KEGG   ORTHOLOGY: K06255
Entry
K06255                      KO                                     

Name
HSPG2
Definition
basement membrane-specific heparan sulfate proteoglycan core protein
Pathway
ko04512  ECM-receptor interaction
ko05161  Hepatitis B
ko05205  Proteoglycans in cancer
Disease
H00493  Heparan sulfate proteoglycan gene defects
H01777  Schwartz-Jampel syndrome
H02155  Dyssegmental dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
  09172 Infectious disease: viral
   05161 Hepatitis B
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
   00535 Proteoglycans
    K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06255  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein
Proteoglycans [BR:ko00535]
 Extracellular matrix (ECM) proteoglycans
  Basement membrane proteoglycans
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Genes
HSA: 3339(HSPG2)
PTR: 100613114(HSPG2)
PPS: 100969025(HSPG2)
GGO: 101138254(HSPG2)
PON: 100446648(HSPG2)
NLE: 100603335(HSPG2)
MCC: 707213(HSPG2)
MCF: 102145976(HSPG2)
CSAB: 103225428(HSPG2)
RRO: 104663240(HSPG2)
RBB: 108538399(HSPG2)
CJC: 100413695(HSPG2)
SBQ: 101035920(HSPG2)
MMU: 15530(Hspg2)
MCAL: 110292307(Hspg2)
MPAH: 110323502(Hspg2)
RNO: 313641(Hspg2)
MUN: 110545004(Hspg2)
CGE: 100689041(Hspg2)
HGL: 101700294(Hspg2)
CCAN: 109694908(Hspg2)
OCU: 100340334(HSPG2)
TUP: 102493755(HSPG2)
CFA: 403440(HSPG2)
VVP: 112929713(HSPG2)
AML: 100467831(HSPG2)
UMR: 103666798(HSPG2)
UAH: 113268545(HSPG2)
ORO: 101366326(HSPG2)
ELK: 111154824
FCA: 101094520(HSPG2)
PTG: 102954270(HSPG2)
PPAD: 109274267(HSPG2)
AJU: 106977608(HSPG2)
BTA: 444872(HSPG2)
BOM: 102271087(HSPG2)
BBUB: 102395253(HSPG2)
CHX: 102188640(HSPG2)
OAS: 101122677(HSPG2)
SSC: 100517288(HSPG2)
CFR: 102522322(HSPG2)
CDK: 105088891(HSPG2)
BACU: 103016583(HSPG2)
LVE: 103071665(HSPG2)
OOR: 101272353(HSPG2)
DLE: 111163281(HSPG2)
PCAD: 102979982(HSPG2)
ECB: 100071701(HSPG2)
EPZ: 103558488(HSPG2)
EAI: 106840047(HSPG2)
MYB: 102241192(HSPG2)
MYD: 102756550(HSPG2)
MNA: 107538321(HSPG2)
HAI: 109396746(HSPG2)
DRO: 112299193(HSPG2)
PALE: 102887886(HSPG2)
RAY: 107513054(HSPG2)
MJV: 108391519(HSPG2)
LAV: 100668646(HSPG2)
TMU: 101349957
MDO: 100617792(HSPG2)
SHR: 100926296(HSPG2)
PCW: 110206031(HSPG2)
OAA: 100093007(HSPG2)
GGA: 429806(HSPG2)
MGP: 100549236
CJO: 107323300(HSPG2)
TGU: 115497983(HSPG2)
LSR: 110474430(HSPG2)
FAB: 101809010(HSPG2)
PHI: 102108967(HSPG2)
ASN: 102377486(HSPG2)
CMY: 102942490(HSPG2)
CPIC: 101931520(HSPG2)
PVT: 110073100(HSPG2)
PBI: 103053870(HSPG2)
PMUA: 114602821(HSPG2)
GJA: 107111588(HSPG2)
XLA: 108696836(hspg2.L)
XTR: 100494785(hspg2)
NPR: 108802213(HSPG2)
DRE: 565429(hspg2)
CCAR: 109055269
IPU: 108275596(hspg2)
PHYP: 113530313(hspg2)
AMEX: 103021689(hspg2)
EEE: 113578609(hspg2)
TRU: 101065556(hspg2)
LCO: 104928635(hspg2)
MZE: 101473055(hspg2)
ONL: 100709308(hspg2)
OLA: 101159991(hspg2)
XMA: 102217130(hspg2)
XCO: 114140465(hspg2)
PRET: 103467813(hspg2)
CVG: 107091679(hspg2)
NFU: 107390415(hspg2)
KMR: 108237624(hspg2)
ALIM: 106529069(hspg2)
AOCE: 111562749(hspg2)
CSEM: 103385274(hspg2)
POV: 109640818(hspg2)
LCF: 108888875(hspg2)
SDU: 111234870(hspg2)
SLAL: 111661952(hspg2)
HCQ: 109520187(hspg2)
BPEC: 110159404(hspg2)
MALB: 109951229(hspg2)
ELS: 105028690(hspg2)
SFM: 108939266(hspg2)
PKI: 111855723(hspg2)
LCM: 102366028(HSPG2)
CMK: 103181437(hspg2)
BFO: 118431007
CIN: 445626
SPU: 589644
NVE: 5507167
HMG: 101240275
 » show all
Reference
PMID:1569102
  Authors
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV
  Title
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
  Journal
J Biol Chem 267:8544-57 (1992)
  Sequence
[hsa:3339]
Reference
  Authors
Whitelock JM, Melrose J, Iozzo RV
  Title
Diverse cell signaling events modulated by perlecan.
  Journal
Biochemistry 47:11174-83 (2008)
DOI:10.1021/bi8013938
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