KEGG   ORTHOLOGY: K05870
Entry
K05870                      KO                                     

Name
CREB1
Definition
cyclic AMP-responsive element-binding protein 1
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04380  Osteoclast differentiation
map04612  Antigen processing and presentation
map04668  TNF signaling pathway
map04710  Circadian rhythm
map04713  Circadian entrainment
map04714  Thermogenesis
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04931  Insulin resistance
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map05016  Huntington disease
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05152  Tuberculosis
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04024 cAMP signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04022 cGMP-PKG signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04151 PI3K-Akt signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04152 AMPK signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09152 Endocrine system
   04911 Insulin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04922 Glucagon signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04915 Estrogen signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04926 Relaxin signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04935 Growth hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04918 Thyroid hormone synthesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04928 Parathyroid hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04916 Melanogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04924 Renin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04925 Aldosterone synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04927 Cortisol synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09156 Nervous system
   04725 Cholinergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04728 Dopaminergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09159 Environmental adaptation
   04710 Circadian rhythm
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04713 Circadian entrainment
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04714 Thermogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05203 Viral carcinogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05161 Hepatitis B
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05163 Human cytomegalovirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05165 Human papillomavirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05020 Prion disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09165 Substance dependence
   05030 Cocaine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05031 Amphetamine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05034 Alcoholism
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04934 Cushing syndrome
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   03029 Mitochondrial biogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Other DBs
GO: 0035497
Genes
HSA: 1385(CREB1)
PTR: 459901(CREB1)
PPS: 100974672(CREB1)
GGO: 101144410(CREB1)
PON: 100294619(CREB1)
NLE: 100586647(CREB1)
MCC: 708717(CREB1)
MCF: 102141699(CREB1)
CSAB: 103217717(CREB1)
CATY: 105580103(CREB1)
RRO: 104680220(CREB1)
RBB: 108540349(CREB1)
TFN: 117094598(CREB1)
PTEH: 111547676(CREB1)
CJC: 100407681(CREB1)
SBQ: 101034085(CREB1)
MMUR: 105864304(CREB1)
MMU: 12912(Creb1)
MCAL: 110285614(Creb1)
MPAH: 110322391(Creb1)
RNO: 81646(Creb1)
MCOC: 116088513(Creb1)
MUN: 110551437(Creb1)
CGE: 100761582(Creb1)
PLEU: 114705057(Creb1)
NGI: 103744440(Creb1)
HGL: 101712503(Creb1)
CCAN: 109691946(Creb1)
OCU: 100351999(CREB1)
TUP: 102500092(CREB1)
CFA: 607922(CREB1)
VVP: 112922611(CREB1)
VLG: 121480493(CREB1)
AML: 100477711(CREB1)
UMR: 103659802(CREB1)
UAH: 113250525(CREB1)
ORO: 101383024(CREB1)
ELK: 111147575
MPUF: 101677618(CREB1)
EJU: 114215964(CREB1)
MLX: 118012101(CREB1)
PTG: 102971333(CREB1)
PPAD: 109265159(CREB1)
AJU: 106967098(CREB1)
HHV: 120220409(CREB1)
BTA: 281713(CREB1)
BOM: 102281756(CREB1)
BIU: 109570093(CREB1)
BBUB: 102401906(CREB1)
CHX: 102186065(CREB1)
OAS: 443118(CREB1)
ODA: 120854564(CREB1)
SSC: 100736562(CREB1)
CFR: 102508765(CREB1)
CDK: 105093562(CREB1)
BACU: 103017577(CREB1)
LVE: 103075978(CREB1)
OOR: 101287685(CREB1)
DLE: 111171769(CREB1)
PCAD: 102989082(CREB1)
ECB: 100066388(CREB1)
EPZ: 103548908(CREB1)
EAI: 106828159(CREB1)
MYB: 102246867(CREB1)
MYD: 102754892(CREB1)
MMYO: 118661646(CREB1)
MNA: 107524712(CREB1)
HAI: 109388316(CREB1)
DRO: 112307981(CREB1)
SHON: 118985184(CREB1)
AJM: 119064343(CREB1)
