KEGG   ORTHOLOGY: K05870
Entry
K05870                      KO                                     

Name
CREB1
Definition
cyclic AMP-responsive element-binding protein 1
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04380  Osteoclast differentiation
ko04612  Antigen processing and presentation
ko04668  TNF signaling pathway
ko04710  Circadian rhythm
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04931  Insulin resistance
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04962  Vasopressin-regulated water reabsorption
ko05016  Huntington disease
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04024 cAMP signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04022 cGMP-PKG signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04151 PI3K-Akt signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04152 AMPK signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09152 Endocrine system
   04911 Insulin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04922 Glucagon signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04915 Estrogen signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04926 Relaxin signaling pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04935 Growth hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04918 Thyroid hormone synthesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04928 Parathyroid hormone synthesis, secretion and action
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04916 Melanogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04924 Renin secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04925 Aldosterone synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04927 Cortisol synthesis and secretion
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09156 Nervous system
   04725 Cholinergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04728 Dopaminergic synapse
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09149 Aging
   04211 Longevity regulating pathway
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09159 Environmental adaptation
   04710 Circadian rhythm
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04713 Circadian entrainment
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04714 Thermogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09162 Cancer: specific types
   05215 Prostate cancer
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05020 Prion disease
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09165 Substance dependence
   05030 Cocaine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05031 Amphetamine addiction
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05034 Alcoholism
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   04934 Cushing syndrome
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05161 Hepatitis B
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05163 Human cytomegalovirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   05165 Human papillomavirus infection
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
   03029 Mitochondrial biogenesis
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    K05870  CREB1; cyclic AMP-responsive element-binding protein 1
Other DBs
GO: 0035497
Genes
HSA: 1385(CREB1)
PTR: 459901(CREB1)
PPS: 100974672(CREB1)
GGO: 101144410(CREB1)
PON: 100294619(CREB1)
NLE: 100586647(CREB1)
MCC: 708717(CREB1)
MCF: 102141699(CREB1)
CSAB: 103217717(CREB1)
RRO: 104680220(CREB1)
RBB: 108540349(CREB1)
CJC: 100407681(CREB1)
SBQ: 101034085(CREB1)
MMU: 12912(Creb1)
MCAL: 110285614(Creb1)
MPAH: 110322391(Creb1)
RNO: 100363500 81646(Creb1)
MUN: 110551437(Creb1)
CGE: 100761582(Creb1)
NGI: 103744440(Creb1)
HGL: 101712503(Creb1)
CCAN: 109691946(Creb1)
OCU: 100351999(CREB1)
TUP: 102500092(CREB1)
CFA: 607922(CREB1)
VVP: 112922611(CREB1)
AML: 100477711(CREB1)
UMR: 103659802(CREB1)
UAH: 113250525(CREB1)
ORO: 101383024(CREB1)
ELK: 111147575
PTG: 102971333(CREB1)
PPAD: 109265159(CREB1)
AJU: 106967098(CREB1)
BTA: 281713(CREB1)
BOM: 102281756(CREB1)
BIU: 109570093(CREB1)
BBUB: 102401906(CREB1)
CHX: 102186065(CREB1)
OAS: 443118(CREB1)
SSC: 100736562(CREB1)
CFR: 102508765(CREB1)
CDK: 105093562(CREB1)
BACU: 103017577(CREB1)
LVE: 103075978(CREB1)
OOR: 101287685(CREB1)
DLE: 111171769(CREB1)
PCAD: 102989082(CREB1)
ECB: 100066388(CREB1)
EPZ: 103548908(CREB1)
EAI: 106828159(CREB1)
MYB: 102246867(CREB1)
MYD: 102754892(CREB1)
MNA: 107524712(CREB1)
HAI: 109388316(CREB1)
DRO: 112307981(CREB1)
PALE: 102888198(CREB1)
RAY: 107505169(CREB1)
MJV: 108396160
LAV: 100675162(CREB1)
TMU: 101356881
MDO: 100014049(CREB1)
SHR: 100913327(CREB1)
PCW: 110223284(CREB1)
OAA: 100093310(CREB1)
GGA: 395099(CREB1)
MGP: 100542127(CREB1)
CJO: 107316551(CREB1)
NMEL: 110400086(CREB1)
ACYG: 106030089(CREB1)
TGU: 751585(CREB1)
LSR: 110475023(CREB1)
SCAN: 103814492(CREB1)
GFR: 102042770(CREB1)
FAB: 101811066(CREB1)
PHI: 102101211(CREB1)
PMAJ: 107207633(CREB1)
CCAE: 111932010(CREB1)
CCW: 104693796(CREB1)
ETL: 114055739(CREB1)
FPG: 101911755(CREB1)
FCH: 102050642(CREB1)
CLV: 102085492(CREB1)
EGZ: 104125074(CREB1)
NNI: 104010208(CREB1)
ACUN: 113482524(CREB1)
PADL: 103923613(CREB1)
ASN: 102385124(CREB1)
AMJ: 102564978(CREB1)
PSS: 102450649(CREB1)
CMY: 102944794(CREB1)
CPIC: 101943249(CREB1)
ACS: 100555818(creb1)
PVT: 110072401(CREB1)
PBI: 103058702(CREB1)
PMUR: 107295640(CREB1)
TSR: 106549740
PMUA: 114581842(CREB1)
GJA: 107105893(CREB1)
XLA: 108701473 379764(creb1.S)
XTR: 407934(creb1)
NPR: 108790202(CREB1)
DRE: 573207(creb1a)
IPU: 108258958 108267006(creb1)
PHYP: 113537276 113547038(creb1)
AMEX: 103024012 103036831(creb1)
EEE: 113567647(creb1) 113577247
MZE: 101465790 101472017(creb1)
ONL: 100697446 100701405(creb1)
XMA: 102221737 102227171(creb1)
XCO: 114140714 114148317(creb1)
PRET: 103473381 103478732(creb1)
CVG: 107084246 107100467(creb1)
POV: 109640884(creb1) 109644135
SALP: 111976709(creb1) 112073124
ELS: 105016260(creb1) 105023145
LCM: 102361965(CREB1)
CMK: 103176821(creb1)
RTP: 109933435
CIN: 100101830(creb/atf-c)
SPU: 100889197
NVE: 5513148
 » show all
Reference
PMID:2142528
  Authors
Berkowitz LA, Gilman MZ
  Title
Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
  Journal
Proc Natl Acad Sci U S A 87:5258-62 (1990)
DOI:10.1073/pnas.87.14.5258
  Sequence
[hsa:1385]
Reference
  Authors
Chen HC, Byrd JC, Muthusamy N
  Title
Differential role for cyclic AMP response element binding protein-1 in multiple stages of B cell development, differentiation, and survival.
