KEGG   ORTHOLOGY: K05858
Entry
K05858                      KO                                     

Name
PLCB
Definition
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04361  Axon regeneration
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04621  NOD-like receptor signaling pathway
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04742  Taste transduction
ko04745  Phototransduction - fly
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04929  GnRH secretion
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
ko05142  Chagas disease
ko05143  African trypanosomiasis
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00606  Early infantile epileptic encephalopathy
H01815  Malignant migrating partial seizures in infancy
H01884  Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04371 Apelin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04072 Phospholipase D signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04071 Sphingolipid signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04022 cGMP-PKG signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04621 NOD-like receptor signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09152 Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04922 Glucagon signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04929 GnRH secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04921 Oxytocin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04926 Relaxin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04935 Growth hormone synthesis, secretion and action
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04918 Thyroid hormone synthesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04919 Thyroid hormone signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04928 Parathyroid hormone synthesis, secretion and action
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04924 Renin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04925 Aldosterone synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04927 Cortisol synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09154 Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04973 Carbohydrate digestion and absorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09156 Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09157 Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04742 Taste transduction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04750 Inflammatory mediator regulation of TRP channels
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09158 Development and regeneration
   04361 Axon regeneration
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09159 Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05017 Spinocerebellar ataxia
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05022 Pathways of neurodegeneration - multiple diseases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04934 Cushing syndrome
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR: 451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS: 100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO: 101129357(PLCB3) 101140350(PLCB2) 101153613(PLCB1) 101154323(PLCB4)
PON: 100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
NLE: 100597115(PLCB1) 100600507(PLCB4) 100600865(PLCB3) 100606558(PLCB2)
MCC: 701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF: 101925220(PLCB4) 102123165(PLCB3) 102136896(PLCB2) 102140615(PLCB1)
CSAB: 103233299(PLCB3) 103245842(PLCB2) 103246591(PLCB4) 103246657(PLCB1)
RRO: 104655777(PLCB4) 104659669(PLCB2) 104668296(PLCB1) 104673127(PLCB3)
RBB: 108526885(PLCB2) 108527553(PLCB1) 108527564(PLCB4) 108542252(PLCB3)
CJC: 100386921(PLCB2) 100400803(PLCB3) 100409716(PLCB1) 100410075(PLCB4)
SBQ: 101029401(PLCB3) 101046851(PLCB4) 101047168(PLCB1) 101052271(PLCB2)
MMU: 18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
MCAL: 110285320(Plcb3) 110286326(Plcb2) 110290514(Plcb4) 110308867(Plcb1)
MPAH: 110317815(Plcb4) 110318415(Plcb2) 110319646(Plcb1) 110336671(Plcb3)
RNO: 24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
MUN: 110550598(Plcb2) 110551595(Plcb3) 110555720(Plcb1) 110563159
CGE: 100751979(Plcb1) 100760134(Plcb3) 100760731(Plcb2) 100770957(Plcb4)
NGI: 103735195(Plcb1) 103738797(Plcb3) 103741502(Plcb2)
HGL: 101696454(Plcb4) 101697744(Plcb3) 101708380(Plcb2) 101725860(Plcb1)
CCAN: 109683285(Plcb3) 109684223(Plcb1) 109701244(Plcb2)
OCU: 100341512(PLCB1) 100348672(PLCB2) 100350395(PLCB4)
TUP: 102472532(PLCB3) 102476196(PLCB4) 102477438(PLCB1) 102492903(PLCB2)
CFA: 100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
VVP: 112919942(PLCB2) 112924037(PLCB3) 112930053(PLCB4) 112930054(PLCB1)
AML: 100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
UMR: 103673552(PLCB2) 103674425(PLCB1) 103674426(PLCB4) 103679549(PLCB3)
UAH: 113242038(PLCB2) 113244175(PLCB3) 113258243(PLCB1) 113258346(PLCB4)
ORO: 101375710(PLCB3) 101379806(PLCB2) 101386162(PLCB4) 101386750(PLCB1)
FCA: 101090005(PLCB4) 101090942(PLCB2) 101092262(PLCB1) 101092961(PLCB3)
PTG: 102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3)
PPAD: 109246661(PLCB3) 109263166(PLCB2) 109274721(PLCB4) 109274722(PLCB1)
AJU: 106968579(PLCB2) 106976431(PLCB4) 106976432(PLCB1) 106981698(PLCB3)
BTA: 281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
BOM: 102264989(PLCB4) 102273347(PLCB1) 102276260(PLCB3) 102278948(PLCB2)
BIU: 109554384(PLCB3) 109564927(PLCB2) 109567852(PLCB1) 109567854(PLCB4)
BBUB: 102389945(PLCB2) 102405830(PLCB1) 102412320(PLCB4) 102413748(PLCB3)
CHX: 102169966(PLCB2) 102180505(PLCB4) 102188148(PLCB1) 102189653(PLCB3)
OAS: 101103585(PLCB1) 101106864(PLCB4) 101113074(PLCB2) 101116105(PLCB3)
SSC: 100152679(PLCB1) 100157641(PLCB2) 100516581(PLCB4) 100525148(PLCB3)
CFR: 102505338(PLCB3) 102509058(PLCB2) 102513431(PLCB4) 102513996(PLCB1)
CDK: 105096910(PLCB2) 105101292(PLCB1) 105101500(PLCB4) 105101545(PLCB3)
BACU: 102997432(PLCB4) 103006361(PLCB3) 103007077(PLCB2) 103020805(PLCB1)
LVE: 103078639(PLCB4) 103079287(PLCB1) 103083884(PLCB3) 103086280(PLCB2)
OOR: 101270548(PLCB1) 101270961(PLCB4) 101274558(PLCB3) 101281417(PLCB2)
