KEGG   ORTHOLOGY: K06269
Entry
K06269                      KO                                     

Name
PPP1C
Definition
serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Pathway
ko03015  mRNA surveillance pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04113  Meiosis - yeast
ko04114  Oocyte meiosis
ko04218  Cellular senescence
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04390  Hippo signaling pathway
ko04510  Focal adhesion
ko04611  Platelet activation
ko04720  Long-term potentiation
ko04728  Dopaminergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04921  Oxytocin signaling pathway
ko04931  Insulin resistance
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05168  Herpes simplex virus 1 infection
ko05205  Proteoglycans in cancer
Disease
H00523  Noonan syndrome and related disorders
H02191  Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04024 cAMP signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04022 cGMP-PKG signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04113 Meiosis - yeast
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04114 Oocyte meiosis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04218 Cellular senescence
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04921 Oxytocin signaling pathway
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04270 Vascular smooth muscle contraction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09156 Nervous system
   04728 Dopaminergic synapse
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   04720 Long-term potentiation
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09165 Substance dependence
   05031 Amphetamine addiction
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   05034 Alcoholism
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
  09182 Protein families: genetic information processing
   03021 Transcription machinery
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03019 Messenger RNA biogenesis
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
   03041 Spliceosome
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Transcription machinery [BR:ko03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Spliceosome [BR:ko03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    K06269  PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit
Other DBs
COG: COG0639
GO: 0004722
Genes
HSA: 5499(PPP1CA) 5500(PPP1CB) 5501(PPP1CC)
PTR: 459118(PPP1CB) 462795(PPP1CC) 743656 745709(PPP1CA)
PPS: 100974889(PPP1CC) 100978326(PPP1CB)
GGO: 101129953(PPP1CB) 101143438(PPP1CC)
PON: 100173410(PPP1CB) 100458223(PPP1CC) 100459799(PPP1CA)
NLE: 100587142(PPP1CB) 100603005(PPP1CA) 100605408(PPP1CC)
MCC: 703302(PPP1CB) 709935(PPP1CC) 721735(PPP1CA)
MCF: 101925057(PPP1CC) 102133300(PPP1CB) 102138402(PPP1CA)
CSAB: 103218909(PPP1CA) 103220572(PPP1CB) 103239526(PPP1CC)
RRO: 104664823(PPP1CA) 104668466(PPP1CB) 104675136(PPP1CC)
RBB: 108512265(PPP1CC) 108518604(PPP1CA) 108532746(PPP1CB)
SBQ: 101030626 101048398(PPP1CB) 101048497(PPP1CA) 101050671(PPP1CC)