MMF: 118624959(CREB1)
PALE: 102888198(CREB1)
RAY: 107505169(CREB1)
MJV: 108396160
TOD: 119256146(CREB1)
LAV: 100675162(CREB1)
TMU: 101356881
MDO: 100014049(CREB1)
SHR: 100913327(CREB1)
PCW: 110223284(CREB1)
OAA: 100093310(CREB1)
GGA: 395099(CREB1)
PCOC: 116234000(CREB1)
MGP: 100542127(CREB1)
CJO: 107316551(CREB1)
NMEL: 110400086(CREB1)
ACYG: 106030089(CREB1)
TGU: 751585(CREB1)
LSR: 110475023(CREB1)
SCAN: 103814492(CREB1)
PMOA: 120501211(CREB1)
GFR: 102042770(CREB1)
FAB: 101811066(CREB1)
PHI: 102101211(CREB1)
PMAJ: 107207633(CREB1)
CCAE: 111932010(CREB1)
CCW: 104693796(CREB1)
ETL: 114055739(CREB1)
FPG: 101911755(CREB1)
FCH: 102050642(CREB1)
CLV: 102085492(CREB1)
EGZ: 104125074(CREB1)
NNI: 104010208(CREB1)
ACUN: 113482524(CREB1)
PADL: 103923613(CREB1)
ASN: 102385124(CREB1)
AMJ: 102564978(CREB1)
CPOO: 109322819(CREB1)
GGN: 109302005(CREB1)
PSS: 102450649(CREB1)
CMY: 102944794(CREB1)
CPIC: 101943249(CREB1)
TST: 117884675(CREB1)
CABI: 116816076(CREB1)
ACS: 100555818(creb1)
PVT: 110072401(CREB1)
PBI: 103058702(CREB1)
PMUR: 107295640(CREB1)
TSR: 106549740
PGUT: 117673970(CREB1)
PMUA: 114581842(CREB1)
ZVI: 118096395(CREB1)
GJA: 107105893(CREB1)
XLA: 108701473(creb1.L) 379764(creb1.S)
XTR: 407934(creb1)
NPR: 108790202(CREB1)
DRE: 573207(creb1a)
IPU: 108258958 108267006(creb1)
PHYP: 113537276 113547038(creb1)
AMEX: 103024012 103036831(creb1)
EEE: 113567647(creb1) 113577247
ELY: 117250102 117251482(creb1b)
PLEP: 121948855(creb1b) 121962741
SLUC: 116036197(creb1b) 116044626
ECRA: 117939398 117952928(creb1b)
PFLV: 114550949 114564244(creb1)
GAT: 120822114 120833724(creb1b)
MSAM: 119904409(creb1b) 119904544
CUD: 121506134 121522312(creb1b)
MZE: 101465790 101472017(creb1)
ONL: 100697446 100701405(creb1)
OAU: 116314793(creb1b) 116332195
XMA: 102221737 102227171(creb1)
XCO: 114140714 114148317(creb1)
XHE: 116716024 116723240(creb1)
PRET: 103473381 103478732(creb1)
CVG: 107084246 107100467(creb1)
KMR: 108238846(creb1b) 108242185
POV: 109640884(creb1) 109644135
XGL: 120798332 120801603(creb1b)
SALP: 111976709(creb1) 112073124
ELS: 105016260(creb1) 105023145
LOC: 102697439(creb1)
LCM: 102361965(CREB1)
CMK: 103176821(creb1)
RTP: 109933435
CIN: 100101830(creb/atf-c)
SCLV: 120342108
SPU: 100889197
APLC: 110973510
DME: Dmel_CG6103(CrebB)
DER: 6550116
DSE: 6614852
DSI: Dsimw501_GD17392(Dsim_GD17392)
DAN: 6505093
DSR: 110175965
DPE: 6601755
DMN: 108160824
DWI: 6641104
DAZ: 108620004
DNV: 115563935
DHE: 111593025
DVI: 6632124
MDE: 101888107
LCQ: 111685990
ACOZ: 120959796
AARA: 120905982
AAG: 23687935
AME: 409401
ACER: 108001656
BIM: 100741354
BTER: 100651248
CCAL: 108632406
OBB: 114871042
MGEN: 117228689
NMEA: 116430409
CGIG: 122395117
SOC: 105200567
MPHA: 105831502
AEC: 105145195
PBAR: 105424320
VEM: 105568668
HST: 105186347
DQU: 106743926
CFO: 105256228
FEX: 115235306
PGC: 109852176
OBO: 105284048
PCF: 106793201
NVI: 100121641(Creb)
CSOL: 105361349
MDL: 103571628
TCA: 656052
DPA: 109539109
ATD: 109595494
AGB: 108903383
NVL: 108563046
APLN: 108738827
OTU: 111427355
BMOR: 692871(CREB)
BMAN: 114251539
MSEX: 115448159
BANY: 112052434
PMAC: 106710823
PPOT: 106109403
PXU: 106128443
PRAP: 110992742
ZCE: 119835024
HAW: 110369905
TNL: 113508022
API: 100160473
DNX: 107166267
AGS: 114126510
RMD: 113560820
BTAB: 109029782
DCI: 103518879
CLEC: 106668638
ZNE: 110840023
CSEC: 111863011
FCD: 110846005
PVM: 113807625
HAME: 121857049
DSV: 119441995
RSAN: 119387563
RMP: 119159702
VDE: 111255458
VJA: 111268730
TUT: 107362324
DPTE: 113793959
PTEP: 107438159
SDM: 118192902
CEL: CELE_Y41C4A.4(crh-1)
CBR: CBG13248(Cbr-crh-1)
BMY: BM_BM6510(Bma-crh-1)
PCAN: 112563796
BGT: 106073796
CRG: 105342835
MYI: 110452284
OBI: 106881849
LAK: 106157277
NVE: 5513148
EPA: 110232327
ATEN: 116294471
ADF: 107335994
AMIL: 114957341
PDAM: 113684239
SPIS: 111323438
DGT: 114515899
HMG: 100200223(CREB)
AQU: 100638625
 » show all
Reference
PMID:2142528
  Authors
Berkowitz LA, Gilman MZ
  Title
Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
  Journal
Proc Natl Acad Sci U S A 87:5258-62 (1990)
DOI:10.1073/pnas.87.14.5258
  Sequence
[hsa:1385]
Reference
  Authors
Chen HC, Byrd JC, Muthusamy N
  Title
Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.
  Journal
J Immunol 176:2208-18 (2006)
DOI:10.4049/jimmunol.176.4.2208
  Sequence
[mmu:12912]
Reference
PMID:8397816
  Authors
Usui T, Smolik SM, Goodman RH
  Title
Isolation of Drosophila CREB-B: a novel CRE-binding protein.
  Journal
DNA Cell Biol 12:589-95 (1993)
DOI:10.1089/dna.1993.12.589
  Sequence
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