DLE: 111165617(PLCB4) 111165653(PLCB1) 111181753(PLCB2) 111183812(PLCB3)
PCAD: 102974165(PLCB3) 102983015(PLCB1) 102985636(PLCB2) 102995357(PLCB4)
ECB: 100051485(PLCB4) 100051558(PLCB1) 100055407(PLCB3) 100057315(PLCB2)
EPZ: 103542193(PLCB3) 103559733(PLCB4) 103561633(PLCB2) 103562440(PLCB1)
EAI: 106823182(PLCB4) 106823191(PLCB1) 106833627(PLCB3) 106835172(PLCB2)
MYB: 102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102254054(PLCB2)
MYD: 102751685(PLCB1) 102751959(PLCB4) 102755123(PLCB3) 102760520(PLCB2)
MNA: 107536366(PLCB4) 107536369(PLCB1) 107539797(PLCB3) 107542967(PLCB2)
HAI: 109378976(PLCB4) 109378977(PLCB1) 109383976(PLCB2) 109384329(PLCB3)
DRO: 112304122(PLCB4) 112304255(PLCB1) 112311437(PLCB2) 112317151(PLCB3)
PALE: 102879238(PLCB3) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2)
RAY: 107497081(PLCB3) 107506114(PLCB1) 107514464(PLCB2) 107519930(PLCB4)
MJV: 108394257(PLCB1) 108394259(PLCB4) 108401653(PLCB2) 108407569(PLCB3)
LAV: 100663829(PLCB3) 100668575(PLCB2) 100670617(PLCB4) 100672435(PLCB1)
MDO: 100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR: 100922938(PLCB3) 100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
PCW: 110195440(PLCB3) 110207938(PLCB1) 110207974(PLCB4) 110223673(PLCB2)
OAA: 100078508(PLCB1) 100081349(PLCB3) 100084272(PLCB4) 100086536(PLCB2)
GGA: 416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
CJO: 107307599 107310934(PLCB4) 107310953(PLCB1) 107314230(PLCB2)
NMEL: 110395536(PLCB4) 110396662(PLCB1) 110401183(PLCB2)
APLA: 101790966(PLCB1) 101804447(PLCB2) 101805172(PLCB4)
ACYG: 106036606(PLCB4) 106036632(PLCB1) 106047056(PLCB2)
TGU: 100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
LSR: 110475845(PLCB4) 110475847(PLCB1) 110484995(PLCB2)
SCAN: 103819233(PLCB4) 103819309(PLCB1) 103822183(PLCB2)
GFR: 102031336(PLCB4) 102037268(PLCB1) 102045029(PLCB2)
FAB: 101806047(PLCB2) 101812094(PLCB4) 101816169(PLCB1)
PHI: 102100609(PLCB4) 102105081(PLCB2) 102113003(PLCB1)
PMAJ: 107201330(PLCB1) 107201331(PLCB4) 107205812(PLCB2)
CCAE: 111926455(PLCB1) 111926460(PLCB4) 111930495(PLCB2)
CCW: 104691519(PLCB1) 104691520(PLCB4) 104692980(PLCB2)
ETL: 114057366(PLCB4) 114065074(PLCB1) 114067935(PLCB2)
FPG: 101912415(PLCB2) 101916711(PLCB4) 101922366(PLCB1)
FCH: 102048018(PLCB2) 102048448(PLCB1) 102054421(PLCB4)
CLV: 102096635(PLCB2) 102097554(PLCB4) 102098150(PLCB1)
EGZ: 104131359(PLCB2) 104132995(PLCB4) 104133001(PLCB1)
NNI: 104020525(PLCB2) 104022433(PLCB4) 104022482(PLCB1)
ACUN: 113477996(PLCB1) 113478160(PLCB4) 113481004(PLCB2)
PADL: 103913124(PLCB4) 103913125(PLCB1) 103924964(PLCB2)
AAM: 106486714(PLCB2) 106490470(PLCB4) 106490480(PLCB1)
ASN: 102371353(PLCB3) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1)
AMJ: 102560430(PLCB4) 102566880(PLCB1) 102572359(PLCB2) 102576994(PLCB3)
PSS: 102449462(PLCB3) 102455767(PLCB4) 102460883(PLCB1) 102461092(PLCB2)
CMY: 102931046(PLCB2) 102932254(PLCB3) 102942020(PLCB1) 102942246(PLCB4)
CPIC: 101930785(PLCB2) 101931546(PLCB4) 101932753(PLCB1) 101940400(PLCB3)
ACS: 100551754(plcb2) 100560758(plcb4) 100566853(plcb1) 100567752(plcb3)
PVT: 110080121(PLCB2) 110083359(PLCB3) 110087369 110087370(PLCB1)
PBI: 103055449(PLCB2) 103057663(PLCB4) 103062216(PLCB1) 103064298(PLCB3) 103066383
PMUR: 107285365(PLCB1) 107285366(PLCB4) 107286221 107290817 107299064(PLCB3)
PMUA: 114586167(PLCB3) 114593658(PLCB1) 114593659(PLCB4) 114593800(PLCB2)
GJA: 107106753(PLCB1) 107115177(PLCB3) 107119642(PLCB2) 107123894(PLCB4)
XLA: 108699254(plcb2.L) 108716399(plcb4.L) 108716400 397692(plcb3.L) 445848(plcb4.S) 733258(plcb1.S)
XTR: 100125098(plcb4) 100487267(plcb3) 101734935(plcb2) 780394(plcb1)
NPR: 108789286(PLCB2) 108793965(PLCB3) 108795338(PLCB4) 108795563(PLCB1)
DRE: 100001532(plcb3) 100149080 100537538 407700(plcb4) 569376(plcb2)
IPU: 108258041(PLCB4) 108258091(PLCB1) 108267602(PLCB3) 108269611(plcb2) 108270307(plcb1) 108270308
LCO: 104919801(plcb4) 104920858(plcb1) 104924817(plcb2) 104928901(plcb3) 104935685
NCC: 104946378(plcb4) 104947200(plcb2) 104948204(plcb3) 104951799(plcb1)
MZE: 101464832(plcb4) 101465812(plcb1) 101474135(plcb3) 101475994(plcb2) 101478971
ONL: 100689896 100698389(plcb1) 100706492(plcb3) 100706628(plcb4) 100706825(plcb2)
OLA: 100049465(plcb2) 100049529 100049535(plcb4) 101172698(plcb1) 101175365
XMA: 102217878 102219479 102223820(plcb4) 102224078(plcb1) 102230660(plcb2)
XCO: 114133784(plcb2) 114138347 114157441 114158603(plcb1) 114158604(plcb4)
PRET: 103457872(plcb1) 103457873(plcb4) 103458561(plcb2) 103476610 103480743(plcb3)
CVG: 107084147(plcb3) 107094391(plcb2) 107097625(plcb4) 107097779(plcb1) 107098647
NFU: 107376107 107377124(plcb3) 107378065(plcb4) 107378111(plcb1) 107392485(plcb2)
ALIM: 106518551(plcb4) 106518553(plcb1) 106519799(plcb2) 106524973(plcb3) 106529251
CSEM: 103381058(plcb1) 103381059(plcb4) 103385127(plcb3) 103387749 103389807(plcb2)
LCF: 108872939 108892548(plcb2) 108893282 108896906(plcb4) 108896922(plcb1)
SDU: 111225989(plcb2) 111227394 111231312(plcb3) 111240392(plcb1) 111240424(plcb4)
SLAL: 111644585 111652449(plcb2) 111653469(plcb3) 111672675(plcb1) 111672676(plcb4)
MALB: 109961174 109962200(plcb4) 109962203(plcb1) 109965817(plcb3) 109968365(plcb2)
ELS: 105007096(plcb3) 105015712(plcb2) 105017520(plcb1) 105017521(plcb4) 105031658
SFM: 108919358(plcb2) 108922946 108925497(plcb3) 108929291 108929356(plcb4)
PKI: 111834703(plcb3) 111837852 111837866(plcb4) 111838879(plcb2) 111857883
LCM: 102345855(PLCB1) 102348275(PLCB4) 102362364(PLCB2) 102365542(PLCB3)
CMK: 103171709 103187499(plcb2) 103187635(plcb1)
DME: Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DSI: Dsimw501_GD16687(Dsim_GD16687) Dsimw501_GD23017(Dsim_GD23017)
DYA: Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C)
DNV: 108658397
BMOR: 100329153(PLCb1) 100329154(PLCb4)
HAW: 110384330
CEL: CELE_B0348.4(egl-8)
CBR: CBG06373(Cbr-egl-8)
EGL: EGR_00105
HMG: 100189549(plcbh1) 100189551(plcbh2) 100200484
AQU: 100641378
 » show all
Reference
  Authors
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC
  Title
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).
