KEGG   ORTHOLOGY: K05870
Entry
K05870                      KO                                     

Name
CREB1
Definition
cyclic AMP-responsive element-binding protein 1
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04380  Osteoclast differentiation
map04612  Antigen processing and presentation
map04668  TNF signaling pathway
map04710  Circadian rhythm
map04713  Circadian entrainment
map04714  Thermogenesis
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04931  Insulin resistance
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map05016  Huntington disease
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05152  Tuberculosis
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04024 cAMP signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04022 cGMP-PKG signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04151 PI3K-Akt signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04152 AMPK signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09152 Endocrine system
   04911 Insulin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04922 Glucagon signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04915 Estrogen signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04926 Relaxin signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04935 Growth hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04918 Thyroid hormone synthesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04928 Parathyroid hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04916 Melanogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04924 Renin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04925 Aldosterone synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04927 Cortisol synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09156 Nervous system
   04725 Cholinergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04728 Dopaminergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09159 Environmental adaptation
   04710 Circadian rhythm
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04713 Circadian entrainment
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04714 Thermogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05203 Viral carcinogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05161 Hepatitis B
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05163 Human cytomegalovirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05165 Human papillomavirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05020 Prion disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09165 Substance dependence
   05030 Cocaine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05031 Amphetamine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05034 Alcoholism
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04934 Cushing syndrome
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   03029 Mitochondrial biogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Other DBs
GO: 0035497
Genes
HSA: 1385(CREB1)
PTR: 459901(CREB1)
PPS: 100974672(CREB1)
GGO: 101144410(CREB1)
PON: 100294619(CREB1)
NLE: 100586647(CREB1)
MCC: 708717(CREB1)
MCF: 102141699(CREB1)
CSAB: 103217717(CREB1)
CATY: 105580103(CREB1)
RRO: 104680220(CREB1)
RBB: 108540349(CREB1)
TFN: 117094598(CREB1)
PTEH: 111547676(CREB1)
CJC: 100407681(CREB1)
SBQ: 101034085(CREB1)
MMUR: 105864304(CREB1)
MMU: 12912(Creb1)
MCAL: 110285614(Creb1)
MPAH: 110322391(Creb1)
RNO: 81646(Creb1)
MCOC: 116088513(Creb1)
MUN: 110551437(Creb1)
CGE: 100761582(Creb1)
PLEU: 114705057(Creb1)
NGI: 103744440(Creb1)
HGL: 101712503(Creb1)
CCAN: 109691946(Creb1)
OCU: 100351999(CREB1)
TUP: 102500092(CREB1)
CFA: 607922(CREB1)
VVP: 112922611(CREB1)
VLG: 121480493(CREB1)
AML: 100477711(CREB1)
UMR: 103659802(CREB1)
UAH: 113250525(CREB1)
ORO: 101383024(CREB1)
ELK: 111147575
MPUF: 101677618(CREB1)
EJU: 114215964(CREB1)
MLX: 118012101(CREB1)
PTG: 102971333(CREB1)
PPAD: 109265159(CREB1)
AJU: 106967098(CREB1)
HHV: 120220409(CREB1)
BTA: 281713(CREB1)
BOM: 102281756(CREB1)
BIU: 109570093(CREB1)
BBUB: 102401906(CREB1)
CHX: 102186065(CREB1)
OAS: 443118(CREB1)
ODA: 120854564(CREB1)
SSC: 100736562(CREB1)
CFR: 102508765(CREB1)
CDK: 105093562(CREB1)
BACU: 103017577(CREB1)
LVE: 103075978(CREB1)
OOR: 101287685(CREB1)
DLE: 111171769(CREB1)
PCAD: 102989082(CREB1)
ECB: 100066388(CREB1)
EPZ: 103548908(CREB1)
EAI: 106828159(CREB1)
MYB: 102246867(CREB1)
MYD: 102754892(CREB1)
MMYO: 118661646(CREB1)
MNA: 107524712(CREB1)
HAI: 109388316(CREB1)
DRO: 112307981(CREB1)
SHON: 118985184(CREB1)
AJM: 119064343(CREB1)
MMF: 118624959(CREB1)
PALE: 102888198(CREB1)
RAY: 107505169(CREB1)
MJV: 108396160
TOD: 119256146(CREB1)
LAV: 100675162(CREB1)
TMU: 101356881
MDO: 100014049(CREB1)
SHR: 100913327(CREB1)
PCW: 110223284(CREB1)
OAA: 100093310(CREB1)
GGA: 395099(CREB1)
PCOC: 116234000(CREB1)
MGP: 100542127(CREB1)
CJO: 107316551(CREB1)
NMEL: 110400086(CREB1)
ACYG: 106030089(CREB1)
TGU: 751585(CREB1)
LSR: 110475023(CREB1)
SCAN: 103814492(CREB1)
PMOA: 120501211(CREB1)
GFR: 102042770(CREB1)
FAB: 101811066(CREB1)
PHI: 102101211(CREB1)
PMAJ: 107207633(CREB1)
CCAE: 111932010(CREB1)
CCW: 104693796(CREB1)
ETL: 114055739(CREB1)
FPG: 101911755(CREB1)
FCH: 102050642(CREB1)
CLV: 102085492(CREB1)
EGZ: 104125074(CREB1)
NNI: 104010208(CREB1)
ACUN: 113482524(CREB1)
PADL: 103923613(CREB1)
ASN: 102385124(CREB1)
AMJ: 102564978(CREB1)
CPOO: 109322819(CREB1)
GGN: 109302005(CREB1)
PSS: 102450649(CREB1)
CMY: 102944794(CREB1)
CPIC: 101943249(CREB1)
TST: 117884675(CREB1)
CABI: 116816076(CREB1)
ACS: 100555818(creb1)
PVT: 110072401(CREB1)
PBI: 103058702(CREB1)
PMUR: 107295640(CREB1)
TSR: 106549740
PGUT: 117673970(CREB1)
PMUA: 114581842(CREB1)
ZVI: 118096395(CREB1)
GJA: 107105893(CREB1)
XLA: 108701473(creb1.L) 379764(creb1.S)
XTR: 407934(creb1)
NPR: 108790202(CREB1)
DRE: 573207(creb1a)
IPU: 108258958 108267006(creb1)
PHYP: 113537276 113547038(creb1)
AMEX: 103024012 103036831(creb1)
EEE: 113567647(creb1) 113577247
ELY: 117250102 117251482(creb1b)
PLEP: 121948855(creb1b) 121962741
SLUC: 116036197(creb1b) 116044626
ECRA: 117939398 117952928(creb1b)
PFLV: 114550949 114564244(creb1)
GAT: 120822114 120833724(creb1b)
MSAM: 119904409(creb1b) 119904544
CUD: 121506134 121522312(creb1b)
MZE: 101465790 101472017(creb1)
ONL: 100697446 100701405(creb1)
OAU: 116314793(creb1b) 116332195
XMA: 102221737 102227171(creb1)
XCO: 114140714 114148317(creb1)
XHE: 116716024 116723240(creb1)
PRET: 103473381 103478732(creb1)
CVG: 107084246 107100467(creb1)
KMR: 108238846(creb1b) 108242185
POV: 109640884(creb1) 109644135
XGL: 120798332 120801603(creb1b)
SALP: 111976709(creb1) 112073124
ELS: 105016260(creb1) 105023145
LOC: 102697439(creb1)
LCM: 102361965(CREB1)
CMK: 103176821(creb1)
RTP: 109933435
CIN: 100101830(creb/atf-c)
SCLV: 120342108
SPU: 100889197
APLC: 110973510
DME: Dmel_CG6103(CrebB)
DER: 6550116
DSE: 6614852
DSI: Dsimw501_GD17392(Dsim_GD17392)
DAN: 6505093
DSR: 110175965
DPE: 6601755
DMN: 108160824
DWI: 6641104
DAZ: 108620004
DNV: 115563935
DHE: 111593025
DVI: 6632124
MDE: 101888107
LCQ: 111685990
ACOZ: 120959796
AARA: 120905982
AAG: 23687935
AME: 409401
ACER: 108001656
BIM: 100741354
BTER: 100651248
CCAL: 108632406
OBB: 114871042
MGEN: 117228689
NMEA: 116430409
CGIG: 122395117
SOC: 105200567
MPHA: 105831502
AEC: 105145195
PBAR: 105424320
VEM: 105568668
HST: 105186347
DQU: 106743926
CFO: 105256228
FEX: 115235306
PGC: 109852176
OBO: 105284048
PCF: 106793201
NVI: 100121641(Creb)
CSOL: 105361349
MDL: 103571628
TCA: 656052
DPA: 109539109
ATD: 109595494
AGB: 108903383
NVL: 108563046
APLN: 108738827
OTU: 111427355
BMOR: 692871(CREB)
BMAN: 114251539
MSEX: 115448159
BANY: 112052434
PMAC: 106710823
PPOT: 106109403
PXU: 106128443
PRAP: 110992742
ZCE: 119835024
HAW: 110369905
TNL: 113508022
API: 100160473
DNX: 107166267
AGS: 114126510
RMD: 113560820
BTAB: 109029782
DCI: 103518879
CLEC: 106668638
ZNE: 110840023
CSEC: 111863011
FCD: 110846005
PVM: 113807625
HAME: 121857049
DSV: 119441995
RSAN: 119387563
RMP: 119159702
VDE: 111255458
VJA: 111268730
TUT: 107362324
DPTE: 113793959
PTEP: 107438159
SDM: 118192902
CEL: CELE_Y41C4A.4(crh-1)
CBR: CBG13248(Cbr-crh-1)
BMY: BM_BM6510(Bma-crh-1)
PCAN: 112563796
BGT: 106073796
CRG: 105342835
MYI: 110452284
OBI: 106881849
LAK: 106157277
NVE: 5513148
EPA: 110232327
ATEN: 116294471
ADF: 107335994
AMIL: 114957341
PDAM: 113684239
SPIS: 111323438
DGT: 114515899
HMG: 100200223(CREB)
AQU: 100638625
 » show all
Reference
PMID:2142528
  Authors
Berkowitz LA, Gilman MZ
  Title
Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
  Journal
Proc Natl Acad Sci U S A 87:5258-62 (1990)
DOI:10.1073/pnas.87.14.5258
  Sequence
[hsa:1385]
Reference
  Authors
Chen HC, Byrd JC, Muthusamy N
  Title
Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.
