KEGG   ORTHOLOGY: K05824Help
Entry
K05824                      KO                                     

Name
LYS12
Definition
homoisocitrate dehydrogenase [EC:1.1.1.87]
Pathway
ko00300  Lysine biosynthesis
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05824  LYS12; homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K05824  LYS12; homoisocitrate dehydrogenase
BRITE hierarchy
Other DBs
RN: R01934 R01936 R04862
COG: COG0473
GO: 0047046
Genes
QSU: 111984152 111991115
SCE: YIL094C(LYS12)
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: CAGL0G02585g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
PIC: PICST_50442(LYS12)
CAL: CAALFM_CR01400WA(LYS12)
SLB: AWJ20_5129(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
MGR: MGG_01566
SSCK: SPSK_09424
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
MBE: MBM_09266
ANI: AN5206.2
ANG: ANI_1_398134(An15g02490)
ABE: ARB_06194
TVE: TRV_01663
PTE: PTT_19273
CNE: CND03850
CNB: CNBD2460
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
MGL: MGL_3003
MRT: MRET_3610
PCQ: PcP3B5_09520(hicd)
PKC: PKB_4900(leub3)
PSET: THL1_4856
AMAH: DLM_3455
RCA: Rcas_3471
CAU: Caur_0331
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
DRA: DR_1674
DGE: Dgeo_1458
DFC: DFI_05685
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378
TSC: TSC_c20650(icd2)
TAQ: TO73_0559
MRB: Mrub_2738
 » show all
TaxonomyKoalaUniProt
Reference
PMID:4395693
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
LinkDB All DBs

KEGG   ORTHOLOGY: K10978Help
Entry
K10978                      KO                                     

Name
aksF
Definition
methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
Pathway
ko00300  Lysine biosynthesis
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K10978  aksF; methanogen homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10978  aksF; methanogen homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K10978  aksF; methanogen homoisocitrate dehydrogenase
    1.1.1.-  
     K10978  aksF; methanogen homoisocitrate dehydrogenase
BRITE hierarchy
Other DBs
RN: R01934 R01936 R04862 R08214 R08215
COG: COG0473
Genes
MJA: MJ_1596
MFE: Mefer_0957
MVU: Metvu_0752
MFS: MFS40622_0058
MIF: Metin_0287
MJH: JH146_0764
MIG: Metig_0040
MMP: MMP0880(aksF)
MMQ: MmarC5_0688
MMX: MmarC6_1775
MMD: GYY_05110
MAE: Maeo_1484
MVO: Mvol_0791
MTH: MTH_184
METC: MTCT_0151
MWO: MWSIV6_0600(leuB1)
METE: tca_00168(hicd_1)
MST: Msp_0674
MSI: Msm_0373
MRU: mru_1033(aksF)
MEB: Abm4_0999(aksF)
MMIL: sm9_0644(aksF)
MEYE: TL18_03130
MOL: YLM1_0578
METH: MBMB1_1404(leuB1)
MFC: BRM9_0639(aksF)
MFI: DSM1535_0612(leuB1)
MCUB: MCBB_1645(leuB1)
MFV: Mfer_1273
MKA: MK1215(leuB_2)
MAC: MA_3748(leuB)
MBAR: MSBR2_2662
MBAK: MSBR3_2764
MMA: MM_0642
MMAC: MSMAC_0669
METM: MSMTP_0734
MTHE: MSTHC_0902
MTHR: MSTHT_2378
MHOR: MSHOH_0789
MMET: MCMEM_2087
MMH: Mmah_0129
MPY: Mpsy_2352
MTP: Mthe_0855
MCJ: MCON_1920(aksF)
MHI: Mhar_2394
MHU: Mhun_1797
MLA: Mlab_0235
MBG: BN140_3039(leuB3)
MEMA: MMAB1_2207(leuB)
MPI: Mpet_2492
MBN: Mboo_0602
MPL: Mpal_2146
MPD: MCP_1963(aksF)
MEZ: Mtc_1557(aksF)
RCI: RCIX2644(leuB-2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Howell DM, Graupner M, Xu H, White RH
  Title
Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000
  Sequence
[mja:MJ_1596]
LinkDB All DBs

KEGG   ORTHOLOGY: K17753Help
Entry
K17753                      KO                                     

Name
HICDH
Definition
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00300  Lysine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
BRITE hierarchy
Other DBs
RN: R00709 R01934 R01936 R04862
COG: COG0473
GO: 0033708
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
TaxonomyKoalaUniProt
Reference
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
LinkDB All DBs

KEGG   REACTION: R01934Help
Entry
R01934                      Reaction                               

Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF.
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
Other DBs
RHEA: 11903
LinkDB All DBs

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