  Journal
Biochim Biophys Acta 1517:63-72 (2000)
DOI:10.1016/S0167-4781(00)00260-8
  Sequence
[hsa:23236]
Reference
PMID:1644792
  Authors
Park D, Jhon DY, Kriz R, Knopf J, Rhee SG
  Title
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
  Journal
J Biol Chem 267:16048-55 (1992)
  Sequence
[hsa:5330]
Reference
PMID:1333955
  Authors
Carozzi AJ, Kriz RW, Webster C, Parker PJ
  Title
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.
  Journal
Eur J Biochem 210:521-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb17450.x
  Sequence
[hsa:5331]
Reference
PMID:8530101
  Authors
Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W
  Title
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).
  Journal
Genomics 29:53-61 (1995)
DOI:10.1006/geno.1995.1214
  Sequence
[hsa:5332]
LinkDB

KEGG   ORTHOLOGY: K05857
Entry
K05857                      KO                                     

Name
PLCD
Definition
phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04020  Calcium signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01307  Nonsyndromic congenital nail disorder
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
   04070 Phosphatidylinositol signaling system
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05857  PLCD; phosphatidylinositol phospholipase C, delta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 113026(PLCD3) 5333(PLCD1) 84812(PLCD4)
PTR: 460267(PLCD1) 468279(PLCD3) 470647(PLCD4)
PPS: 100969236(PLCD1) 100980795(PLCD3) 100988032(PLCD4)
GGO: 101136081(PLCD4) 101139984(PLCD1) 101142984(PLCD3)
PON: 100171640(PLCD4) 100443819(PLCD3) 100462440(PLCD1)
NLE: 100596702(PLCD1) 100598366(PLCD4) 100604799(PLCD3)
MCC: 696860(PLCD1) 699569(PLCD4) 715924(PLCD3)
MCF: 101866682(PLCD1) 102122144(PLCD4) 102138566(PLCD3)
CSAB: 103217873(PLCD4) 103221069(PLCD1) 103243297(PLCD3)
RRO: 104654736(PLCD3) 104657452(PLCD1) 104660025(PLCD4)
RBB: 108512236(PLCD1) 108518456(PLCD4) 108532211(PLCD3)
CJC: 100395085(PLCD3) 100408539(PLCD4) 100408597(PLCD1)
SBQ: 101030401(PLCD4) 101045153(PLCD3) 101053112(PLCD1)
MMU: 18799(Plcd1) 18802(Plcd4) 72469(Plcd3)
MCAL: 110293847(Plcd4) 110301135(Plcd1) 110305200(Plcd3)
MPAH: 110322413(Plcd4) 110328624(Plcd1) 110331704(Plcd3)
RNO: 140693(Plcd4) 24655(Plcd1) 287745(Plcd3)
MUN: 110545647(Plcd3) 110555042(Plcd1) 110566641(Plcd4)
CGE: 100751509(Plcd1) 100751872(Plcd4) 100759620(Plcd3)
NGI: 103727720(Plcd4) 103738313(Plcd3) 103751602(Plcd1)
HGL: 101704621(Plcd3) 101704999(Plcd4) 101715010(Plcd1)
CCAN: 109678350(Plcd4) 109691551(Plcd3) 109698346(Plcd1)
OCU: 100347485(PLCD4) 100352032(PLCD3) 103347252(PLCD1)
TUP: 102468499(PLCD3) 102475249(PLCD4) 102500184(PLCD1)
CFA: 478910(PLCD4) 485586(PLCD1) 490929(PLCD3)
VVP: 112910679(PLCD3) 112921661(PLCD1) 112922548(PLCD4)
AML: 100469148(PLCD4) 100471021(PLCD3) 100476035(PLCD1)
UMR: 103662760(PLCD4) 103665878(PLCD3) 103682206(PLCD1)
UAH: 113250452(PLCD4) 113253779(PLCD1) 113265331(PLCD3)
ORO: 101364446(PLCD1) 101364713(PLCD3) 101372489(PLCD4)
FCA: 101086518(PLCD3) 101087777(PLCD1) 101090455(PLCD4)
PTG: 102952633(PLCD1) 102956201(PLCD4) 102963235(PLCD3)
PPAD: 109248742 109248743 109258216(PLCD3) 109265062(PLCD4)
AJU: 106966690(PLCD1) 106970106(PLCD4) 106988142(PLCD3)
BTA: 281986(PLCD1) 513057(PLCD3) 540771(PLCD4)
BOM: 102269641(PLCD3) 102270277 102273490(PLCD4)
BBUB: 102394200(PLCD4) 102395019(PLCD3) 102397395(PLCD1)
CHX: 102169343(PLCD4) 102184479(PLCD1) 102190639(PLCD3)
OAS: 101110367(PLCD1) 101111344(PLCD4) 101118035(PLCD3)
SSC: 100521111(PLCD3) 100627099(PLCD1) 397119(PLCD4)
CFR: 102506571(PLCD3) 102507363(PLCD1) 102515536(PLCD4)
CDK: 105090726(PLCD1) 105094408(PLCD3) 105096083(PLCD4)
BACU: 103014054(PLCD1) 103014562(PLCD3) 103019165(PLCD4)
LVE: 103073047(PLCD1) 103080679(PLCD3) 103081712(PLCD4)
OOR: 101271088(PLCD3) 101279487(PLCD1) 101282608(PLCD4)
DLE: 111164251(PLCD1) 111170182(PLCD3) 111171832(PLCD4)
PCAD: 102975151(PLCD1) 102978526(PLCD4) 102988490(PLCD3)
ECB: 100054233(PLCD1) 100058665(PLCD4) 100064142(PLCD3)
EPZ: 103553904(PLCD1) 103554680(PLCD3) 103561954(PLCD4)
EAI: 106834270(PLCD1) 106836472(PLCD3) 106838452(PLCD4)
MYB: 102241313(PLCD3) 102252971(PLCD4) 102262661(PLCD1)
MYD: 102758829(PLCD4) 102760213(PLCD3) 102760355(PLCD1)
MNA: 107524330(PLCD1) 107524764(PLCD4) 107528831(PLCD3)
HAI: 109380562(PLCD4) 109385184(PLCD1) 109394976(PLCD3)
DRO: 112298878(PLCD3) 112307779(PLCD4) 112309785(PLCD1)
PALE: 102878454(PLCD1) 102884893(PLCD4) 102896686(PLCD3)
RAY: 107499598(PLCD1) 107508158(PLCD3) 107516722(PLCD4)
MJV: 108388410(PLCD1) 108390511(PLCD4) 108403685(PLCD3)
LAV: 100656701(PLCD3) 100660015(PLCD1) 100676480(PLCD4)
MDO: 100011291(PLCD4) 100024144(PLCD3)