  Journal
J Immunol 176:2208-18 (2006)
DOI:10.4049/jimmunol.176.4.2208
  Sequence
[mmu:12912]
Reference
PMID:8397816
  Authors
Usui T, Smolik SM, Goodman RH
  Title
Isolation of Drosophila CREB-B: a novel CRE-binding protein.
  Journal
DNA Cell Biol 12:589-95 (1993)
DOI:10.1089/dna.1993.12.589
  Sequence
LinkDB

KEGG   ORTHOLOGY: K04450
Entry
K04450                      KO                                     

Name
ATF2, CREBP1
Definition
cyclic AMP-dependent transcription factor ATF-2
Pathway
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04022  cGMP-PKG signaling pathway
map04151  PI3K-Akt signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04624  Toll and Imd signaling pathway
map04668  TNF signaling pathway
map04714  Thermogenesis
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04013 MAPK signaling pathway - fly
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04668 TNF signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04022 cGMP-PKG signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04151 PI3K-Akt signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09152 Endocrine system
   04911 Insulin secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04922 Glucagon signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04915 Estrogen signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04926 Relaxin signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04935 Growth hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04918 Thyroid hormone synthesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04928 Parathyroid hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04925 Aldosterone synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04927 Cortisol synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09156 Nervous system
   04728 Dopaminergic synapse
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09149 Aging
   04211 Longevity regulating pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05203 Viral carcinogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05161 Hepatitis B
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05163 Human cytomegalovirus infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09164 Neurodegenerative disease
   05020 Prion disease
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09165 Substance dependence
   05030 Cocaine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05031 Amphetamine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05034 Alcoholism
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Other DBs
GO: 0035497
Genes
HSA: 1386(ATF2)
PTR: 101059354(ATF2)
PPS: 100985706(ATF2)
GGO: 101135003(ATF2)
PON: 100450554(ATF2)
NLE: 100582751(ATF2)
MCC: 699072(ATF2)
MCF: 101925838(ATF2)
CSAB: 103217363(ATF2)
CATY: 105579833(ATF2)
PANU: 101011350(ATF2)
RRO: 104672399(ATF2)
RBB: 108527163(ATF2)
TFN: 117094833(ATF2)
PTEH: 111542753(ATF2)
CJC: 100414156(ATF2)
SBQ: 101035834(ATF2)
MMUR: 105865052(ATF2)
MMU: 11909(Atf2)
MCAL: 110286367(Atf2)
MPAH: 110317821(Atf2)
RNO: 81647(Atf2)
MCOC: 116091666(Atf2)
MUN: 110556579(Atf2)
CGE: 100754663(Atf2)
PLEU: 114700827(Atf2)
NGI: 103751761(Atf2)
HGL: 101717365(Atf2)
CCAN: 109689841(Atf2)
OCU: 100355367(ATF2)
TUP: 102473406(ATF2)
CFA: 478806(ATF2)
VVP: 112916383(ATF2)
VLG: 121501564(ATF2)
AML: 100474135(ATF2)
UMR: 103659593(ATF2)
UAH: 113250749(ATF2)
ORO: 101374034(ATF2)
ELK: 111142901
MPUF: 101690544(ATF2)
EJU: 114224124(ATF2)
MLX: 118012308(ATF2)
FCA: 101090884(ATF2)
PTG: 102954603(ATF2)
PPAD: 109273371(ATF2)
AJU: 106988085(ATF2)
HHV: 120243894(ATF2)
BTA: 509827(ATF2)
BOM: 102283891(ATF2)
BIU: 109566270(ATF2)
BBUB: 102410577(ATF2)
CHX: 102180634(ATF2)
OAS: 101108548(ATF2)
ODA: 120854293(ATF2)
SSC: 100513441(ATF2)
CFR: 102512476(ATF2)
CDK: 105097571(ATF2)
BACU: 102999133(ATF2)
LVE: 103089070(ATF2)
OOR: 101276923(ATF2)
DLE: 111172890(ATF2)
PCAD: 102974369(ATF2)
ECB: 100053304(ATF2)
EPZ: 103553756(ATF2)
EAI: 106837905(ATF2)
MYB: 102241887(ATF2)
MYD: 102761389(ATF2)
MMYO: 118661230(ATF2)
MNA: 107532468(ATF2)
HAI: 109388738(ATF2)
DRO: 112305718(ATF2)
SHON: 118985682(ATF2)
AJM: 119057201(ATF2)
MMF: 118625175(ATF2)
PALE: 102889014(ATF2)
RAY: 107504977(ATF2)
MJV: 108407377
TOD: 119255950(ATF2)
LAV: 100657989(ATF2)
TMU: 101359884
MDO: 100025939(ATF2)
SHR: 100914193(ATF2)
PCW: 110211588(ATF2)
OAA: 100077942(ATF2)
GGA: 395727(ATF2)
PCOC: 116232833(ATF2)
MGP: 100549420(ATF2)
CJO: 107316660(ATF2)
NMEL: 110399453(ATF2)
APLA: 101800932(ATF2)
ACYG: 106030015(ATF2)
TGU: 100226584(ATF2)
LSR: 110482896(ATF2)
SCAN: 103814449(ATF2)
PMOA: 120500700(ATF2)
GFR: 102034606(ATF2)
FAB: 101812575(ATF2)
PHI: 102105113(ATF2)
PMAJ: 107207532(ATF2)
CCAE: 111932059(ATF2)
CCW: 104693853(ATF2)
ETL: 114054885(ATF2)
FPG: 101912040(ATF2)
FCH: 102052727(ATF2)
CLV: 102084432(ATF2)
EGZ: 104128067(ATF2)
NNI: 104010014(ATF2)
ACUN: 113482190(ATF2)
PADL: 103924112(ATF2)
AAM: 106499205(ATF2)
ASN: 102387336(ATF2)
AMJ: 102572172(ATF2)
CPOO: 109322848(ATF2)
GGN: 109301712(ATF2)
PSS: 102460331(ATF2)
CMY: 102939131(ATF2)
CPIC: 101945668(ATF2)
TST: 117884769(ATF2)
CABI: 116827201(ATF2)
ACS: 100557710(atf2)
PVT: 110085213(ATF2)
PBI: 103053462(ATF2)
PMUR: 107301365(ATF2)
TSR: 106548735(ATF2)
PGUT: 117671729(ATF2)
PMUA: 114606668(ATF2) 114606722
ZVI: 118094461(ATF2)
GJA: 107123397(ATF2)
XLA: 108701386(atf2.L) 108703012
XTR: 100485532(atf2)
NPR: 108800395(ATF2)
DRE: 100006516(atf2)
SGH: 107600703
CAUA: 113053545 113109105(atf2)
IPU: 108266715(atf2)
PHYP: 113525280(atf2)
AMEX: 103028069(atf2)
EEE: 113582331(atf2)
TRU: 101063333(atf2)
LCO: 104924439(atf2)
NCC: 104965544(atf2)
ELY: 117251515(atf2)
PLEP: 121949234(atf2)
SLUC: 116048273(atf2)
ECRA: 117952621(atf2)
PFLV: 114564663(atf2)
GAT: 120833901(atf2)
MSAM: 119904115(atf2)
CUD: 121523045(atf2)
MZE: 101463949(atf2)
ONL: 100699389(atf2)
OAU: 116322969(atf2)
OLA: 101161843(atf2)
OML: 112155414(atf2)
XMA: 102234028(atf2)
XCO: 114148083(atf2)
XHE: 116723009(atf2)
PRET: 103458305(atf2)
CVG: 107085739(atf2)
CTUL: 119797535(atf2)
NFU: 107390001(atf2)
KMR: 108239783(atf2)
ALIM: 106512883(atf2)
AOCE: 111577835(atf2)
CSEM: 103391862 107988055(atf2)
POV: 109631016(atf2)
LCF: 108882968(atf2)
SDU: 111218870(atf2)
SLAL: 111654625(atf2)
XGL: 120801815(atf2)
HCQ: 109507870(atf2)
BPEC: 110166549(atf2)
MALB: 109958112(atf2)
SASA: 106582491 106586246(atf2)
OTW: 112236821(atf2)
OMY: 110501941 110520124(atf2)
SALP: 111959522 111975332(atf2)
ELS: 105016218(atf2)
SFM: 108920372(atf2) 108928057
PKI: 111838634(atf2)
LOC: 102687984(atf2)
ARUT: 117409383 117426833(atf2)
LCM: 102366239(ATF2) 106703183
CMK: 103176469(atf2)
RTP: 109914907 109929477(atf2)
BFO: 118403115
SPU: 577426
APLC: 110984186
DME: Dmel_CG44246(Atf-2)
DER: 6548433
DSE: 6618893
DSI: Dsimw501_GD11905(Dsim_GD11905)
DAN: 6496187
DSR: 110184110
DPE: 6592285
DWI: 6640182
DAZ: 108617045
DNV: 108654709
DHE: 111593910
DVI: 6627255
MDE: 101890809
LCQ: 111685726
ACOZ: 120957666
AARA: 120899786
AAG: 5577542
CPII: 120415596
AME: 100576527
ACER: 107998814
BIM: 100749459
BTER: 100649707