  Journal
J Immunol 176:2208-18 (2006)
DOI:10.4049/jimmunol.176.4.2208
  Sequence
[mmu:12912]
LinkDB

KEGG   ORTHOLOGY: K04450
Entry
K04450                      KO                                     

Name
ATF2, CREBP1
Definition
cyclic AMP-dependent transcription factor ATF-2
Pathway
ko04010  MAPK signaling pathway
ko04013  MAPK signaling pathway - fly
ko04022  cGMP-PKG signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04624  Toll and Imd signaling pathway
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04013 MAPK signaling pathway - fly
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04668 TNF signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04022 cGMP-PKG signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04151 PI3K-Akt signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09150 Organismal Systems
  09151 Immune system
   04624 Toll and Imd signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09152 Endocrine system
   04911 Insulin secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04922 Glucagon signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04915 Estrogen signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04926 Relaxin signaling pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04935 Growth hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04918 Thyroid hormone synthesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04928 Parathyroid hormone synthesis, secretion and action
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04925 Aldosterone synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   04927 Cortisol synthesis and secretion
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09156 Nervous system
   04728 Dopaminergic synapse
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09149 Aging
   04211 Longevity regulating pathway
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09164 Neurodegenerative disease
   05020 Prion disease
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09165 Substance dependence
   05030 Cocaine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05031 Amphetamine addiction
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05034 Alcoholism
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05161 Hepatitis B
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
   05163 Human cytomegalovirus infection
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04450  ATF2, CREBP1; cyclic AMP-dependent transcription factor ATF-2
Other DBs
GO: 0035497
Genes
HSA: 1386(ATF2)
PTR: 101059354(ATF2)
PPS: 100985706(ATF2)
GGO: 101135003(ATF2)
PON: 100450554(ATF2)
NLE: 100582751(ATF2)
MCC: 699072(ATF2)
MCF: 101925838(ATF2)
CSAB: 103217363(ATF2)
RRO: 104672399(ATF2)
RBB: 108527163(ATF2)
CJC: 100414156(ATF2)
SBQ: 101035834(ATF2)
MMU: 11909(Atf2)
MCAL: 110286367(Atf2)
MPAH: 110317821(Atf2)
RNO: 81647(Atf2)
MUN: 110556579(Atf2)
CGE: 100754663(Atf2)
NGI: 103751761(Atf2)
HGL: 101717365(Atf2)
CCAN: 109689841(Atf2)
OCU: 100355367(ATF2)
TUP: 102473406(ATF2)
CFA: 478806(ATF2)
VVP: 112916383(ATF2)
AML: 100474135(ATF2)
UMR: 103659593(ATF2)
UAH: 113250749(ATF2)
ORO: 101374034(ATF2)
ELK: 111142901
FCA: 101090884(ATF2)
PTG: 102954603(ATF2)
PPAD: 109273371(ATF2)
AJU: 106988085(ATF2)
BTA: 509827(ATF2)
BOM: 102283891(ATF2)
BIU: 109566270(ATF2)
BBUB: 102410577(ATF2)
CHX: 102180634(ATF2)
OAS: 101108548(ATF2)
SSC: 100513441(ATF2)
CFR: 102512476(ATF2)
CDK: 105097571(ATF2)
BACU: 102999133(ATF2)
LVE: 103089070(ATF2)
OOR: 101276923(ATF2)
DLE: 111172890(ATF2)
PCAD: 102974369(ATF2)
ECB: 100053304(ATF2)
EPZ: 103553756(ATF2)
EAI: 106837905(ATF2)
MYB: 102241887(ATF2)
MYD: 102761389(ATF2)
MNA: 107532468(ATF2)
HAI: 109388738(ATF2)
DRO: 112305718(ATF2)
PALE: 102889014(ATF2)
RAY: 107504977(ATF2)
MJV: 108407377
LAV: 100657989(ATF2)
TMU: 101359884
MDO: 100025939(ATF2)
SHR: 100914193(ATF2)
PCW: 110211588(ATF2)
OAA: 100077942(ATF2)
GGA: 395727(ATF2)
MGP: 100549420(ATF2)
CJO: 107316660(ATF2)
NMEL: 110399453(ATF2)
APLA: 101800932(ATF2)
ACYG: 106030015(ATF2)
TGU: 100226584(ATF2)
LSR: 110482896(ATF2)
SCAN: 103814449(ATF2)
GFR: 102034606(ATF2)
FAB: 101812575(ATF2)
PHI: 102105113(ATF2)
PMAJ: 107207532(ATF2)
CCAE: 111932059(ATF2)
CCW: 104693853(ATF2)
ETL: 114054885(ATF2)
FPG: 101912040(ATF2)
FCH: 102052727(ATF2)
CLV: 102084432(ATF2)
EGZ: 104128067(ATF2)
NNI: 104010014(ATF2)
ACUN: 113482190(ATF2)
PADL: 103924112(ATF2)
AAM: 106499205(ATF2)
ASN: 102387336(ATF2)
AMJ: 102572172(ATF2)
PSS: 102460331(ATF2)
CMY: 102939131(ATF2)
CPIC: 101945668(ATF2)
ACS: 100557710(atf2)
PVT: 110085213(ATF2)
PBI: 103053462(ATF2)
PMUR: 107301365(ATF2)
TSR: 106548735(ATF2)
PMUA: 114606668(ATF2) 114606722
GJA: 107123397(ATF2)
XLA: 108701386(atf2.L) 108703012 378533(atf2.S)
XTR: 100485532(atf2)
NPR: 108800395(ATF2)
DRE: 100006516(atf2)
SGH: 107600703
IPU: 108266715(atf2)
PHYP: 113525280(atf2)
AMEX: 103028069(atf2)
EEE: 113582331(atf2)
TRU: 101063333(atf2)
LCO: 104924439(atf2)
NCC: 104965544(atf2)
MZE: 101463949(atf2)
ONL: 100699389(atf2)
OLA: 101161843(atf2)
XMA: 102234028(atf2)
XCO: 114148083(atf2)
PRET: 103458305(atf2)
CVG: 107085739(atf2)
NFU: 107390001(atf2)
KMR: 108239783(atf2)
ALIM: 106512883(atf2)
AOCE: 111577835(atf2)
CSEM: 103391862 107988055(atf2)
POV: 109631016(atf2)
LCF: 108882968(atf2)
SDU: 111218870(atf2)
SLAL: 111654625(atf2)
HCQ: 109507870(atf2)
BPEC: 110166549(atf2)
MALB: 109958112(atf2)
SASA: 106582491 106586246(atf2)
OTW: 112236821(atf2)
SALP: 111959522 111975332(atf2)
ELS: 105016218(atf2)
SFM: 108920372(atf2) 108928057
PKI: 111838634(atf2)
LCM: 102366239(ATF2) 106703183
CMK: 103176469(atf2)
RTP: 109914907 109929477(atf2)
BFO: 118403115
SPU: 577426
APLC: 110984186
DME: Dmel_CG44246(Atf-2)
DER: 6548433
DSE: 6618893
DSI: Dsimw501_GD11905(Dsim_GD11905)
DAN: 6496187
DSR: 110184110
DPE: 6592285
DWI: 6640182
DAZ: 108617045
DNV: 108654709
DHE: 111593910
DVI: 6627255
MDE: 101890809
LCQ: 111685726
AAG: 5577542
AME: 100576527
BIM: 100749459
BTER: 100649707
CCAL: 108632989
OBB: 114879534
SOC: 105202168
MPHA: 105839911
AEC: 105145677
ACEP: 105627948
PBAR: 105426825
VEM: 105565082
HST: 105192642
DQU: 106742046
CFO: 105249521
LHU: 105677106
PGC: 109858507
PCF: 106791946
NVI: 100119270
CSOL: 105361172
MDL: 103576287
TCA: 663103
DPA: 109539767
ATD: 109608283
NVL: 108569504
BMOR: 100862750
BMAN: 114250244
PMAC: 106715142
PRAP: 110993434
HAW: 110369623
TNL: 113499958
PXY: 105390395
BTAB: 109041413
CLEC: 106663685
ZNE: 110833127
FCD: 110852191
PVM: 113822147
CSCU: 111619050
PTEP: 107440184
PCAN: 112556639
CRG: 105323178
MYI: 110446621
OBI: 106878431
LAK: 106161773
NVE: 5514292
EPA: 110232304
ADF: 107348901
AMIL: 114967441
PDAM: 113668572
SPIS: 111331051
DGT: 114523073
HMG: 100213904
AQU: 100632529
APRO: F751_3120
MAW: MAC_08741
MAJ: MAA_01331
CMT: CCM_09413
 » show all
Reference
PMID:2529117
  Authors
Maekawa T, Sakura H, Kanei-Ishii C, Sudo T, Yoshimura T, Fujisawa J, Yoshida M, Ishii S
  Title
Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.