MMU: 19045(Ppp1ca) 19046(Ppp1cb) 19047(Ppp1cc) 434233(Ppp1ccb)
MCAL: 110285541(Ppp1ca) 110288037 110294013(Ppp1cb) 110294931(Ppp1cc)
MPAH: 110312794(Ppp1cc) 110317198(Ppp1ca) 110324329(Ppp1cb)
RNO: 100363225 24668(Ppp1ca) 24669(Ppp1cc) 25594(Ppp1cb)
MUN: 110545313(Ppp1cc) 110554524(Ppp1cb) 110560352(Ppp1ca)
CGE: 100760810(Ppp1ca) 100761524(Ppp1cb) 100774547(Ppp1cc)
NGI: 103725581(Ppp1ca) 103730228(Ppp1cb) 103739088(Ppp1cc)
HGL: 101698044(Ppp1cb) 101705408(Ppp1ca) 101714468(Ppp1cc)
CCAN: 109679334(Ppp1cb) 109685544 109688628(Ppp1ca)
OCU: 100009298(PPP1CA) 100009587(PPP1CB) 100353054(PPP1CC)
TUP: 102469176 102476316(PPP1CC) 102477186(PPP1CA) 102496931(PPP1CB)
CFA: 403557(PPP1CC) 403558(PPP1CB) 403609(PPP1CA)
VVP: 112924187(PPP1CA) 112933024(PPP1CB) 112935190(PPP1CC)
AML: 100464499(PPP1CA) 100471456(PPP1CB) 100476029(PPP1CC)
UMR: 103661277(PPP1CC) 103671909(PPP1CB) 103679611(PPP1CA)
UAH: 113240761(PPP1CB) 113244033(PPP1CA) 113266966(PPP1CC)
ORO: 101372346(PPP1CB) 101382867(PPP1CA) 101386053(PPP1CC)
FCA: 101092932(PPP1CB) 101100922(PPP1CC) 109492306(PPP1CA)
PTG: 102948702(PPP1CC) 102970154(PPP1CB) 107180886(PPP1CA)
PPAD: 109246846(PPP1CA) 109266491(PPP1CB) 109277658(PPP1CC)
AJU: 106967586(PPP1CC) 106967920(PPP1CB) 106971182(PPP1CA)
BTA: 282318(PPP1CC) 516175(PPP1CA) 538829(PPP1CB)
BOM: 102266876(PPP1CB) 102270793(PPP1CA) 102275429(PPP1CC)
BIU: 109554414(PPP1CA) 109566263(PPP1CB) 109571193(PPP1CC)
BBUB: 102393123(PPP1CC) 102395266(PPP1CA) 102396799(PPP1CB)
CHX: 102170985(PPP1CB) 102181064(PPP1CC) 102181571(PPP1CA)
OAS: 101106284(PPP1CC) 101119264(PPP1CA) 101123197(PPP1CB) 114118855
SSC: 397378(PPP1CB) 733611(PPP1CA) 733612(PPP1CC)
CFR: 102505354(PPP1CA) 102520782(PPP1CB) 102522874(PPP1CC)
CDK: 105098564(PPP1CB) 105102484(PPP1CC) 105104430(PPP1CA)
BACU: 103000500(PPP1CB) 103008250 103008309(PPP1CA) 103017316(PPP1CC)
LVE: 103072994(PPP1CC) 103074387(PPP1CA) 103080471(PPP1CB) 103086084
OOR: 101280558(PPP1CB) 101285623(PPP1CA) 101286983(PPP1CC)
DLE: 111174925(PPP1CB) 111183676(PPP1CA) 111186906(PPP1CC)
PCAD: 102981359(PPP1CC) 102981740(PPP1CA) 102992996(PPP1CB)
ECB: 100058160(PPP1CC) 100059233(PPP1CA) 100071067(PPP1CB)
EPZ: 103541647(PPP1CC) 103549472(PPP1CB) 103560150(PPP1CA)
EAI: 106833503(PPP1CA) 106837075(PPP1CB) 106842216(PPP1CC)
MYB: 102239740(PPP1CC) 102244214(PPP1CA) 102248545(PPP1CB) 102253559
MYD: 102760260(PPP1CB) 102764391(PPP1CA) 102775047
MNA: 107529564(PPP1CC) 107533957 107534692(PPP1CB)
HAI: 109384139(PPP1CA) 109385685(PPP1CB) 109386108(PPP1CC)
DRO: 112297802(PPP1CB) 112310655(PPP1CC) 112317227(PPP1CA)
PALE: 102881448(PPP1CB) 102887827(PPP1CC) 102892254(PPP1CA)
RAY: 107503728(PPP1CA) 107511165(PPP1CB) 107513247(PPP1CC)
MJV: 108393155(PPP1CA) 108400557(PPP1CC) 108407321(PPP1CB)
LAV: 100660199(PPP1CB) 100671604(PPP1CC) 100673814(PPP1CA)
MDO: 100019898(PPP1CC) 100029055(PPP1CA) 100031298(PPP1CB)
SHR: 100915116(PPP1CA) 100920526(PPP1CC) 100930570(PPP1CB)
PCW: 110195486(PPP1CA) 110196829(PPP1CC) 110206445(PPP1CB)
OAA: 100074395(PPP1CC) 100078635(PPP1CB) 100092226(PPP1CA)