CCAL: 108632989
OBB: 114879534
MGEN: 117222605
NMEA: 116432713
CGIG: 122403408
SOC: 105202168
MPHA: 105839911
AEC: 105145677
ACEP: 105627948
PBAR: 105426825
VEM: 105565082
HST: 105192642
DQU: 106742046
CFO: 105249521
LHU: 105677106
PGC: 109858507
PCF: 106791946
NVI: 100119270
CSOL: 105361172
MDL: 103576287
TCA: 663103
DPA: 109539767
ATD: 109608283
AGB: 108907836
NVL: 108569504
PPYR: 116172949
BMOR: 100862750
BMAN: 114250244
BANY: 112043820
PMAC: 106715142
PPOT: 106107463
PXU: 106124939
PRAP: 110993434
ZCE: 119836510
HAW: 110369623
TNL: 113499958
PXY: 105390395
BTAB: 109041413
DCI: 103505653
CLEC: 106663685
NLU: 111051786
ZNE: 110833127
CSEC: 111864946
FCD: 110852191
PVM: 113822147
EAF: 111696387
DSV: 119456025
RSAN: 119394757
RMP: 119172692
VJA: 111268659
CSCU: 111619050
PTEP: 107440184
SDM: 118182201
PCAN: 112556639
BGT: 106070610
GAE: 121385639
CRG: 105323178
MYI: 110446621
PMAX: 117322365
OBI: 106878431
LAK: 106161773
NVE: 5514292
EPA: 110232304
ATEN: 116293486
ADF: 107348901
AMIL: 114967441
PDAM: 113668572
SPIS: 111331051
DGT: 114523073
HMG: 100213904
AQU: 100632529
APRO: F751_3120
MAW: MAC_08741
MAJ: MAA_01331
CMT: CCM_09413
 » show all
Reference
PMID:2529117
  Authors
Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M, Ishii S
  Title
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.
  Journal
EMBO J 8:2023-8 (1989)
DOI:10.1002/j.1460-2075.1989.tb03610.x
  Sequence
[hsa:1386]
Reference
  Authors
Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama KK
  Title
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
  Journal
Nature 405:195-200 (2000)
DOI:10.1038/35012097
  Sequence
[hsa:1386]
LinkDB

KEGG   ORTHOLOGY: K04374
Entry
K04374                      KO                                     

Name
ATF4, CREB2
Definition
cyclic AMP-dependent transcription factor ATF-4
Pathway
map04010  MAPK signaling pathway
map04022  cGMP-PKG signaling pathway
map04137  Mitophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04214  Apoptosis - fly
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04932  Non-alcoholic fatty liver disease
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04668 TNF signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04022 cGMP-PKG signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09143 Cell growth and death
   04210 Apoptosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04214 Apoptosis - fly
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04922 Glucagon signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04926 Relaxin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04935 Growth hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04918 Thyroid hormone synthesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04928 Parathyroid hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04925 Aldosterone synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04927 Cortisol synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09156 Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09149 Aging
   04211 Longevity regulating pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04212 Longevity regulating pathway - worm
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09162 Cancer: specific types
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05163 Human cytomegalovirus infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05012 Parkinson disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05014 Amyotrophic lateral sclerosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05020 Prion disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05022 Pathways of neurodegeneration - multiple diseases
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09165 Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04934 Cushing syndrome
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Other DBs
GO: 0035497
Genes
HSA: 468(ATF4)
PTR: 744513(ATF4)
PPS: 100988487(ATF4)
GGO: 101139584(ATF4)
PON: 100431578 100462459(ATF4)
NLE: 100588160(ATF4)
MCC: 703965(ATF4)
MCF: 102117938(ATF4)
CSAB: 103223345(ATF4)
CATY: 105572871(ATF4)
PANU: 101013627(ATF4)
RRO: 104682563(ATF4)
RBB: 108520463(ATF4)
TFN: 117096463(ATF4)
PTEH: 111548140 111548991(ATF4)
CJC: 100392193(ATF4)
SBQ: 101034435(ATF4)
MMUR: 105858535(ATF4)
MMU: 11911(Atf4)
MCAL: 110310868(Atf4)
MPAH: 110334651(Atf4)
RNO: 79255(Atf4)
MCOC: 116076129(Atf4)
CGE: 100689386(Atf4)
PLEU: 114687991 114694285(Atf4)
NGI: 103748563(Atf4)
HGL: 101724287(Atf4)
CCAN: 109693025(Atf4)
OCU: 100339383(ATF4)
TUP: 102478154(ATF4)
CFA: 474503(ATF4)
VVP: 112934037(ATF4)
VLG: 121492052(ATF4)
AML: 100476284(ATF4)
UMR: 103676372(ATF4)
UAH: 113241758(ATF4)
ORO: 101368122(ATF4)
ELK: 111157635
MPUF: 101680524(ATF4) 101694124
EJU: 114218458(ATF4)
MLX: 117998657(ATF4)
FCA: 101084297(ATF4)
PTG: 102950077(ATF4)
PPAD: 109265586(ATF4)
AJU: 106979942(ATF4)
HHV: 120235229(ATF4)
BTA: 509107(ATF4)
BOM: 102267423(ATF4)
BIU: 109559832(ATF4)
BBUB: 102393344(ATF4)
CHX: 102185072(ATF4)
OAS: 100216465(ATF4)
ODA: 120857618(ATF4)
SSC: 100144302(ATF4)
CFR: 102508076(ATF4)
CDK: 105091928(ATF4)
BACU: 103017770(ATF4)
LVE: 103083306(ATF4)
OOR: 101283438(ATF4)
DLE: 111186212(ATF4)
PCAD: 102984157(ATF4)
ECB: 100070334(ATF4)
EPZ: 103565289(ATF4)
EAI: 106842437(ATF4)
MYB: 102238786(ATF4)
MYD: 102763654(ATF4)
MMYO: 118649462(ATF4) 118666845
MNA: 107531265(ATF4)
HAI: 109392248(ATF4)
DRO: 112321682(ATF4)
SHON: 119002317(ATF4)
AJM: 119045974 119060217(ATF4)
MMF: 118623538(ATF4)
PALE: 102896553(ATF4)
RAY: 107500816(ATF4)
MJV: 108397369(ATF4)
TOD: 119247241(ATF4)
LAV: 100662521(ATF4)
TMU: 101345357
MDO: 100012224(ATF4)
SHR: 100913697(ATF4)
PCW: 110205802(ATF4)
OAA: 100089902(ATF4)
GGA: 395693(ATF4)
PCOC: 116233367(ATF4)
MGP: 100550984(ATF4)
CJO: 107312723(ATF4)
NMEL: 110392532(ATF4)
APLA: 101800475(ATF4)
ACYG: 106035925(ATF4)
TGU: 100190733(ATF4)
LSR: 110483790(ATF4)
SCAN: 103813275(ATF4)
PMOA: 120510126(ATF4)
GFR: 102036875(ATF4)
FAB: 101814204(ATF4)
PHI: 102100681(ATF4)
PMAJ: 107204914(ATF4)
CCAE: 111934860(ATF4)
CCW: 104696333(ATF4)
ETL: 114055356(ATF4)
FPG: 101921834(ATF4)
FCH: 102049324(ATF4)
CLV: 102093872(ATF4)
EGZ: 104134330(ATF4)
NNI: 104021625(ATF4)
ACUN: 113491317(ATF4)
PADL: 103915003(ATF4)
AAM: 106488703(ATF4)
ASN: 102369745(ATF4)
AMJ: 102564186(ATF4)
CPOO: 109316697(ATF4)
GGN: 109295982(ATF4)
PSS: 102449551(ATF4)
CMY: 102941988(ATF4)
CPIC: 101952513(ATF4)
TST: 117880204(ATF4)
CABI: 116824554(ATF4)
ACS: 100565177(atf4)
PVT: 110088080(ATF4)
PBI: 103055721(ATF4)
PMUR: 107288132(ATF4)
TSR: 106550401(ATF4)
PGUT: 117655911(ATF4)
PMUA: 114605162(ATF4)
ZVI: 118090901(ATF4)
GJA: 107117129(ATF4)
XLA: 398804(atf4.L) 734165(atf4.S)
XTR: 448005(atf4)
DRE: 406514(atf4a) 556410(atf4b)
IPU: 108273192(atf4)
PHYP: 113538304(atf4)
AMEX: 103027942(atf4)
EEE: 113579485(atf4)
TRU: 101070714(atf4) 101075957
NCC: 104958969 104967853(atf4)
ELY: 117255624(atf4a) 117269048(atf4b)
PLEP: 121942202(atf4a) 121957242(atf4b)
SLUC: 116042704(atf4a) 116065263(atf4b)
ECRA: 117952445(atf4a)
GAT: 120824619(atf4a) 120828216(atf4b)