  Journal
EMBO J 8:2023-8 (1989)
DOI:10.1002/j.1460-2075.1989.tb03610.x
  Sequence
[hsa:1386]
Reference
  Authors
Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama KK
  Title
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
  Journal
Nature 405:195-200 (2000)
DOI:10.1038/35012097
  Sequence
[hsa:1386]
LinkDB

KEGG   ORTHOLOGY: K09048
Entry
K09048                      KO                                     

Name
CREB3
Definition
cyclic AMP-responsive element-binding protein 3
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04931  Insulin resistance
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04962  Vasopressin-regulated water reabsorption
ko05016  Huntington disease
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Disease
H00506  Osteogenesis imperfecta
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04024 cAMP signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04022 cGMP-PKG signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04151 PI3K-Akt signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04152 AMPK signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04922 Glucagon signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04915 Estrogen signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04926 Relaxin signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04935 Growth hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04918 Thyroid hormone synthesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04928 Parathyroid hormone synthesis, secretion and action
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04916 Melanogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04925 Aldosterone synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04927 Cortisol synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09156 Nervous system
   04725 Cholinergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04728 Dopaminergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09149 Aging
   04211 Longevity regulating pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09159 Environmental adaptation
   04714 Thermogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09162 Cancer: specific types
   05215 Prostate cancer
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05020 Prion disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09165 Substance dependence
   05030 Cocaine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05031 Amphetamine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05034 Alcoholism
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04934 Cushing syndrome
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05161 Hepatitis B
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05163 Human cytomegalovirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05165 Human papillomavirus infection
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Other DBs
GO: 0008140
Genes
HSA: 10488(CREB3) 148327(CREB3L4) 64764(CREB3L2) 84699(CREB3L3) 90993(CREB3L1)
PTR: 451704(CREB3L1) 457341(CREB3L4) 465081(CREB3) 468672(CREB3L3) 738928(CREB3L2)
PPS: 100977358(CREB3L3) 100977804(CREB3L4) 100981063(CREB3L1) 100986194(CREB3L2) 100989680(CREB3)
GGO: 101128609(CREB3L2) 101144135(CREB3) 101144628(CREB3L1) 101152081(CREB3L4)
PON: 100127093(CREB3L2) 100432292(CREB3L1) 100436186(CREB3L4) 100438869(CREB3) 100441756(CREB3L3)
NLE: 100592170(CREB3L3) 100594080(CREB3L1) 100595943(CREB3L2) 100597876(CREB3) 100603387(CREB3L4)
MCC: 696350(CREB3) 713391(CREB3L1) 714981(CREB3L2) 715951(CREB3L4) 721825(CREB3L3)
MCF: 102134095(CREB3L4) 102136437(CREB3L3) 102139679(CREB3) 102142378(CREB3L1) 102146405(CREB3L2)
CSAB: 103219209(CREB3) 103223942(CREB3L4) 103226974(CREB3L2) 103233716(CREB3L3) 103236571(CREB3L1)
RRO: 104656623(CREB3L2) 104663511(CREB3L4) 104665486(CREB3L3) 104668385(CREB3L1) 104672444(CREB3)
RBB: 108512141(CREB3L3) 108518846(CREB3L4) 108518996(CREB3) 108519245(CREB3L1) 108542557(CREB3L2)
CJC: 100394351(CREB3L3) 100406635(CREB3L1) 100408954(CREB3) 100409637(CREB3L2) 100411140(CREB3L4)
SBQ: 101036473(CREB3L3) 101041199(CREB3L4) 101042795(CREB3L2) 101044974(CREB3L1) 101052885(CREB3)
MMU: 12913(Creb3) 208647(Creb3l2) 208677(Creb3l3) 26427(Creb3l1) 78284(Creb3l4)
MCAL: 110289497(Creb3l1) 110291408(Creb3l4) 110292754(Creb3) 110296066(Creb3l2) 110303337(Creb3l3)
MPAH: 110316152(Creb3l2) 110318364(Creb3l1) 110320678(Creb3l4) 110326077(Creb3l3) 110338975(Creb3)
RNO: 310616(Creb3l4) 314638(Creb3l3) 362165(Creb3l1) 362339(Creb3l2)
MUN: 110549233(Creb3l2) 110549859(Creb3l1) 110554250(Creb3l4) 110555614(Creb3l3) 110561882(Creb3)
CGE: 100762192(Creb3l1) 100766300(Creb3l4) 100771872(Creb3l2) 100772940(Creb3) 100774488(Creb3l3)
NGI: 103726130(Creb3l2) 103737277(Creb3l3) 103741536(Creb3) 103748795(Creb3l1) 103751688(Creb3l4)
HGL: 101698748(Creb3l1) 101706643(Creb3l4) 101715715(Creb3l2) 101716023(Creb3l3) 101718447(Creb3)