GGA: 100858156(PPP1CA) 396019(PPP1CB) 416872(PPP1CC)
MGP: 100544698(PPP1CB) 100546973(PPP1CC) 100550782(PPP1CA)
CJO: 107311180(PPP1CB) 107314245(PPP1CA) 107321188(PPP1CC)
NMEL: 110396314(PPP1CB) 110400859(PPP1CA) 110406337(PPP1CC)
APLA: 101798783(PPP1CB)
ACYG: 106029776(PPP1CB) 106031410(PPP1CC)
TGU: 100190013(PPP1CA) 100190751(PPP1CC) 100224238(PPP1CB)
LSR: 110478165(PPP1CC) 110482805(PPP1CB) 110485072(PPP1CA)
SCAN: 103817249(PPP1CB) 103818147(PPP1CC) 103822255(PPP1CA)
GFR: 102032151(PPP1CB) 102039437(PPP1CA) 102042078(PPP1CC)
FAB: 101810420(PPP1CA) 101813100(PPP1CB) 107603979(PPP1CC)
PHI: 102099963(PPP1CA) 102101654(PPP1CC) 102114757(PPP1CB)
PMAJ: 107201313(PPP1CB) 107205266(PPP1CA) 107211824(PPP1CC)
CCAE: 111927633(PPP1CB) 111936713(PPP1CC)
CCW: 104684134 104685699(PPP1CB) 104688680(PPP1CC)
ETL: 114055006(PPP1CC) 114063365(PPP1CA) 114064849(PPP1CB)
FPG: 101913968(PPP1CA) 101916649(PPP1CB) 101924787(PPP1CC)
FCH: 102053170(PPP1CA) 102054093 102058478(PPP1CB)
CLV: 102083732(PPP1CB) 102086082(PPP1CC) 102096027(PPP1CA)
EGZ: 104122715(PPP1CC) 104135633(PPP1CB)
NNI: 104011867(PPP1CA) 104020653(PPP1CC) 104021492(PPP1CB)
ACUN: 113478943(PPP1CB) 113486130(PPP1CC)
PADL: 103914295(PPP1CB) 103914541(PPP1CC)
AAM: 106485498(PPP1CB) 106495691(PPP1CC) 106495808
ASN: 102373171(PPP1CA) 102375415(PPP1CC) 102383008(PPP1CB)
AMJ: 102560817(PPP1CB) 102564750(PPP1CC) 102565419(PPP1CA)
PSS: 102449920 102450584(PPP1CC) 102463695(PPP1CA) 102463789(PPP1CB)
CPIC: 101931881(PPP1CC) 101942402 101946001(PPP1CB) 101948239(PPP1CA)
ACS: 100552053(ppp1cb) 100558590(ppp1ca) 100565990(ppp1cc)
PVT: 110078692(PPP1CB) 110083839(PPP1CC) 110085633(PPP1CA)
PBI: 103056218(PPP1CC) 103057409(PPP1CA) 103062218(PPP1CB)
PMUR: 107286959(PPP1CC) 107298021(PPP1CB) 107302715(PPP1CA)
TSR: 106538243(PPP1CB) 106547126(PPP1CA) 106548633
PMUA: 114594578 114594579 114602049(PPP1CA) 114602733(PPP1CC)
GJA: 107112146(PPP1CC) 107124492(PPP1CB)
XLA: 108704179 108717671 379914(ppp1ca.L) 380598(ppp1cc) 397767(ppp1cc.L) 443852(ppp1cb.L)
XTR: 100145598(ppp1ca) 407879(ppp1cc) 496958(ppp1cb)
NPR: 108786345(PPP1CB) 108788527(PPP1CC) 108796512
DRE: 100003223(ppp1cb) 327301(ppp1cab) 334597(ppp1cbl) 407980(ppp1caa) 571753(ppp1cc)
LCM: 102359594 102359947(PPP1CB) 102361180(PPP1CA) 102361284 102362859(PPP1CC)
CMK: 103184322(ppp1cc) 103189617(ppp1cb)
RTP: 109910556(ppp1cb) 109935119(ppp1cc)
DME: Dmel_CG10138(PpD5) Dmel_CG10930(PpY-55A) Dmel_CG2096(flw) Dmel_CG3245(PpN58A) Dmel_CG40448(Pp1-Y2) Dmel_CG41534(Pp1-Y1) Dmel_CG5650(Pp1-87B) Dmel_CG6593(Pp1alpha-96A) Dmel_CG8822(PpD6) Dmel_CG9156(Pp1-13C)
DSI: Dsimw501_GD15211(Dsim_GD15211) Dsimw501_GD15806(Dsim_GD15806) Dsimw501_GD16975(Dsim_GD16975) Dsimw501_GD20567(Dsim_GD20567) Dsimw501_GD21106(Dsim_GD21106) Dsimw501_GD23208(Dsim_GD23208) Dsimw501_GD25158(Dsim_GD25158) Dsimw501_GD25428(Dsim_GD25428)
ACEP: 105617778
CEL: CELE_C05A2.1(pph-1) CELE_C09H5.7(C09H5.7) CELE_C34D4.2(C34D4.2) CELE_F29F11.6(gsp-1) CELE_F52H3.6(F52H3.6) CELE_F56C9.1(gsp-2) CELE_T03F1.5(gsp-4) CELE_T16G12.7(T16G12.7) CELE_W09C3.6(gsp-3) CELE_ZK938.1(ZK938.1)