SHR: 100916816(PLCD3) 100919591(PLCD4) 100933386(PLCD1)
PCW: 110192977(PLCD1) 110215698(PLCD3) 110219452(PLCD4)
OAA: 100083809(PLCD1) 103168316(PLCD4) 103169159(PLCD3)
GGA: 420416(PLCD1) 424214(PLCD4) 428279(PLCD3)
MGP: 100540750(PLCD4) 100542227(PLCD1) 100551436(PLCD3)
CJO: 107308792(PLCD1) 107316914(PLCD4) 107325007(PLCD3)
NMEL: 110388519(PLCD3) 110394675(PLCD1) 110400529(PLCD4)
APLA: 101796325(PLCD1) 101804382(PLCD4)
ACYG: 106036853(PLCD1) 106039320(PLCD4) 106046916(PLCD3)
TGU: 100224924(PLCD3) 100227504(PLCD4) 100229323(PLCD1)
LSR: 110468342(PLCD4) 110475601(PLCD3) 110484535(PLCD1)
SCAN: 103812698(PLCD1) 103814352(PLCD4) 103821776(PLCD3)
GFR: 102034984(PLCD4) 102040502(PLCD1) 102041993(PLCD3)
FAB: 101809831(PLCD3) 101816161(PLCD1) 101817537(PLCD4)
PHI: 102100115(PLCD4) 102100695(PLCD3) 102108822(PLCD1)
PMAJ: 107200537(PLCD1) 107207601(PLCD4) 107215288(PLCD3)
CCAE: 111925533(PLCD1) 111932186(PLCD4) 111940037(PLCD3)
CCW: 104686410(PLCD1) 104693970(PLCD4) 104698537(PLCD3)
ETL: 114055274(PLCD4) 114065141(PLCD1) 114071516(PLCD3)
FPG: 101911097(PLCD3) 101919734(PLCD1) 101920700(PLCD4)
FCH: 102049427(PLCD1) 102050720(PLCD3) 102054061(PLCD4)
CLV: 102083893(PLCD4) 102086985(PLCD1) 102096927(PLCD3)
EGZ: 104130960(PLCD1) 104132360(PLCD3) 104132408(PLCD4)
NNI: 104010071(PLCD4) 104018910(PLCD3) 104021751(PLCD1)
ACUN: 113476372(PLCD1) 113482391(PLCD4) 113489183(PLCD3)
PADL: 103917674(PLCD4) 103920631(PLCD3) 103924728(PLCD1)
AAM: 106494848(PLCD1) 106495647(PLCD3) 106499321
ASN: 102368121(PLCD1) 102387019(PLCD3)
AMJ: 102575027(PLCD3) 102576343(PLCD1)
PSS: 102455868(PLCD1) 102459349(PLCD4)
CMY: 102932314(PLCD1) 102935898(PLCD4) 102944425(PLCD3)
CPIC: 101933267(PLCD3) 101941573(PLCD1) 101944484(PLCD4)
ACS: 100552636(plcd4) 100559401(plcd3) 100567266(plcd1)
PVT: 110078238(PLCD4) 110081386(PLCD3) 110085836(PLCD1)
PBI: 103051665(PLCD4) 103053551(PLCD3) 103056024(PLCD1)
PMUR: 107284364(PLCD1) 107286281(PLCD3) 107291489(PLCD4)
TSR: 106546230(PLCD4) 106547864 106551134(PLCD3) 106555250(PLCD1)
PMUA: 114582375(PLCD3) 114603199(PLCD4) 114607475(PLCD1)
XLA: 108700851(plcd3.L) 108702553(plcd3.S) 108702938(plcd4.S) 108718712(plcd1.L) 108719811(plcd1.S) 735225(plcd4.L)
XTR: 100379715(plcd4) 100488677(plcd1) 100497993(plcd3)
NPR: 108784616(PLCD1) 108785980(PLCD3)
DRE: 337489(plcd1b) 555443(plcd1a) 562569(plcd3b) 565669(plcd4a) 569040(plcd3a)
TRU: 101062624(plcd1) 101066005 101076189(plcd3) 101077179(plcd4) 101078575
LCM: 102347797(PLCD1) 102348562(PLCD3) 102349822 102354402(PLCD4)
SPU: 100891267
APLC: 110990341
DPA: 109542350
ZNE: 110830423
PVM: 113808841
TUT: 107366993
DPTE: 113789841
CSCU: 111628530
PTEP: 107439279
CEL: CELE_R05G6.8(plc-4)
CBR: CBG05896(Cbr-plc-4)
PCAN: 112559861
CRG: 105342681
MYI: 110459893
OBI: 106880478
AMIL: 114959282
PDAM: 113669269
SPIS: 111340408
DGT: 114527324
HMG: 100198602
ATH: AT2G40116 AT3G08510(PLC2) AT3G55940 AT4G38530(PLC1) AT5G58670(PLC1) AT5G58690(PLC5) AT5G58700(PLC4)
LJA: Lj0g3v0130579.1(Lj0g3v0130579.1) Lj0g3v0130589.1(Lj0g3v0130589.1) Lj2g3v2256390.1(Lj2g3v2256390.1) Lj2g3v2256400.1(Lj2g3v2256400.1) Lj2g3v2747660.1(Lj2g3v2747660.1) Lj2g3v2747660.2(Lj2g3v2747660.2) Lj2g3v2748690.1(Lj2g3v2748690.1) Lj6g3v0521600.2(Lj6g3v0521600.2) Lj6g3v0521600.3(Lj6g3v0521600.3) Lj6g3v0521670.1(Lj6g3v0521670.1)
DOSA: Os03t0289300-00(Os03g0289300) Os05t0127200-01(Os05g0127200) Os07t0694000-01(Os07g0694000) Os12t0562400-00(Os12g0562400)
ATS: 109738024(LOC109738024) 109738751(LOC109738751) 109747792(LOC109747792) 109756963(LOC109756963) 109762675(LOC109762675) 109771034(LOC109771034)
SCE: YPL268W(PLC1)
ERC: Ecym_3005
KMX: KLMA_80017(plc1)
NCS: NCAS_0D02230(NCAS0D02230)
NDI: NDAI_0I02690(NDAI0I02690)
TPF: TPHA_0J00210(TPHA0J00210)
TBL: TBLA_0A07020(TBLA0A07020)
TDL: TDEL_0G04680(TDEL0G04680)
KAF: KAFR_0B06460(KAFR0B06460)
PIC: PICST_42966(PLC1)
CAL: CAALFM_C703710CA(PLC1)
CDU: CD36_73380(PLC1)
SLB: AWJ20_1237(PLC1)
NCR: NCU01266
NTE: NEUTE1DRAFT127609(NEUTE1DRAFT_127609)
MGR: MGG_02444
BFU: BCIN_05g02840(Bcplc1)
ANI: AN0664.2
ANG: ANI_1_884074(An08g06320)
ABE: ARB_06692
TVE: TRV_04036
SPO: SPAC22F8.11(plc1)
CNE: CNC04820
CNB: CNBC2360
ABP: AGABI1DRAFT129320(AGABI1DRAFT_129320) AGABI1DRAFT131468(AGABI1DRAFT_131468) AGABI1DRAFT72480(AGABI1DRAFT_72480)
ABV: AGABI2DRAFT120986(AGABI2DRAFT_120986) AGABI2DRAFT122377(AGABI2DRAFT_122377) AGABI2DRAFT212030(AGABI2DRAFT_212030)
MGL: MGL_2569
MRT: MRET_0520
DDI: DDB_G0292736(plc)
DFA: DFA_07345 DFA_07346(plc)
TAN: TA06965
TPV: TP01_0775
BBO: BBOV_IV011070(23.m06338)
CPV: cgd4_2560
SMIN: v1.2.010004.t1(symbB.v1.2.010004.t1) v1.2.033641.t1(symbB.v1.2.033641.t1)
SPAR: SPRG_04373
 » show all