CCAN: 109687810(Creb3l3) 109688048(Creb3l4) 109692000(Creb3l1) 109693373(Creb3) 109700597(Creb3l2)
OCU: 100343130(CREB3L2) 100345475(CREB3L1) 100357876(CREB3) 100358175(CREB3L4)
TUP: 102468245 102469074(CREB3) 102471928(CREB3L2) 102484102(CREB3L3) 102491362(CREB3L1) 102494703(CREB3L4)
CFA: 483636(CREB3L1) 485046(CREB3L3) 491369(CREB3L2) 611934(CREB3) 612303(CREB3L4)
VVP: 112908881(CREB3L2) 112918871(CREB3L4) 112924095(CREB3L1) 112930843(CREB3) 112935546(CREB3L3)
AML: 100465448(CREB3L3) 100470867(CREB3L1) 100472104(CREB3) 100483482(CREB3L2) 100484531(CREB3L4)
UMR: 103667087(CREB3) 103668409(CREB3L4) 103669052(CREB3L2) 103672393(CREB3L1) 103681679(CREB3L3)
UAH: 113242823(CREB3L3) 113245324(CREB3L4) 113260470(CREB3) 113264732(CREB3L2) 113264990(CREB3L1)
ORO: 101376293(CREB3L3) 101381943(CREB3L4) 101383806(CREB3) 101385675(CREB3L2) 101385783(CREB3L1)
FCA: 101087097(CREB3L1) 101089838(CREB3L3) 101093555(CREB3) 101100293(CREB3L2) 101100442(CREB3L4)
PTG: 102949496(CREB3L2) 102949885(CREB3L1) 102950730(CREB3) 102954009(CREB3L4) 102956516(CREB3L3)
PPAD: 109245089(CREB3L1) 109255940(CREB3L3) 109256215(CREB3L4) 109269067(CREB3L2) 109270166(CREB3)
AJU: 106970423(CREB3L2) 106975473(CREB3L3) 106978069(CREB3L1) 106981255(CREB3) 106987262(CREB3L4)
BTA: 281715(CREB3) 513010(CREB3L3) 513105(CREB3L1) 529566(CREB3L4) 785086(CREB3L2)
BOM: 102264680(CREB3L2) 102268154(CREB3L1) 102271999(CREB3L3) 102277321(CREB3) 102281505(CREB3L4)
BIU: 109554418(CREB3L4) 109557676(CREB3L2) 109561750(CREB3L3) 109563018(CREB3) 109569868(CREB3L1)
BBUB: 102395032(CREB3) 102398301(CREB3L4) 102400784(CREB3L3) 102406078(CREB3L1) 102416630(CREB3L2)
CHX: 102170199(CREB3L2) 102174829(CREB3L3) 102180221(CREB3) 102183745(CREB3L4) 102183893(CREB3L1)
OAS: 101107485(CREB3L4) 101108743(CREB3L2) 101113586(CREB3L3) 101113882(CREB3L1) 101114243(CREB3)
SSC: 100142688(CREB3L4) 100142689(CREB3) 100516663(CREB3L1) 100520468(CREB3L2) 100522979(CREB3L3)
CFR: 102510171(CREB3L2) 102510394(CREB3) 102511454(CREB3L3) 102516586(CREB3L4) 102516625(CREB3L1)
CDK: 105089327(CREB3L4) 105091622(CREB3L2) 105102288(CREB3) 105105303(CREB3L3) 105106926(CREB3L1)
BACU: 102999898(CREB3L2) 103001736(CREB3) 103003868(CREB3L4) 103007680(CREB3L1) 103018056(CREB3L3)
LVE: 103071696(CREB3L2) 103085711(CREB3L4) 103086171(CREB3) 103087008(CREB3L1) 103091030(CREB3L3)
OOR: 101272184(CREB3) 101283835(CREB3L2) 101284966(CREB3L1) 101286338(CREB3L4) 101287411(CREB3L3)
DLE: 111166195(CREB3L3) 111167181(CREB3L4) 111177962(CREB3L2) 111183987(CREB3L1) 111188007(CREB3)
PCAD: 102975387(CREB3L2) 102986078(CREB3L4) 102987194(CREB3L1) 102994621(CREB3L3)
ECB: 100057002(CREB3L1) 100062307(CREB3L4) 100063153(CREB3L3) 100064828(CREB3L2) 100067794(CREB3)
EPZ: 103555399(CREB3L4) 103560297(CREB3) 103564266(CREB3L2) 103566499(CREB3L1)
EAI: 106829982(CREB3L2) 106832323(CREB3L3) 106843990(CREB3L1) 106846249(CREB3L4) 106846981(CREB3)
MYB: 102241829(CREB3) 102244833(CREB3L1) 102245296(CREB3L2) 102251355(CREB3L3) 102258024(CREB3L4)
MYD: 102762431(CREB3) 102764297(CREB3L3) 102768092(CREB3L1) 102772259(CREB3L4) 102773515(CREB3L2)
MNA: 107525737(CREB3L3) 107530327(CREB3L1) 107543873(CREB3L4) 107544136(CREB3L2) 107544933(CREB3)
HAI: 109373471(CREB3L4) 109388532(CREB3L2) 109388636(CREB3L3) 109390233(CREB3L1) 109393756(CREB3)
DRO: 112299769(CREB3L2) 112303463(CREB3L1) 112304550(CREB3) 112312688(CREB3L3) 112316383(CREB3L4)
PALE: 102878515(CREB3L4) 102879289(CREB3L3) 102882888(CREB3L2) 102886510(CREB3) 102894633(CREB3L1)
RAY: 107499057(CREB3L2) 107502779(CREB3) 107509179(CREB3L4) 107510647(CREB3L3) 107511864(CREB3L1)
MJV: 108385045(CREB3L3) 108401935(CREB3L2) 108406808(CREB3L1) 108407563(CREB3) 108408210(CREB3L4)
LAV: 100653565(CREB3L1) 100666211(CREB3L2) 100670574(CREB3L3) 100673694(CREB3L4) 100677344(CREB3)
MDO: 100015046(CREB3L1) 100017208(CREB3L2) 100020067(CREB3L4) 100022547(CREB3L3) 103104366(CREB3)
SHR: 100913890(CREB3L1) 100916355(CREB3) 100917654(CREB3L3) 100923082(CREB3L4) 100926416(CREB3L2)
PCW: 110197489(CREB3L3) 110201451(CREB3) 110211994(CREB3L4) 110216252(CREB3L2) 110224036(CREB3L1)
OAA: 100076562(CREB3L1) 100078176(CREB3L3) 100092528(CREB3L2) 103165821(CREB3)
GGA: 100859610(CREB3L1) 418123(CREB3L2) 427417(CREB3) 428333(CREB3L3)
MGP: 100539552(CREB3L1) 100551035(CREB3L2) 100551184(CREB3L3) 104914805(CREB3)
CJO: 107305791(CREB3) 107314830(CREB3L1) 107315837(CREB3L2) 107325596(CREB3L3)
NMEL: 110388853(CREB3L3) 110389944(CREB3) 110394585(CREB3L2) 110400949(CREB3L1)
APLA: 101792907(CREB3L2) 101795642(CREB3L1) 101798346 113840230(CREB3)
ACYG: 106030991(CREB3L2) 106036307(CREB3) 106043464(CREB3L1) 106044950(CREB3L3)
TGU: 100219636(CREB3L2) 100220102(CREB3L1) 100222350(CREB3) 115490820(CREB3L3) 115498485(CREB3L4)
LSR: 110472078(CREB3L1) 110478465(CREB3L3) 110482629(CREB3L2) 110484175(CREB3)
SCAN: 103819702(CREB3L2) 103822893(CREB3) 103824532(CREB3L3) 103825377 103826679(CREB3L1) 115484624(CREB3L4)
