KEGG   ORTHOLOGY: K05858
Entry
K05858                      KO                                     

Name
PLCB
Definition
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04310  Wnt signaling pathway
ko04361  Axon regeneration
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04621  NOD-like receptor signaling pathway
ko04713  Circadian entrainment
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04742  Taste transduction
ko04745  Phototransduction - fly
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04922  Glucagon signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04929  GnRH secretion
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04961  Endocrine and other factor-regulated calcium reabsorption
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
ko05142  Chagas disease
ko05143  African trypanosomiasis
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00606  Early infantile epileptic encephalopathy
H01815  Malignant migrating partial seizures in infancy
H01884  Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04310 Wnt signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04371 Apelin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04020 Calcium signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04070 Phosphatidylinositol signaling system
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04072 Phospholipase D signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04071 Sphingolipid signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04022 cGMP-PKG signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04621 NOD-like receptor signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04062 Chemokine signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09152 Endocrine system
   04911 Insulin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04922 Glucagon signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04929 GnRH secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04912 GnRH signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04915 Estrogen signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04921 Oxytocin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04926 Relaxin signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04935 Growth hormone synthesis, secretion and action
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04918 Thyroid hormone synthesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04919 Thyroid hormone signaling pathway
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04928 Parathyroid hormone synthesis, secretion and action
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04916 Melanogenesis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04924 Renin secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04925 Aldosterone synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04927 Cortisol synthesis and secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04270 Vascular smooth muscle contraction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09154 Digestive system
   04970 Salivary secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04971 Gastric acid secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04972 Pancreatic secretion
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04973 Carbohydrate digestion and absorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09156 Nervous system
   04724 Glutamatergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04725 Cholinergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04728 Dopaminergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04726 Serotonergic synapse
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04720 Long-term potentiation
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04730 Long-term depression
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04723 Retrograde endocannabinoid signaling
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09157 Sensory system
   04745 Phototransduction - fly
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04742 Taste transduction
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04750 Inflammatory mediator regulation of TRP channels
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09158 Development and regeneration
   04361 Axon regeneration
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09159 Environmental adaptation
   04713 Circadian entrainment
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05016 Huntington disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05017 Spinocerebellar ataxia
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05022 Pathways of neurodegeneration - multiple diseases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   04934 Cushing syndrome
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05142 Chagas disease
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
   05143 African trypanosomiasis
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05858  PLCB; phosphatidylinositol phospholipase C, beta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05858  PLCB; phosphatidylinositol phospholipase C, beta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
PTR: 451290(PLCB3) 453330(PLCB2) 458093(PLCB4) 469875(PLCB1)
PPS: 100969344(PLCB2) 100969660(PLCB1) 100978643(PLCB4) 100987524(PLCB3)
GGO: 101129357(PLCB3) 101140350(PLCB2) 101153613(PLCB1) 101154323(PLCB4)
PON: 100434502(PLCB1) 100458716(PLCB2) 100460060(PLCB3) 100461961(PLCB4)
NLE: 100597115(PLCB1) 100600507(PLCB4) 100600865(PLCB3) 100606558(PLCB2)
MCC: 701951(PLCB2) 717764(PLCB3) 718387(PLCB1) 718418(PLCB4)
MCF: 101925220(PLCB4) 102123165(PLCB3) 102136896(PLCB2) 102140615(PLCB1)
CSAB: 103233299(PLCB3) 103245842(PLCB2) 103246591(PLCB4) 103246657(PLCB1)
RRO: 104655777(PLCB4) 104659669(PLCB2) 104668296(PLCB1) 104673127(PLCB3)
RBB: 108526885(PLCB2) 108527553(PLCB1) 108527564(PLCB4) 108542252(PLCB3)
CJC: 100386921(PLCB2) 100400803(PLCB3) 100409716(PLCB1) 100410075(PLCB4)
SBQ: 101029401(PLCB3) 101046851(PLCB4) 101047168(PLCB1) 101052271(PLCB2)
MMU: 18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
MCAL: 110285320(Plcb3) 110286326(Plcb2) 110290514(Plcb4) 110308867(Plcb1)
MPAH: 110317815(Plcb4) 110318415(Plcb2) 110319646(Plcb1) 110336671(Plcb3)
RNO: 24654(Plcb1) 25031(Plcb4) 29322(Plcb3) 85240(Plcb2)
MUN: 110550598(Plcb2) 110551595(Plcb3) 110555720(Plcb1) 110563159
CGE: 100751979(Plcb1) 100760134(Plcb3) 100760731(Plcb2) 100770957(Plcb4)
NGI: 103735195(Plcb1) 103738797(Plcb3) 103741502(Plcb2)
HGL: 101696454(Plcb4) 101697744(Plcb3) 101708380(Plcb2) 101725860(Plcb1)
CCAN: 109683285(Plcb3) 109684223(Plcb1) 109701244(Plcb2)
OCU: 100341512(PLCB1) 100348672(PLCB2) 100350395(PLCB4)
TUP: 102472532(PLCB3) 102476196(PLCB4) 102477438(PLCB1) 102492903(PLCB2)
CFA: 100856190(PLCB2) 476034(PLCB3) 477160(PLCB4) 485773(PLCB1)
VVP: 112919942(PLCB2) 112924037(PLCB3) 112930053(PLCB4) 112930054(PLCB1)
AML: 100465232(PLCB3) 100474779(PLCB2) 100480603(PLCB4) 100481755(PLCB1)
UMR: 103673552(PLCB2) 103674425(PLCB1) 103674426(PLCB4) 103679549(PLCB3)
UAH: 113242038(PLCB2) 113244175(PLCB3) 113258243(PLCB1) 113258346(PLCB4)
ORO: 101375710(PLCB3) 101379806(PLCB2) 101386162(PLCB4) 101386750(PLCB1)
FCA: 101090005(PLCB4) 101090942(PLCB2) 101092262(PLCB1) 101092961(PLCB3)
PTG: 102959485(PLCB2) 102960646(PLCB4) 102961121(PLCB1) 102961437(PLCB3)
PPAD: 109246661(PLCB3) 109263166(PLCB2) 109274721(PLCB4) 109274722(PLCB1)
AJU: 106968579(PLCB2) 106976431(PLCB4) 106976432(PLCB1) 106981698(PLCB3)
BTA: 281985(PLCB4) 287026(PLCB1) 508888(PLCB2) 515669(PLCB3)