MSAM: 119885408(atf4b) 119898630(atf4a)
CUD: 121503840(atf4b) 121508535(atf4a)
MZE: 101464981(atf4) 101475680
ONL: 100706109 100711796(atf4)
OAU: 116312590(atf4a) 116327828(atf4b)
OLA: 101168714(atf4-2) 101172388(atf4)
OML: 112137117(atf4a) 112146289(atf4b)
CVG: 107087200(atf4) 107090074
CTUL: 119771569(atf4b) 119796308(atf4a)
KMR: 108231541(atf4a) 108236059(atf4b)
ALIM: 106522498(atf4) 106534845
XGL: 120800522(atf4a) 120804743(atf4b)
HCQ: 109511289(atf4) 109520247
ELS: 105008440(atf4) 105029665
SFM: 108930667(atf4)
LOC: 102686890(atf4) 102690285
LCM: 102365086(ATF4)
RTP: 109919490
BFO: 118428974
CIN: 778545(atf4/5)
SCLV: 120332842
SPU: 586579
APLC: 110980911
SKO: 100376413
DME: Dmel_CG8669(crc)
DER: 6548901
DSI: Dsimw501_GD24316(Dsim_GD24316)
DPE: 6596600
DMN: 108163164
DWI: 6646727
DAZ: 108610991
DNV: 108658875
DHE: 111594286
MDE: 101900076
LCQ: 111689832
ACOZ: 120959921
AARA: 120905189
AAG: 5576642
CPII: 120427768
AME: 410226
ACER: 108001217
BIM: 100743669
BTER: 100651688
CCAL: 108622952
OBB: 114874933
MGEN: 117220162
NMEA: 116431894
CGIG: 122403079
SOC: 105196269
MPHA: 105837964
AEC: 105150924
ACEP: 105624047
PBAR: 105427649
VEM: 105557230
HST: 105183921
DQU: 106740699
CFO: 105254686
FEX: 115233306
LHU: 105676463
PGC: 109855311
OBO: 105286490
PCF: 106789497
NVI: 100122826
CSOL: 105362052
MDL: 103572891
TCA: 658480(ATF4)
DPA: 109541967
AGB: 108909348
NVL: 108565295
APLN: 108743374
PPYR: 116179953
OTU: 111417404
BMOR: 692594(Atf)
BMAN: 114249574
MSEX: 115451201
BANY: 112051663
PMAC: 106711673
PPOT: 106104652
PXU: 106121235
PRAP: 111003028
ZCE: 119828359
HAW: 110370227
TNL: 113496582
API: 100161513
DNX: 107161833
AGS: 114122290
RMD: 113551242
BTAB: 109033366
CLEC: 106663140
NLU: 111055672
ZNE: 110834497
CSEC: 111867610
FCD: 110848208
PVM: 113817207
EAF: 111703235
DSV: 119453228
RSAN: 119399950
RMP: 119180296
CSCU: 111613017
PTEP: 107437627
SDM: 118183614
CEL: CELE_T04C10.4(atf-4)
CBR: CBG07594(Cbr-atf-5)
BMY: BM_BM6228(Bma-zip-3)
PCAN: 112557459
BGT: 106056861
GAE: 121378299
CRG: 105336468
MYI: 110465611
OBI: 106880212
NVE: 116611673
EPA: 110239948
ATEN: 116307396
AMIL: 114953195
PDAM: 113670326
SPIS: 111330254
DGT: 114529187
HMG: 100197237
AQU: 100634724
DOSA: Os01t0211800-01(Os01g0211800)
MUS: 103997104
 » show all
Reference
  Authors
Ameri K, Harris AL
  Title
Activating transcription factor 4.
  Journal
Int J Biochem Cell Biol 40:14-21 (2008)
DOI:10.1016/j.biocel.2007.01.020
Reference
PMID:1534408
  Authors
Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM
  Title
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
  Journal
Proc Natl Acad Sci U S A 89:4820-4 (1992)
DOI:10.1073/pnas.89.11.4820
  Sequence
[hsa:468]
Reference
  Authors
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
  Title
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
  Journal
Nat Genet 38:674-81 (2006)
DOI:10.1038/ng1786
  Sequence
[hsa:468]
LinkDB

KEGG   ORTHOLOGY: K09048
Entry
K09048                      KO                                     

Name
CREB3
Definition
cyclic AMP-responsive element-binding protein 3
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04714  Thermogenesis
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04931  Insulin resistance
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map05016  Huntington disease
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
Disease
H00506  Osteogenesis imperfecta
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04024 cAMP signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04022 cGMP-PKG signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04151 PI3K-Akt signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04152 AMPK signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04922 Glucagon signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04915 Estrogen signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04926 Relaxin signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04935 Growth hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04918 Thyroid hormone synthesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04928 Parathyroid hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04916 Melanogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04925 Aldosterone synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04927 Cortisol synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09156 Nervous system
   04725 Cholinergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04728 Dopaminergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09149 Aging
   04211 Longevity regulating pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05203 Viral carcinogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09162 Cancer: specific types
   05215 Prostate cancer
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05161 Hepatitis B
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05163 Human cytomegalovirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05165 Human papillomavirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05020 Prion disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09165 Substance dependence
   05030 Cocaine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05031 Amphetamine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05034 Alcoholism
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04934 Cushing syndrome
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Other DBs
GO: 0008140
Genes
HSA: 10488(CREB3) 148327(CREB3L4) 64764(CREB3L2) 84699(CREB3L3) 90993(CREB3L1)
PTR: 451704(CREB3L1) 457341(CREB3L4) 465081(CREB3) 468672(CREB3L3) 738928(CREB3L2)
PPS: 100977358(CREB3L3) 100977804(CREB3L4) 100981063(CREB3L1) 100986194(CREB3L2) 100989680(CREB3)
GGO: 101128609(CREB3L2) 101144135(CREB3) 101144628(CREB3L1) 101152081(CREB3L4)
PON: 100127093(CREB3L2) 100432292(CREB3L1) 100436186(CREB3L4) 100438869(CREB3) 100441756(CREB3L3)
NLE: 100592170(CREB3L3) 100594080(CREB3L1) 100595943(CREB3L2) 100597876(CREB3) 100603387(CREB3L4)
MCC: 696350(CREB3) 713391(CREB3L1) 714981(CREB3L2) 715951(CREB3L4) 721825(CREB3L3)
MCF: 102134095(CREB3L4) 102136437(CREB3L3) 102139679(CREB3) 102142378(CREB3L1) 102146405(CREB3L2)
CSAB: 103219209(CREB3) 103223942(CREB3L4) 103226974(CREB3L2) 103233716(CREB3L3) 103236571(CREB3L1)
CATY: 105589639(CREB3L2) 105591802(CREB3L3) 105592792(CREB3L1) 105593478(CREB3L4) 105598130(CREB3)
PANU: 101004296(CREB3L2) 101004434(CREB3L3) 101008452(CREB3L1) 101017891(CREB3L4) 101020406(CREB3)
RRO: 104656623(CREB3L2) 104663511(CREB3L4) 104665486(CREB3L3) 104668385(CREB3L1) 104672444(CREB3)
RBB: 108512141(CREB3L3) 108518846(CREB3L4) 108518996(CREB3) 108519245(CREB3L1) 108542557(CREB3L2)
TFN: 117073578(CREB3L2) 117075642(CREB3L3) 117079895(CREB3L1) 117099006(CREB3)
PTEH: 111521981(CREB3L3) 111524755(CREB3L2) 111536760(CREB3) 111543707(CREB3L4) 111544982(CREB3L1)
CJC: 100394351(CREB3L3) 100406635(CREB3L1) 100408954(CREB3) 100409637(CREB3L2) 100411140(CREB3L4)