GFR: 102032931(CREB3L1) 102037565(CREB3L2) 102040985(CREB3L3) 102041988(CREB3)
FAB: 101807577(CREB3L1) 101807611(CREB3) 101810924(CREB3L2) 101814634(CREB3L3)
PHI: 102100666(CREB3L1) 102102105(CREB3L3) 102104228(CREB3L2) 102110548(CREB3L4) 102110913(CREB3)
PMAJ: 107204840(CREB3L2) 107206327(CREB3L1) 107214697(CREB3L4) 107215468(CREB3L3) 107216394(CREB3)
CCAE: 111930186(CREB3L1) 111936759(CREB3L2) 111940201(CREB3L3) 111941176(CREB3)
CCW: 104686582(CREB3) 104696487(CREB3L2) 104697409(CREB3L3) 104698184(CREB3L1)
ETL: 114056194(CREB3L2) 114059138(CREB3L1) 114068838(CREB3L3) 114069771(CREB3)
FPG: 101915392(CREB3L1) 101915893(CREB3) 101922621(CREB3L2) 101924469(CREB3L3)
FCH: 102049519(CREB3L3) 102052762(CREB3) 102055433(CREB3L2) 102060195(CREB3L1)
CLV: 102083943(CREB3L2) 102089621(CREB3L1) 102093765(CREB3L3) 102095967(CREB3)
EGZ: 104124398(CREB3L3) 104126149(CREB3L2) 104133839(CREB3) 104134083(CREB3L1)
NNI: 104012401(CREB3L2) 104015313 104018284(CREB3L4) 104018462 104018808(CREB3L3) 104020372(CREB3L1)
ACUN: 113480521(CREB3L1) 113489424(CREB3L3) 113489898(CREB3) 113490242(CREB3L2)
PADL: 103921718(CREB3L1) 103924510(CREB3L2) 103926010
AAM: 106488699(CREB3L2) 106492194(CREB3L3) 106498354(CREB3L1) 106499571(CREB3)
ASN: 102371679(CREB3L2) 102375258(CREB3L3) 102378465(CREB3L1) 102380509(CREB3L4)
AMJ: 102558288(CREB3L1) 102562994(CREB3L3) 102565945(CREB3) 102571170(CREB3L4) 102574172(CREB3L2)
PSS: 102446107(CREB3L1) 102446716(CREB3L2) 102457323(CREB3L3)
CMY: 102939907(CREB3L2) 102940413(CREB3L1) 102941831(CREB3L3) 102946430(CREB3L4) 102948242(CREB3)
CPIC: 101931889(CREB3L1) 101933099(CREB3L3) 101933490(CREB3) 101941397(CREB3L2) 101949087(CREB3L4)
ACS: 100557424(creb3l2) 100565677(creb3l1) 103281351(creb3)
PVT: 110072462(CREB3L3) 110078269(CREB3L2) 110081714(CREB3L1) 110082837(CREB3) 110088478(CREB3L4)
PBI: 103048883(CREB3L1) 103049180 103057599(CREB3L2) 103066719 107326149(CREB3L4)
PMUR: 107290408(CREB3L1) 107294181(CREB3L2) 107295319(CREB3L3) 107300011
TSR: 106546013(CREB3L1) 106552868(CREB3L4) 106554690(CREB3)
PMUA: 114588541(CREB3L3) 114596052(CREB3L1) 114605296(CREB3L2) 114606604(CREB3)
GJA: 107107817(CREB3L1) 107110879(CREB3L4) 107118239(CREB3L3) 107120250 107121734(CREB3L2)
XLA: 100037168(creb3l2.L) 108699636(creb3l4.L) 108700416(creb3l4.S) 108712546(creb3l2.S) 108713769(creb3l1.L) 108715242 735076(creb3.S)
XTR: 100127204(creb3) 100145418(creb3l2) 100496679(creb3l1) 101733496 780164(creb3l4)
NPR: 108785446(CREB3L1) 108788718(CREB3L2) 108798798(CREB3L4) 108801809
DRE: 100333318(creb3l4) 100538072(creb3l3b) 338317(creb3l1) 406853(creb3l3l) 553700(creb3l3a) 791169(creb3l2)
IPU: 108259676(creb3l1) 108263495(CREB3L4) 108264943 108271409 108280078(creb3l2) 108280217(creb3l3)
AMEX: 103023873(creb3l2) 103037168 103039026 103040796(creb3l3) 103042370(creb3l1)
TRU: 101063133(creb3l4) 101065014 101067583 101070432(creb3l1) 101078259(creb3l2) 115247989
LCO: 104917983(creb3l1) 104920685(creb3l3) 104921083 104929667 104935986(creb3l2) 104938216
MZE: 101466226(creb3l4) 101469085(creb3l1) 101480575(creb3l2) 101483965 101486384 101487513
ONL: 100702359 100703380(creb3l1) 100705423(creb3l2) 100708760 100709801 100710280(creb3l4)
OLA: 101164317 101164631(creb3l4) 101165931(creb3l2) 101167274(creb3l1) 101171479 105356229
XMA: 102216562 102218843 102222043(creb3l4) 102226512(creb3l2) 102233894 102237210(creb3l1)
PRET: 103459160(creb3l2) 103460971 103463663(creb3l3) 103470136 103475175(creb3l1) 103477467
NFU: 107379008 107380915(creb3l1) 107384140(creb3l3) 107387370(creb3l2) 107394107 107395105
ALIM: 106513612 106515012(creb3l3) 106524439(creb3l2) 106526404 106529646(creb3l1) 106532492
POV: 109625400 109639345 109640074(creb3l1) 109641651(creb3l3) 109642995(creb3l2) 109643269
LCF: 108877321 108882528 108883606 108884667(creb3l4) 108892924(creb3l1) 108895942(creb3l2)
HCQ: 109507313 109512147(creb3l4) 109517508 109520937(creb3l1) 109530066(creb3l2) 109531892
MALB: 109953821 109956522 109960567(creb3l1) 109964980(creb3l2) 109965712 109970108(creb3l4)
LCM: 102350106(CREB3L3) 102352986(CREB3L4) 102353080(CREB3L2) 102357132(CREB3L1) 102361726
CMK: 103180995(creb3) 103181867(creb3l2) 103183529(creb3l3) 103186023(creb3l1)
RTP: 109911765(creb3l3) 109915849(creb3l2) 109916114 109918439(creb3l1) 109925779
CIN: 778569(creb/atf-a) 778570(creb/atf-b)
DPE: 6597062
DMN: 108151035
DNV: 108650160
MDE: 101895237
LCQ: 111674972
AALB: 109407640
NVI: 100120780
CSOL: 105365458
FCD: 110842466
CSCU: 111625880
BMY: Bm1_36045
SHX: MS3_02458
 » show all
Reference
  Authors
Jang SW, Kim YS, Kim YR, Sung HJ, Ko J
  Title
Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.
  Journal
J Biol Chem 282:11092-100 (2007)
DOI:10.1074/jbc.M607962200
  Sequence
[hsa:10488]
Reference
PMID:9271389
  Authors
Lu R, Yang P, O'Hare P, Misra V
  Title
Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.