BOM: 102264989(PLCB4) 102273347(PLCB1) 102276260(PLCB3) 102278948(PLCB2)
BIU: 109554384(PLCB3) 109564927(PLCB2) 109567852(PLCB1) 109567854(PLCB4)
BBUB: 102389945(PLCB2) 102405830(PLCB1) 102412320(PLCB4) 102413748(PLCB3)
CHX: 102169966(PLCB2) 102180505(PLCB4) 102188148(PLCB1) 102189653(PLCB3)
OAS: 101103585(PLCB1) 101106864(PLCB4) 101113074(PLCB2) 101116105(PLCB3)
SSC: 100152679(PLCB1) 100157641(PLCB2) 100516581(PLCB4) 100525148(PLCB3)
CFR: 102505338(PLCB3) 102509058(PLCB2) 102513431(PLCB4) 102513996(PLCB1)
CDK: 105096910(PLCB2) 105101292(PLCB1) 105101500(PLCB4) 105101545(PLCB3)
BACU: 102997432(PLCB4) 103006361(PLCB3) 103007077(PLCB2) 103020805(PLCB1)
LVE: 103078639(PLCB4) 103079287(PLCB1) 103083884(PLCB3) 103086280(PLCB2)
OOR: 101270548(PLCB1) 101270961(PLCB4) 101274558(PLCB3) 101281417(PLCB2)
DLE: 111165617(PLCB4) 111165653(PLCB1) 111181753(PLCB2) 111183812(PLCB3)
PCAD: 102974165(PLCB3) 102983015(PLCB1) 102985636(PLCB2) 102995357(PLCB4)
ECB: 100051485(PLCB4) 100051558(PLCB1) 100055407(PLCB3) 100057315(PLCB2)
EPZ: 103542193(PLCB3) 103559733(PLCB4) 103561633(PLCB2) 103562440(PLCB1)
EAI: 106823182(PLCB4) 106823191(PLCB1) 106833627(PLCB3) 106835172(PLCB2)
MYB: 102238655(PLCB3) 102240650(PLCB1) 102241255(PLCB4) 102254054(PLCB2)
MYD: 102751685(PLCB1) 102751959(PLCB4) 102755123(PLCB3) 102760520(PLCB2)
MNA: 107536366(PLCB4) 107536369(PLCB1) 107539797(PLCB3) 107542967(PLCB2)
HAI: 109378976(PLCB4) 109378977(PLCB1) 109383976(PLCB2) 109384329(PLCB3)
DRO: 112304122(PLCB4) 112304255(PLCB1) 112311437(PLCB2) 112317151(PLCB3)
PALE: 102879238(PLCB3) 102885207(PLCB4) 102885781(PLCB1) 102885953(PLCB2)
RAY: 107497081(PLCB3) 107506114(PLCB1) 107514464(PLCB2) 107519930(PLCB4)
MJV: 108394257(PLCB1) 108394259(PLCB4) 108401653(PLCB2) 108407569(PLCB3)
LAV: 100663829(PLCB3) 100668575(PLCB2) 100670617(PLCB4) 100672435(PLCB1)
MDO: 100031263(PLCB3) 100031660(PLCB1) 100031869(PLCB2) 100033281(PLCB4)
SHR: 100922938(PLCB3) 100929015(PLCB2) 100934049(PLCB4) 100934311(PLCB1)
PCW: 110195440(PLCB3) 110207938(PLCB1) 110207974(PLCB4) 110223673(PLCB2)
OAA: 100078508(PLCB1) 100081349(PLCB3) 100084272(PLCB4) 100086536(PLCB2)
GGA: 416730(PLCB4) 423014(PLCB2) 427687(PLCB1)
CJO: 107307599 107310934(PLCB4) 107310953(PLCB1) 107314230(PLCB2)
NMEL: 110395536(PLCB4) 110396662(PLCB1) 110401183(PLCB2)
APLA: 101790966(PLCB1) 101804447(PLCB2) 101805172(PLCB4)
ACYG: 106036606(PLCB4) 106036632(PLCB1) 106047056(PLCB2)
TGU: 100219122(PLCB1) 100221959(PLCB4) 100229635(PLCB2)
LSR: 110475845(PLCB4) 110475847(PLCB1) 110484995(PLCB2)
SCAN: 103819233(PLCB4) 103819309(PLCB1) 103822183(PLCB2)
GFR: 102031336(PLCB4) 102037268(PLCB1) 102045029(PLCB2)
FAB: 101806047(PLCB2) 101812094(PLCB4) 101816169(PLCB1)
PHI: 102100609(PLCB4) 102105081(PLCB2) 102113003(PLCB1)
PMAJ: 107201330(PLCB1) 107201331(PLCB4) 107205812(PLCB2)
CCAE: 111926455(PLCB1) 111926460(PLCB4) 111930495(PLCB2)
CCW: 104691519(PLCB1) 104691520(PLCB4) 104692980(PLCB2)
ETL: 114057366(PLCB4) 114065074(PLCB1) 114067935(PLCB2)
FPG: 101912415(PLCB2) 101916711(PLCB4) 101922366(PLCB1)
FCH: 102048018(PLCB2) 102048448(PLCB1) 102054421(PLCB4)
CLV: 102096635(PLCB2) 102097554(PLCB4) 102098150(PLCB1)
EGZ: 104131359(PLCB2) 104132995(PLCB4) 104133001(PLCB1)
NNI: 104020525(PLCB2) 104022433(PLCB4) 104022482(PLCB1)
ACUN: 113477996(PLCB1) 113478160(PLCB4) 113481004(PLCB2)
PADL: 103913124(PLCB4) 103913125(PLCB1) 103924964(PLCB2)
AAM: 106486714(PLCB2) 106490470(PLCB4) 106490480(PLCB1)
ASN: 102371353(PLCB3) 102379390(PLCB4) 102381048(PLCB2) 102381939(PLCB1)
AMJ: 102560430(PLCB4) 102566880(PLCB1) 102572359(PLCB2) 102576994(PLCB3)
PSS: 102449462(PLCB3) 102455767(PLCB4) 102460883(PLCB1) 102461092(PLCB2)
CMY: 102931046(PLCB2) 102932254(PLCB3) 102942020(PLCB1) 102942246(PLCB4)
CPIC: 101930785(PLCB2) 101931546(PLCB4) 101932753(PLCB1) 101940400(PLCB3)
ACS: 100551754(plcb2) 100560758(plcb4) 100566853(plcb1) 100567752(plcb3)
PVT: 110080121(PLCB2) 110083359(PLCB3) 110087369 110087370(PLCB1)
PBI: 103055449(PLCB2) 103057663(PLCB4) 103062216(PLCB1) 103064298(PLCB3) 103066383
PMUR: 107285365(PLCB1) 107285366(PLCB4) 107286221 107290817 107299064(PLCB3)
PMUA: 114586167(PLCB3) 114593658(PLCB1) 114593659(PLCB4) 114593800(PLCB2)
GJA: 107106753(PLCB1) 107115177(PLCB3) 107119642(PLCB2) 107123894(PLCB4)
XLA: 108699254(plcb2.L) 108716399(plcb4.L) 108716400 397692(plcb3.L) 445848(plcb4.S) 733258(plcb1.S)
XTR: 100125098(plcb4) 100487267(plcb3) 101734935(plcb2) 780394(plcb1)
NPR: 108789286(PLCB2) 108793965(PLCB3) 108795338(PLCB4) 108795563(PLCB1)
DRE: 100001532(plcb3) 100149080 100537538 407700(plcb4) 569376(plcb2)
IPU: 108258041(PLCB4) 108258091(PLCB1) 108267602(PLCB3) 108269611(plcb2) 108270307(plcb1) 108270308
LCO: 104919801(plcb4) 104920858(plcb1) 104924817(plcb2) 104928901(plcb3) 104935685
NCC: 104946378(plcb4) 104947200(plcb2) 104948204(plcb3) 104951799(plcb1)
MZE: 101464832(plcb4) 101465812(plcb1) 101474135(plcb3) 101475994(plcb2) 101478971
ONL: 100689896 100698389(plcb1) 100706492(plcb3) 100706628(plcb4) 100706825(plcb2)
OLA: 100049465(plcb2) 100049529 100049535(plcb4) 101172698(plcb1) 101175365
XMA: 102217878 102219479 102223820(plcb4) 102224078(plcb1) 102230660(plcb2)
XCO: 114133784(plcb2) 114138347 114157441 114158603(plcb1) 114158604(plcb4)
PRET: 103457872(plcb1) 103457873(plcb4) 103458561(plcb2) 103476610 103480743(plcb3)
CVG: 107084147(plcb3) 107094391(plcb2) 107097625(plcb4) 107097779(plcb1) 107098647
NFU: 107376107 107377124(plcb3) 107378065(plcb4) 107378111(plcb1) 107392485(plcb2)
ALIM: 106518551(plcb4) 106518553(plcb1) 106519799(plcb2) 106524973(plcb3) 106529251
CSEM: 103381058(plcb1) 103381059(plcb4) 103385127(plcb3) 103387749 103389807(plcb2)
LCF: 108872939 108892548(plcb2) 108893282 108896906(plcb4) 108896922(plcb1)
SDU: 111225989(plcb2) 111227394 111231312(plcb3) 111240392(plcb1) 111240424(plcb4)
SLAL: 111644585 111652449(plcb2) 111653469(plcb3) 111672675(plcb1) 111672676(plcb4)
MALB: 109961174 109962200(plcb4) 109962203(plcb1) 109965817(plcb3) 109968365(plcb2)
ELS: 105007096(plcb3) 105015712(plcb2) 105017520(plcb1) 105017521(plcb4) 105031658
SFM: 108919358(plcb2) 108922946 108925497(plcb3) 108929291 108929356(plcb4)
PKI: 111834703(plcb3) 111837852 111837866(plcb4) 111838879(plcb2) 111857883
LCM: 102345855(PLCB1) 102348275(PLCB4) 102362364(PLCB2) 102365542(PLCB3)
CMK: 103171709 103187499(plcb2) 103187635(plcb1)
DME: Dmel_CG3620(norpA) Dmel_CG4574(Plc21C)
DSI: Dsimw501_GD16687(Dsim_GD16687) Dsimw501_GD23017(Dsim_GD23017)
DYA: Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C)
DNV: 108658397
BMOR: 100329153(PLCb1) 100329154(PLCb4)
HAW: 110384330
CEL: CELE_B0348.4(egl-8)
CBR: CBG06373(Cbr-egl-8)
EGL: EGR_00105
HMG: 100189549(plcbh1) 100189551(plcbh2) 100200484
AQU: 100641378
 » show all
Reference
  Authors
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC
  Title
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).
  Journal
Biochim Biophys Acta 1517:63-72 (2000)
DOI:10.1016/S0167-4781(00)00260-8
  Sequence
[hsa:23236]
Reference
PMID:1644792
  Authors
Park D, Jhon DY, Kriz R, Knopf J, Rhee SG
  Title
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
  Journal
J Biol Chem 267:16048-55 (1992)
  Sequence
[hsa:5330]
Reference
PMID:1333955
  Authors
Carozzi AJ, Kriz RW, Webster C, Parker PJ
  Title
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.
  Journal
Eur J Biochem 210:521-9 (1992)
DOI:10.1111/j.1432-1033.1992.tb17450.x
  Sequence
[hsa:5331]
Reference
PMID:8530101
  Authors
Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W
  Title
cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).
