KEGG ORTHOLOGY: K05870

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04024 cAMP signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04022 cGMP-PKG signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04151 PI3K-Akt signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04152 AMPK signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09152 Endocrine system
   04911 Insulin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04922 Glucagon signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04915 Estrogen signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04926 Relaxin signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04935 Growth hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04918 Thyroid hormone synthesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04928 Parathyroid hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04916 Melanogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04924 Renin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04925 Aldosterone synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04927 Cortisol synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09156 Nervous system
   04725 Cholinergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04728 Dopaminergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09159 Environmental adaptation
   04710 Circadian rhythm
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04713 Circadian entrainment
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04714 Thermogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05203 Viral carcinogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05161 Hepatitis B
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05163 Human cytomegalovirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05165 Human papillomavirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05020 Prion disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09165 Substance dependence
   05030 Cocaine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05031 Amphetamine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05034 Alcoholism
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04934 Cushing syndrome
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   03029 Mitochondrial biogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1

Other DBs

GO:

0035497

Genes

HSA:	1385(CREB1)

PTR:	459901(CREB1)

PPS:	100974672(CREB1)

GGO:	101144410(CREB1)

PON:	100294619(CREB1)

NLE:	100586647(CREB1)

MCC:	708717(CREB1)

MCF:	102141699(CREB1)

CSAB:

103217717(CREB1)

CATY:

105580103(CREB1)

RRO:	104680220(CREB1)

RBB:	108540349(CREB1)

TFN:	117094598(CREB1)

PTEH:

111547676(CREB1)

CJC:	100407681(CREB1)

SBQ:	101034085(CREB1)

MMUR:

105864304(CREB1)

MMU:	12912(Creb1)

MCAL:

110285614(Creb1)

MPAH:

110322391(Creb1)

RNO:	81646(Creb1)

MCOC:

116088513(Creb1)

MUN:	110551437(Creb1)

CGE:	100761582(Creb1)

PLEU:

114705057(Creb1)

NGI:	103744440(Creb1)

HGL:	101712503(Creb1)

CCAN:

109691946(Creb1)

OCU:	100351999(CREB1)

TUP:	102500092(CREB1)

CFA:	607922(CREB1)

VVP:	112922611(CREB1)

VLG:	121480493(CREB1)

AML:	100477711(CREB1)

UMR:	103659802(CREB1)

UAH:	113250525(CREB1)

ORO:	101383024(CREB1)

ELK:

111147575

MPUF:

101677618(CREB1)

EJU:	114215964(CREB1)

MLX:	118012101(CREB1)

PTG:	102971333(CREB1)

PPAD:

109265159(CREB1)

AJU:	106967098(CREB1)

HHV:	120220409(CREB1)

BTA:	281713(CREB1)

BOM:	102281756(CREB1)

BIU:	109570093(CREB1)

BBUB:

102401906(CREB1)

CHX:	102186065(CREB1)

OAS:	443118(CREB1)

ODA:	120854564(CREB1)

SSC:	100736562(CREB1)

CFR:	102508765(CREB1)

CDK:	105093562(CREB1)

BACU:

103017577(CREB1)

LVE:	103075978(CREB1)

OOR:	101287685(CREB1)

DLE:	111171769(CREB1)

PCAD:

102989082(CREB1)

ECB:	100066388(CREB1)

EPZ:	103548908(CREB1)

EAI:	106828159(CREB1)

MYB:	102246867(CREB1)

MYD:	102754892(CREB1)

MMYO:

118661646(CREB1)

MNA:	107524712(CREB1)

HAI:	109388316(CREB1)

DRO:	112307981(CREB1)

SHON:

118985184(CREB1)

AJM:	119064343(CREB1)

MMF:	118624959(CREB1)

PALE:

102888198(CREB1)

RAY:	107505169(CREB1)

MJV:

108396160

TOD:	119256146(CREB1)

LAV:	100675162(CREB1)

TMU:

101356881

MDO:	100014049(CREB1)

SHR:	100913327(CREB1)

PCW:	110223284(CREB1)

OAA:	100093310(CREB1)

GGA:	395099(CREB1)

PCOC:

116234000(CREB1)

MGP:	100542127(CREB1)

CJO:	107316551(CREB1)

NMEL:

110400086(CREB1)

ACYG:

106030089(CREB1)

TGU:	751585(CREB1)

LSR:	110475023(CREB1)

SCAN:

103814492(CREB1)

PMOA:

120501211(CREB1)

GFR:	102042770(CREB1)

FAB:	101811066(CREB1)

PHI:	102101211(CREB1)

PMAJ:

107207633(CREB1)

CCAE:

111932010(CREB1)

CCW:	104693796(CREB1)

ETL:	114055739(CREB1)

FPG:	101911755(CREB1)

FCH:	102050642(CREB1)

CLV:	102085492(CREB1)

EGZ:	104125074(CREB1)

NNI:	104010208(CREB1)

ACUN:

113482524(CREB1)

PADL:

103923613(CREB1)

ASN:	102385124(CREB1)

AMJ:	102564978(CREB1)

CPOO:

109322819(CREB1)

GGN:	109302005(CREB1)

PSS:	102450649(CREB1)

CMY:	102944794(CREB1)

CPIC:

101943249(CREB1)

TST:	117884675(CREB1)

CABI:

116816076(CREB1)

ACS:	100555818(creb1)

PVT:	110072401(CREB1)

PBI:	103058702(CREB1)

PMUR:

107295640(CREB1)

TSR:

106549740

PGUT:

117673970(CREB1)

PMUA:

114581842(CREB1)