  Journal
Mol Cell Biol 17:5117-26 (1997)
DOI:10.1128/MCB.17.9.5117
  Sequence
[hsa:10488]
LinkDB

KEGG   ORTHOLOGY: K04374
Entry
K04374                      KO                                     

Name
ATF4, CREB2
Definition
cyclic AMP-dependent transcription factor ATF-4
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04137  Mitophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04214  Apoptosis - fly
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04932  Non-alcoholic fatty liver disease
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04668 TNF signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04022 cGMP-PKG signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09143 Cell growth and death
   04210 Apoptosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04214 Apoptosis - fly
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04922 Glucagon signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04926 Relaxin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04935 Growth hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04918 Thyroid hormone synthesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04928 Parathyroid hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04925 Aldosterone synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04927 Cortisol synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09156 Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09149 Aging
   04211 Longevity regulating pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04212 Longevity regulating pathway - worm
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09162 Cancer: specific types
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05012 Parkinson disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05014 Amyotrophic lateral sclerosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05020 Prion disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05022 Pathways of neurodegeneration - multiple diseases
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09165 Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04934 Cushing syndrome
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05163 Human cytomegalovirus infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Other DBs
GO: 0035497
Genes
HSA: 468(ATF4)
PTR: 744513(ATF4)
PPS: 100988487(ATF4)
GGO: 101139584(ATF4)
PON: 100431578 100462459(ATF4)
NLE: 100588160(ATF4)
MCC: 703965(ATF4)
MCF: 102117938(ATF4)
CSAB: 103223345(ATF4)
RRO: 104682563(ATF4)
RBB: 108520463(ATF4)
CJC: 100392193(ATF4)
SBQ: 101034435(ATF4)
MMU: 11911(Atf4)
MCAL: 110310868(Atf4)
MPAH: 110334651(Atf4)
RNO: 79255(Atf4)
CGE: 100689386(Atf4)
NGI: 103748563(Atf4)
HGL: 101724287(Atf4)
CCAN: 109693025(Atf4)
OCU: 100339383(ATF4)
TUP: 102478154(ATF4)
CFA: 474503(ATF4)
VVP: 112934037(ATF4)
AML: 100476284(ATF4)
UMR: 103676372(ATF4)
UAH: 113241758(ATF4)
ORO: 101368122(ATF4)
ELK: 111157635
FCA: 101084297(ATF4)
PTG: 102950077(ATF4)
PPAD: 109265586(ATF4)
AJU: 106979942(ATF4)
BTA: 509107(ATF4)
BOM: 102267423(ATF4)
BIU: 109559832(ATF4)
BBUB: 102393344(ATF4)
CHX: 102185072(ATF4)
OAS: 100216465(ATF4)
SSC: 100144302(ATF4)
CFR: 102508076(ATF4)
CDK: 105091928(ATF4)
BACU: 103017770(ATF4)
LVE: 103083306(ATF4)
OOR: 101283438(ATF4)
DLE: 111186212(ATF4)
PCAD: 102984157(ATF4)
ECB: 100070334(ATF4)
EPZ: 103565289(ATF4)
EAI: 106842437(ATF4)
MYB: 102238786(ATF4)
MYD: 102763654(ATF4)
MNA: 107531265(ATF4)
HAI: 109392248(ATF4)
DRO: 112321682(ATF4)
PALE: 102896553(ATF4)
RAY: 107500816(ATF4)
MJV: 108397369(ATF4)
LAV: 100662521(ATF4)
TMU: 101345357
MDO: 100012224(ATF4)
SHR: 100913697(ATF4)
PCW: 110205802(ATF4)
OAA: 100089902(ATF4)
GGA: 395693(ATF4)
MGP: 100550984(ATF4)
CJO: 107312723(ATF4)
NMEL: 110392532(ATF4)
APLA: 101800475(ATF4)
ACYG: 106035925(ATF4)
TGU: 100190733(ATF4)
LSR: 110483790(ATF4)
SCAN: 103813275(ATF4)
GFR: 102036875(ATF4)
FAB: 101814204(ATF4)
PHI: 102100681(ATF4)
PMAJ: 107204914(ATF4)
CCAE: 111934860(ATF4)
CCW: 104696333(ATF4)
ETL: 114055356(ATF4)
FPG: 101921834(ATF4)
FCH: 102049324(ATF4)
CLV: 102093872(ATF4)
EGZ: 104134330(ATF4)
NNI: 104021625(ATF4)
ACUN: 113491317(ATF4)
PADL: 103915003(ATF4)
AAM: 106488703(ATF4)
ASN: 102369745(ATF4)
AMJ: 102564186(ATF4)
PSS: 102449551(ATF4)
CMY: 102941988(ATF4)
CPIC: 101952513(ATF4)
ACS: 100565177(atf4)
PVT: 110088080(ATF4)
PBI: 103055721(ATF4)
PMUR: 107288132(ATF4)
TSR: 106550401(ATF4)
PMUA: 114605162(ATF4)
GJA: 107117129(ATF4)
XLA: 398804(atf4.L) 733336(atf4-iii) 734165(atf4.S)
XTR: 448005(atf4)
DRE: 406514(atf4a) 556410(atf4b)
IPU: 108273192(atf4)
PHYP: 113538304(atf4)
AMEX: 103027942(atf4)
EEE: 113579485(atf4)
TRU: 101070714(atf4) 101075957
NCC: 104958969 104967853(atf4)
MZE: 101464981(atf4) 101475680
ONL: 100706109 100711796(atf4)
OLA: 101168714(atf4-2) 101172388(atf4)
CVG: 107087200(atf4) 107090074
ALIM: 106522498(atf4) 106534845
HCQ: 109511289(atf4) 109520247
ELS: 105008440(atf4) 105029665
SFM: 108930667(atf4)
LCM: 102365086(ATF4)
RTP: 109919490
BFO: 118428974
CIN: 778545(atf4/5)
SPU: 586579
APLC: 110980911
SKO: 100376413
DME: Dmel_CG8669(crc)
DER: 6548901
DSI: Dsimw501_GD24316(Dsim_GD24316)
DPE: 6596600
DMN: 108163164
DWI: 6646727
DAZ: 108610991
DNV: 108658875
DHE: 111594286
MDE: 101900076
LCQ: 111689832
AAG: 5576642
AME: 410226
BIM: 100743669
BTER: 100651688
CCAL: 108622952
OBB: 114874933
SOC: 105196269
MPHA: 105837964
AEC: 105150924
ACEP: 105624047
PBAR: 105427649
VEM: 105557230
HST: 105183921
DQU: 106740699
CFO: 105254686
LHU: 105676463
PGC: 109855311
OBO: 105286490
PCF: 106789497
NVI: 100122826
CSOL: 105362052
MDL: 103572891
TCA: 658480(ATF4)
DPA: 109541967
NVL: 108565295
BMOR: 692594(Atf)
BMAN: 114249574
PMAC: 106711673
PRAP: 111003028
HAW: 110370227
TNL: 113496582
API: 100161513
DNX: 107161833
AGS: 114122290
RMD: 113551242
BTAB: 109033366
CLEC: 106663140
ZNE: 110834497
FCD: 110848208
PVM: 113817207
CSCU: 111613017
PTEP: 107437627
CEL: CELE_T04C10.4(atf-4)
CBR: CBG07594(Cbr-atf-5)
BMY: Bm1_39495
PCAN: 112557459
CRG: 105336468
MYI: 110465611
OBI: 106880212
NVE: 116611673
EPA: 110239948
AMIL: 114953195
PDAM: 113670326
SPIS: 111330254
DGT: 114529187
HMG: 100197237
AQU: 100634724
DOSA: Os01t0211800-01(Os01g0211800)
MUS: 103997104
 » show all
Reference
  Authors
Ameri K, Harris AL
  Title
Activating transcription factor 4.