  Journal
Genomics 29:53-61 (1995)
DOI:10.1006/geno.1995.1214
  Sequence
[hsa:5332]
LinkDB

KEGG   ORTHOLOGY: K05857
Entry
K05857                      KO                                     

Name
PLCD
Definition
phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04020  Calcium signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01307  Nonsyndromic congenital nail disorder
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
   04070 Phosphatidylinositol signaling system
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05857  PLCD; phosphatidylinositol phospholipase C, delta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05857  PLCD; phosphatidylinositol phospholipase C, delta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 113026(PLCD3) 5333(PLCD1) 84812(PLCD4)
PTR: 460267(PLCD1) 468279(PLCD3) 470647(PLCD4)
PPS: 100969236(PLCD1) 100980795(PLCD3) 100988032(PLCD4)
GGO: 101136081(PLCD4) 101139984(PLCD1) 101142984(PLCD3)
PON: 100171640(PLCD4) 100443819(PLCD3) 100462440(PLCD1)
NLE: 100596702(PLCD1) 100598366(PLCD4) 100604799(PLCD3)
MCC: 696860(PLCD1) 699569(PLCD4) 715924(PLCD3)
MCF: 101866682(PLCD1) 102122144(PLCD4) 102138566(PLCD3)
CSAB: 103217873(PLCD4) 103221069(PLCD1) 103243297(PLCD3)
RRO: 104654736(PLCD3) 104657452(PLCD1) 104660025(PLCD4)
RBB: 108512236(PLCD1) 108518456(PLCD4) 108532211(PLCD3)
CJC: 100395085(PLCD3) 100408539(PLCD4) 100408597(PLCD1)
SBQ: 101030401(PLCD4) 101045153(PLCD3) 101053112(PLCD1)
MMU: 18799(Plcd1) 18802(Plcd4) 72469(Plcd3)
MCAL: 110293847(Plcd4) 110301135(Plcd1) 110305200(Plcd3)
MPAH: 110322413(Plcd4) 110328624(Plcd1) 110331704(Plcd3)
RNO: 140693(Plcd4) 24655(Plcd1) 287745(Plcd3)
MUN: 110545647(Plcd3) 110555042(Plcd1) 110566641(Plcd4)
CGE: 100751509(Plcd1) 100751872(Plcd4) 100759620(Plcd3)
NGI: 103727720(Plcd4) 103738313(Plcd3) 103751602(Plcd1)
HGL: 101704621(Plcd3) 101704999(Plcd4) 101715010(Plcd1)
CCAN: 109678350(Plcd4) 109691551(Plcd3) 109698346(Plcd1)
OCU: 100347485(PLCD4) 100352032(PLCD3) 103347252(PLCD1)
TUP: 102468499(PLCD3) 102475249(PLCD4) 102500184(PLCD1)
CFA: 478910(PLCD4) 485586(PLCD1) 490929(PLCD3)
VVP: 112910679(PLCD3) 112921661(PLCD1) 112922548(PLCD4)
AML: 100469148(PLCD4) 100471021(PLCD3) 100476035(PLCD1)
UMR: 103662760(PLCD4) 103665878(PLCD3) 103682206(PLCD1)
UAH: 113250452(PLCD4) 113253779(PLCD1) 113265331(PLCD3)
ORO: 101364446(PLCD1) 101364713(PLCD3) 101372489(PLCD4)
FCA: 101086518(PLCD3) 101087777(PLCD1) 101090455(PLCD4)
PTG: 102952633(PLCD1) 102956201(PLCD4) 102963235(PLCD3)
PPAD: 109248742 109248743 109258216(PLCD3) 109265062(PLCD4)
AJU: 106966690(PLCD1) 106970106(PLCD4) 106988142(PLCD3)
BTA: 281986(PLCD1) 513057(PLCD3) 540771(PLCD4)
BOM: 102269641(PLCD3) 102270277 102273490(PLCD4)
BBUB: 102394200(PLCD4) 102395019(PLCD3) 102397395(PLCD1)
CHX: 102169343(PLCD4) 102184479(PLCD1) 102190639(PLCD3)
OAS: 101110367(PLCD1) 101111344(PLCD4) 101118035(PLCD3)
SSC: 100521111(PLCD3) 100627099(PLCD1) 397119(PLCD4)
CFR: 102506571(PLCD3) 102507363(PLCD1) 102515536(PLCD4)
CDK: 105090726(PLCD1) 105094408(PLCD3) 105096083(PLCD4)
BACU: 103014054(PLCD1) 103014562(PLCD3) 103019165(PLCD4)
LVE: 103073047(PLCD1) 103080679(PLCD3) 103081712(PLCD4)
OOR: 101271088(PLCD3) 101279487(PLCD1) 101282608(PLCD4)
DLE: 111164251(PLCD1) 111170182(PLCD3) 111171832(PLCD4)
PCAD: 102975151(PLCD1) 102978526(PLCD4) 102988490(PLCD3)
ECB: 100054233(PLCD1) 100058665(PLCD4) 100064142(PLCD3)
EPZ: 103553904(PLCD1) 103554680(PLCD3) 103561954(PLCD4)
EAI: 106834270(PLCD1) 106836472(PLCD3) 106838452(PLCD4)
MYB: 102241313(PLCD3) 102252971(PLCD4) 102262661(PLCD1)
MYD: 102758829(PLCD4) 102760213(PLCD3) 102760355(PLCD1)
MNA: 107524330(PLCD1) 107524764(PLCD4) 107528831(PLCD3)
HAI: 109380562(PLCD4) 109385184(PLCD1) 109394976(PLCD3)
DRO: 112298878(PLCD3) 112307779(PLCD4) 112309785(PLCD1)
PALE: 102878454(PLCD1) 102884893(PLCD4) 102896686(PLCD3)
RAY: 107499598(PLCD1) 107508158(PLCD3) 107516722(PLCD4)
MJV: 108388410(PLCD1) 108390511(PLCD4) 108403685(PLCD3)
LAV: 100656701(PLCD3) 100660015(PLCD1) 100676480(PLCD4)
MDO: 100011291(PLCD4) 100024144(PLCD3)
SHR: 100916816(PLCD3) 100919591(PLCD4) 100933386(PLCD1)
PCW: 110192977(PLCD1) 110215698(PLCD3) 110219452(PLCD4)
OAA: 100083809(PLCD1) 103168316(PLCD4) 103169159(PLCD3)
GGA: 420416(PLCD1) 424214(PLCD4) 428279(PLCD3)
MGP: 100540750(PLCD4) 100542227(PLCD1) 100551436(PLCD3)
CJO: 107308792(PLCD1) 107316914(PLCD4) 107325007(PLCD3)
NMEL: 110388519(PLCD3) 110394675(PLCD1) 110400529(PLCD4)
APLA: 101796325(PLCD1) 101804382(PLCD4)
ACYG: 106036853(PLCD1) 106039320(PLCD4) 106046916(PLCD3)
TGU: 100224924(PLCD3) 100227504(PLCD4) 100229323(PLCD1)
LSR: 110468342(PLCD4) 110475601(PLCD3) 110484535(PLCD1)
SCAN: 103812698(PLCD1) 103814352(PLCD4) 103821776(PLCD3)
GFR: 102034984(PLCD4) 102040502(PLCD1) 102041993(PLCD3)
FAB: 101809831(PLCD3) 101816161(PLCD1) 101817537(PLCD4)
PHI: 102100115(PLCD4) 102100695(PLCD3) 102108822(PLCD1)
PMAJ: 107200537(PLCD1) 107207601(PLCD4) 107215288(PLCD3)
CCAE: 111925533(PLCD1) 111932186(PLCD4) 111940037(PLCD3)
CCW: 104686410(PLCD1) 104693970(PLCD4) 104698537(PLCD3)
ETL: 114055274(PLCD4) 114065141(PLCD1) 114071516(PLCD3)
FPG: 101911097(PLCD3) 101919734(PLCD1) 101920700(PLCD4)
FCH: 102049427(PLCD1) 102050720(PLCD3) 102054061(PLCD4)
CLV: 102083893(PLCD4) 102086985(PLCD1) 102096927(PLCD3)
EGZ: 104130960(PLCD1) 104132360(PLCD3) 104132408(PLCD4)
NNI: 104010071(PLCD4) 104018910(PLCD3) 104021751(PLCD1)
ACUN: 113476372(PLCD1) 113482391(PLCD4) 113489183(PLCD3)
PADL: 103917674(PLCD4) 103920631(PLCD3) 103924728(PLCD1)
AAM: 106494848(PLCD1) 106495647(PLCD3) 106499321
ASN: 102368121(PLCD1) 102387019(PLCD3)
AMJ: 102575027(PLCD3) 102576343(PLCD1)
PSS: 102455868(PLCD1) 102459349(PLCD4)
CMY: 102932314(PLCD1) 102935898(PLCD4) 102944425(PLCD3)
CPIC: 101933267(PLCD3) 101941573(PLCD1) 101944484(PLCD4)
ACS: 100552636(plcd4) 100559401(plcd3) 100567266(plcd1)
PVT: 110078238(PLCD4) 110081386(PLCD3) 110085836(PLCD1)
PBI: 103051665(PLCD4) 103053551(PLCD3) 103056024(PLCD1)
PMUR: 107284364(PLCD1) 107286281(PLCD3) 107291489(PLCD4)
TSR: 106546230(PLCD4) 106547864 106551134(PLCD3) 106555250(PLCD1)
PMUA: 114582375(PLCD3) 114603199(PLCD4) 114607475(PLCD1)
XLA: 108700851(plcd3.L) 108702553(plcd3.S) 108702938(plcd4.S) 108718712(plcd1.L) 108719811(plcd1.S) 735225(plcd4.L)
XTR: 100379715(plcd4) 100488677(plcd1) 100497993(plcd3)
NPR: 108784616(PLCD1) 108785980(PLCD3)
DRE: 337489(plcd1b) 555443(plcd1a) 562569(plcd3b) 565669(plcd4a) 569040(plcd3a)
TRU: 101062624(plcd1) 101066005 101076189(plcd3) 101077179(plcd4) 101078575
LCM: 102347797(PLCD1) 102348562(PLCD3) 102349822 102354402(PLCD4)
SPU: 100891267
APLC: 110990341
DPA: 109542350
ZNE: 110830423
PVM: 113808841
TUT: 107366993
DPTE: 113789841
CSCU: 111628530
PTEP: 107439279
CEL: CELE_R05G6.8(plc-4)
CBR: CBG05896(Cbr-plc-4)
PCAN: 112559861
CRG: 105342681
MYI: 110459893
OBI: 106880478
AMIL: 114959282
PDAM: 113669269
SPIS: 111340408
DGT: 114527324
HMG: 100198602
ATH: AT2G40116 AT3G08510(PLC2) AT3G55940 AT4G38530(PLC1) AT5G58670(PLC1) AT5G58690(PLC5) AT5G58700(PLC4)
LJA: Lj0g3v0130579.1(Lj0g3v0130579.1) Lj0g3v0130589.1(Lj0g3v0130589.1) Lj2g3v2256390.1(Lj2g3v2256390.1) Lj2g3v2256400.1(Lj2g3v2256400.1) Lj2g3v2747660.1(Lj2g3v2747660.1) Lj2g3v2747660.2(Lj2g3v2747660.2) Lj2g3v2748690.1(Lj2g3v2748690.1) Lj6g3v0521600.2(Lj6g3v0521600.2) Lj6g3v0521600.3(Lj6g3v0521600.3) Lj6g3v0521670.1(Lj6g3v0521670.1)
DOSA: Os03t0289300-00(Os03g0289300) Os05t0127200-01(Os05g0127200) Os07t0694000-01(Os07g0694000) Os12t0562400-00(Os12g0562400)
ATS: 109738024(LOC109738024) 109738751(LOC109738751) 109747792(LOC109747792) 109756963(LOC109756963) 109762675(LOC109762675) 109771034(LOC109771034)
SCE: YPL268W(PLC1)
ERC: Ecym_3005
KMX: KLMA_80017(plc1)
NCS: NCAS_0D02230(NCAS0D02230)
NDI: NDAI_0I02690(NDAI0I02690)
TPF: TPHA_0J00210(TPHA0J00210)
TBL: TBLA_0A07020(TBLA0A07020)
TDL: TDEL_0G04680(TDEL0G04680)
KAF: KAFR_0B06460(KAFR0B06460)
PIC: PICST_42966(PLC1)
CAL: CAALFM_C703710CA(PLC1)
CDU: CD36_73380(PLC1)
SLB: AWJ20_1237(PLC1)
NCR: NCU01266
NTE: NEUTE1DRAFT127609(NEUTE1DRAFT_127609)
MGR: MGG_02444
BFU: BCIN_05g02840(Bcplc1)
ANI: AN0664.2
ANG: ANI_1_884074(An08g06320)
ABE: ARB_06692
TVE: TRV_04036
SPO: SPAC22F8.11(plc1)
CNE: CNC04820
CNB: CNBC2360
ABP: AGABI1DRAFT129320(AGABI1DRAFT_129320) AGABI1DRAFT131468(AGABI1DRAFT_131468) AGABI1DRAFT72480(AGABI1DRAFT_72480)
ABV: AGABI2DRAFT120986(AGABI2DRAFT_120986) AGABI2DRAFT122377(AGABI2DRAFT_122377) AGABI2DRAFT212030(AGABI2DRAFT_212030)
MGL: MGL_2569
MRT: MRET_0520
DDI: DDB_G0292736(plc)
DFA: DFA_07345 DFA_07346(plc)
TAN: TA06965
TPV: TP01_0775
BBO: BBOV_IV011070(23.m06338)
CPV: cgd4_2560
SMIN: v1.2.010004.t1(symbB.v1.2.010004.t1) v1.2.033641.t1(symbB.v1.2.033641.t1)
SPAR: SPRG_04373
 » show all
Reference
PMID:8550568
  Authors
Lee SB, Rhee SG
  Title
Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4.