ATH: AT1G64040(TOPP3) AT2G29400(TOPP1) AT2G39840(TOPP4) AT3G05580(TOPP9) AT3G46820(TOPP5) AT4G11240(TOPP7) AT5G27840(TOPP8) AT5G43380(TOPP6) AT5G59160(TOPP2)
LJA: Lj0g3v0300529.1(Lj0g3v0300529.1) Lj1g3v4918780.1(Lj1g3v4918780.1) Lj2g3v2661450.1(Lj2g3v2661450.1) Lj4g3v2991200.1(Lj4g3v2991200.1) Lj5g3v1170950.1(Lj5g3v1170950.1) Lj5g3v1341890.1(Lj5g3v1341890.1)
DOSA: Os01t0349400-01(Os01g0349400) Os02t0820000-01(Os02g0820000) Os03t0268000-01(Os03g0268000) Os06t0164100-02(Os06g0164100) Os08t0455600-01(Os08g0455600)
ATS: 109732086(LOC109732086) 109733774(LOC109733774) 109743491(LOC109743491) 109743734(LOC109743734) 109755301(LOC109755301) 109756658(LOC109756658) 109765679(LOC109765679) 109769708(LOC109769708)
CRE: CHLREDRAFT_160030(PP1A)
MNG: MNEG_1738
APRO: F751_2630
MIS: MICPUN_104871(PP1)
SCE: YDR436W(PPZ2) YER133W(GLC7) YML016C(PPZ1) YPL179W(PPQ1)
KMX: KLMA_30142(GLC7) KLMA_30328(PPQ1) KLMA_40596(PPZ1)
NCS: NCAS_0B04450(NCAS0B04450) NCAS_0H01100(NCAS0H01100) NCAS_0H02660(NCAS0H02660)
NDI: NDAI_0B01900(NDAI0B01900) NDAI_0C00960(NDAI0C00960) NDAI_0F02190(NDAI0F02190)
TPF: TPHA_0D02470(TPHA0D02470) TPHA_0H00280(TPHA0H00280) TPHA_0K00420(TPHA0K00420) TPHA_0N01200(TPHA0N01200)
TBL: TBLA_0A06980(TBLA0A06980) TBLA_0A08840(TBLA0A08840) TBLA_0B05260(TBLA0B05260) TBLA_0D01510(TBLA0D01510)
TDL: TDEL_0A04110(TDEL0A04110) TDEL_0B04530(TDEL0B04530) TDEL_0F01790(TDEL0F01790)
KAF: KAFR_0B02190(KAFR0B02190) KAFR_0C05490(KAFR0C05490) KAFR_0G03660(KAFR0G03660)
SLB: AWJ20_1480(PPZ1) AWJ20_1973(GLC7) AWJ20_1974(GLC7) AWJ20_2933(PPZ1)
NCR: NCU00043(pph-3) NCU07489(pzl-1)
NTE: NEUTE1DRAFT116927(NEUTE1DRAFT_116927) NEUTE1DRAFT70184(NEUTE1DRAFT_70184)
ANG: ANI_1_1062064(An07g08600) ANI_1_1610104(An12g02980) ANI_1_2466014(An01g04120)
SPO: SPAC57A7.08(pzh1) SPBC776.02c(dis2) SPCC31H12.05c(sds21)
ABP: AGABI1DRAFT117366(AGABI1DRAFT_117366) AGABI1DRAFT86604(AGABI1DRAFT_86604)
ABV: AGABI2DRAFT147675(AGABI2DRAFT_147675) AGABI2DRAFT152533(AGABI2DRAFT_152533)
DDI: DDB_G0275619(pppB)
DFA: DFA_09009(pppB)
EHI: EHI_045530(78.t00036) EHI_048970(184.t00018) EHI_067900(8.t00054) EHI_097970(185.t00009) EHI_176170(156.t00006)
PCB: PCHAS_102910(PC302339.00.0)
TAN: TA12680
TPV: TP02_0350
BBO: BBOV_III006130(17.m07543)
CPV: cgd7_2670
SMIN: v1.2.001664.t1(symbB.v1.2.001664.t1) v1.2.001666.t1(symbB.v1.2.001666.t1) v1.2.006043.t1(symbB.v1.2.006043.t1) v1.2.018377.t1(symbB.v1.2.018377.t1) v1.2.018377.t2(symbB.v1.2.018377.t2) v1.2.025541.t1(symbB.v1.2.025541.t1) v1.2.028716.t1(symbB.v1.2.028716.t1) v1.2.028944.t1(symbB.v1.2.028944.t1) v1.2.036995.t1(symbB.v1.2.036995.t1)
MBAR: MSBR2_0799
MBAK: MSBR3_0059
METM: MSMTP_1218
VG: 20041718(JO84_gp297)
 » show all
Reference
PMID:8392016
  Authors
Song Q, Khanna KK, Lu H, Lavin MF
  Title
Cloning and characterization of a human protein phosphatase 1-encoding cDNA.
  Journal
Gene 129:291-5 (1993)
DOI:10.1016/0378-1119(93)90282-8
  Sequence
[hsa:5499]
Reference
  Authors
Lee JH, You J, Dobrota E, Skalnik DG
  Title
Identification and characterization of a novel human PP1 phosphatase complex.