SBQ: 101036473(CREB3L3) 101041199(CREB3L4) 101042795(CREB3L2) 101044974(CREB3L1) 101052885(CREB3)
MMUR: 105859108(CREB3L2) 105873936(CREB3L3) 105874305(CREB3) 105885209(CREB3L1) 105885942(CREB3L4)
MMU: 12913(Creb3) 208647(Creb3l2) 208677(Creb3l3) 26427(Creb3l1) 78284(Creb3l4)
MCAL: 110289497(Creb3l1) 110291408(Creb3l4) 110292754(Creb3) 110296066(Creb3l2) 110303337(Creb3l3)
MPAH: 110316152(Creb3l2) 110318364(Creb3l1) 110320678(Creb3l4) 110326077(Creb3l3) 110338975(Creb3)
RNO: 310616(Creb3l4) 314638(Creb3l3) 362165(Creb3l1) 362339(Creb3l2)
MCOC: 116076210(Creb3l3) 116090490(Creb3l1) 116093212(Creb3l4) 116095903(Creb3) 116098735(Creb3l2)
MUN: 110549233(Creb3l2) 110549859(Creb3l1) 110554250(Creb3l4) 110555614(Creb3l3) 110561882(Creb3)
CGE: 100762192(Creb3l1) 100766300(Creb3l4) 100771872(Creb3l2) 100772940(Creb3) 100774488(Creb3l3)
PLEU: 114688126(Creb3l3) 114691010(Creb3l2) 114699702(Creb3l1) 114703207(Creb3) 114707907(Creb3l4)
NGI: 103726130(Creb3l2) 103737277(Creb3l3) 103741536(Creb3) 103748795(Creb3l1) 103751688(Creb3l4)
HGL: 101698748(Creb3l1) 101706643(Creb3l4) 101715715(Creb3l2) 101716023(Creb3l3) 101718447(Creb3)
CCAN: 109687810(Creb3l3) 109688048(Creb3l4) 109692000(Creb3l1) 109693373(Creb3) 109700597(Creb3l2)
OCU: 100343130(CREB3L2) 100345475(CREB3L1) 100357876(CREB3) 100358175(CREB3L4)
TUP: 102468245 102469074(CREB3) 102471928(CREB3L2) 102484102(CREB3L3) 102491362(CREB3L1) 102494703(CREB3L4)
CFA: 483636(CREB3L1) 485046(CREB3L3) 491369(CREB3L2) 611934(CREB3) 612303(CREB3L4)
VVP: 112908881(CREB3L2) 112918871(CREB3L4) 112924095(CREB3L1) 112930843(CREB3) 112935546(CREB3L3)
VLG: 121484743(CREB3L4) 121489094(CREB3L2) 121494424(CREB3) 121494648(CREB3L3) 121501517(CREB3L1)
AML: 100465448(CREB3L3) 100470867(CREB3L1) 100472104(CREB3) 100483482(CREB3L2) 100484531(CREB3L4)
UMR: 103667087(CREB3) 103668409(CREB3L4) 103669052(CREB3L2) 103672393(CREB3L1) 103681679(CREB3L3)
UAH: 113242823(CREB3L3) 113245324(CREB3L4) 113260470(CREB3) 113264732(CREB3L2) 113264990(CREB3L1)
ORO: 101376293(CREB3L3) 101381943(CREB3L4) 101383806(CREB3) 101385675(CREB3L2) 101385783(CREB3L1)
MPUF: 101679245(CREB3L3) 101681981(CREB3) 101684712(CREB3L4) 101685244(CREB3L1) 101688320(CREB3L2)
EJU: 114198708(CREB3L4) 114211711(CREB3L2) 114215177(CREB3L1) 114218277(CREB3) 114226347(CREB3L3)
MLX: 118005189(CREB3L3) 118013832(CREB3L4) 118015807(CREB3L1) 118017967(CREB3) 118021134(CREB3L2)
FCA: 101087097(CREB3L1) 101089838(CREB3L3) 101093555(CREB3) 101100293(CREB3L2) 101100442(CREB3L4)
PTG: 102949496(CREB3L2) 102949885(CREB3L1) 102950730(CREB3) 102954009(CREB3L4) 102956516(CREB3L3)
PPAD: 109245089(CREB3L1) 109255940(CREB3L3) 109256215(CREB3L4) 109269067(CREB3L2) 109270166(CREB3)
AJU: 106970423(CREB3L2) 106975473(CREB3L3) 106978069(CREB3L1) 106981255(CREB3) 106987262(CREB3L4)
HHV: 120221289(CREB3) 120221513(CREB3L4) 120228497(CREB3L1) 120232978(CREB3L2) 120242085(CREB3L3)
BTA: 281715(CREB3) 513010(CREB3L3) 513105(CREB3L1) 529566(CREB3L4) 785086(CREB3L2)
BOM: 102264680(CREB3L2) 102268154(CREB3L1) 102271999(CREB3L3) 102277321(CREB3) 102281505(CREB3L4)
BIU: 109554418(CREB3L4) 109557676(CREB3L2) 109561750(CREB3L3) 109563018(CREB3) 109569868(CREB3L1)
BBUB: 102395032(CREB3) 102398301(CREB3L4) 102400784(CREB3L3) 102406078(CREB3L1) 102416630(CREB3L2)
CHX: 102170199(CREB3L2) 102174829(CREB3L3) 102180221(CREB3) 102183745(CREB3L4) 102183893(CREB3L1)
OAS: 101107485(CREB3L4) 101108743(CREB3L2) 101113586(CREB3L3) 101113882(CREB3L1) 101114243(CREB3)
ODA: 120855782(CREB3L4) 120864822(CREB3L3) 120876928(CREB3L1) 120877626(CREB3L2) 120880365(CREB3)
SSC: 100142688(CREB3L4) 100142689(CREB3) 100516663(CREB3L1) 100520468(CREB3L2) 100522979(CREB3L3)
CFR: 102510171(CREB3L2) 102510394(CREB3) 102511454(CREB3L3) 102516586(CREB3L4) 102516625(CREB3L1)
CDK: 105089327(CREB3L4) 105091622(CREB3L2) 105102288(CREB3) 105105303(CREB3L3) 105106926(CREB3L1)
BACU: 102999898(CREB3L2) 103001736(CREB3) 103003868(CREB3L4) 103007680(CREB3L1) 103018056(CREB3L3)
LVE: 103071696(CREB3L2) 103085711(CREB3L4) 103086171(CREB3) 103087008(CREB3L1) 103091030(CREB3L3)
OOR: 101272184(CREB3) 101283835(CREB3L2) 101284966(CREB3L1) 101286338(CREB3L4) 101287411(CREB3L3)
DLE: 111166195(CREB3L3) 111167181(CREB3L4) 111177962(CREB3L2) 111183987(CREB3L1) 111188007(CREB3)
PCAD: 102975387(CREB3L2) 102986078(CREB3L4) 102987194(CREB3L1) 102994621(CREB3L3)
ECB: 100057002(CREB3L1) 100062307(CREB3L4) 100063153(CREB3L3) 100064828(CREB3L2) 100067794(CREB3)
EPZ: 103555399(CREB3L4) 103560297(CREB3) 103564266(CREB3L2) 103566499(CREB3L1)
EAI: 106829982(CREB3L2) 106832323(CREB3L3) 106843990(CREB3L1) 106846249(CREB3L4) 106846981(CREB3)
MYB: 102241829(CREB3) 102244833(CREB3L1) 102245296(CREB3L2) 102251355(CREB3L3) 102258024(CREB3L4)
MYD: 102762431(CREB3) 102764297(CREB3L3) 102768092(CREB3L1) 102772259(CREB3L4) 102773515(CREB3L2)
MMYO: 118658839(CREB3L3) 118665089(CREB3L1) 118666355(CREB3L2) 118667339(CREB3) 118673054(CREB3L4)
MNA: 107525737(CREB3L3) 107530327(CREB3L1) 107543873(CREB3L4) 107544136(CREB3L2) 107544933(CREB3)
HAI: 109373471(CREB3L4) 109388532(CREB3L2) 109388636(CREB3L3) 109390233(CREB3L1) 109393756(CREB3)
DRO: 112299769(CREB3L2) 112303463(CREB3L1) 112304550(CREB3) 112312688(CREB3L3) 112316383(CREB3L4)
SHON: 118974492(CREB3L1) 118979891(CREB3) 118984506(CREB3L3) 118989103(CREB3L2) 118990202(CREB3L4)
AJM: 119048742(CREB3) 119061780(CREB3L4) 119063765(CREB3L3) 119064485(CREB3L1) 119065205(CREB3L2)
MMF: 118615816(CREB3L3) 118620417(CREB3L2) 118628166(CREB3L1) 118629628(CREB3) 118637511(CREB3L4)
PALE: 102878515(CREB3L4) 102879289(CREB3L3) 102882888(CREB3L2) 102886510(CREB3) 102894633(CREB3L1)
RAY: 107499057(CREB3L2) 107502779(CREB3) 107509179(CREB3L4) 107510647(CREB3L3) 107511864(CREB3L1)
MJV: 108385045(CREB3L3) 108401935(CREB3L2) 108406808(CREB3L1) 108407563(CREB3) 108408210(CREB3L4)
TOD: 119232783(CREB3) 119235594(CREB3L4) 119239846(CREB3L3) 119246923 119247555(CREB3L2) 119255317(CREB3L1)
LAV: 100653565(CREB3L1) 100666211(CREB3L2) 100670574(CREB3L3) 100673694(CREB3L4) 100677344(CREB3)
MDO: 100015046(CREB3L1) 100017208(CREB3L2) 100020067(CREB3L4) 100022547(CREB3L3) 103104366(CREB3)
SHR: 100913890(CREB3L1) 100916355(CREB3) 100917654(CREB3L3) 100923082(CREB3L4) 100926416(CREB3L2)
PCW: 110197489(CREB3L3) 110201451(CREB3) 110211994(CREB3L4) 110216252(CREB3L2) 110224036(CREB3L1)
OAA: 100076562(CREB3L1) 100078176(CREB3L3) 100092528(CREB3L2) 103165821(CREB3)
GGA: 100859610(CREB3L1) 418123(CREB3L2) 427417(CREB3) 428333(CREB3L3)
PCOC: 116226824(CREB3L2) 116229173(CREB3L1) 116235835 116239709(CREB3)
MGP: 100539552(CREB3L1) 100551035(CREB3L2) 100551184(CREB3L3) 104914805(CREB3)
CJO: 107305791(CREB3) 107314830(CREB3L1) 107315837(CREB3L2) 107325596(CREB3L3)
NMEL: 110388853(CREB3L3) 110389944(CREB3) 110394585(CREB3L2) 110400949(CREB3L1)
APLA: 101792907(CREB3L2) 101795642(CREB3L1) 101798346 113840230(CREB3)
ACYG: 106030991(CREB3L2) 106036307(CREB3) 106043464(CREB3L1) 106044950(CREB3L3)
TGU: 100219636(CREB3L2) 100220102(CREB3L1) 100222350(CREB3) 115490820(CREB3L3) 115498485(CREB3L4)
LSR: 110472078(CREB3L1) 110478465(CREB3L3) 110482629(CREB3L2) 110484175(CREB3)