  Journal
J Biol Chem 271:25-31 (1996)
DOI:10.1074/jbc.271.1.25
  Sequence
[rno:140693]
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

KEGG   ORTHOLOGY: K05860
Entry
K05860                      KO                                     

Name
PLCE
Definition
phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
ko05205  Proteoglycans in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01657  Nephrotic syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04015 Rap1 signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04020 Calcium signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04070 Phosphatidylinositol signaling system
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
   04024 cAMP signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05860  PLCE; phosphatidylinositol phospholipase C, epsilon
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 51196(PLCE1)
PTR: 450620(PLCE1)
PPS: 100992707(PLCE1)
GGO: 101125007(PLCE1)
PON: 100444145(PLCE1)
NLE: 100599747(PLCE1)
MCC: 701758(PLCE1)
MCF: 102142941(PLCE1)
CSAB: 103216291(PLCE1)
RRO: 104666130(PLCE1)
RBB: 108521233(PLCE1)
CJC: 100385383(PLCE1)
SBQ: 101043700(PLCE1)
MMU: 74055(Plce1)
MCAL: 110285551(Plce1)
MPAH: 110320362(Plce1)
RNO: 114633(Plce1)
CGE: 100754217(Plce1)
NGI: 103750131(Plce1)
HGL: 101706315(Plce1)
CCAN: 109681766(Plce1)
OCU: 100344504(PLCE1)
TUP: 102499439(PLCE1)
CFA: 486808(PLCE1)
VVP: 112913979(PLCE1)
AML: 100479318
UMR: 103667971(PLCE1)
UAH: 113243183(PLCE1)
ORO: 101367598(PLCE1)
ELK: 111144941
FCA: 101088695(PLCE1)
PTG: 102949488(PLCE1)
PPAD: 109264678
AJU: 106965849(PLCE1)
BTA: 519037(PLCE1)
BOM: 102268410(PLCE1)
BIU: 109553155(PLCE1)
BBUB: 102400189(PLCE1)
CHX: 102178972(PLCE1)
OAS: 101105703(PLCE1)
SSC: 100157745(PLCE1)
CFR: 102519191(PLCE1)
CDK: 105084245(PLCE1)
BACU: 103016185(PLCE1)
LVE: 103080930(PLCE1)
OOR: 101280643(PLCE1)
DLE: 111172471(PLCE1)
PCAD: 102989081
ECB: 100061676(PLCE1)
EPZ: 103559297(PLCE1)
EAI: 106846085
MYB: 102241624(PLCE1)
MYD: 102754476(PLCE1)
MNA: 107543248(PLCE1)
HAI: 109380957
DRO: 112307376(PLCE1)
PALE: 102898319(PLCE1)
RAY: 107520393(PLCE1)
MJV: 108393532(PLCE1)
LAV: 100677444(PLCE1)
TMU: 101349251
MDO: 100023487(PLCE1)
SHR: 100917022
PCW: 110192723(PLCE1)
OAA: 103169567(PLCE1)
GGA: 425224(PLCE1)
MGP: 100540174(PLCE1)
CJO: 107316035(PLCE1)
NMEL: 110399282(PLCE1)
APLA: 101794187(PLCE1)
ACYG: 106042534(PLCE1)
TGU: 100222852(PLCE1)
LSR: 110475436(PLCE1)
SCAN: 103814177(PLCE1)
GFR: 102031533(PLCE1)
FAB: 101810240(PLCE1)
PHI: 102113055(PLCE1)
PMAJ: 107206711(PLCE1)
CCAE: 111931184(PLCE1)
CCW: 104696321(PLCE1)
ETL: 114071591(PLCE1)
FPG: 101913673(PLCE1)
FCH: 102055055(PLCE1)
CLV: 102086659(PLCE1)
EGZ: 104129054(PLCE1)
NNI: 104013033(PLCE1)
ACUN: 113481439(PLCE1)
PADL: 103921343(PLCE1)
AAM: 106494113
ASN: 102373514(PLCE1)
AMJ: 102565045(PLCE1)
PSS: 102447740
CMY: 102943550(PLCE1)
CPIC: 101944378(PLCE1)
ACS: 100552081(plce1)
PVT: 110084128(PLCE1)
PBI: 103066924(PLCE1)
PMUR: 107293540(PLCE1)
PMUA: 114597322(PLCE1)
GJA: 107106488(PLCE1)
XTR: 100495530(plce1)
NPR: 108792005(PLCE1)
DRE: 568288(plce1)
SANH: 107653923 107664595(plce1)
CCAR: 109065353
IPU: 108273837(plce1)
PHYP: 113527060(plce1)
AMEX: 103036293(plce1)
EEE: 113584760(plce1)
TRU: 101065955(plce1)
LCO: 104932513(plce1)
NCC: 104963128(plce1)
MZE: 101480055(plce1)
ONL: 100711552(plce1)
OLA: 101164102(plce1)
XMA: 102228460(plce1)
XCO: 114152048(plce1)
PRET: 103481305(plce1)
CVG: 107085092(plce1)
NFU: 107387902(plce1)
KMR: 108249170(plce1)
ALIM: 106533025(plce1)
AOCE: 111585075(plce1)
CSEM: 103381430(plce1)
POV: 109627036(plce1)
LCF: 108898737(plce1)
SDU: 111219885(plce1)
SLAL: 111669649(plce1)
HCQ: 109523888(plce1)
BPEC: 110170982(plce1)
MALB: 109962903(plce1)
ELS: 105021417 105025138(plce1)
SFM: 108939627(plce1)
PKI: 111859557(plce1)
LCM: 102345110(PLCE1)
CMK: 103180693(plce1)
RTP: 109913650(plce1)
BFO: 118414021
SPU: 592193
APLC: 110977130
SKO: 102809018
AAG: 5570306
AME: 408804
BIM: 100744997
BTER: 100649725
CCAL: 108633016
OBB: 114874280
SOC: 105194827
MPHA: 105829082
AEC: 105151783
ACEP: 105627765
PBAR: 105425147
VEM: 105569386
HST: 105182316
DQU: 106741309
CFO: 105253013
LHU: 105673877
PGC: 109853979
OBO: 105281196
PCF: 106789771
NVI: 100116596
CSOL: 105361155
MDL: 103574729
TCA: 661312
DPA: 109536544
ATD: 109608601
NVL: 108556911
BMOR: 101735646
BMAN: 114246148
PMAC: 106714294
PRAP: 110996604
TNL: 113505537
API: 100168206
DNX: 107169403
AGS: 114119437
RMD: 113557079
BTAB: 109033369
CLEC: 112126115
ZNE: 110832898
PVM: 113816314
TUT: 107360575
DPTE: 113789238
PTEP: 107439832
CEL: CELE_F31B12.1(plc-1)
CBR: CBG17587(Cbr-plc-1)
BMY: Bm1_40160
TSP: Tsp_05005
PCAN: 112565388
CRG: 105331084
MYI: 110449213
OBI: 106874430
LAK: 106171793
 » show all
Reference
  Authors
Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T
  Title
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.