  Journal
J Biol Chem 285:24466-76 (2010)
DOI:10.1074/jbc.M110.109801
  Sequence
[hsa:5499 5500 5501]
LinkDB

KEGG   ORTHOLOGY: K06270
Entry
K06270                      KO                                     

Name
PPP1R12A, MYPT1
Definition
protein phosphatase 1 regulatory subunit 12A
Pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04270  Vascular smooth muscle contraction
ko04510  Focal adhesion
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
   04022 cGMP-PKG signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06270  PPP1R12A, MYPT1; protein phosphatase 1 regulatory subunit 12A
Genes
HSA: 4659(PPP1R12A)
PTR: 452095(PPP1R12A)
PPS: 100989468(PPP1R12A)
GGO: 101139376(PPP1R12A)
PON: 100172617(PPP1R12A)
NLE: 100602476(PPP1R12A)
MCC: 695735(PPP1R12A)
MCF: 101864805(PPP1R12A)
CSAB: 103238782(PPP1R12A)
RRO: 104675773(PPP1R12A)
RBB: 108528527(PPP1R12A)
CJC: 100393191(PPP1R12A)
SBQ: 101034840(PPP1R12A)
MMU: 17931(Ppp1r12a)
MCAL: 110302933(Ppp1r12a)
MPAH: 110326185(Ppp1r12a)
RNO: 116670(Ppp1r12a)
MUN: 110558205(Ppp1r12a)
CGE: 100754718(Ppp1r12a)
NGI: 103749250(Ppp1r12a)
HGL: 101700150(Ppp1r12a)
CCAN: 109697808(Ppp1r12a)
OCU: 100350558(PPP1R12A)
TUP: 102473894(PPP1R12A)
CFA: 475411(PPP1R12A)
VVP: 112914878(PPP1R12A)
AML: 100483995(PPP1R12A)
UMR: 103680852(PPP1R12A)
UAH: 113256222(PPP1R12A)
ORO: 101384536(PPP1R12A)
ELK: 111141992
FCA: 101089624(PPP1R12A)
PTG: 102951696(PPP1R12A)
PPAD: 109270552(PPP1R12A)
AJU: 106967400(PPP1R12A)
BTA: 538606(PPP1R12A)
BOM: 102268036(PPP1R12A)
BIU: 109558936(PPP1R12A)
BBUB: 102395084(PPP1R12A)
CHX: 102183294(PPP1R12A)
OAS: 641303(PPP1R12A)
SSC: 397190(PPP1R12A)
CFR: 102511361(PPP1R12A)
CDK: 105084895(PPP1R12A)
BACU: 103020020(PPP1R12A)
LVE: 103071997(PPP1R12A)
OOR: 101279306(PPP1R12A)
DLE: 111167253(PPP1R12A)
PCAD: 102992707(PPP1R12A)
ECB: 100060501(PPP1R12A)
EPZ: 103549928(PPP1R12A)
EAI: 106831522(PPP1R12A)
MYB: 102251394(PPP1R12A)
MYD: 102765262(PPP1R12A)
MNA: 107526828(PPP1R12A)
HAI: 109375211(PPP1R12A)
DRO: 112322163(PPP1R12A)
PALE: 102898474(PPP1R12A)
RAY: 107503696(PPP1R12A)
MJV: 108408094(PPP1R12A)
LAV: 100673922(PPP1R12A)
TMU: 101341352
MDO: 100019488(PPP1R12A)
SHR: 100926931(PPP1R12A)
PCW: 110213174(PPP1R12A)
OAA: 100077235(PPP1R12A)
GGA: 396020(PPP1R12A)
MGP: 100539276(PPP1R12A)
CJO: 107311018(PPP1R12A)
NMEL: 110392872(PPP1R12A)
APLA: 101800288(PPP1R12A)
ACYG: 106046454(PPP1R12A)
TGU: 100220857(PPP1R12A)
LSR: 110469380(PPP1R12A)
SCAN: 103813426(PPP1R12A)
GFR: 102037308(PPP1R12A)
FAB: 101822232(PPP1R12A)
PHI: 102107346(PPP1R12A)
PMAJ: 107204392(PPP1R12A)
CCAE: 111933170(PPP1R12A)
CCW: 104698411(PPP1R12A)
ETL: 114063665(PPP1R12A)
FPG: 101914871(PPP1R12A)
FCH: 102052384(PPP1R12A)
CLV: 102098984(PPP1R12A)
EGZ: 104132935(PPP1R12A)
NNI: 104010975(PPP1R12A)
ACUN: 113488441(PPP1R12A)
PADL: 103919928(PPP1R12A)