SCAN: 103819702(CREB3L2) 103822893(CREB3) 103824532(CREB3L3) 103825377 103826679(CREB3L1) 115484624(CREB3L4)
PMOA: 120499029(CREB3L3) 120500551(CREB3L1) 120501561(CREB3L2) 120502605(CREB3L4)
GFR: 102032931(CREB3L1) 102037565(CREB3L2) 102040985(CREB3L3) 102041988(CREB3)
FAB: 101807577(CREB3L1) 101807611(CREB3) 101810924(CREB3L2) 101814634(CREB3L3)
PHI: 102100666(CREB3L1) 102102105(CREB3L3) 102104228(CREB3L2) 102110548(CREB3L4) 102110913(CREB3)
PMAJ: 107204840(CREB3L2) 107206327(CREB3L1) 107214697(CREB3L4) 107215468(CREB3L3) 107216394(CREB3)
CCAE: 111930186(CREB3L1) 111936759(CREB3L2) 111940201(CREB3L3) 111941176(CREB3)
CCW: 104686582(CREB3) 104696487(CREB3L2) 104697409(CREB3L3) 104698184(CREB3L1)
ETL: 114056194(CREB3L2) 114059138(CREB3L1) 114068838(CREB3L3) 114069771(CREB3)
FPG: 101915392(CREB3L1) 101915893(CREB3) 101922621(CREB3L2) 101924469(CREB3L3)
FCH: 102049519(CREB3L3) 102052762(CREB3) 102055433(CREB3L2) 102060195(CREB3L1)
CLV: 102083943(CREB3L2) 102089621(CREB3L1) 102093765(CREB3L3) 102095967(CREB3)
EGZ: 104124398(CREB3L3) 104126149(CREB3L2) 104133839(CREB3) 104134083(CREB3L1)
NNI: 104012401(CREB3L2) 104015313 104018284(CREB3L4) 104018462 104018808(CREB3L3) 104020372(CREB3L1)
ACUN: 113480521(CREB3L1) 113489424(CREB3L3) 113489898(CREB3) 113490242(CREB3L2)
PADL: 103921718(CREB3L1) 103924510(CREB3L2) 103926010
AAM: 106488699(CREB3L2) 106492194(CREB3L3) 106498354(CREB3L1) 106499571(CREB3)
ASN: 102371679(CREB3L2) 102375258(CREB3L3) 102378465(CREB3L1) 102380509(CREB3L4)
AMJ: 102558288(CREB3L1) 102562994(CREB3L3) 102565945(CREB3) 102571170(CREB3L4) 102574172(CREB3L2)
CPOO: 109316517(CREB3L2) 109320958(CREB3L1) 109324769(CREB3L4) 109324878(CREB3L3)
GGN: 109294595(CREB3L4) 109294861(CREB3L3) 109296175(CREB3L2) 109297927(CREB3) 109298914(CREB3L1)
PSS: 102446107(CREB3L1) 102446716(CREB3L2) 102457323(CREB3L3)
CMY: 102939907(CREB3L2) 102940413(CREB3L1) 102941831(CREB3L3) 102946430(CREB3L4) 102948242(CREB3)
CPIC: 101931889(CREB3L1) 101933099(CREB3L3) 101933490(CREB3) 101941397(CREB3L2) 101949087(CREB3L4)
TST: 117868753(CREB3L3) 117876961(CREB3L1) 117881885(CREB3L2) 117889280(CREB3L4)
CABI: 116821709(CREB3L1) 116826454(CREB3L2) 116832743(CREB3L4) 116836951 116840024(CREB3L3)
ACS: 100557424(creb3l2) 100565677(creb3l1) 103281351(creb3)
PVT: 110072462(CREB3L3) 110078269(CREB3L2) 110081714(CREB3L1) 110082837(CREB3) 110088478(CREB3L4)
PBI: 103048883(CREB3L1) 103049180 103057599(CREB3L2) 103066719 107326149(CREB3L4)
PMUR: 107290408(CREB3L1) 107294181(CREB3L2) 107295319(CREB3L3) 107300011
TSR: 106546013(CREB3L1) 106552868(CREB3L4) 106554690(CREB3)
PGUT: 117655721(CREB3L2) 117656237 117658156 117665511(CREB3L1) 117679717(CREB3)
PMUA: 114588541(CREB3L3) 114596052(CREB3L1) 114605296(CREB3L2) 114606604(CREB3)
ZVI: 118076548(CREB3L4) 118077277(CREB3) 118085172(CREB3L1) 118087690(CREB3L3) 118090656(CREB3L2)
GJA: 107107817(CREB3L1) 107110879(CREB3L4) 107118239(CREB3L3) 107120250 107121734(CREB3L2)
XLA: 100037168(creb3l2.L) 108699636(creb3l4.L) 108700416(creb3l4.S) 108712546(creb3l2.S) 108713769(creb3l1.L) 108715242 735076(creb3.S)
XTR: 100127204(creb3) 100145418(creb3l2) 100496679(creb3l1) 101733496 780164(creb3l4)
NPR: 108785446(CREB3L1) 108788718(CREB3L2) 108798798(CREB3L4) 108801809
DRE: 100333318(creb3l4) 100538072(creb3l3b) 338317(creb3l1) 406853(creb3l3l) 553700(creb3l3a) 791169(creb3l2)
IPU: 108259676(creb3l1) 108263495(CREB3L4) 108264943 108271409 108280078(creb3l2) 108280217(creb3l3)
AMEX: 103023873(creb3l2) 103037168 103039026 103040796(creb3l3) 103042370(creb3l1)
TRU: 101063133(creb3l4) 101065014 101067583 101070432(creb3l1) 101078259(creb3l2) 115247989
LCO: 104917983(creb3l1) 104920685(creb3l3) 104921083 104929667 104935986(creb3l2) 104938216
ELY: 117249402(creb3l2) 117250858(creb3l4) 117251919(creb3l3l) 117253420(creb3l3a) 117255561(creb3l1) 117266051 117271672
PLEP: 121941097(creb3l3a) 121944897(creb3l3l) 121945706 121951935 121962840(creb3l1) 121964668
SLUC: 116037440 116044725(creb3l1) 116054161(creb3l3l) 116060046(creb3l2) 116063448(creb3l3a) 116064666(creb3l4)
ECRA: 117938597(creb3l2) 117939139(creb3l1) 117945116(creb3l3l) 117945906 117950952(creb3l3a) 117954839
GAT: 120809995(creb3l4) 120815737(creb3l1) 120815742 120817596(creb3l2) 120824412(creb3l3a) 120831393(creb3l3l)
MSAM: 119891704(creb3l3l) 119896924(creb3l4) 119900896(creb3l3a) 119902927 119903161(creb3l1) 119918174(creb3l2)
CUD: 121505649(creb3l2) 121506027(creb3l1) 121510160(creb3l3l) 121512620(creb3l3a) 121513130(creb3l4) 121520209
MZE: 101466226(creb3l4) 101469085(creb3l1) 101480575(creb3l2) 101483965 101486384 101487513
ONL: 100702359 100703380(creb3l1) 100705423(creb3l2) 100708760 100709801 100710280(creb3l4)
OAU: 116310036(creb3l3a) 116310531(creb3l3l) 116318705 116325482(creb3l2) 116327751(creb3l4) 116327942(creb3l1)
OLA: 101164317 101164631(creb3l4) 101165931(creb3l2) 101167274(creb3l1) 101171479 105356229
OML: 112136598(creb3l4) 112138382(creb3l1) 112140965(creb3l3a) 112147604 112148825(creb3l3l) 112158189(creb3l2)
XMA: 102216562 102218843 102222043(creb3l4) 102226512(creb3l2) 102233894 102237210(creb3l1)
PRET: 103459160(creb3l2) 103460971 103463663(creb3l3) 103470136 103475175(creb3l1) 103477467
CTUL: 119773527 119780926(creb3l4) 119788604(creb3l1) 119792560(creb3l3a) 119793187(creb3l2) 119798591(creb3l3l)
NFU: 107379008 107380915(creb3l1) 107384140(creb3l3) 107387370(creb3l2) 107394107 107395105
KMR: 108228863 108230557(creb3l3a) 108233180(creb3l2) 108233549(creb3l3l) 108239471 108244130(creb3l1)
ALIM: 106513612 106515012(creb3l3) 106524439(creb3l2) 106526404 106529646(creb3l1) 106532492
POV: 109625400 109639345 109640074(creb3l1) 109641651(creb3l3) 109642995(creb3l2) 109643269
LCF: 108877321 108882528 108883606 108884667(creb3l4) 108892924(creb3l1) 108895942(creb3l2)
XGL: 120783898(creb3l4) 120790421(creb3l3a) 120798076(creb3l1) 120798641 120801124(creb3l2) 120805285(creb3l3l)
HCQ: 109507313 109512147(creb3l4) 109517508 109520937(creb3l1) 109530066(creb3l2) 109531892
MALB: 109953821 109956522 109960567(creb3l1) 109964980(creb3l2) 109965712 109970108(creb3l4)
LOC: 102692984(creb3l4) 102693476 102693721(creb3l3) 102694259(creb3l1) 102695734
LCM: 102350106(CREB3L3) 102352986(CREB3L4) 102353080(CREB3L2) 102357132(CREB3L1) 102361726
CMK: 103180995(creb3) 103181867(creb3l2) 103183529(creb3l3) 103186023(creb3l1)
RTP: 109911765(creb3l3) 109915849(creb3l2) 109916114 109918439(creb3l1) 109925779
CIN: 778569(creb/atf-a) 778570(creb/atf-b)
DME: Dmel_CG7450(CrebA)
DER: 6544563
DSE: 6605789
DSI: Dsimw501_GD14552(Dsim_GD14552)
DAN: 6492931
DSR: 110176261
DPE: 6597062
DMN: 108151035
DWI: 6651979
DAZ: 108612280
DNV: 108650160
DVI: 6623712
MDE: 101895237
LCQ: 111674972
AARA: 120904156
AALB: 109407640
NVI: 100120780
CSOL: 105365458
APLN: 108739296
ZCE: 119833684
FCD: 110842466
CSCU: 111625880
SDM: 118187672
BMY: BM_BM4516(Bma-let-607)
 » show all
Reference
  Authors
Jang SW, Kim YS, Kim YR, Sung HJ, Ko J
  Title
Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.