  Journal
J Biol Chem 276:2752-7 (2001)
DOI:10.1074/jbc.M008324200
  Sequence
[hsa:51196]
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

KEGG   ORTHOLOGY: K01116
Entry
K01116                      KO                                     

Name
PLCG1
Definition
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05135  Yersinia infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04014 Ras signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04015 Rap1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04370 VEGF signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04064 NF-kappa B signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04066 HIF-1 signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04020 Calcium signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04070 Phosphatidylinositol signaling system
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04072 Phospholipase D signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04660 T cell receptor signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04658 Th1 and Th2 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04659 Th17 cell differentiation
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04664 Fc epsilon RI signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04666 Fc gamma R-mediated phagocytosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04670 Leukocyte transendothelial migration
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04062 Chemokine signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   04919 Thyroid hormone signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09158 Development and regeneration
   04360 Axon guidance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05206 MicroRNAs in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05205 Proteoglycans in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05231 Choline metabolism in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05214 Glioma
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05223 Non-small cell lung cancer
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05022 Pathways of neurodegeneration - multiple diseases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05131 Shigellosis
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05135 Yersinia infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05171 Coronavirus disease - COVID-19
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K01116  PLCG1; phosphatidylinositol phospholipase C, gamma-1
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5335(PLCG1)
PTR: 458253(PLCG1)
PPS: 100995010(PLCG1)
GGO: 101135199(PLCG1)
PON: 100450941(PLCG1)
NLE: 100591458(PLCG1)
MCC: 697069(PLCG1)
MCF: 102138726(PLCG1)
CSAB: 103245987(PLCG1)
RRO: 104672220(PLCG1)
RBB: 108519825(PLCG1)
CJC: 100397497(PLCG1)
SBQ: 101046976(PLCG1)
MMU: 18803(Plcg1)
MCAL: 110290454(Plcg1)
MPAH: 110319649(Plcg1)
RNO: 25738(Plcg1)
MUN: 110552794(Plcg1)
CGE: 100769697(Plcg1)
NGI: 103747244(Plcg1)
HGL: 101705192(Plcg1)
CCAN: 109683399(Plcg1)
OCU: 100349958(PLCG1)
TUP: 102469651(PLCG1)
CFA: 485874(PLCG1)
VVP: 112928123(PLCG1)
AML: 100480586(PLCG1)
UMR: 103669754(PLCG1)
UAH: 113258609(PLCG1)
ORO: 101380728(PLCG1)
ELK: 111141423
FCA: 101092925(PLCG1)
PTG: 102952137(PLCG1)
PPAD: 109272437(PLCG1)
AJU: 106974495(PLCG1)
BTA: 281987(PLCG1)
BOM: 102265099(PLCG1)
BIU: 109567698(PLCG1)
BBUB: 102400354(PLCG1)
CHX: 102181878(PLCG1)
OAS: 101103341(PLCG1)
SSC: 100152497(PLCG1)
CFR: 102524452(PLCG1)
CDK: 105085024(PLCG1)
BACU: 103016663(PLCG1)
LVE: 103068930(PLCG1)
OOR: 101281412(PLCG1)
DLE: 111184170(PLCG1)
PCAD: 102992700(PLCG1)
ECB: 100070545(PLCG1)
EPZ: 103562208(PLCG1)
EAI: 106834358(PLCG1)
MYB: 102248243(PLCG1)
MYD: 102756475(PLCG1)
MNA: 107542131(PLCG1)
HAI: 109379925(PLCG1)
DRO: 112303845(PLCG1)
PALE: 102896228(PLCG1)
RAY: 107506741(PLCG1)
MJV: 108407248(PLCG1)
LAV: 100677739(PLCG1)
TMU: 101359597
MDO: 100032696(PLCG1)
SHR: 100923119(PLCG1)
PCW: 110216705(PLCG1)
OAA: 100078757(PLCG1)
GGA: 419175(PLCG1) 776273
MGP: 100542272 100548670(PLCG1)
CJO: 107310620 107322901(PLCG1)
NMEL: 110393955 110408143(PLCG1)
APLA: 101792010 101798692(PLCG1)
ACYG: 106042207 106043486(PLCG1)
TGU: 100220070(PLCG1) 115494036
LSR: 110469274(PLCG1) 110475168
SCAN: 103818789(PLCG1) 103826392
GFR: 102032882(PLCG1) 102038983
FAB: 101806517(PLCG1) 101820005
PHI: 102100949 102114427(PLCG1)
PMAJ: 107200506 107213300(PLCG1)
CCAE: 111925206 111938259(PLCG1)
CCW: 104687887(PLCG1) 104692596
FPG: 101912447(PLCG1) 101918282
FCH: 102046961 102057302(PLCG1)
CLV: 102098341(PLCG1) 102098590
EGZ: 104128859 104132170(PLCG1)
NNI: 104009589(PLCG1) 104020599
ACUN: 113477170 113487655(PLCG1)
PADL: 103912439(PLCG1) 103925979
AAM: 106488145(PLCG1) 106494802
ASN: 102368895 102369875(PLCG1)
AMJ: 102563626(PLCG1) 102574067
PSS: 102459944(PLCG1) 102461099
CMY: 102944142(PLCG1) 102946940
CPIC: 101930905 101935550(PLCG1)
ACS: 100559347(plcg1) 100566976
PVT: 110070157 110076765(PLCG1)
PBI: 103062888 103064933(PLCG1)
PMUR: 107287257(PLCG1) 107298984
TSR: 106549424(PLCG1)
PMUA: 114599554(PLCG1) 114600186
GJA: 107109685(PLCG1) 107121439
XLA: 108702812 108719445 398359(plcg1.L) 398360(plcg1.S)
XTR: 100496658 100496674(plcg1)
NPR: 108786812(PLCG1) 108789042
DRE: 373867(plcg1)
SANH: 107663201(plcg1) 107703619
CCAR: 109066470 109071906(plcg1)
IPU: 108275796(plcg1)
PHYP: 113545570(plcg1)
AMEX: 103023099(plcg1)
EEE: 113588884(plcg1)
TRU: 101065481 101069039(plcg1)
LCO: 104925092(plcg1) 104927718
NCC: 104954784 104964925(plcg1)
MZE: 101470576(plcg1) 101473405
ONL: 100704581(plcg1) 100711065
OLA: 101163005(plcg1) 101167946
XMA: 102217766(plcg1) 102229810
XCO: 114146805(plcg1) 114151085
PRET: 103463411 103467475(plcg1)
CVG: 107083024 107087598(plcg1)
NFU: 107391021(plcg1) 107393039
KMR: 108235263(plcg1) 108248356
ALIM: 106523657(plcg1) 106526007
AOCE: 111576272(plcg1) 111582127
CSEM: 103385539(plcg1) 103399890
LCF: 108877896(plcg1) 108879537
SDU: 111219324(plcg1) 111227542
SLAL: 111668916(plcg1) 111671648
HCQ: 109514977(plcg1) 109524567
BPEC: 110164633(plcg1) 110172233
MALB: 109961232 109964670(plcg1)
SASA: 106560399 106566556(plcg1)
OTW: 112222319(plcg1)
SALP: 111975516 111976591(plcg1)
ELS: 105011953 105013964(plcg1)
LCM: 102352804 102362442(PLCG1)
CMK: 103186275(plcg1)
RTP: 109912305 109939029(plcg1)
BFO: 118417806
CIN: 100178711
APLC: 110980002
SKO: 100377901
DME: Dmel_CG4200(sl)
DER: 6550553
DSE: 116801966
DSI: Dsimw501_GD17281(Dsim_GD17281)
DAN: 6501908
DSR: 110181712
DPO: Dpse_GA18024(Dpse_small-wing)
DPE: 6599358
DMN: 108156056
DWI: 6648777
DAZ: 108617824
DNV: 108655465
DHE: 111594077
DVI: 6631556
MDE: 101900328
LCQ: 111684567
AAG: 5564766
AME: 551709
BIM: 100748682
BTER: 100647687
CCAL: 108629199
OBB: 114871263
SOC: 105196430
MPHA: 105833149
AEC: 105144421
ACEP: 105624086
PBAR: 105431231
VEM: 105560673
HST: 105188458
DQU: 106743174
CFO: 105257806
LHU: 105673001
PGC: 109852947
OBO: 105286217
PCF: 106786441
NVI: 100123217
CSOL: 105368048
MDL: 103577678
TCA: 660210
DPA: 109537047
ATD: 109597552
NVL: 108561344
BMOR: 100329155(PLCg)
BMAN: 114250026
PMAC: 106717301
PRAP: 110998146
HAW: 110374501
TNL: 113505041
PXY: 105381166
API: 100166969
DNX: 107163682
AGS: 114120080
RMD: 113553363
BTAB: 109035929
CLEC: 106662403
ZNE: 110834677
FCD: 110851828
PVM: 113828575
TUT: 107359684
CSCU: 111628132
PTEP: 107452539
CEL: CELE_T01E8.3(plc-3)
CBR: CBG18715(Cbr-plc-3)
BMY: Bm1_42205
TSP: Tsp_10563
CRG: 105340725
MYI: 110450840
OBI: 106874041
LAK: 106152397
EPA: 110244579
ADF: 107357605
AMIL: 114966528
PDAM: 113679030
SPIS: 111332971
HMG: 100212273
AQU: 100633163
 » show all
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
Reference
  Authors
Carpenter G, Ji Q
  Title
Phospholipase C-gamma as a signal-transducing element.