AAM: 106488611(PPP1R12A)
ASN: 102381466(PPP1R12A)
AMJ: 102562278(PPP1R12A)
PSS: 102460329(PPP1R12A)
CMY: 102930708(PPP1R12A)
CPIC: 101949705(PPP1R12A)
ACS: 100560455(ppp1r12a)
PVT: 110084990(PPP1R12A)
PBI: 103053749(PPP1R12A)
PMUR: 107284036(PPP1R12A)
TSR: 106547769(PPP1R12A)
GJA: 107113829(PPP1R12A)
XLA: 108711109(ppp1r12a.L) 108713841 108715193 733200(ppp1r12a.S)
XTR: 100487727 100493563(ppp1r12a)
DRE: 445393(ppp1r12a) 571837(zmp:0000001167)
SGH: 107560300(ppp1r12a) 107561184 107591124
CCAR: 109076480
IPU: 108279475(ppp1r12a)
AMEX: 103046804(ppp1r12a)
TRU: 101079088(ppp1r12a)
LCO: 104924035(ppp1r12a) 104928858
NCC: 104949170(ppp1r12a) 104956193
MZE: 101469187
ONL: 100691168 100701481(ppp1r12a)
XCO: 114160902(ppp1r12a)
PRET: 103459134(ppp1r12a)
KMR: 108233296(ppp1r12a)
AOCE: 111568454(ppp1r12a)
CSEM: 103380280 103382552(ppp1r12a)
POV: 109641125(ppp1r12a)
LCF: 108873647(ppp1r12a) 108886890
SDU: 111229837
SLAL: 111660032(ppp1r12a) 111666970
HCQ: 109530079(ppp1r12a)
BPEC: 110161521(ppp1r12a)
MALB: 109967812(ppp1r12a) 109972924
SALP: 111951439
BFO: 118407388
CIN: 100187107
AAG: 5576767
AALB: 109416470
AME: 726541
BIM: 100749351
BTER: 100646538
CCAL: 108628490
OBB: 114871136
SOC: 105198893
MPHA: 105827753
AEC: 105145669
ACEP: 105617107
PBAR: 105426810
VEM: 105565091
HST: 105192635
DQU: 106741992
CFO: 105251152
LHU: 105677120
PGC: 109854374
PCF: 106791741
NVI: 100114433
TCA: 659634
CEL: CELE_C06C3.1(mel-11)
CBR: CBG00870(Cbr-mel-11)
BMY: Bm1_46800
NVE: 5515674
HMG: 100214665
 » show all
Reference
PMID:8543033
  Authors
Haystead CM, Gailly P, Somlyo AP, Somlyo AV, Haystead TA
  Title
Molecular cloning and functional expression of a recombinant 72.5 kDa fragment of the 110 kDa regulatory subunit of smooth muscle protein phosphatase 1M.
  Journal
FEBS Lett 377:123-7 (1995)
DOI:10.1016/0014-5793(95)01318-0
  Sequence
[rno:116670]
Reference
  Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
  Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
  Journal
Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018
LinkDB

KEGG   ORTHOLOGY: K12329
Entry
K12329                      KO                                     

Name
PPP1R12B, MYPT2
Definition
protein phosphatase 1 regulatory subunit 12B
Pathway
ko04270  Vascular smooth muscle contraction
ko04510  Focal adhesion
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K12329  PPP1R12B, MYPT2; protein phosphatase 1 regulatory subunit 12B
Genes
HSA: 4660(PPP1R12B)
PTR: 457629(PPP1R12B)
PPS: 100970244(PPP1R12B)
PON: 103890237(PPP1R12B)
NLE: 100592313(PPP1R12B)
MCC: 705775(PPP1R12B)
MCF: 102121021(PPP1R12B)
CSAB: 103230309(PPP1R12B)
RRO: 104674509(PPP1R12B)
RBB: 108545061(PPP1R12B)
CJC: 100404247(PPP1R12B)
SBQ: 101053159(PPP1R12B)
MMU: 329251(Ppp1r12b)
MCAL: 110293509(Ppp1r12b)
MPAH: 110322008(Ppp1r12b)
RNO: 304813(Ppp1r12b)