  Journal
J Biol Chem 282:11092-100 (2007)
DOI:10.1074/jbc.M607962200
  Sequence
[hsa:10488]
Reference
PMID:9271389
  Authors
Lu R, Yang P, O'Hare P, Misra V
  Title
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.
  Journal
Mol Cell Biol 17:5117-26 (1997)
DOI:10.1128/MCB.17.9.5117
  Sequence
[hsa:10488]
LinkDB

KEGG   ORTHOLOGY: K09047
Entry
K09047                      KO                                     

Name
CREB5, CREBPA
Definition
cyclic AMP-responsive element-binding protein 5
Pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04714  Thermogenesis
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04931  Insulin resistance
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map05016  Huntington disease
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04024 cAMP signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04022 cGMP-PKG signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04151 PI3K-Akt signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04152 AMPK signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04922 Glucagon signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04915 Estrogen signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04926 Relaxin signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04935 Growth hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04918 Thyroid hormone synthesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04928 Parathyroid hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04925 Aldosterone synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04927 Cortisol synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09156 Nervous system
   04725 Cholinergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04728 Dopaminergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09149 Aging
   04211 Longevity regulating pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05203 Viral carcinogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09162 Cancer: specific types
   05215 Prostate cancer
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05161 Hepatitis B
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05163 Human cytomegalovirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05165 Human papillomavirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05020 Prion disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09165 Substance dependence
   05030 Cocaine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05031 Amphetamine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05034 Alcoholism
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04934 Cushing syndrome
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Other DBs
GO: 0035497
Genes
HSA: 9586(CREB5)
PTR: 463318(CREB5)
PPS: 100973232(CREB5)
GGO: 101153965
PON: 100439720(CREB5)
NLE: 100600059(CREB5)
MCC: 697718(CREB5)
MCF: 102123367(CREB5)
CSAB: 103226299(CREB5)
CATY: 105595971(CREB5)
PANU: 101007514(CREB5)
RRO: 104681895(CREB5)
RBB: 108535460(CREB5)
TFN: 117072944(CREB5)
PTEH: 111551841(CREB5)
CJC: 100392579(CREB5)
SBQ: 101054090(CREB5)
MMUR: 105855129
MMU: 231991(Creb5)
MCAL: 110296203(Creb5)
MPAH: 110315994(Creb5)
RNO: 500131(Creb5)
MCOC: 116098936(Creb5)
MUN: 110554970
CGE: 100764159(Creb5)
PLEU: 114689726(Creb5)
NGI: 103740829(Creb5)
HGL: 101703315(Creb5)
CCAN: 109676751
OCU: 100357483(CREB5)
TUP: 102487006(CREB5)
CFA: 475266(CREB5)
VVP: 112915694
VLG: 121474745(CREB5)
AML: 100474261(CREB5)
UMR: 103658932(CREB5)
UAH: 113262153(CREB5)
ORO: 101384862(CREB5)
ELK: 111147321
MPUF: 101677234(CREB5)
EJU: 114221152(CREB5)
MLX: 118021299(CREB5)
FCA: 101084784(CREB5)
PTG: 102972337(CREB5)
PPAD: 109263891(CREB5)
AJU: 106987665(CREB5)
HHV: 120230339(CREB5)
BTA: 534129(CREB5)
BOM: 102275204(CREB5)
BIU: 109557489(CREB5)
BBUB: 102400864(CREB5)
CHX: 102190378(CREB5)
OAS: 101112976(CREB5)
ODA: 120877414(CREB5)
SSC: 100515635(CREB5)
CFR: 102514154(CREB5)
CDK: 105095833(CREB5)
BACU: 103009193(CREB5)
LVE: 103081811(CREB5)
OOR: 101289047(CREB5)
DLE: 111180225(CREB5)
PCAD: 102985635(CREB5)
ECB: 100054803(CREB5)
EPZ: 103549839(CREB5)
EAI: 106831046(CREB5)
MYB: 102240701(CREB5)
MYD: 102769297(CREB5)
MMYO: 118666077(CREB5)
MNA: 107544390(CREB5)
HAI: 109381368(CREB5)
DRO: 112306927(CREB5)
SHON: 118983579(CREB5)
AJM: 119035286(CREB5)
MMF: 118620061(CREB5)
PALE: 102884583(CREB5)
RAY: 107505683(CREB5)
MJV: 108405132(CREB5)
TOD: 119243789(CREB5)
LAV: 100675079(CREB5)
TMU: 101345798
MDO: 100032634(CREB5)
SHR: 100922067(CREB5)
PCW: 110213063(CREB5)
OAA: 100080655(CREB5)
GGA: 428435(CREB5)
PCOC: 116227073(CREB5)
MGP: 100541001(CREB5)
CJO: 107309226(CREB5)
NMEL: 110394289(CREB5)
APLA: 101797962(CREB5)
ACYG: 106030241(CREB5)
TGU: 100228299(CREB5)
LSR: 110474631(CREB5)
SCAN: 103812908(CREB5)
PMOA: 120501239(CREB5)
GFR: 102044631(CREB5)
FAB: 101805839(CREB5)
PHI: 102103048(CREB5)
PMAJ: 107200380(CREB5)
CCAE: 111923428(CREB5)
CCW: 104689082(CREB5)
ETL: 114055673(CREB5)
FPG: 101920362(CREB5)
FCH: 102055392(CREB5)
CLV: 102084581(CREB5)
EGZ: 104126134(CREB5)
NNI: 104013914(CREB5)
ACUN: 113476866(CREB5)
PADL: 103918402(CREB5)
AAM: 106483468(CREB5)
ASN: 102372372
AMJ: 102576266(CREB5)
CPOO: 109310251(CREB5)
GGN: 109291585(CREB5)
PSS: 102453617(CREB5)
CMY: 102933695(CREB5)
CPIC: 101933432(CREB5)
TST: 117872346(CREB5)
CABI: 116820977(CREB5)
ACS: 100567734(creb5)
PVT: 110072290(CREB5)
PBI: 103060982(CREB5)
PMUR: 107282774
TSR: 106541450(CREB5)
PGUT: 117655170(CREB5)
PMUA: 114607489(CREB5)
ZVI: 118092189(CREB5)
GJA: 107105766(CREB5)
XLA: 108718906(creb5.L) 108719935(creb5.S)
XTR: 100498464(creb5)
NPR: 108803870(CREB5)
DRE: 101886947(creb5a) 565910(creb5b)
IPU: 108257012(ATF2) 108270486(creb5)
PHYP: 113536287 113542461(creb5)
AMEX: 103036725(creb5)
EEE: 113571214(creb5) 113580399
TRU: 101061266(creb5) 101065138
LCO: 104927758(creb5) 104940561
NCC: 104941125 104949893(creb5)
ELY: 117263157(creb5a) 117265323(creb5b)
PLEP: 121945545(creb5b) 121957945(creb5a)
SLUC: 116049397(creb5b) 116066858
ECRA: 117946489(creb5b) 117956234(creb5a)
PFLV: 114557902(creb5) 114567851
GAT: 120810763(creb5b) 120826619
MSAM: 119897742(creb5b) 119907284
CUD: 121513984(creb5b) 121523912
MZE: 101464485 101486831(creb5)
ONL: 100690870(creb5) 100707290
OAU: 116325419(creb5b) 120435909
OLA: 101157318(creb5) 101173798
OML: 112143939(creb5b) 112159861(creb5a)
XMA: 102224332(creb5) 102237102
XCO: 114141104(creb5) 114155699
XHE: 116717012(creb5) 116730719
PRET: 103472184 103478569(creb5)
CVG: 107082305(creb5) 107084368
CTUL: 119772846(creb5b) 119779523(creb5a)
NFU: 107383381 107395571(creb5)
KMR: 108238370 108241930(creb5b)
AOCE: 111570283 111588838(creb5)
CSEM: 103388419(creb5) 103394221
LCF: 108877062 108891362(creb5)
SDU: 111223427 111238792(creb5)
SLAL: 111652760(creb5) 111673321
XGL: 120783634(creb5b) 120785962(creb5a)
HCQ: 109512009 109525639(creb5)
BPEC: 110171756(creb5)
MALB: 109967324(creb5) 109968120
SALP: 111954764 111955868(creb5)
ELS: 105018814(creb5) 105023646
LOC: 102686564(creb5)
PSPA: 121313641 121315117(creb5b)
LCM: 102347706(CREB5)
CMK: 103183158(creb5)
RTP: 109932100
SCLV: 120342157
 » show all
Reference
PMID:8440710
  Authors
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S
  Title
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.