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

KEGG   ORTHOLOGY: K05860
Entry
K05860                      KO                                     

Name
PLCE
Definition
phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
ko05205  Proteoglycans in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01657  Nephrotic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04015 Rap1 signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04020 Calcium signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04070 Phosphatidylinositol signaling system
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04024 cAMP signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 51196(PLCE1)
PTR: 450620(PLCE1)
PPS: 100992707(PLCE1)
GGO: 101125007(PLCE1)
PON: 100444145(PLCE1)
NLE: 100599747(PLCE1)
MCC: 701758(PLCE1)
MCF: 102142941(PLCE1)
CSAB: 103216291(PLCE1)
RRO: 104666130(PLCE1)
RBB: 108521233(PLCE1)
CJC: 100385383(PLCE1)
SBQ: 101043700(PLCE1)
MMU: 74055(Plce1)
MCAL: 110285551(Plce1)
MPAH: 110320362(Plce1)
RNO: 114633(Plce1)
CGE: 100754217(Plce1)
NGI: 103750131(Plce1)
HGL: 101706315(Plce1)
CCAN: 109681766(Plce1)
OCU: 100344504(PLCE1)
TUP: 102499439(PLCE1)
CFA: 486808(PLCE1)
VVP: 112913979(PLCE1)
AML: 100479318
UMR: 103667971(PLCE1)
UAH: 113243183(PLCE1)
ORO: 101367598(PLCE1)
ELK: 111144941
FCA: 101088695(PLCE1)
PTG: 102949488(PLCE1)
PPAD: 109264678
AJU: 106965849(PLCE1)
BTA: 519037(PLCE1)
BOM: 102268410(PLCE1)
BIU: 109553155(PLCE1)
BBUB: 102400189(PLCE1)
CHX: 102178972(PLCE1)
OAS: 101105703(PLCE1)
SSC: 100157745(PLCE1)
CFR: 102519191(PLCE1)
CDK: 105084245(PLCE1)
BACU: 103016185(PLCE1)
LVE: 103080930(PLCE1)
OOR: 101280643(PLCE1)
DLE: 111172471(PLCE1)
PCAD: 102989081
ECB: 100061676(PLCE1)
EPZ: 103559297(PLCE1)
EAI: 106846085
MYB: 102241624(PLCE1)
MYD: 102754476(PLCE1)
MNA: 107543248(PLCE1)
HAI: 109380957
DRO: 112307376(PLCE1)
PALE: 102898319(PLCE1)
RAY: 107520393(PLCE1)
MJV: 108393532(PLCE1)
LAV: 100677444(PLCE1)
TMU: 101349251
MDO: 100023487(PLCE1)
SHR: 100917022
PCW: 110192723(PLCE1)
OAA: 103169567(PLCE1)
GGA: 425224(PLCE1)
MGP: 100540174(PLCE1)
CJO: 107316035(PLCE1)
NMEL: 110399282(PLCE1)
APLA: 101794187(PLCE1)
ACYG: 106042534(PLCE1)
TGU: 100222852(PLCE1)
LSR: 110475436(PLCE1)
SCAN: 103814177(PLCE1)
GFR: 102031533(PLCE1)
FAB: 101810240(PLCE1)
PHI: 102113055(PLCE1)
PMAJ: 107206711(PLCE1)
CCAE: 111931184(PLCE1)
CCW: 104696321(PLCE1)
ETL: 114071591(PLCE1)
FPG: 101913673(PLCE1)
FCH: 102055055(PLCE1)
CLV: 102086659(PLCE1)
EGZ: 104129054(PLCE1)
NNI: 104013033(PLCE1)
ACUN: 113481439(PLCE1)
PADL: 103921343(PLCE1)
AAM: 106494113
ASN: 102373514(PLCE1)
AMJ: 102565045(PLCE1)
PSS: 102447740
CMY: 102943550(PLCE1)
CPIC: 101944378(PLCE1)
ACS: 100552081(plce1)
PVT: 110084128(PLCE1)
PBI: 103066924(PLCE1)
PMUR: 107293540(PLCE1)
PMUA: 114597322(PLCE1)
GJA: 107106488(PLCE1)
XTR: 100495530(plce1)
NPR: 108792005(PLCE1)
DRE: 568288(plce1)
SANH: 107653923 107664595(plce1)
CCAR: 109065353
IPU: 108273837(plce1)
PHYP: 113527060(plce1)
AMEX: 103036293(plce1)
EEE: 113584760(plce1)
TRU: 101065955(plce1)
LCO: 104932513(plce1)
NCC: 104963128(plce1)
MZE: 101480055(plce1)
ONL: 100711552(plce1)
OLA: 101164102(plce1)
XMA: 102228460(plce1)
XCO: 114152048(plce1)
PRET: 103481305(plce1)
CVG: 107085092(plce1)
NFU: 107387902(plce1)
KMR: 108249170(plce1)
ALIM: 106533025(plce1)
AOCE: 111585075(plce1)
CSEM: 103381430(plce1)
POV: 109627036(plce1)
LCF: 108898737(plce1)
SDU: 111219885(plce1)
SLAL: 111669649(plce1)
HCQ: 109523888(plce1)
BPEC: 110170982(plce1)
MALB: 109962903(plce1)
ELS: 105021417 105025138(plce1)
SFM: 108939627(plce1)
PKI: 111859557(plce1)
LCM: 102345110(PLCE1)
CMK: 103180693(plce1)
RTP: 109913650(plce1)
BFO: 118414021
SPU: 592193
APLC: 110977130
SKO: 102809018
AAG: 5570306
AME: 408804
BIM: 100744997
BTER: 100649725
CCAL: 108633016
OBB: 114874280
SOC: 105194827
MPHA: 105829082
AEC: 105151783
ACEP: 105627765
PBAR: 105425147
VEM: 105569386
HST: 105182316
DQU: 106741309
CFO: 105253013
LHU: 105673877
PGC: 109853979
OBO: 105281196
PCF: 106789771
NVI: 100116596
CSOL: 105361155
MDL: 103574729
TCA: 661312
DPA: 109536544
ATD: 109608601
NVL: 108556911
BMOR: 101735646
BMAN: 114246148
PMAC: 106714294
PRAP: 110996604
TNL: 113505537
API: 100168206
DNX: 107169403
AGS: 114119437
RMD: 113557079
BTAB: 109033369
CLEC: 112126115
ZNE: 110832898
PVM: 113816314
TUT: 107360575
DPTE: 113789238
PTEP: 107439832
CEL: CELE_F31B12.1(plc-1)
CBR: CBG17587(Cbr-plc-1)
BMY: Bm1_40160
TSP: Tsp_05005
PCAN: 112565388
CRG: 105331084
MYI: 110449213
OBI: 106874430
LAK: 106171793
 » show all
Reference
  Authors
Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T
  Title
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.