  Journal
Exp Cell Res 253:15-24 (1999)
DOI:10.1006/excr.1999.4671
Reference
PMID:2167438
  Authors
Burgess WH, Dionne CA, Kaplow J, Mudd R, Friesel R, Zilberstein A, Schlessinger J, Jaye M
  Title
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
  Journal
Mol Cell Biol 10:4770-7 (1990)
DOI:10.1128/MCB.10.9.4770
  Sequence
[hsa:5335]
LinkDB

KEGG   ORTHOLOGY: K05859
Entry
K05859                      KO                                     

Name
PLCG2
Definition
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04020  Calcium signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04611  Platelet activation
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01743  Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04625 C-type lectin receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04062 Chemokine signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09158 Development and regeneration
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05131 Shigellosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05171 Coronavirus disease - COVID-19
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5336(PLCG2)
PTR: 454268(PLCG2)
PPS: 100984694(PLCG2)
GGO: 101133643(PLCG2)
PON: 100457650(PLCG2)
NLE: 100604145(PLCG2)
MCC: 714173(PLCG2)
MCF: 102117471(PLCG2)
CSAB: 103233371(PLCG2)
RRO: 104671624(PLCG2)
RBB: 108539491(PLCG2)
CJC: 100390347(PLCG2)
SBQ: 101030999(PLCG2)
MMU: 234779(Plcg2)
MCAL: 110300336(Plcg2)
MPAH: 110337392(Plcg2)
RNO: 29337(Plcg2)
MUN: 110550263(Plcg2)
CGE: 100752475(Plcg2)
HGL: 101715321(Plcg2)
CCAN: 109696649(Plcg2)
OCU: 100340139(PLCG2)
TUP: 102483786(PLCG2)
CFA: 489692(PLCG2)
AML: 100481994(PLCG2)
UMR: 103662093(PLCG2)
UAH: 113252535(PLCG2)
ORO: 101378505(PLCG2)
ELK: 111152978
FCA: 101080675(PLCG2)
PTG: 102963653(PLCG2)
PPAD: 109245637(PLCG2)
AJU: 106984018(PLCG2)
BTA: 100337091(PLCG2)
BOM: 102285300(PLCG2)
BIU: 109572707(PLCG2)
BBUB: 102396307(PLCG2)
CHX: 102180337(PLCG2)
OAS: 101122126(PLCG2)
SSC: 100518663(PLCG2)
CFR: 102514470(PLCG2)
CDK: 105089440(PLCG2)
BACU: 103014764(PLCG2)
LVE: 103070997(PLCG2)
OOR: 101285216(PLCG2)
DLE: 111179463(PLCG2)
PCAD: 102983230(PLCG2)
ECB: 100055670(PLCG2)
EPZ: 103558212(PLCG2)
EAI: 106832855(PLCG2)
MYB: 102261553(PLCG2)
MYD: 102773476(PLCG2)
MNA: 107524904(PLCG2)
HAI: 109378365(PLCG2)
DRO: 112300725(PLCG2)
PALE: 102883128(PLCG2)
RAY: 107521319(PLCG2)
MJV: 108400464(PLCG2)
LAV: 100658990(PLCG2)
TMU: 101346393
MDO: 100027579(PLCG2)
SHR: 100919206(PLCG2)
PCW: 110212621(PLCG2)
OAA: 100076776(PLCG2)
GGA: 415805(PLCG2)
MGP: 100549684(PLCG2)
CJO: 107319403(PLCG2)
NMEL: 110404260(PLCG2)
APLA: 101799246(PLCG2)
ACYG: 106044837
TGU: 100219388(PLCG2)
LSR: 110476350(PLCG2)
SCAN: 103816730(PLCG2)
GFR: 102039725(PLCG2)
FAB: 101811465(PLCG2)
PHI: 102103443(PLCG2)
PMAJ: 107209788(PLCG2)
CCAE: 111934454(PLCG2)
CCW: 104691823(PLCG2)
ETL: 114066562(PLCG2)
FPG: 101914329(PLCG2)
FCH: 102058636(PLCG2)
CLV: 102095823(PLCG2)
EGZ: 104133768(PLCG2)
NNI: 104014569(PLCG2)
ACUN: 113484485(PLCG2)
PADL: 103923865(PLCG2)
AAM: 106483269(PLCG2)
ASN: 102378303(PLCG2)
AMJ: 106736910(PLCG2)
PSS: 102454220(PLCG2)
CMY: 102930635(PLCG2)
CPIC: 101932685(PLCG2)
ACS: 100566814(plcg2)
PVT: 110085508(PLCG2)
PBI: 103052396(PLCG2)
PMUR: 107292601(PLCG2)
TSR: 106539149(PLCG2)
PMUA: 114601931(PLCG2)
GJA: 107105783(PLCG2)
XLA: 108714087(plcg2.L)
XTR: 100496686(plcg2)
NPR: 108786572(PLCG2)
DRE: 561747(plcg2)
IPU: 108264222(plcg2)
PHYP: 113534527(plcg2)
AMEX: 103036277(plcg2)
EEE: 113577174(plcg2)
TRU: 101072923(plcg2)
LCO: 104932460(plcg2)
MZE: 101479429(plcg2)
ONL: 100697485(plcg2)
OLA: 101157053(plcg2)
XMA: 102220131(plcg2)
XCO: 114137117(plcg2)
PRET: 103466833(plcg2)
CVG: 107084318(plcg2)
NFU: 107389305(plcg2)
KMR: 108237447(plcg2)
ALIM: 106536649(plcg2)
AOCE: 111563111(plcg2)
CSEM: 103379748(plcg2)
POV: 109641214(plcg2)
LCF: 108902239(plcg2)
SDU: 111229657(plcg2)
SLAL: 111647676(plcg2)
HCQ: 109513068(plcg2)
BPEC: 110169397(plcg2)
MALB: 109967271(plcg2)
SASA: 106573684(plcg2)
OTW: 112252303(plcg2)
SALP: 111952198(plcg2)
ELS: 105018577(plcg2)
SFM: 108926548 108926652(plcg2)
PKI: 111851875(plcg2)
LCM: 102358132(PLCG2)
CMK: 103175953(plcg2)
RTP: 109928136
API: 100161327
 » show all
Reference
PMID:2849563
  Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
  Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
  Journal
FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7
  Sequence
[hsa:5336]
Reference
  Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
  Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
  Journal
PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842
LinkDB

KEGG   ORTHOLOGY: K05861
Entry
K05861                      KO                                     

Name
PLCZ
Definition
phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04020  Calcium signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04114  Oocyte meiosis
ko04919  Thyroid hormone signaling pathway
ko05131  Shigellosis
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01282  Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
   04070 Phosphatidylinositol signaling system
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05861  PLCZ; phosphatidylinositol phospholipase C, zeta
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 89869(PLCZ1)
PTR: 743002(PLCZ1)
PPS: 100988020(PLCZ1)
GGO: 101151875(PLCZ1)
PON: 100442086(PLCZ1)
NLE: 100580724(PLCZ1)
MCC: 703293(PLCZ1)
MCF: 102122753(PLCZ1)
CSAB: 103218714(PLCZ1)
RRO: 104655304(PLCZ1)
RBB: 108539721(PLCZ1)
CJC: 100406733(PLCZ1)
SBQ: 101050254(PLCZ1)
MMU: 114875(Plcz1)
MCAL: 110296889(Plcz1)
MPAH: 110317052(Plcz1)
RNO: 497197(Plcz1)
MUN: 110555434(Plcz1)
CGE: 100754031(Plcz1)
NGI: 103733964(Plcz1)
HGL: 101709944(Plcz1)
CCAN: 109701042(Plcz1)
OCU: 100359131(PLCZ1)
TUP: 102481589(PLCZ1)
CFA: 486657(PLCZ1)
VVP: 112917544(PLCZ1)
AML: 100471118(PLCZ1)
UMR: 103677800(PLCZ1)
UAH: 113257833(PLCZ1)
ORO: 101377048(PLCZ1)
ELK: 111142271
FCA: 101085554(PLCZ1)
PTG: 102968210(PLCZ1)
PPAD: 109268558(PLCZ1)
AJU: 106977172(PLCZ1)
BTA: 497026(PLCZ1)
BOM: 102274303(PLCZ1)
BIU: 109558802(PLCZ1)
BBUB: 102403754(PLCZ1)
CHX: 102170761(PLCZ1)
OAS: 101122850(PLCZ1)
SSC: 397632(PLCZ1)
CFR: 102506863(PLCZ1)
CDK: 105096497(PLCZ1)
BACU: 102999522(PLCZ1)
LVE: 103075635(PLCZ1)
OOR: 101270450(PLCZ1)
DLE: 111176817(PLCZ1)
PCAD: 102987010(PLCZ1)
ECB: 100067798(PLCZ1) 111767502
EPZ: 103555928(PLCZ1)
EAI: 106824736(PLCZ1)
MYB: 102261189(PLCZ1)
MYD: 102752787(PLCZ1)
MNA: 107525326(PLCZ1)
HAI: 109371226(PLCZ1)
DRO: 112318678(PLCZ1)
PALE: 102887168(PLCZ1)
RAY: 107499675(PLCZ1)
MJV: 108384333(PLCZ1)
LAV: 100663854(PLCZ1)
TMU: 101342467
MDO: 100012056(PLCZ1)
SHR: 116419277(PLCZ1)
PCW: 110213825(PLCZ1)
OAA: 103167538(PLCZ1)
GGA: 418182(PLCZ1)
MGP: 100549451
CJO: 107316456(PLCZ1)
NMEL: 110395900(PLCZ1)
APLA: 101801909(PLCZ1)
ACYG: 106030891(PLCZ1)
TGU: 100229724(PLCZ1)
LSR: 110472993(PLCZ1)
SCAN: 103820488(PLCZ1)
GFR: 102035295(PLCZ1)
FAB: 101810163(PLCZ1)
PHI: 102108407(PLCZ1)
CCAE: 111928307(PLCZ1)
CCW: 104692298(PLCZ1)
ETL: 114068823(PLCZ1)
FPG: 101924543(PLCZ1)
FCH: 102059240(PLCZ1)
CLV: 102083512(PLCZ1)
EGZ: 104135118(PLCZ1)
NNI: 104017952(PLCZ1)
ACUN: 113491128(PLCZ1)
PADL: 103924343(PLCZ1)
AAM: 106488477(PLCZ1)
ASN: 102382411(PLCZ1)
AMJ: 102576997(PLCZ1)
PSS: 102463553(PLCZ1)
CMY: 102941985(PLCZ1)
CPIC: 101931350(PLCZ1)
TSR: 106540722(PLCZ1)
GJA: 107109019(PLCZ1) 107121264
NPR: 108791809(PLCZ1)
NCC: 104942417
OLA: 101167285
XMA: 102221186
XCO: 114159779
PRET: 103466390(plcz1)
CVG: 107092730
KMR: 108229959
ALIM: 106523397
AOCE: 111573644
SDU: 111229863
HCQ: 109507629
BPEC: 110169443(plcz1)
MALB: 109974502
SASA: 106561743
OTW: 112220510
LCM: 102347584
CMK: 103185584(plcz1)
RTP: 109931132
 » show all
Reference
  Authors
Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA
  Title
Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.
