KEGG   ORTHOLOGY: K05747
Entry
K05747                      KO                                     

Name
WAS
Definition
Wiskott-Aldrich syndrome protein
Pathway
ko04062  Chemokine signaling pathway
ko04520  Adherens junction
ko04530  Tight junction
ko04666  Fc gamma R-mediated phagocytosis
ko05135  Yersinia infection
ko05231  Choline metabolism in cancer
Disease
H00100  Neutropenic disorders
H00107  Other well-defined immunodeficiency syndromes
H00978  Thrombocytopenia (THC)
H01523  Wiskott-Aldrich syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04530 Tight junction
    K05747  WAS; Wiskott-Aldrich syndrome protein
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04062 Chemokine signaling pathway
    K05747  WAS; Wiskott-Aldrich syndrome protein
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K05747  WAS; Wiskott-Aldrich syndrome protein
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05747  WAS; Wiskott-Aldrich syndrome protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05747  WAS; Wiskott-Aldrich syndrome protein
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04990 Domain-containing proteins not elsewhere classified
    K05747  WAS; Wiskott-Aldrich syndrome protein
Membrane trafficking [BR:ko04131]
 Others
  Actin-binding proteins
   Nucleation-promoting factors (NPFs)
    K05747  WAS; Wiskott-Aldrich syndrome protein
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K05747  WAS; Wiskott-Aldrich syndrome protein
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EVH1 / WASP  homology  (WH) domain-containing proteins
  WH1 domain-containing proteins
   K05747  WAS; Wiskott-Aldrich syndrome protein
Genes
HSA: 7454(WAS)
PTR: 743187(WAS)
PPS: 100977168(WAS)
GGO: 101154232(WAS)
PON: 100452449(WAS)
NLE: 100598058(WAS)
MCC: 714474(WAS)
MCF: 102133786(WAS)
CSAB: 103231940(WAS)
RRO: 104660661(WAS)
RBB: 108517463(WAS)
CJC: 100412947(WAS)
SBQ: 101051876(WAS)
MMU: 22376(Was)
MCAL: 110287161(Was)
MPAH: 110314062(Was)
RNO: 317371(Was)
MUN: 110541344(Was)
CGE: 100769113(Was)
NGI: 103741643(Was)
HGL: 101704700(Was)
CCAN: 109675666(Was)
OCU: 100354471(WAS)
TUP: 102469132(WAS)
CFA: 491867(WAS)
VVP: 112907257(WAS)
AML: 100479480(WAS)
UMR: 103663384(WAS)
UAH: 113265921(WAS)
ORO: 101380859(WAS)
ELK: 111150530
FCA: 101095721(WAS)
PTG: 102951203(WAS)
PPAD: 109248068(WAS)
AJU: 106970863(WAS)
BTA: 107131173(WAS)
BOM: 102271473(WAS)
BBUB: 102403922(WAS)
CHX: 102183859(WAS)
OAS: 101114336(WAS)
SSC: 445527(WAS)
CFR: 102512738(WAS)
CDK: 105103310(WAS)
BACU: 103013907(WAS)
LVE: 103073648(WAS)
OOR: 101289436(WAS)
DLE: 111169497(WAS)
PCAD: 102988824(WAS)
ECB: 100147507(WAS)
EPZ: 103542531
EAI: 106827440(WAS)
MYB: 102242874(WAS)
MYD: 102763663(WAS)
MNA: 107541349(WAS)
HAI: 109374777(WAS)
DRO: 112322501(WAS)
PALE: 102888774(WAS)
RAY: 107515028(WAS)
MJV: 108408402(WAS)
LAV: 100677772(WAS)
TMU: 101348260
MDO: 100018699(WAS)
SHR: 100934222(WAS)
PCW: 110201059(WAS)
OAA: 100089883(WAS)
GGA: 100857640(SUV39H1)
CJO: 107307196(WAS)
PHI: 102112094(WAS)
ASN: 102370091(WAS)
AMJ: 102561988(WAS)
CMY: 102938058(WAS)
CPIC: 101951223(WAS)
ACS: 100565618(was)
PVT: 110081165(WAS)
PBI: 103051900(WAS)
PMUR: 107300285(WAS)
TSR: 106546034(WAS)
PMUA: 114588108(WAS)
XLA: 100036872(was.S) 100037214(was.L) 733265
XTR: 496673(was)
NPR: 108788265(WAS)
DRE: 335158(wasb) 571256(wasa)
IPU: 108265497(was) 108265595
PHYP: 113528430 113536338(was)
AMEX: 103022907 103041172(was)
EEE: 113579131(was) 113581095
TRU: 101071646
LCO: 104924684(was)
NCC: 104951558(was)
MZE: 101473005(was)
ONL: 100703588(was)
OLA: 101169454(was)
XMA: 102228585(was)
XCO: 114148545(was)
PRET: 103467699(was)
CVG: 107086771(was)
NFU: 107390524(was)
KMR: 108231959(was)
ALIM: 106519334(was)
AOCE: 111588329(was)
CSEM: 103385368(was)
POV: 109635246(was)
LCF: 108882168(was)
SDU: 111235011(was)
SLAL: 111654216(was)
HCQ: 109512953(was)
BPEC: 110164836(was)
MALB: 109966727(was)
SASA: 106567248(WASP) 106572383(WASP)
OTW: 112216175
SALP: 111966635(was)
ELS: 105022376(was)
SFM: 108934794(was)
PKI: 111847811(was)
LCM: 102351644(WAS)
PVM: 113827926
EGL: EGR_06151
AMIL: 114953783
 » show all
Reference
  Authors
Cory GO, Garg R, Cramer R, Ridley AJ
  Title
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
  Journal
J Biol Chem 277:45115-21 (2002)
DOI:10.1074/jbc.M203346200
Reference
PMID:8069912
  Authors
Derry JM, Ochs HD, Francke U
  Title
Isolation of a novel gene mutated in Wiskott-Aldrich syndrome.
  Journal
Cell 78:635-44 (1994)
DOI:10.1016/0092-8674(94)90528-2
  Sequence
[hsa:7454]
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