  Journal
J Biol Chem 276:2752-7 (2001)
DOI:10.1074/jbc.M008324200
  Sequence
[hsa:51196]
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

KEGG   ORTHOLOGY: K01116
Entry
K01116                      KO                                     

Name
PLCG1
Definition
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05135  Yersinia infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04072 Phospholipase D signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04658 Th1 and Th2 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04659 Th17 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04062 Chemokine signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09158 Development and regeneration
   04360 Axon guidance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05231 Choline metabolism in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05022 Pathways of neurodegeneration - multiple diseases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05131 Shigellosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05135 Yersinia infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5335(PLCG1)
PTR: 458253(PLCG1)
PPS: 100995010(PLCG1)
GGO: 101135199(PLCG1)
PON: 100450941(PLCG1)
NLE: 100591458(PLCG1)
MCC: 697069(PLCG1)
MCF: 102138726(PLCG1)
CSAB: 103245987(PLCG1)
RRO: 104672220(PLCG1)
RBB: 108519825(PLCG1)
CJC: 100397497(PLCG1)
SBQ: 101046976(PLCG1)
MMU: 18803(Plcg1)
MCAL: 110290454(Plcg1)
MPAH: 110319649(Plcg1)
RNO: 25738(Plcg1)
MUN: 110552794(Plcg1)
CGE: 100769697(Plcg1)
NGI: 103747244(Plcg1)
HGL: 101705192(Plcg1)
CCAN: 109683399(Plcg1)
OCU: 100349958(PLCG1)
TUP: 102469651(PLCG1)
CFA: 485874(PLCG1)
VVP: 112928123(PLCG1)
AML: 100480586(PLCG1)
UMR: 103669754(PLCG1)
UAH: 113258609(PLCG1)
ORO: 101380728(PLCG1)
ELK: 111141423
FCA: 101092925(PLCG1)
PTG: 102952137(PLCG1)
PPAD: 109272437(PLCG1)
AJU: 106974495(PLCG1)
BTA: 281987(PLCG1)
BOM: 102265099(PLCG1)
BIU: 109567698(PLCG1)
BBUB: 102400354(PLCG1)
CHX: 102181878(PLCG1)
OAS: 101103341(PLCG1)
SSC: 100152497(PLCG1)
CFR: 102524452(PLCG1)
CDK: 105085024(PLCG1)
BACU: 103016663(PLCG1)
LVE: 103068930(PLCG1)
OOR: 101281412(PLCG1)
DLE: 111184170(PLCG1)
PCAD: 102992700(PLCG1)
ECB: 100070545(PLCG1)
EPZ: 103562208(PLCG1)
EAI: 106834358(PLCG1)
MYB: 102248243(PLCG1)
MYD: 102756475(PLCG1)
MNA: 107542131(PLCG1)
HAI: 109379925(PLCG1)
DRO: 112303845(PLCG1)
PALE: 102896228(PLCG1)
RAY: 107506741(PLCG1)
MJV: 108407248(PLCG1)
LAV: 100677739(PLCG1)
TMU: 101359597
MDO: 100032696(PLCG1)
SHR: 100923119(PLCG1)
PCW: 110216705(PLCG1)
OAA: 100078757(PLCG1)
GGA: 419175(PLCG1) 776273
MGP: 100542272 100548670(PLCG1)
CJO: 107310620 107322901(PLCG1)
NMEL: 110393955 110408143(PLCG1)
APLA: 101792010 101798692(PLCG1)
ACYG: 106042207 106043486(PLCG1)
TGU: 100220070(PLCG1) 115494036
LSR: 110469274(PLCG1) 110475168
SCAN: 103818789(PLCG1) 103826392
GFR: 102032882(PLCG1) 102038983
FAB: 101806517(PLCG1) 101820005
PHI: 102100949 102114427(PLCG1)
PMAJ: 107200506 107213300(PLCG1)
CCAE: 111925206 111938259(PLCG1)
CCW: 104687887(PLCG1) 104692596
FPG: 101912447(PLCG1) 101918282
FCH: 102046961 102057302(PLCG1)
CLV: 102098341(PLCG1) 102098590
EGZ: 104128859 104132170(PLCG1)
NNI: 104009589(PLCG1) 104020599
ACUN: 113477170 113487655(PLCG1)
PADL: 103912439(PLCG1) 103925979
AAM: 106488145(PLCG1) 106494802
ASN: 102368895 102369875(PLCG1)
AMJ: 102563626(PLCG1) 102574067
PSS: 102459944(PLCG1) 102461099
CMY: 102944142(PLCG1) 102946940
CPIC: 101930905 101935550(PLCG1)
ACS: 100559347(plcg1) 100566976
PVT: 110070157 110076765(PLCG1)
PBI: 103062888 103064933(PLCG1)
PMUR: 107287257(PLCG1) 107298984
TSR: 106549424(PLCG1)
PMUA: 114599554(PLCG1) 114600186
GJA: 107109685(PLCG1) 107121439
XLA: 108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR: 100496658 100496674(plcg1)
NPR: 108786812(PLCG1) 108789042
DRE: 373867(plcg1)
SANH: 107663201(plcg1) 107703619
CCAR: 109066470 109071906(plcg1)
IPU: 108275796(plcg1)
PHYP: 113545570(plcg1)
AMEX: 103023099(plcg1)
EEE: 113588884(plcg1)
TRU: 101065481 101069039(plcg1)
LCO: 104925092(plcg1) 104927718
NCC: 104954784 104964925(plcg1)
MZE: 101470576(plcg1) 101473405
ONL: 100704581(plcg1) 100711065
OLA: 101163005(plcg1) 101167946
XMA: 102217766(plcg1) 102229810
XCO: 114146805(plcg1) 114151085
PRET: 103463411 103467475(plcg1)
CVG: 107083024 107087598(plcg1)
NFU: 107391021(plcg1) 107393039
KMR: 108235263(plcg1) 108248356
ALIM: 106523657(plcg1) 106526007
AOCE: 111576272(plcg1) 111582127
CSEM: 103385539(plcg1) 103399890
LCF: 108877896(plcg1) 108879537
SDU: 111219324(plcg1) 111227542
SLAL: 111668916(plcg1) 111671648
HCQ: 109514977(plcg1) 109524567
BPEC: 110164633(plcg1) 110172233
MALB: 109961232 109964670(plcg1)
