KEGG   ORTHOLOGY: K05855Help
Entry
K05855                      KO                                     

Name
SYK
Definition
spleen tyrosine kinase [EC:2.7.10.2]
Pathway
ko04064  NF-kappa B signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04380  Osteoclast differentiation
ko04611  Platelet activation
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko05152  Tuberculosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04072 Phospholipase D signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04151 PI3K-Akt signaling pathway
    K05855  SYK; spleen tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05855  SYK; spleen tyrosine kinase
   04625 C-type lectin receptor signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04650 Natural killer cell mediated cytotoxicity
    K05855  SYK; spleen tyrosine kinase
   04662 B cell receptor signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04664 Fc epsilon RI signaling pathway
    K05855  SYK; spleen tyrosine kinase
   04666 Fc gamma R-mediated phagocytosis
    K05855  SYK; spleen tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05855  SYK; spleen tyrosine kinase
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05855  SYK; spleen tyrosine kinase
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05855  SYK; spleen tyrosine kinase
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K05855  SYK; spleen tyrosine kinase
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05855  SYK; spleen tyrosine kinase
   05169 Epstein-Barr virus infection
    K05855  SYK; spleen tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05855  SYK; spleen tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05855  SYK; spleen tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SYK family
   K05855  SYK; spleen tyrosine kinase
BRITE hierarchy
Other DBs
GO: 0004715 0004716
Genes
HSA: 6850(SYK)
PTR: 464586(SYK)
PPS: 100978194(SYK)
GGO: 101138129(SYK)
PON: 100438875(SYK)
NLE: 100590261(SYK)
MCC: 704102(SYK)
MCF: 102145713(SYK)
CSAB: 103219736(SYK)
RRO: 104662008(SYK)
RBB: 108516810 108538610(SYK)
CJC: 100394657(SYK)
SBQ: 101031617(SYK)
MMU: 20963(Syk)
MCAL: 110308005(Syk)
MPAH: 110333852(Syk)
RNO: 25155(Syk)
MUN: 110552352(Syk)
CGE: 100758656(Syk)
NGI: 103745419(Syk)
HGL: 101719494(Syk)
CCAN: 109688078(Syk)
OCU: 100345556(SYK)
TUP: 102472653(SYK)
CFA: 484196(SYK)
VVP: 112908642(SYK)
AML: 100474543(SYK)
UAH: 113270132(SYK)
ORO: 101373095(SYK)
FCA: 101087013(SYK)
PTG: 102964642(SYK)
AJU: 106976132(SYK)
BTA: 515515(SYK)
BOM: 102271008(SYK)
BIU: 109563281(SYK)
BBUB: 102412306(SYK)
PHD: 102317343(SYK)
CHX: 102174120(SYK)
OAS: 101105303(SYK)
SSC: 100125540(SYK)
BACU: 103013608(SYK)
LVE: 103079796(SYK)
OOR: 101281971(SYK)
DLE: 111167662(SYK)
PCAD: 102993186(SYK)
ECB: 100063383(SYK)
EPZ: 103565660(SYK)
EAI: 106839739(SYK)
MYB: 102243247(SYK)
MYD: 102772593(SYK)
MNA: 107529171(SYK)
HAI: 109375897(SYK)
RSS: 109435789(SYK)
DRO: 112307282(SYK)
PALE: 102888426(SYK)
RAY: 107518638(SYK)
LAV: 100663651(SYK)
TMU: 101351806
MDO: 100028356
SHR: 100915147 100932859(SYK)
PCW: 110203252(SYK)
OAA: 114808729(SYK)
GGA: 427272(SYK)
MGP: 104909903
CJO: 107306310(SYK)
NMEL: 110389570(SYK)
APLA: 101795007(SYK)
ACYG: 106045101(SYK)
TGU: 100229485(SYK)
LSR: 110470628(SYK)
SCAN: 103821247(SYK)
GFR: 102040272(SYK)
FAB: 101821765(SYK)
PHI: 102109009(SYK)
PMAJ: 107216019(SYK)
CCAE: 111941719(SYK)
CCW: 104689725(SYK)
ETL: 114067715(SYK)
FPG: 101913951(SYK)
FCH: 102056879(SYK)
CLV: 102092767(SYK)
EGZ: 104126918(SYK)
NNI: 104013397(SYK)
ACUN: 113490089(SYK)
PADL: 103922194(SYK)
AAM: 106495447(SYK)
ASN: 102369846(SYK)
AMJ: 102568856(SYK)
PSS: 102447364(SYK)
CMY: 102938012(SYK)
CPIC: 101948627(SYK)
ACS: 100554859(syk)
PVT: 110081110(SYK)
PBI: 103067015(SYK)
PMUR: 107291984(SYK)
GJA: 107108630(SYK)
XLA: 399022(syk.S) 446500(syk.L)
XTR: 100486846(syk)
NPR: 108787186(SYK)
DRE: 405769(syk)
SANH: 107670033
SGH: 107558251 107560409(syk)
IPU: 108277200(syk)
PHYP: 113543957(syk)
AMEX: 103026241(syk)
EEE: 113576751(syk)
TRU: 101063503(syk)
LCO: 104935660(syk)
MZE: 101475188(syk)
OLA: 101155127(syk)
XCO: 114150136(syk)
PRET: 103473520(syk)
NFU: 107395023(syk)
KMR: 108246454(syk)
AOCE: 111579152(syk)
CSEM: 103389853(syk)
POV: 109625997(syk)
LCF: 108900733(syk)
SDU: 111221242(syk)
HCQ: 109530546(syk)
BPEC: 110161579(syk)
MALB: 109970889(syk)
SASA: 100380388(syk)
OTW: 112219981(syk)
SALP: 111960920(syk)
ELS: 105020452(syk)
SFM: 108929949(syk)
PKI: 111841163(syk)
LCM: 102351878(SYK)
CMK: 103182860(syk)
CIN: 100181565
SPU: 589201
APLC: 110984393
SKO: 102804792
PCAN: 112574278
MYI: 110441512
LAK: 106164633
SHX: MS3_03215
ADF: 107332469
PDAM: 113671641
SPIS: 111327664
HMG: 100215395
AQU: 100640238
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9535867
  Authors
Deckert M, Elly C, Altman A, Liu YC
  Title
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
  Journal
J Biol Chem 273:8867-74 (1998)
DOI:10.1074/jbc.273.15.8867
  Sequence
[hsa:6850]
Reference
PMID:7513161
  Authors
Yagi S, Suzuki K, Hasegawa A, Okumura K, Ra C
  Title
Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812).
  Journal
Biochem Biophys Res Commun 200:28-34 (1994)
DOI:10.1006/bbrc.1994.1409
  Sequence
[hsa:6850]
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