326926(Itgb2) 110330040
RNO: 309684(Itgb2)
MUN: 110545086(Itgb2)
CGE: 100756135(Itgb2)
NGI: 103739950(Itgb2)
HGL: 101703921(Itgb2)
CCAN: 109694990(Itgb2) 109702039
OCU: 100339049(ITGB2)
TUP: 102497567 102501274(ITGB2)
CFA: 403770(ITGB2)
VVP: 112909536(ITGB2)
AML: 100484264(ITGB2)
UMR: 103680739(ITGB2)
UAH: 113250821(ITGB2)
ORO: 101383612(ITGB2)
ELK: 111155758
FCA: 101087258(ITGB2)
PTG: 102962262(ITGB2)
PPAD: 109258109(ITGB2)
AJU: 106985666(ITGB2)
BTA: 281877(ITGB2)
BOM: 102285348(ITGB2)
BIU: 109560786(ITGB2)
BBUB: 102400120(ITGB2)
CHX: 100861185(ITGB2)
OAS: 494433(ITGB2)
SSC: 396943(ITGB2)
CFR: 102512225(ITGB2)
CDK: 105101515(ITGB2)
BACU: 103008120(ITGB2)
LVE: 103079755(ITGB2)
OOR: 101285903(ITGB2)
DLE: 111186435(ITGB2)
PCAD: 102983789(ITGB2)
ECB: 100056049 100056128(ITGB2)
EPZ: 103543384
EAI: 106827902 106842975(ITGB2)
MYB: 102248879(ITGB2)
MYD: 102760033(ITGB2)
MNA: 107543669(ITGB2)
HAI: 109372101(ITGB2)
DRO: 112304402(ITGB2)
PALE: 102896231(ITGB2)
RAY: 107510212(ITGB2)
MJV: 108388833(ITGB2)
LAV: 100665256(ITGB2)
TMU: 101349050
MDO: 100024596(ITGB2)
SHR: 100925715(ITGB2)
PCW: 110198845(ITGB2)
OAA: 100092394(ITGB2)
GGA: 396181(ITGB2)
MGP: 100543565(ITGB2)
CJO: 107316393(ITGB2)
NMEL: 110399666(ITGB2)
APLA: 101796803(ITGB2)
ACYG: 106030119(ITGB2)
TGU: 100229042(ITGB2)
LSR: 110471688(ITGB2)
SCAN: 103814562(ITGB2)
GFR: 102035991(ITGB2)
FAB: 101806243(ITGB2)
PHI: 102111289(ITGB2)
PMAJ: 107207766(ITGB2)
CCAE: 111931900(ITGB2)
CCW: 104698247(ITGB2)
ETL: 114068111(ITGB2)
FPG: 101919496(ITGB2)
FCH: 102051822(ITGB2)
CLV: 102087554(ITGB2)
EGZ: 104132401(ITGB2)
NNI: 104013641(ITGB2)
ACUN: 113482437(ITGB2)
PADL: 103914154(ITGB2)
AAM: 106492316(ITGB2)
ASN: 102383861(ITGB2)
AMJ: 102563942(ITGB2)
PSS: 102455278(ITGB2)
CMY: 102947116(ITGB2)
CPIC: 101951111(ITGB2)
ACS: 100564287(itgb2)
PVT: 110087486(ITGB2)
PBI: 103050081(ITGB2)
PMUR: 107284294(ITGB2)
TSR: 106553055(ITGB2)
PMUA: 114582534(ITGB2)
GJA: 107117606(ITGB2)
XLA: 379708(itgb2.S)
XTR: 100492659(itgb2)
DRE: 557797(itgb2)
IPU: 100304487
PHYP: 113525914
AMEX: 103028506
EEE: 113577217
TRU: 101071641
LCO: 104938242
NCC: 104946113
MZE: 101476106
XMA: 102231373
XCO: 114148797
PRET: 103482508
CVG: 107102807(itgb2) 107102808
NFU: 107390286
KMR: 108238776
ALIM: 106530485
AOCE: 111588445
CSEM: 103392358(itgb2)
POV: 109637398
SDU: 111228090
SLAL: 111663463
HCQ: 109519258
BPEC: 110165161
MALB: 109963778
SASA: 100306785(itb2) 106581859
ELS: 105016184
LCM: 102365824(ITGB2)
CMK: 103176852(itgb2)
RTP: 109915473
 » show all
Reference
PMID:3028646
  Authors
Kishimoto TK, O'Connor K, Lee A, Roberts TM, Springer TA
  Title
Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family.
  Journal
Cell 48:681-90 (1987)
DOI:10.1016/0092-8674(87)90246-7
  Sequence
[hsa:3689]
Reference
  Authors
Xu J, Gao XP, Ramchandran R, Zhao YY, Vogel SM, Malik AB
  Title
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
  Journal
Nat Immunol 9:880-6 (2008)
DOI:10.1038/ni.1628
LinkDB

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