  Journal
Reproduction 124:611-23 (2002)
DOI:10.1530/rep.0.1240611
  Sequence
[hsa:89869]
Reference
  Authors
Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH
  Title
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
  Journal
BMB Rep 41:415-34 (2008)
DOI:10.5483/bmbrep.2008.41.6.415
LinkDB

KEGG   ORTHOLOGY: K01114
Entry
K01114                      KO                                     

Name
plc
Definition
phospholipase C [EC:3.1.4.3]
Pathway
ko00562  Inositol phosphate metabolism
ko00564  Glycerophospholipid metabolism
ko00565  Ether lipid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
ko04919  Thyroid hormone signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K01114  plc; phospholipase C
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K01114  plc; phospholipase C
   00565 Ether lipid metabolism
    K01114  plc; phospholipase C
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K01114  plc; phospholipase C
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K01114  plc; phospholipase C
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02042 Bacterial toxins
    K01114  plc; phospholipase C
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.3  phospholipase C
     K01114  plc; phospholipase C
Bacterial toxins [BR:ko02042]
 Type II toxins: Membrane damaging toxins
  Toxins that enzymatically damage the membrane
   K01114  plc; phospholipase C
Other DBs
RN: R01312 R02027 R02052 R03332 R07381
COG: COG3511
GO: 0004629
Genes
NAI: NECAME_18973
ATH: AT1G07230(NPC1) AT2G26870(NPC2) AT3G03530(NPC4) AT3G03540(NPC5) AT3G48610(NPC6)
ALY: 9313689 9316909 9320457 9320458 9328451
CRB: 17884902 17888378 17893062 17893396 17899115
CSAT: 104703502 104711356 104739289 104744445 104752587 104754889 104761389 104763976 104763977 104765258 104780675 104787579 104791079
EUS: EUTSA_v10001963mg EUTSA_v10007332mg EUTSA_v10010294mg EUTSA_v10020472mg
BRP: 103843966 103844249 103864845 103873127 103874784
BNA: 106365514 106376581 106382672 106387555 106391128 106400982 106430809 106432877 106445438 106446778 111212171
BOE: 106293041 106295442 106308215 106315255 106337025
RSZ: 108805872 108812142 108843000 108849719 108858009 108863325
LJA: Lj0g3v0152469.1(Lj0g3v0152469.1) Lj0g3v0241399.1(Lj0g3v0241399.1) Lj1g3v1500500.1(Lj1g3v1500500.1) Lj6g3v0964670.1(Lj6g3v0964670.1)
DOSA: Os01t0102000-01(Os01g0102000) Os01t0955000-02(Os01g0955000) Os03t0826600-01(Os03g0826600) Os03t0852800-00(Os03g0852800) Os11t0593000-01(Os11g0593000)
ATS: 109737151(LOC109737151) 109747180(LOC109747180) 109759365(LOC109759365) 109767204(LOC109767204) 109777514(LOC109777514)
ANG: ANI_1_2022014(An01g14940) ANI_1_3028014(An01g11130) ANI_1_448114(An13g03600)
DFA: DFA_00818
SMAR: SM39_3662
SPE: Spro_4198
SRL: SOD_c40420(plcN)
SPLY: Q5A_021980(plcN_2)
SMAF: D781_3962
SERF: L085_07240
SFJ: SAMEA4384070_4195(plcN)
SOF: NCTC11214_02444(plcN)
XDO: XDD1_3773(plcN)
XCC: XCC0947 XCC3037(plcN)
XCV: XCV1054(phlN1) XCV3291(phlN2)
XAX: XACM_1007(phlN1) XACM_3079(phlN2)
XAC: XAC1024 XAC3160(plcN)
XCI: XCAW_03446(plcC) XCAW_03558(plcC)
XOM: XOO1535(XOO1535) XOO3479(XOO3479)
XOO: XOO1651(plcN) XOO3682(PlcC)
XPH: XppCFBP6546_03415(XppCFBP6546P_03415) XppCFBP6546_06345(XppCFBP6546P_06345)
SML: Smlt1755(plcN1)
SMT: Smal_1494
SMZ: SMD_1690(plcC)
PSD: DSC_12570
LEZ: GLE_1552(plcN) GLE_1923(plcN)
PAE: PA0844(plcH) PA3319(plcN)
PAU: PA14_21110(plcN) PA14_53360(plcH)
PAG: PLES_17461(plcN) PLES_44741(plcH)
PAF: PAM18_1646(plcN) PAM18_4196(plcH)
PNC: NCGM2_1618(plcH) NCGM2_4449(plcN)
PAEB: NCGM1900_1882(plcH) NCGM1900_2957(plcN)
PAEU: BN889_00870(plcH_1) BN889_00871(plcH_2) BN889_03687(plcN)
PFL: PFL_3126
PPRC: PFLCHA0_c31570(plcN)
PPRO: PPC_3154
PSEM: TO66_16060
POJ: PtoMrB4_28090(plcN)
ABM: ABSDF0054(plc) ABSDF2207(plc)
ABY: ABAYE1520(plc) ABAYE3825(plc)
ABB: ABBFA_01400(plcN_1) ABBFA_03438(plcN_2)
ABAD: ABD1_00420(plcD) ABD1_20510(plc)
ACC: BDGL_001526(plcN) BDGL_002961(plcN)
AUG: URS_1180
ILO: IL2595(plcC)
MMAI: sS8_0501
FTU: FTT_0221(acpA)
FTQ: RO31_0255
FTF: FTF0221(acpA)
FTW: FTW_1838
FTT: FTV_0207(acpA)
FTG: FTU_0207(acpA)
FTL: FTL_0158
FTA: FTA_0172
FTS: F92_00885
FTC: DA46_564
FTV: CH67_429
FTZ: CH68_166
FTM: FTM_1599
FTN: FTN_0090
FTX: AW25_111
FTD: AS84_624
FTY: CH70_38
FPH: Fphi_0739
FPT: BZ13_1287
FPI: BF30_949
FPX: KU46_606
FRC: KX01_1540
NTT: TAO_1633
CVI: CV_0909(plcN)
RSO: RSc0319(plcN)
RSL: RPSI07_3091(plcN)
RSN: RSPO_c03330(acpA)
RSE: F504_340
RSY: RSUY_00380(plcC_1) RSUY_29590(plcN)
REH: H16_A2724(plcN1) H16_B0534(plcN2) H16_B1067(plcN3) H16_B1166(plcN4)
CNC: CNE_2c04740(plcN1) CNE_2c10260(plcN2) CNE_2c11270(plcN3)
RME: Rmet_4192(plcN) Rmet_4624(plcN2)
CTI: RALTA_A2216(plcN1) RALTA_B0343(plcN2) RALTA_B1069(plcN3)
CGD: CR3_3843(plcC) CR3_3844(plcC) CR3_3880(plcC)
CABA: SBC2_39140(plcN_1) SBC2_40850 SBC2_56990(plcC) SBC2_66200(plcN_2) SBC2_71020(plcN_3) SBC2_73550(plcN_4)
BPE: BP2337
BPC: BPTD_2296
BPER: BN118_2262
BPET: B1917_2250
BPEU: Q425_22910
BPA: BPP1702
BBR: BB3406
BAV: BAV1084(plcN1) BAV1803(plcN2)
BHZ: ACR54_02024(plcN_1) ACR54_03336(plcN_2)
AXY: AXYL_01269(plcN1) AXYL_01506(plcN2) AXYL_02003(plcN3) AXYL_02675(plcN4)
AXX: ERS451415_01415(plcN_1) ERS451415_01888(plcN_2) ERS451415_02376(plcN_3) ERS451415_05203(plcN_4)
ODI: ODI_R4164
AAA: Acav_0273
CTES: O987_25980
JAG: GJA_4137
HSE: Hsero_2607(plcN)
HRB: Hrubri_2689(plcN) Hrubri_3787(plcN)
CFU: CFU_0030 CFU_0341 CFU_0674(plcN) CFU_3159(plcN2)
TIN: Tint_2706
THI: THI_3248
RGE: RGE_22010(plc)
PBH: AAW51_0637(plcC)
GEB: GM18_2899
SCL: sce3773 sce6979(phlC2) sce7154(phlC1)
HOH: Hoch_4899
ARA: Arad_3908
BJA: bll6723
BRA: BRADO5754(plcN)
BBT: BBta_1163(plcN) BBta_6264(plcN)
BRO: BRAD285_5724(plcN) BRAD285_6387(plcN)
PLEO: OHA_1_00518(plcN)
CCR: CC_3031
CSE: Cseg_3204
NAR: Saro_1552
SPHK: SKP52_18755(plcN)
SPHI: TS85_12050
SSAN: NX02_19790
SPMI: K663_03485
SPHR: BSY17_988
SMIC: SmB9_03910(plcN)
AAY: WYH_02185(plcN)
ALB: AEB_P1101
GDI: GDI2475(plcA) GDI2477(plcN)
KSC: CD178_00286(plcN)
APK: APA386B_447(plcN)
ASZ: ASN_2503(plcN) ASN_643
ATX: GCD22_01333(plcN) GCD22_03008(plcN)
BAN: BA_0677(plC)
BAR: GBAA_0677(plC)
BAT: BAS0643
BAH: BAMEG_3909(plC)
BAI: BAA_0760(plC)
BANT: A16_07400
BANR: A16R_07460
BANS: BAPAT_0654
BANV: DJ46_5135(plc)
BCE: BC0670
BCA: BCE_0744(plC)
BCZ: BCE33L0588(plc)
BCR: BCAH187_A0804(plC)
BCB: BCB4264_A0707(plC)
BCU: BCAH820_0732(plC)