MUN: 110546742
CGE: 100753601(Ppp1r12b)
NGI: 103731836(Ppp1r12b)
HGL: 101711489(Ppp1r12b)
CCAN: 109690053(Ppp1r12b)
OCU: 100356902(PPP1R12B)
TUP: 102500634(PPP1R12B)
CFA: 490230(PPP1R12B)
VVP: 112934572(PPP1R12B)
AML: 100470069(PPP1R12B)
UAH: 113242537(PPP1R12B)
ORO: 101369772(PPP1R12B)
ELK: 111151011
FCA: 101098766(PPP1R12B)
PTG: 102950482(PPP1R12B)
PPAD: 109256388(PPP1R12B)
AJU: 106973120(PPP1R12B)
BTA: 107131237(PPP1R12B)
BOM: 102286584(PPP1R12B)
BBUB: 102409062(PPP1R12B)
CHX: 102181773(PPP1R12B)
OAS: 101114596(PPP1R12B)
SSC: 100525832(PPP1R12B)
BACU: 103012518(PPP1R12B)
LVE: 103071840(PPP1R12B)
OOR: 101289221(PPP1R12B)
DLE: 111168304(PPP1R12B)
PCAD: 102980129(PPP1R12B)
ECB: 100063928(PPP1R12B)
EPZ: 103561986(PPP1R12B)
EAI: 106840263(PPP1R12B)
MYB: 102263913(PPP1R12B)
MYD: 102762227(PPP1R12B)
MNA: 107536013(PPP1R12B)
HAI: 109380462(PPP1R12B)
DRO: 112318742(PPP1R12B)
PALE: 102879733(PPP1R12B)
MJV: 108385698
LAV: 100675940(PPP1R12B)
MDO: 100011797(PPP1R12B)
SHR: 100925265(PPP1R12B)
PCW: 110219617(PPP1R12B)
OAA: 100077407(PPP1R12B)
GGA: 395478(PPP1R12B)
MGP: 100545452 104914452(PPP1R12B)
CJO: 107324641(PPP1R12B)
NMEL: 110388357(PPP1R12B)
APLA: 101797997(PPP1R12B)
TGU: 100224964(PPP1R12B)
LSR: 110469188
SCAN: 103822442(PPP1R12B)
GFR: 102044251
FAB: 101818016
PHI: 102113018(PPP1R12B)
PMAJ: 107214882(PPP1R12B)
CCAE: 111939610(PPP1R12B)
CCW: 104692457(PPP1R12B)
ETL: 114064784(PPP1R12B)
FPG: 101915795(PPP1R12B)
FCH: 102059378(PPP1R12B)
EGZ: 104122002
NNI: 104011079
ACUN: 113488963(PPP1R12B)
PADL: 103913809(PPP1R12B)
AAM: 106500257(PPP1R12B)
ASN: 102387200(PPP1R12B)
AMJ: 102561475(PPP1R12B)
PSS: 102450232(PPP1R12B)
CMY: 102943607
CPIC: 101931457(PPP1R12B)
ACS: 100566099(ppp1r12b)
PVT: 110073397(PPP1R12B)
PBI: 103051701(PPP1R12B)
PMUR: 107284458(PPP1R12B)
PMUA: 114599419(PPP1R12B)
XLA: 108708153(ppp1r12b.L)
XTR: 780217(ppp1r12b)
DRE: 101885790
SRX: 107746501
SANH: 107697018
SGH: 107601321
CCAR: 109081823
AMEX: 103026736
EEE: 113588809(ppp1r12b)
LCO: 104927444
MZE: 101471341
ONL: 100701156
OLA: 101165234
XMA: 102217927
XCO: 114139678
PRET: 103467653
CVG: 107083900
NFU: 107391259
KMR: 108232022
ALIM: 106519285
AOCE: 111572093
CSEM: 103385321
POV: 109635001
LCF: 108882116
SDU: 111224778(ppp1r12a) 111238191
SLAL: 111654989
HCQ: 109514994
BPEC: 110164829
MALB: 109966768
SASA: 106572423
SALP: 111966596
ELS: 105013718
SFM: 114909186
PKI: 111855304
CMK: 103179091
RTP: 109927189(ppp1r12b)
 » show all
Reference
PMID:9570949
  Authors
Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M
  Title
A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping.
  Journal
Genomics 49:59-68 (1998)
DOI:10.1006/geno.1998.5222
  Sequence
[hsa:4660]
Reference
  Authors
Grassie ME, Moffat LD, Walsh MP, MacDonald JA
  Title
The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1delta.
