KEGG   ORTHOLOGY: K05870
Entry
K05870                      KO                                     

Name
CREB1
Definition
cyclic AMP-responsive element-binding protein 1
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04380  Osteoclast differentiation
ko04612  Antigen processing and presentation
ko04668  TNF signaling pathway
ko04710  Circadian rhythm
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04931  Insulin resistance
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04962  Vasopressin-regulated water reabsorption
ko05016  Huntington disease
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04024 cAMP signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04022 cGMP-PKG signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04151 PI3K-Akt signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04152 AMPK signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09152 Endocrine system
   04911 Insulin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04922 Glucagon signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04915 Estrogen signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04926 Relaxin signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04935 Growth hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04918 Thyroid hormone synthesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04928 Parathyroid hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04916 Melanogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04924 Renin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04925 Aldosterone synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04927 Cortisol synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09156 Nervous system
   04725 Cholinergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04728 Dopaminergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09159 Environmental adaptation
   04710 Circadian rhythm
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04713 Circadian entrainment
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04714 Thermogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05161 Hepatitis B
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05163 Human cytomegalovirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05165 Human papillomavirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05020 Prion disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09165 Substance dependence
   05030 Cocaine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05031 Amphetamine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05034 Alcoholism
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04934 Cushing syndrome
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   03029 Mitochondrial biogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Other DBs
GO: 0035497
Genes
HSA: 1385(CREB1)
PTR: 459901(CREB1)
PPS: 100974672(CREB1)
GGO: 101144410(CREB1)
PON: 100294619(CREB1)
NLE: 100586647(CREB1)
MCC: 708717(CREB1)
MCF: 102141699(CREB1)
CSAB: 103217717(CREB1)
RRO: 104680220(CREB1)
RBB: 108540349(CREB1)
CJC: 100407681(CREB1)
SBQ: 101034085(CREB1)
MMU: 12912(Creb1)
MCAL: 110285614(Creb1)
MPAH: 110322391(Creb1)
RNO: 81646(Creb1)
MUN: 110551437(Creb1)
CGE: 100761582(Creb1)
NGI: 103744440(Creb1)
HGL: 101712503(Creb1)
CCAN: 109691946(Creb1)
OCU: 100351999(CREB1)
TUP: 102500092(CREB1)
CFA: 607922(CREB1)
VVP: 112922611(CREB1)
AML: 100477711(CREB1)
UMR: 103659802(CREB1)
UAH: 113250525(CREB1)
ORO: 101383024(CREB1)
ELK: 111147575
PTG: 102971333(CREB1)
PPAD: 109265159(CREB1)
AJU: 106967098(CREB1)
BTA: 281713(CREB1)
BOM: 102281756(CREB1)
BIU: 109570093(CREB1)
BBUB: 102401906(CREB1)
CHX: 102186065(CREB1)
OAS: 443118(CREB1)
SSC: 100736562(CREB1)
CFR: 102508765(CREB1)
CDK: 105093562(CREB1)
BACU: 103017577(CREB1)
LVE: 103075978(CREB1)
OOR: 101287685(CREB1)
DLE: 111171769(CREB1)
PCAD: 102989082(CREB1)
ECB: 100066388(CREB1)
EPZ: 103548908(CREB1)
EAI: 106828159(CREB1)
MYB: 102246867(CREB1)
MYD: 102754892(CREB1)
MNA: 107524712(CREB1)
HAI: 109388316(CREB1)
DRO: 112307981(CREB1)
PALE: 102888198(CREB1)
RAY: 107505169(CREB1)
MJV: 108396160
LAV: 100675162(CREB1)
TMU: 101356881
MDO: 100014049(CREB1)
SHR: 100913327(CREB1)
PCW: 110223284(CREB1)
OAA: 100093310(CREB1)
GGA: 395099(CREB1)
MGP: 100542127(CREB1)
CJO: 107316551(CREB1)
NMEL: 110400086(CREB1)
ACYG: 106030089(CREB1)
TGU: 751585(CREB1)
LSR: 110475023(CREB1)
SCAN: 103814492(CREB1)
GFR: 102042770(CREB1)
FAB: 101811066(CREB1)
PHI: 102101211(CREB1)
PMAJ: 107207633(CREB1)
CCAE: 111932010(CREB1)
CCW: 104693796(CREB1)
ETL: 114055739(CREB1)
FPG: 101911755(CREB1)
FCH: 102050642(CREB1)
CLV: 102085492(CREB1)
EGZ: 104125074(CREB1)
NNI: 104010208(CREB1)
ACUN: 113482524(CREB1)
PADL: 103923613(CREB1)
ASN: 102385124(CREB1)
AMJ: 102564978(CREB1)
PSS: 102450649(CREB1)
CMY: 102944794(CREB1)
CPIC: 101943249(CREB1)
ACS: 100555818(creb1)
PVT: 110072401(CREB1)
PBI: 103058702(CREB1)
PMUR: 107295640(CREB1)
TSR: 106549740
PMUA: 114581842(CREB1)
GJA: 107105893(CREB1)
XLA: 108701473 379764(creb1.S)
XTR: 407934(creb1)
NPR: 108790202(CREB1)
DRE: 573207(creb1a)
SRX: 107714305 107733657 107738506 107757658
SANH: 107655119 107663917 107691602 107698524
SGH: 107551947 107552236 107598164 107598781
CCAR: 109090350 109094170 109096014 109096669
IPU: 108258958 108267006(creb1)
PHYP: 113537276 113547038(creb1)
AMEX: 103024012 103036831(creb1)
EEE: 113567647(creb1) 113577247
TRU: 101074451 101076471
TNG: GSTEN00001372G001 GSTEN00010058G001 GSTEN00015873G001 GSTEN00015879G001
LCO: 104923591 104928338
NCC: 104950718 104957759
MZE: 101465790 101472017(creb1)
ONL: 100697446 100701405(creb1)
OLA: 101158674 101164105
XMA: 102221737 102227171(creb1)
XCO: 114140714 114148317(creb1)
PRET: 103473381 103478732(creb1)
CVG: 107084246 107100467(creb1)
NFU: 107377220 107389684
KMR: 108238846(creb1b) 108242185
ALIM: 106526083 106536062
AOCE: 111563020 111567084
CSEM: 103389560 103391910
POV: 109640884(creb1) 109644135
LCF: 108873038 108901273
SDU: 111218531 111233626
SLAL: 111652073 111665325 111673158
HCQ: 109519410 109528643
BPEC: 110165862 110170896
MALB: 109968772 109972458
SASA: 106574945 106575835 106582380 106586339(creb1)
OTW: 112225620 112236481 112237973
SALP: 111976709(creb1) 112073124
ELS: 105016260(creb1) 105023145
SFM: 108918913 108922300
PKI: 111851608 111852787
LCM: 102361965(CREB1)
CMK: 103176821(creb1)
RTP: 109933435
CIN: 100101830(creb/atf-c)
SPU: 100889197
NVE: 5513148
 » show all
Reference
PMID:2142528
  Authors
Berkowitz LA, Gilman MZ
  Title
Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
  Journal
Proc Natl Acad Sci U S A 87:5258-62 (1990)
DOI:10.1073/pnas.87.14.5258
  Sequence
[hsa:1385]
Reference
  Authors
Chen HC, Byrd JC, Muthusamy N
  Title
Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.
  Journal
J Immunol 176:2208-18 (2006)
DOI:10.4049/jimmunol.176.4.2208
  Sequence
[mmu:12912]
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