BCG: BCG9842_B4629(plC)
BCQ: BCQ_0743(plC)
BCX: BCA_0713(plC)
BAL: BACI_c06850(plcB)
BNC: BCN_0652
BCF: bcf_03465
BCER: BCK_04770
BTK: BT9727_0587(plc)
BTL: BALH_0617(plC)
BTB: BMB171_C0589(plC)
BTT: HD73_0751
BTHI: BTK_03835
BTC: CT43_CH0600(plC)
BTM: MC28_1098 MC28_5401(cerA)
BTG: BTB_c06910(cerA)
BTI: BTG_17775
BTW: BF38_1922(plc)
BWW: bwei_4921(plc) bwei_5379(plc2)
BMYO: BG05_5249(plc) BG05_5484
BMYC: DJ92_3267(plc) DJ92_3544(plc) DJ92_5342(plc)
BTRO: FJR70_25650(plC)
SAU: SA1811(truncated(hlb))
SAV: SAV2003(truncated-hlb)
SAW: SAHV_1989
SAM: MW1940(truncated_hlb)
SAC: SACOL2003(hlb)
SAE: NWMN_1926
SAD: SAAV_2071(hlb)
SUU: M013TW_1975(sph)
SUE: SAOV_2040
SUC: ECTR2_1875(sph)
SUQ: HMPREF0772_11179(sph)
SUZ: MS7_2035(sph)
SUW: SATW20_19320(hlb)
SUG: SAPIG2059(sph)
SUF: SARLGA251_18220(hlb)
SAUA: SAAG_02520
SAUS: SA40_1779(hlb)
SAUU: SA957_1863(hlb)
SAUG: SA268_1935(hlb)
SAUF: X998_1994(sph)
SAB: SAB1874
SUY: SA2981_1965(hlb)
SAUB: C248_2026
SAUC: CA347_2096(sph)
SAUR: SABB_02524(hlb)
SAUI: AZ30_10655
SAUD: CH52_08880
SER: SERP2544(hlb)
SEP: SE0008
SEPP: SEB_00009
SEPS: DP17_1390(sph)
SLN: SLUG_00320(hlb)
SDT: SPSE_2228(hlb)
SCAP: AYP1020_1985(hlb)
SSCH: LH95_11415
SSCZ: RN70_12120
SAGQ: EP23_08555(sph)
SFQ: C7J90_04160(sph)
SCAR: DWB96_00165(sph)
SFF: FOB90_08000(sph)
SDP: NCTC12225_02433(hlb)
SCHR: DWB92_01330(sph)
LMO: lmo0205(plcB)
LMN: LM5578_2813(plcB)
LMY: LM5923_2762(plcB)
LMOC: LMOSLCC5850_0199(plcB)
LMOE: BN418_0216
LMOB: BN419_0221
LMOD: LMON_0203(plcB)
LMOW: AX10_09480
LMOQ: LM6179_0495(plcB)
LMR: LMR479A_0214(plcB)
LMOM: IJ09_09340
LMF: LMOf2365_0216(plcB)
LMC: Lm4b_00203(plcB)
LMOG: BN389_02190(plcB)
LMP: MUO_01170
LMOL: LMOL312_0203(plcB)
LMOZ: LM1816_04672(plcB)
LMOX: AX24_13635
LMQ: LMM7_0226(plcB)
LML: lmo4a_0221(plcB)
LMS: LMLG_2380
LMW: LMOSLCC2755_0204(plcB)
LMX: LMOSLCC2372_0206(plcB)
LMZ: LMOSLCC2482_0205(plcB)
LMON: LMOSLCC2376_0176(plcB)
LMOS: LMOSLCC7179_0199(plcB)
LMOO: LMOSLCC2378_0218(plcB)
LMOY: LMOSLCC2479_0205(plcB)
LMOT: LMOSLCC2540_0208(plcB)
LMOA: LMOATCC19117_0213(plcB)
LMOK: CQ02_01100
LMV: Y193_00190(plcB)
LSG: lse_0189(plcB)
LIV: LIV_1186(smcL)
AAC: Aaci_1827
AAD: TC41_1922(plcC)
BTS: Btus_0254
CAC: CA_C1019 CA_P0148(phlc)
CAE: SMB_G1037 SMB_P146(phlc)
CAY: CEA_G1031 CEA_P0147(phlc)
CTC: CTC_00990
CBO: CBO2632
CBA: CLB_2576
CBH: CLC_2507
CBY: CLM_2998
CBL: CLK_2020
CBK: CLL_A2118
CBB: CLD_1931
CBI: CLJ_B2864
CBN: CbC4_0821
CBF: CLI_2699
CBM: CBF_2691
CKL: CKL_1485
CKR: CKR_1379
CPAS: Clopa_3296
CSQ: CSCA_1331
CTYK: CTK_C17380
CCOH: SAMEA4530647_0814(plc)
AMT: Amet_0549
ASF: SFBM_0315
CTH: Cthe_3193
DRM: Dred_2741
PTH: PTH_1370
HMO: HM1_3138
SAY: TPY_0920(plcC)
CHY: CHY_0741
PUF: UFO1_3703
PFT: JBW_01122
MTU: Rv2349c(plcC) Rv2350c(plcB) Rv2351c(plcA)
MRA: MRA_1766(plcD) MRA_2369(plcC) MRA_2370(plcB) MRA_2371(plcA)
MTUR: CFBS_2487(plcC) CFBS_2488(plcB) CFBS_2489(plcA)
MTO: MTCTRI2_2392(plcC) MTCTRI2_2393(plcB)
MTD: UDA_2349c(plcC) UDA_2350c(plcB) UDA_2351c(plcA)
MTUH: I917_16505
MTUT: HKBT1_2478(plcC) HKBT1_2479(plcB) HKBT1_2480(plcA)
MTUU: HKBT2_2480(plcC) HKBT2_2481(plcB) HKBT2_2482(plcA)
MTQ: HKBS1_2484(plcC) HKBS1_2485(plcB) HKBS1_2486(plcA)
MBO: BQ2027_MB1784C(plcD)
MBB: BCG_1794c(plcD)
MBT: JTY_1769(plcD)
MBM: BCGMEX_1766c(plcD)
MBX: BCGT_1572
MAF: MAF_17740(plcD) MAF_23620(plcC) MAF_23630(plcB) MAF_23640(plcA)
MCE: MCAN_17701(plcD) MCAN_23811(plcC) MCAN_23821(plcB) MCAN_23831(plcA)
MCQ: BN44_40004(plcD) BN44_50315(plcC) BN44_50316(plcB) BN44_50317(plcA)
MCV: BN43_30889 BN43_31613(plcC) BN43_31614(plcB) BN43_31615(plcA)
MCX: BN42_30004(plcD) BN42_40281(plcC) BN42_40282(plcB) BN42_40283(plcA)
MCZ: BN45_50007(plcD) BN45_50712(plcC) BN45_50713(plcB) BN45_50714(plcA)
MUL: MUL_2799(plcB)
MMI: MMAR_0284(plcB_3) MMAR_1485(plcB_2) MMAR_3566(plcB) MMAR_3656(plcB_5) MMAR_3657(plcB_4) MMAR_3823(plcB_1) MMAR_4722(plcB_6)
MLI: MULP_03825(plcB) MULP_03907(plcB_5) MULP_04061(plcB_1) MULP_04944(plcB_6)
MHAD: B586_19435
MAB: MAB_0555
MABB: MASS_0524
ASD: AS9A_1033
CJK: jk0010(acpA)
COA: DR71_1073
NNO: NONO_c24950(plcD)
RER: RER_56920(plc)
REY: O5Y_27190
ROP: ROP_22030(plc)
GOM: D7316_01625(plcA)
TPR: Tpau_2452
SRT: Srot_1710
SCO: SCO6691(SC4C6.01)
SMA: SAVERM_1715(plcA)
SBH: SBI_08798
SDV: BN159_1732(plcN)
SALS: SLNWT_0477
SLV: SLIV_05055(plcN)
SGU: SGLAU_27995(plcN)
SAMB: SAM23877_6344(plcN)
SPRI: SPRI_2371
SRW: TUE45_07240(plcN)
SLE: sle_11360(sle_11360)
STRD: NI25_04950
SALF: SMD44_06112(plcC) SMD44_07208(plcC)
SALJ: SMD11_2069(plcC) SMD11_2773 SMD11_3735(plcC)
SLX: SLAV_09770(plcN1) SLAV_12120(plcN2) SLAV_33870(plcN3)
SGE: DWG14_01483(plcN_1) DWG14_08083(plcN_2)
CMI: CMM_0504
CMS: CMS0264
MOY: CVS54_03814(plcC)
ARR: ARUE_c31850(plcN)
AAU: AAur_3036
LMOI: VV02_03990
NCA: Noca_3201
KFL: Kfla_2643
NAL: B005_3638(sph)
SEN: SACE_5775(plcN)
AMD: AMED_3228(plcC) AMED_7590(plcC) AMED_8964(plcC)
AMM: AMES_3193(plcC) AMES_7478(plcC) AMES_8827(plcC)
AMZ: B737_3193(plcC) B737_7478(plcC) B737_8828(plcC)
AOI: AORI_1438(plcC) AORI_2698(plcC)
AMQ: AMETH_4401(plcC)
AMYY: YIM_17615(plcN) YIM_28450(plcB)
PDX: Psed_4307
ASE: ACPL_2371(plcN) ACPL_5685(plcN)
ACTN: L083_0276(plcN)
AFS: AFR_15205
PFLA: Pflav_022140(plcN)
MIN: Minf_0120(plcC)
FTJ: FTUN_8316
PBOR: BSF38_03162(plcN)
FLN: FLA_3819
SMIZ: 4412673_01610(plcN_1) 4412673_01915(plcN_2)
SDJ: NCTC13534_02679(plcN)
STHA: NCTC11429_00763(plcN_1) NCTC11429_01211(plcN_2) NCTC11429_02554(plcN_3)
MGOT: MgSA37_01973(plcN_1) MgSA37_01976(plcN_2)
SLI: Slin_1378
LBY: Lbys_2889
FAE: FAES_4673(plcN)
ZPR: ZPR_3206
MYR: MYRA21_0324(plcN)
MPW: MPR_2859
KAN: IMCC3317_04680(plcN)
EAO: BD94_2498
ELB: VO54_00215(plcN)
CHZ: CHSO_4611
NJA: NSJP_3236
SID: M164_0637
SIH: SiH_0446
MCN: Mcup_1169
STEP: IC006_0900
TUZ: TUZN_1521
 » show all
Reference
PMID:2120196
  Authors
Ostroff RM, Vasil AI, Vasil ML
  Title
Molecular comparison of a nonhemolytic and a hemolytic phospholipase C from Pseudomonas aeruginosa.
  Journal
J Bacteriol 172:5915-23 (1990)
DOI:10.1128/JB.172.10.5915-5923.1990
  Sequence
[pae:PA3319]
Reference
PMID:3087958
  Authors
Pritchard AE, Vasil ML
  Title
Nucleotide sequence and expression of a phosphate-regulated gene encoding a secreted hemolysin of Pseudomonas aeruginosa.
  Journal
J Bacteriol 167:291-8 (1986)
DOI:10.1128/JB.167.1.291-298.1986
  Sequence
[pae:PA0844]
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