  Journal
Arch Biochem Biophys 510:147-59 (2011)
DOI:10.1016/j.abb.2011.01.018
LinkDB

KEGG   ORTHOLOGY: K17457
Entry
K17457                      KO                                     

Name
PPP1R12C, MBS85
Definition
protein phosphatase 1 regulatory subunit 12C
Pathway
ko04270  Vascular smooth muscle contraction
ko04510  Focal adhesion
ko04810  Regulation of actin cytoskeleton
ko04921  Oxytocin signaling pathway
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K17457  PPP1R12C, MBS85; protein phosphatase 1 regulatory subunit 12C
Genes
HSA: 54776(PPP1R12C)
PTR: 456295(PPP1R12C)
PPS: 100967966(PPP1R12C)
GGO: 101136268(PPP1R12C) 115933218
PON: 100444334(PPP1R12C)
NLE: 100596166(PPP1R12C)
MCC: 114674157(PPP1R12C) 698538
MCF: 102119955(PPP1R12C)
CSAB: 103235290(PPP1R12C)
RRO: 104674755(PPP1R12C)
RBB: 108542522(PPP1R12C)
CJC: 100407435(PPP1R12C)
SBQ: 101046107(PPP1R12C)
MMU: 232807(Ppp1r12c)
MCAL: 110297840(Ppp1r12c)
MPAH: 110336360(Ppp1r12c)
RNO: 499076(Ppp1r12c)
MUN: 110561072(Ppp1r12c)
CGE: 100765970(Ppp1r12c)
NGI: 103744825(Ppp1r12c)
HGL: 101714373(Ppp1r12c)
CCAN: 109696269(Ppp1r12c)
OCU: 103347470(PPP1R12C)
TUP: 102475906(PPP1R12C)
CFA: 100683226(PPP1R12C)
VVP: 112909382(PPP1R12C)
AML: 100476917(PPP1R12C)
UMR: 103680310(PPP1R12C)
UAH: 113247365(PPP1R12C)
ORO: 101384064(PPP1R12C)
ELK: 111140038
FCA: 101092809(PPP1R12C)
PTG: 102964615(PPP1R12C)
PPAD: 109259902(PPP1R12C)
AJU: 106980875(PPP1R12C)
BTA: 512431(PPP1R12C)
BOM: 102273254(PPP1R12C)
BIU: 109571856(PPP1R12C)
BBUB: 102403593(PPP1R12C)
CHX: 102187707(PPP1R12C)
OAS: 101122546(PPP1R12C)
SSC: 100626700(PPP1R12C)
CFR: 102511905(PPP1R12C)
CDK: 105098775(PPP1R12C)
BACU: 103010788(PPP1R12C)
LVE: 103085204(PPP1R12C)
OOR: 101277066(PPP1R12C)
DLE: 111180975(PPP1R12C)
PCAD: 102987074(PPP1R12C)
EPZ: 103562875(PPP1R12C)
EAI: 106840918(PPP1R12C)
MYB: 102245599(PPP1R12C)
MYD: 102759047(PPP1R12C) 102760558
MNA: 107541310(PPP1R12C)
HAI: 109373751(PPP1R12C)
DRO: 112314020(PPP1R12C)
PALE: 102878573(PPP1R12C)
RAY: 107515441(PPP1R12C)
MJV: 108396329(PPP1R12C)
LAV: 100669550(PPP1R12C)
TMU: 101355540
SHR: 116422717(PPP1R12C)
PCW: 110219818(PPP1R12C)
OAA: 100087416(PPP1R12C)
GGA: 107049646(PPP1R12C)
CJO: 107307229(PPP1R12C)
NMEL: 110391351(PPP1R12C)
ASN: 102380217(PPP1R12C)
AMJ: 102559388(PPP1R12C)
CMY: 102934075
CPIC: 101937529(PPP1R12C)
ACS: 100561659(ppp1r12c)
PVT: 110078487(PPP1R12C)
PBI: 103051816(PPP1R12C)
PMUR: 107282540(PPP1R12C) 107299194
TSR: 106548413(PPP1R12C)
PMUA: 114608033(PPP1R12C)
GJA: 107125719(PPP1R12C)
XTR: 734022(ppp1r12c)
DRE: 570218(ppp1r12c)
SANH: 107688807 107694908(ppp1r12c)
CCAR: 109080602
IPU: 108273132
PHYP: 113538332(ppp1r12c)
AMEX: 103031099
EEE: 113590831
TRU: 101061089(ppp1r12c)
LCO: 104920398(ppp1r12c)
NCC: 104956269(ppp1r12c)
MZE: 101469213(ppp1r12c)
ONL: 109194150(ppp1r12c)
XMA: 102219491
XCO: 114144272
PRET: 103463409
CVG: 107085515(ppp1r12c)
NFU: 107396436
KMR: 108251359(ppp1r12c)
ALIM: 106526908(ppp1r12c)
AOCE: 111575061(ppp1r12c)
CSEM: 103384367
POV: 109627557(ppp1r12c)
LCF: 108884541(ppp1r12c)
SDU: 111217994
SLAL: 111660421
HCQ: 109521847
BPEC: 110173828(ppp1r12c)
MALB: 109956791(ppp1r12c)
SASA: 100194922(pp12c) 106564933
ELS: 105021605
SFM: 108918682
PKI: 111850734
LCM: 102356480(PPP1R12C)
 » show all
Reference
  Authors
Tan I, Ng CH, Lim L, Leung T
  Title
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
  Journal
J Biol Chem 276:21209-16 (2001)
DOI:10.1074/jbc.M102615200
  Sequence
[hsa:54776]
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