SASA: 106560399 106566556(plcg1)
OTW: 112222319(plcg1)
SALP: 111975516 111976591(plcg1)
ELS: 105011953 105013964(plcg1)
LCM: 102352804 102362442(PLCG1)
CMK: 103186275(plcg1)
RTP: 109912305 109939029(plcg1)
BFO: 118417806
CIN: 100178711
APLC: 110980002
SKO: 100377901
DME: Dmel_CG4200(sl)
DER: 6550553
DSE: 116801966
DSI: Dsimw501_GD17281(Dsim_GD17281)
DAN: 6501908
DSR: 110181712
DPO: Dpse_GA18024(Dpse_small-wing)
DPE: 6599358
DMN: 108156056
DWI: 6648777
DAZ: 108617824
DNV: 108655465
DHE: 111594077
DVI: 6631556
MDE: 101900328
LCQ: 111684567
AAG: 5564766
AME: 551709
BIM: 100748682
BTER: 100647687
CCAL: 108629199
OBB: 114871263
SOC: 105196430
MPHA: 105833149
AEC: 105144421
ACEP: 105624086
PBAR: 105431231
VEM: 105560673
HST: 105188458
DQU: 106743174
CFO: 105257806
LHU: 105673001
PGC: 109852947
OBO: 105286217
PCF: 106786441
NVI: 100123217
CSOL: 105368048
MDL: 103577678
TCA: 660210
DPA: 109537047
ATD: 109597552
NVL: 108561344
BMOR: 100329155(PLCg)
BMAN: 114250026
PMAC: 106717301
PRAP: 110998146
HAW: 110374501
TNL: 113505041
PXY: 105381166
API: 100166969
DNX: 107163682
AGS: 114120080
RMD: 113553363
BTAB: 109035929
CLEC: 106662403
ZNE: 110834677
FCD: 110851828
PVM: 113828575
TUT: 107359684
CSCU: 111628132
PTEP: 107452539
CEL: CELE_T01E8.3(plc-3)
CBR: CBG18715(Cbr-plc-3)
BMY: Bm1_42205
TSP: Tsp_10563
CRG: 105340725
MYI: 110450840
OBI: 106874041
LAK: 106152397
EPA: 110244579
ADF: 107357605
AMIL: 114966528
PDAM: 113679030
SPIS: 111332971
HMG: 100212273
AQU: 100633163
 » show all
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671
Reference
PMID:2167438
  Authors
Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M
  Title
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
  Journal
Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770
  Sequence
[hsa:5335]
LinkDB

KEGG   ORTHOLOGY: K05859
Entry
K05859                      KO                                     

Name
PLCG2
Definition
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04020  Calcium signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04611  Platelet activation
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01743  Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04625 C-type lectin receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04062 Chemokine signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09158 Development and regeneration
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05131 Shigellosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5336(PLCG2)
PTR: 454268(PLCG2)
PPS: 100984694(PLCG2)
GGO: 101133643(PLCG2)
PON: 100457650(PLCG2)
NLE: 100604145(PLCG2)
MCC: 714173(PLCG2)
MCF: 102117471(PLCG2)
CSAB: 103233371(PLCG2)
RRO: 104671624(PLCG2)
RBB: 108539491(PLCG2)
CJC: 100390347(PLCG2)
SBQ: 101030999(PLCG2)
MMU: 234779(Plcg2)
MCAL: 110300336(Plcg2)
MPAH: 110337392(Plcg2)
RNO: 29337(Plcg2)
MUN: 110550263(Plcg2)
CGE: 100752475(Plcg2)
HGL: 101715321(Plcg2)
CCAN: 109696649(Plcg2)
OCU: 100340139(PLCG2)
TUP: 102483786(PLCG2)
CFA: 489692(PLCG2)
AML: 100481994(PLCG2)
UMR: 103662093(PLCG2)
UAH: 113252535(PLCG2)
ORO: 101378505(PLCG2)
ELK: 111152978
FCA: 101080675(PLCG2)
PTG: 102963653(PLCG2)
PPAD: 109245637(PLCG2)
AJU: 106984018(PLCG2)
BTA: 100337091(PLCG2)
BOM: 102285300(PLCG2)
BIU: 109572707(PLCG2)
BBUB: 102396307(PLCG2)
CHX: 102180337(PLCG2)
OAS: 101122126(PLCG2)
SSC: 100518663(PLCG2)
CFR: 102514470(PLCG2)
CDK: 105089440(PLCG2)
BACU: 103014764(PLCG2)
LVE: 103070997(PLCG2)
OOR: 101285216(PLCG2)
DLE: 111179463(PLCG2)
PCAD: 102983230(PLCG2)
ECB: 100055670(PLCG2)
EPZ: 103558212(PLCG2)
EAI: 106832855(PLCG2)
MYB: 102261553(PLCG2)
MYD: 102773476(PLCG2)
MNA: 107524904(PLCG2)
HAI: 109378365(PLCG2)
DRO: 112300725(PLCG2)
PALE: 102883128(PLCG2)
RAY: 107521319(PLCG2)
MJV: 108400464(PLCG2)
LAV: 100658990(PLCG2)
TMU: 101346393
MDO: 100027579(PLCG2)
SHR: 100919206(PLCG2)
PCW: 110212621(PLCG2)
OAA: 100076776(PLCG2)
GGA: 415805(PLCG2)
MGP: 100549684(PLCG2)
CJO: 107319403(PLCG2)
NMEL: 110404260(PLCG2)
APLA: 101799246(PLCG2)
ACYG: 106044837
TGU: 100219388(PLCG2)
LSR: 110476350(PLCG2)
SCAN: 103816730(PLCG2)
GFR: 102039725(PLCG2)
FAB: 101811465(PLCG2)
PHI: 102103443(PLCG2)
PMAJ: 107209788(PLCG2)
CCAE: 111934454(PLCG2)
CCW: 104691823(PLCG2)
ETL: 114066562(PLCG2)
FPG: 101914329(PLCG2)
FCH: 102058636(PLCG2)
CLV: 102095823(PLCG2)
EGZ: 104133768(PLCG2)
NNI: 104014569(PLCG2)
ACUN: 113484485(PLCG2)
PADL: 103923865(PLCG2)
AAM: 106483269(PLCG2)
ASN: 102378303(PLCG2)
AMJ: 106736910(PLCG2)
PSS: 102454220(PLCG2)
CMY: 102930635(PLCG2)
CPIC: 101932685(PLCG2)
ACS: 100566814(plcg2)
PVT: 110085508(PLCG2)
PBI: 103052396(PLCG2)
PMUR: 107292601(PLCG2)
TSR: 106539149(PLCG2)
PMUA: 114601931(PLCG2)