  Journal
J Biol Chem 268:4259-66 (1993)
  Sequence
[hsa:9586]
Reference
  Authors
Qi L, Ding Y
  Title
Involvement of the CREB5 regulatory network in colorectal cancer metastasis.
  Journal
Yi Chuan 36:679-84 (2014)
DOI:10.3724/SP.J.1005.2014.0679
  Sequence
[hsa:9586]
LinkDB

KEGG   ORTHOLOGY: K09049
Entry
K09049                      KO                                     

Name
ATF6B, CREBL1
Definition
cyclic AMP-dependent transcription factor ATF-6 beta
Pathway
map04022  cGMP-PKG signaling pathway
map04141  Protein processing in endoplasmic reticulum
map04151  PI3K-Akt signaling pathway
map04211  Longevity regulating pathway
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05020  Prion disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04022 cGMP-PKG signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04151 PI3K-Akt signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04915 Estrogen signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04926 Relaxin signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04935 Growth hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04918 Thyroid hormone synthesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04928 Parathyroid hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04925 Aldosterone synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04927 Cortisol synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09156 Nervous system
   04728 Dopaminergic synapse
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09149 Aging
   04211 Longevity regulating pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05203 Viral carcinogenesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05161 Hepatitis B
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05163 Human cytomegalovirus infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09164 Neurodegenerative disease
   05020 Prion disease
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09165 Substance dependence
   05030 Cocaine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05031 Amphetamine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05034 Alcoholism
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Genes
HSA: 1388(ATF6B)
PTR: 107975108(ATF6B)
PPS: 100993334(ATF6B)
GGO: 101146740(ATF6B)
PON: 100172895(ATF6B)
NLE: 100598020(ATF6B)
MCC: 717050(ATF6B)
MCF: 102129446(ATF6B)
CSAB: 103221718(ATF6B)
CATY: 105574100(ATF6B)
RRO: 104674035(ATF6B)
RBB: 108519898(ATF6B)
TFN: 117086987(ATF6B)
PTEH: 111528965(ATF6B)
CJC: 100411862(ATF6B)
SBQ: 101047355(ATF6B)
MMUR: 105858143(ATF6B)
MMU: 12915(Atf6b)
MCAL: 110312537(Atf6b)
MPAH: 110335526(Atf6b)
RNO: 406169(Atf6b)
MCOC: 116075007(Atf6b)
MUN: 110565383(Atf6b)
CGE: 100767112(Atf6b)
PLEU: 114705847(Atf6b)
NGI: 103724413(Atf6b)
HGL: 101715793(Atf6b)
CCAN: 109699672(Atf6b)
OCU: 100357489(ATF6B)
TUP: 102484080(ATF6B)
CFA: 474855(ATF6B)
VVP: 112913633(ATF6B)
VLG: 121500790(ATF6B)
AML: 100476017(ATF6B)
UMR: 103682282(ATF6B)
UAH: 113243741(ATF6B)
ORO: 101381436(ATF6B)
ELK: 111152366
MPUF: 101688202(ATF6B)
MLX: 118027308(ATF6B)
FCA: 101094849(ATF6B)
PTG: 102965640(ATF6B)
PPAD: 109260558(ATF6B)
AJU: 106983500(ATF6B)
HHV: 120221927(ATF6B)
BTA: 513928(ATF6B)
BOM: 102288212(ATF6B)
BIU: 109576848(ATF6B)
BBUB: 102392963(ATF6B)
CHX: 102171671(ATF6B)
OAS: 101113631(ATF6B)
ODA: 120870582(ATF6B)
SSC: 100144516(ATF6B)
CFR: 102521467(ATF6B)
CDK: 105090854(ATF6B)
BACU: 103014625(ATF6B)
LVE: 103069101(ATF6B)
OOR: 101273605(ATF6B)
DLE: 111170946(ATF6B)
PCAD: 102978131(ATF6B)
ECB: 100059348(ATF6B)
EPZ: 103563297(ATF6B)
EAI: 106831009(ATF6B)
MYB: 102261840(ATF6B)
MYD: 102767346(ATF6B)
MMYO: 118679616(ATF6B)
MNA: 107539006(ATF6B)
HAI: 109373089(ATF6B)
DRO: 112302085(ATF6B)
SHON: 118991453(ATF6B)
AJM: 119053748(ATF6B)
MMF: 118621725(ATF6B)
PALE: 102898128(ATF6B)
RAY: 107498439(ATF6B)
MJV: 108393793(ATF6B)
TOD: 119252241(ATF6B)
LAV: 100666885(ATF6B)
TMU: 101359783
MDO: 100025603(ATF6B)
SHR: 100932966(ATF6B)
PCW: 110199423(ATF6B)
OAA: 100080771(ATF6B)
PHI: 102113904(ATF6B)
ASN: 102383000(ATF6B)
AMJ: 102575911(ATF6B)
CMY: 114019910(ATF6B)
CPIC: 101948982(ATF6B)
CABI: 116815179(ATF6B)
ACS: 100557347(atf6b)
PVT: 110070069(ATF6B)
PBI: 103058912(ATF6B)
PMUR: 107298366
TSR: 106546721(ATF6B)
PGUT: 117667838(ATF6B)
PMUA: 114592080(ATF6B)
ZVI: 118080979(ATF6B)
GJA: 107118458(ATF6B)
XLA: 108698555(atf6b.L) 108700226(atf6b.S)
XTR: 100488855(atf6b)
NPR: 108786537(ATF6B)
DRE: 777612(atf6b)
CCAR: 109111390
CAUA: 113119112
IPU: 108274800(atf6b)
AMEX: 103031559
EEE: 113583832(atf6b)
TRU: 101073153
LCO: 104930576(atf6b)
ELY: 117263546(atf6b)
PLEP: 121957909(atf6b)
SLUC: 116051692(atf6b) 116060846
ECRA: 117957210(atf6b)
PFLV: 114568759(atf6b)
GAT: 120826729(atf6b)
MSAM: 119907199(atf6b)
CUD: 121523769(atf6b)
MZE: 101468193(atf6b)
ONL: 100705378
OAU: 116333507(atf6b)
OML: 112162627(atf6b)
XMA: 102225633(atf6b)
XCO: 114156358(atf6b)
XHE: 116731547(atf6b)
PRET: 103472821(atf6b)
CVG: 107104477(atf6b)
CTUL: 119779916(atf6b)
NFU: 107394433(atf6b)
KMR: 108246380(atf6b)
ALIM: 106528703(atf6b)
AOCE: 111568555(atf6b)
CSEM: 103393796(atf6b)
POV: 109645876(atf6b)
LCF: 108891249(atf6b)
SDU: 111230666(atf6b)
SLAL: 111665658(atf6b)
XGL: 120786065(atf6b)
HCQ: 109515145(atf6b)
BPEC: 110160837(atf6b)
MALB: 109952481(atf6b)
SASA: 106569944(ATF6) 106588375(ATF6)
ELS: 105028060
SFM: 108935684(atf6b)
PKI: 111842807(atf6b)
LCM: 102345323(ATF6B)
RTP: 109913847
BFO: 118420980
SPU: 589006
APLC: 110976451
AARA: 120903376
PPOT: 106107789
VDE: 111243024
VJA: 111264044
SDM: 118188216
PCAN: 112575671
BGT: 106076369
GAE: 121382590
MYI: 110464394
PMAX: 117322044
ATEN: 116303196
AMIL: 114954997
 » show all
Reference
PMID:8586413
  Authors
Min J, Shukla H, Kozono H, Bronson SK, Weissman SM, Chaplin DD
  Title
A novel Creb family gene telomeric of HLA-DRA in the HLA complex.
  Journal
Genomics 30:149-56 (1995)
DOI:10.1006/geno.1995.9891
  Sequence
[hsa:1388]
Reference
  Authors
Thuerauf DJ, Morrison L, Glembotski CC
  Title
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
  Journal
J Biol Chem 279:21078-84 (2004)
DOI:10.1074/jbc.M400713200
  Sequence
[hsa:1388]
LinkDB

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