  Journal
Int J Biochem Cell Biol 40:14-21 (2008)
DOI:10.1016/j.biocel.2007.01.020
Reference
PMID:1534408
  Authors
Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM
  Title
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
  Journal
Proc Natl Acad Sci U S A 89:4820-4 (1992)
DOI:10.1073/pnas.89.11.4820
  Sequence
[hsa:468]
Reference
  Authors
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
  Title
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
  Journal
Nat Genet 38:674-81 (2006)
DOI:10.1038/ng1786
  Sequence
[hsa:468]
LinkDB

KEGG   ORTHOLOGY: K09047
Entry
K09047                      KO                                     

Name
CREB5, CREBPA
Definition
cyclic AMP-responsive element-binding protein 5
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04714  Thermogenesis
ko04725  Cholinergic synapse
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04922  Glucagon signaling pathway
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04931  Insulin resistance
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04962  Vasopressin-regulated water reabsorption
ko05016  Huntington disease
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04024 cAMP signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04022 cGMP-PKG signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04151 PI3K-Akt signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04152 AMPK signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04922 Glucagon signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04915 Estrogen signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04926 Relaxin signaling pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04935 Growth hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04918 Thyroid hormone synthesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04928 Parathyroid hormone synthesis, secretion and action
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04925 Aldosterone synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04927 Cortisol synthesis and secretion
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09156 Nervous system
   04725 Cholinergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04728 Dopaminergic synapse
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09149 Aging
   04211 Longevity regulating pathway
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09159 Environmental adaptation
   04714 Thermogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09162 Cancer: specific types
   05215 Prostate cancer
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05020 Prion disease
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09165 Substance dependence
   05030 Cocaine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05031 Amphetamine addiction
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05034 Alcoholism
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   04934 Cushing syndrome
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05161 Hepatitis B
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05163 Human cytomegalovirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
   05165 Human papillomavirus infection
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K09047  CREB5, CREBPA; cyclic AMP-responsive element-binding protein 5
Other DBs
GO: 0035497
Genes
HSA: 9586(CREB5)
PTR: 463318(CREB5)
PPS: 100973232(CREB5)
GGO: 101153965
PON: 100439720(CREB5)
NLE: 100600059(CREB5)
MCC: 697718(CREB5)
MCF: 102123367(CREB5)
CSAB: 103226299(CREB5)
RRO: 104681895(CREB5)
RBB: 108535460(CREB5)
CJC: 100392579(CREB5)
SBQ: 101054090(CREB5)
MMU: 231991(Creb5)
MCAL: 110296203(Creb5)
MPAH: 110315994(Creb5)
RNO: 500131(Creb5)
MUN: 110554970
CGE: 100764159(Creb5)
NGI: 103740829(Creb5)
HGL: 101703315(Creb5)
CCAN: 109676751
OCU: 100357483(CREB5)
TUP: 102487006(CREB5)
CFA: 475266(CREB5)
VVP: 112915694
AML: 100474261(CREB5)
UMR: 103658932(CREB5)
UAH: 113262153(CREB5)
ORO: 101384862(CREB5)
ELK: 111147321
FCA: 101084784(CREB5)
PTG: 102972337(CREB5)
PPAD: 109263891(CREB5)
AJU: 106987665(CREB5)
BTA: 534129(CREB5)
BOM: 102275204(CREB5)
BIU: 109557489(CREB5)
BBUB: 102400864(CREB5)
CHX: 102190378(CREB5)
OAS: 101112976(CREB5)
SSC: 100515635(CREB5)
CFR: 102514154(CREB5)
CDK: 105095833(CREB5)
BACU: 103009193(CREB5)
LVE: 103081811(CREB5)
OOR: 101289047(CREB5)
DLE: 111180225(CREB5)
PCAD: 102985635(CREB5)
ECB: 100054803(CREB5)
EPZ: 103549839(CREB5)
EAI: 106831046(CREB5)
MYB: 102240701(CREB5)
MYD: 102769297(CREB5)
MNA: 107544390(CREB5)
HAI: 109381368(CREB5)
DRO: 112306927(CREB5)
PALE: 102884583(CREB5)
RAY: 107505683(CREB5)
MJV: 108405132(CREB5)
LAV: 100675079(CREB5)
TMU: 101345798
MDO: 100032634(CREB5)
SHR: 100922067(CREB5)
PCW: 110213063(CREB5)
OAA: 100080655(CREB5)
GGA: 428435(CREB5)
MGP: 100541001(CREB5)
CJO: 107309226(CREB5)
NMEL: 110394289(CREB5)
APLA: 101797962(CREB5)
ACYG: 106030241(CREB5)
TGU: 100228299(CREB5)
LSR: 110474631(CREB5)
SCAN: 103812908(CREB5)
GFR: 102044631(CREB5)
FAB: 101805839(CREB5)
PHI: 102103048(CREB5)
PMAJ: 107200380(CREB5)
CCAE: 111923428(CREB5)
CCW: 104689082(CREB5)
ETL: 114055673(CREB5)
FPG: 101920362(CREB5)
FCH: 102055392(CREB5)
CLV: 102084581(CREB5)
EGZ: 104126134(CREB5)
NNI: 104013914(CREB5)
ACUN: 113476866(CREB5)
PADL: 103918402(CREB5)
AAM: 106483468(CREB5)
ASN: 102372372
AMJ: 102576266(CREB5)
PSS: 102453617(CREB5)
CMY: 102933695(CREB5)
CPIC: 101933432(CREB5)
ACS: 100567734(creb5)
PVT: 110072290(CREB5)
PBI: 103060982(CREB5)
PMUR: 107282774
TSR: 106541450(CREB5)
PMUA: 114607489(CREB5)
GJA: 107105766(CREB5)
XLA: 108718906(creb5.L) 108719935(creb5.S)
XTR: 100498464(creb5)
NPR: 108803870(CREB5)
DRE: 101886947(creb5a) 565910(creb5b)
IPU: 108257012(ATF2) 108270486(creb5)
PHYP: 113536287 113542461(creb5)
AMEX: 103036725(creb5)
EEE: 113571214(creb5) 113580399
TRU: 101061266(creb5) 101065138
LCO: 104927758(creb5) 104940561
NCC: 104941125 104949893(creb5)
MZE: 101464485 101486831(creb5)
ONL: 100690870(creb5) 100707290
OLA: 101157318(creb5) 101173798
XMA: 102224332(creb5) 102237102
XCO: 114141104(creb5) 114155699
PRET: 103472184 103478569(creb5)
CVG: 107082305(creb5) 107084368
NFU: 107383381 107395571(creb5)
KMR: 108238370 108241930(creb5)
AOCE: 111570283 111588838(creb5)
CSEM: 103388419(creb5) 103394221
LCF: 108877062 108891362(creb5)
SDU: 111223427 111238792(creb5)
SLAL: 111652760(creb5) 111673321
HCQ: 109512009 109525639(creb5)
BPEC: 110171756(creb5)
MALB: 109967324(creb5) 109968120
SALP: 111954764 111955868(creb5)
ELS: 105018814(creb5) 105023646
LCM: 102347706(CREB5)
CMK: 103183158(creb5)
RTP: 109932100
 » show all
Reference
PMID:8440710
  Authors
Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S
  Title
Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.