GJA: 107105783(PLCG2)
XLA: 108714087(plcg2.L)
XTR: 100496686(plcg2)
NPR: 108786572(PLCG2)
DRE: 561747(plcg2)
IPU: 108264222(plcg2)
PHYP: 113534527(plcg2)
AMEX: 103036277(plcg2)
EEE: 113577174(plcg2)
TRU: 101072923(plcg2)
LCO: 104932460(plcg2)
MZE: 101479429(plcg2)
ONL: 100697485(plcg2)
OLA: 101157053(plcg2)
XMA: 102220131(plcg2)
XCO: 114137117(plcg2)
PRET: 103466833(plcg2)
CVG: 107084318(plcg2)
NFU: 107389305(plcg2)
KMR: 108237447(plcg2)
ALIM: 106536649(plcg2)
AOCE: 111563111(plcg2)
CSEM: 103379748(plcg2)
POV: 109641214(plcg2)
LCF: 108902239(plcg2)
SDU: 111229657(plcg2)
SLAL: 111647676(plcg2)
HCQ: 109513068(plcg2)
BPEC: 110169397(plcg2)
MALB: 109967271(plcg2)
SASA: 106573684(plcg2)
OTW: 112252303(plcg2)
SALP: 111952198(plcg2)
ELS: 105018577(plcg2)
SFM: 108926548 108926652(plcg2)
PKI: 111851875(plcg2)
LCM: 102358132(PLCG2)
CMK: 103175953(plcg2)
RTP: 109928136
API: 100161327
 » show all
Reference
PMID:2849563
  Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
  Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
  Journal
FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7
  Sequence
[hsa:5336]
Reference
  Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
  Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
  Journal
PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842
LinkDB

KEGG   ORTHOLOGY: K05861
Entry
K05861                      KO                                     

Name
PLCZ
Definition
phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04020  Calcium signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04114  Oocyte meiosis
ko04919  Thyroid hormone signaling pathway
ko05131  Shigellosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01282  Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
   04070 Phosphatidylinositol signaling system
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 89869(PLCZ1)
PTR: 743002(PLCZ1)
PPS: 100988020(PLCZ1)
GGO: 101151875(PLCZ1)
PON: 100442086(PLCZ1)
NLE: 100580724(PLCZ1)
MCC: 703293(PLCZ1)
MCF: 102122753(PLCZ1)
CSAB: 103218714(PLCZ1)
RRO: 104655304(PLCZ1)
RBB: 108539721(PLCZ1)
CJC: 100406733(PLCZ1)
SBQ: 101050254(PLCZ1)
MMU: 114875(Plcz1)
MCAL: 110296889(Plcz1)
MPAH: 110317052(Plcz1)
RNO: 497197(Plcz1)
MUN: 110555434(Plcz1)
CGE: 100754031(Plcz1)
NGI: 103733964(Plcz1)
HGL: 101709944(Plcz1)
CCAN: 109701042(Plcz1)
OCU: 100359131(PLCZ1)
TUP: 102481589(PLCZ1)
CFA: 486657(PLCZ1)
VVP: 112917544(PLCZ1)
AML: 100471118(PLCZ1)
UMR: 103677800(PLCZ1)
UAH: 113257833(PLCZ1)
ORO: 101377048(PLCZ1)
ELK: 111142271
FCA: 101085554(PLCZ1)
PTG: 102968210(PLCZ1)
PPAD: 109268558(PLCZ1)
AJU: 106977172(PLCZ1)
BTA: 497026(PLCZ1)
BOM: 102274303(PLCZ1)
BIU: 109558802(PLCZ1)
BBUB: 102403754(PLCZ1)
CHX: 102170761(PLCZ1)
OAS: 101122850(PLCZ1)
SSC: 397632(PLCZ1)
CFR: 102506863(PLCZ1)
CDK: 105096497(PLCZ1)
BACU: 102999522(PLCZ1)
LVE: 103075635(PLCZ1)
OOR: 101270450(PLCZ1)
DLE: 111176817(PLCZ1)
PCAD: 102987010(PLCZ1)
ECB: 100067798(PLCZ1) 111767502
EPZ: 103555928(PLCZ1)
EAI: 106824736(PLCZ1)
MYB: 102261189(PLCZ1)
MYD: 102752787(PLCZ1)
MNA: 107525326(PLCZ1)
HAI: 109371226(PLCZ1)
DRO: 112318678(PLCZ1)
PALE: 102887168(PLCZ1)
RAY: 107499675(PLCZ1)
MJV: 108384333(PLCZ1)
LAV: 100663854(PLCZ1)
TMU: 101342467
MDO: 100012056(PLCZ1)
SHR: 116419277(PLCZ1)
PCW: 110213825(PLCZ1)
OAA: 103167538(PLCZ1)
GGA: 418182(PLCZ1)
MGP: 100549451
CJO: 107316456(PLCZ1)
NMEL: 110395900(PLCZ1)
APLA: 101801909(PLCZ1)
ACYG: 106030891(PLCZ1)
TGU: 100229724(PLCZ1)
LSR: 110472993(PLCZ1)
SCAN: 103820488(PLCZ1)
GFR: 102035295(PLCZ1)
FAB: 101810163(PLCZ1)
PHI: 102108407(PLCZ1)
CCAE: 111928307(PLCZ1)
CCW: 104692298(PLCZ1)
ETL: 114068823(PLCZ1)
FPG: 101924543(PLCZ1)
FCH: 102059240(PLCZ1)
CLV: 102083512(PLCZ1)
EGZ: 104135118(PLCZ1)
NNI: 104017952(PLCZ1)
ACUN: 113491128(PLCZ1)
PADL: 103924343(PLCZ1)
AAM: 106488477(PLCZ1)
ASN: 102382411(PLCZ1)
AMJ: 102576997(PLCZ1)
PSS: 102463553(PLCZ1)
CMY: 102941985(PLCZ1)
CPIC: 101931350(PLCZ1)
TSR: 106540722(PLCZ1)
GJA: 107109019(PLCZ1) 107121264
NPR: 108791809(PLCZ1)
NCC: 104942417
OLA: 101167285
XMA: 102221186
XCO: 114159779
PRET: 103466390(plcz1)
CVG: 107092730
KMR: 108229959
ALIM: 106523397
AOCE: 111573644
SDU: 111229863
HCQ: 109507629
BPEC: 110169443(plcz1)
MALB: 109974502
SASA: 106561743
OTW: 112220510
LCM: 102347584
CMK: 103185584(plcz1)
RTP: 109931132
 » show all
Reference
  Authors
Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA
  Title
Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.
  Journal
Reproduction 124:611-23 (2002)
DOI:10.1530/rep.0.1240611
  Sequence
[hsa:89869]
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

DBGET integrated database retrieval system