ZVI:	118096395(CREB1)

GJA:	107105893(CREB1)

XLA:	108701473(creb1.L) 379764(creb1.S)

XTR:	407934(creb1)

NPR:	108790202(CREB1)

DRE:	573207(creb1a)

SRX:	107714305 107733657 107738506 107757658

SANH:

107655119 107663917 107691602 107698524

SGH:	107551947 107552236 107598164 107598781

CCAR:

109090350 109094170 109096014 109096669

CAUA:

113044283 113053225 113075942 113108775 113110806

IPU:	108258958 108267006(creb1)

PHYP:

113537276 113547038(creb1)

AMEX:

103024012 103036831(creb1)

EEE:	113567647(creb1) 113577247

TRU:	101074451 101076471

TNG:	GSTEN00001372G001 GSTEN00010058G001 GSTEN00015873G001 GSTEN00015879G001

LCO:	104923591 104928338

NCC:	104950718 104957759

ELY:	117250102 117251482(creb1b)

PLEP:

121948855(creb1b) 121962741

SLUC:

116036197(creb1b) 116044626

ECRA:

117939398 117952928(creb1b)

PFLV:

114550949 114564244(creb1)

GAT:	120822114 120833724(creb1b)

MSAM:

119904409(creb1b) 119904544

CUD:	121506134 121522312(creb1b)

MZE:	101465790 101472017(creb1)

ONL:	100697446 100701405(creb1)

OAU:	116314793(creb1b) 116332195

OLA:	101158674 101164105

OML:	112154837 112155243(creb1b) 112156702

XMA:	102221737 102227171(creb1)

XCO:	114140714 114148317(creb1)

XHE:	116716024 116723240(creb1)

PRET:

103473381 103478732(creb1)

CVG:	107084246 107100467(creb1)

CTUL:

119780813 119787947 119791389(creb1b)

NFU:	107377220 107389684

KMR:	108238846(creb1b) 108242185

ALIM:

106526083 106536062

AOCE:

111563020 111567084

CSEM:

103389560 103391910

POV:	109640884(creb1) 109644135

LCF:	108873038 108901273

SDU:	111218531 111233626

SLAL:

111652073 111665325 111673158

XGL:	120798332 120801603(creb1b)

HCQ:	109519410 109528643

BPEC:

110165862 110170896

MALB:

109968772 109972458

SASA:

106574945 106575835 106582380 106586339(creb1)

OTW:	112225620 112236481 112237973

OMY:	110495586 110495599 110501854 110520224(creb1b)

SALP:

111976709(creb1) 112073124

ELS:	105016260(creb1) 105023145

SFM:	108918913 108922300

PKI:	111851608 111852787

LOC:	102697439(creb1)

PSPA:

121322469 121323571

ARUT:

117400312 117427000

LCM:	102361965(CREB1)

CMK:	103176821(creb1)

RTP:

109933435

CIN:	100101830(creb/atf-c)

SCLV:

120342108

SPU:

100889197

APLC:

110973510

SKO:	100372540 102804530

DME:	Dmel_CG6103(CrebB)

DER:

6550116

DSE:

6614852

DSI:	Dsimw501_GD17392(Dsim_GD17392)

DYA:	Dyak_GE17723

DAN:

6505093

DSR:

110175965

DPO:	Dpse_GA22328

DPE:

6601755

DMN:

108160824

DWI:

6641104

DGR:	Dgri_GH17726

DMO:	Dmoj_GI15475

DAZ:

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP000237

ACOZ:

120959796

AARA:

120905982

AAG:

23687935

AALB:

109415675 109431112 115253974

CQU:	CpipJ_CPIJ003805

AME:

ACER:

BIM:

BTER:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

PGC:

OBO:

PCF:

NVI:	100121641(Creb)

CSOL:

MDL:

TCA:

DPA:

ATD:

AGB:

NVL:

APLN:

PPYR:

OTU:

BMOR:

692871(CREB)

BMAN:

114251539

MSEX:

115448159

DPL:	KGM_206083

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

NLU:	111047954 120356111

PHU:	Phum_PHUM613960

ZNE:

110840023

CSEC:

111863011

FCD:

110846005

DPX:	DAPPUDRAFT_330320

PVM:

113807625

HAME:

121857049

EAF:	111716715 111717943

ISC:	IscW_ISCW012507

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

CSCU:

PTEP:

SDM:

CEL:	CELE_Y41C4A.4(crh-1)

CBR:	CBG13248(Cbr-crh-1)

BMY:	BM_BM6510(Bma-crh-1)

LOA:	LOAG_06769

NAI:	NECAME_06452

PCAN:

BGT:

CRG:

MYI:

OBI:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:	100200223(CREB)

TAD:	TRIADDRAFT_54968

AQU:

100638625

» show all

Reference

PMID:2142528

Authors

Berkowitz LA, Gilman MZ

Title

Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

Journal

Proc Natl Acad Sci U S A 87:5258-62 (1990)
DOI:10.1073/pnas.87.14.5258

Sequence

[hsa:1385]

Reference

PMID:16455977

Authors

Chen HC, Byrd JC, Muthusamy N

Title

Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.

Journal

J Immunol 176:2208-18 (2006)
DOI:10.4049/jimmunol.176.4.2208

Sequence

[mmu:12912]

Reference

PMID:8397816

Authors

Usui T, Smolik SM, Goodman RH

Title

Isolation of Drosophila CREB-B: a novel CRE-binding protein.

Journal

DNA Cell Biol 12:589-95 (1993)
DOI:10.1089/dna.1993.12.589

Sequence

[dme:Dmel_CG6103]

LinkDB

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