  Journal
J Biol Chem 268:4259-66 (1993)
  Sequence
[hsa:9586]
Reference
  Authors
Qi L, Ding Y
  Title
Involvement of the CREB5 regulatory network in colorectal cancer metastasis.
  Journal
Yi Chuan 36:679-84 (2014)
DOI:10.3724/SP.J.1005.2014.0679
  Sequence
[hsa:9586]
LinkDB

KEGG   ORTHOLOGY: K09049
Entry
K09049                      KO                                     

Name
ATF6B, CREBL1
Definition
cyclic AMP-dependent transcription factor ATF-6 beta
Pathway
ko04022  cGMP-PKG signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04151  PI3K-Akt signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04022 cGMP-PKG signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04151 PI3K-Akt signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04915 Estrogen signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04926 Relaxin signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04935 Growth hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04918 Thyroid hormone synthesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04928 Parathyroid hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04925 Aldosterone synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04927 Cortisol synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09156 Nervous system
   04728 Dopaminergic synapse
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09149 Aging
   04211 Longevity regulating pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09164 Neurodegenerative disease
   05020 Prion disease
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09165 Substance dependence
   05030 Cocaine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05031 Amphetamine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05034 Alcoholism
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05161 Hepatitis B
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05163 Human cytomegalovirus infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Genes
HSA: 1388(ATF6B)
PTR: 107975108(ATF6B)
PPS: 100993334(ATF6B)
GGO: 101146740(ATF6B)
PON: 100172895(ATF6B)
NLE: 100598020(ATF6B)
MCC: 717050(ATF6B)
MCF: 102129446(ATF6B)
CSAB: 103221718(ATF6B)
RRO: 104674035(ATF6B)
RBB: 108519898(ATF6B)
CJC: 100411862(ATF6B)
SBQ: 101047355(ATF6B)
MMU: 12915(Atf6b)
MCAL: 110312537(Atf6b)
MPAH: 110335526(Atf6b)
RNO: 406169(Atf6b)
MUN: 110565383(Atf6b)
CGE: 100767112(Atf6b)
NGI: 103724413(Atf6b)
HGL: 101715793(Atf6b)
CCAN: 109699672(Atf6b)
OCU: 100357489(ATF6B)
TUP: 102484080(ATF6B)
CFA: 474855(ATF6B)
VVP: 112913633(ATF6B)
AML: 100476017(ATF6B)
UMR: 103682282(ATF6B)
UAH: 113243741(ATF6B)
ORO: 101381436(ATF6B)
ELK: 111152366
FCA: 101094849(ATF6B)
PTG: 102965640(ATF6B)
PPAD: 109260558(ATF6B)
AJU: 106983500(ATF6B)
BTA: 513928(ATF6B)
BOM: 102288212(ATF6B)
BIU: 109576848(ATF6B)
BBUB: 102392963(ATF6B)
CHX: 102171671(ATF6B)
OAS: 101113631(ATF6B)
SSC: 100144516(ATF6B)
CFR: 102521467(ATF6B)
CDK: 105090854(ATF6B)
BACU: 103014625(ATF6B)
LVE: 103069101(ATF6B)
OOR: 101273605(ATF6B)
DLE: 111170946(ATF6B)
PCAD: 102978131(ATF6B)
ECB: 100059348(ATF6B)
EPZ: 103563297(ATF6B)
EAI: 106831009(ATF6B)
MYB: 102261840(ATF6B)
MYD: 102767346(ATF6B)
MNA: 107539006(ATF6B)
HAI: 109373089(ATF6B)
DRO: 112302085(ATF6B)
PALE: 102898128(ATF6B)
RAY: 107498439(ATF6B)
MJV: 108393793(ATF6B)
LAV: 100666885(ATF6B)
TMU: 101359783
MDO: 100025603(ATF6B)
SHR: 100932966(ATF6B)
PCW: 110199423(ATF6B)
OAA: 100080771(ATF6B)
PHI: 102113904(ATF6B)
ASN: 102383000(ATF6B)
AMJ: 102575911(ATF6B)
CPIC: 101948982(ATF6B)
ACS: 100557347(atf6b)
PVT: 110070069(ATF6B)
PBI: 103058912(ATF6B)
PMUR: 107298366
TSR: 106546721(ATF6B)
PMUA: 114592080(ATF6B)
GJA: 107118458(ATF6B)
XLA: 108698555(atf6b.L) 108700226(atf6b.S)
XTR: 100488855(atf6b)
NPR: 108786537(ATF6B)
DRE: 777612(atf6b)
CCAR: 109111390
IPU: 108274800(atf6b)
AMEX: 103031559
EEE: 113583832(atf6b)
TRU: 101073153
LCO: 104930576(atf6b)
MZE: 101468193(atf6b)
ONL: 100705378
XMA: 102225633(atf6b)
XCO: 114156358(atf6b)
PRET: 103472821(atf6b)
CVG: 107104477(atf6b)
NFU: 107394433(atf6b)
KMR: 108246380
ALIM: 106528703(atf6b)
AOCE: 111568555(atf6b)
CSEM: 103393796(atf6b)
POV: 109645876(atf6b)
LCF: 108891249(atf6b)
SDU: 111230666(atf6b)
SLAL: 111665658(atf6b)
HCQ: 109515145(atf6b)
BPEC: 110160837(atf6b)
MALB: 109952481(atf6b)
SASA: 106569944(ATF6) 106588375(ATF6)
ELS: 105028060
SFM: 108935684(atf6b)
PKI: 111842807(atf6b)
LCM: 102345323(ATF6B)
RTP: 109913847
BFO: 118420980
CIN: 778962
SPU: 589006
APLC: 110976451
PCAN: 112575671
MYI: 110464394
AMIL: 114954997
 » show all
Reference
PMID:8586413
  Authors
Min J, Shukla H, Kozono H, Bronson SK, Weissman SM, Chaplin DD
  Title
A novel Creb family gene telomeric of HLA-DRA in the HLA complex.
  Journal
Genomics 30:149-56 (1995)
DOI:10.1006/geno.1995.9891
  Sequence
[hsa:1388]
Reference
  Authors
Thuerauf DJ, Morrison L, Glembotski CC
  Title
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
  Journal
J Biol Chem 279:21078-84 (2004)
DOI:10.1074/jbc.M400713200
  Sequence
[hsa:1388]
LinkDB

DBGET integrated database retrieval system