KEGG   ORTHOLOGY: K06279Help
Entry
K06279                      KO                                     

Name
SHC1
Definition
SHC-transforming protein 1
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04510  Focal adhesion
ko04650  Natural killer cell mediated cytotoxicity
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04926  Relaxin signaling pathway
ko05034  Alcoholism
ko05100  Bacterial invasion of epithelial cells
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05220  Chronic myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04013 MAPK signaling pathway - fly
    K06279  SHC1; SHC-transforming protein 1
   04012 ErbB signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04072 Phospholipase D signaling pathway
    K06279  SHC1; SHC-transforming protein 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06279  SHC1; SHC-transforming protein 1
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06279  SHC1; SHC-transforming protein 1
   04062 Chemokine signaling pathway
    K06279  SHC1; SHC-transforming protein 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04915 Estrogen signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04917 Prolactin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04926 Relaxin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
 09160 Human Diseases
  09161 Cancers
   05206 MicroRNAs in cancer
    K06279  SHC1; SHC-transforming protein 1
   05225 Hepatocellular carcinoma
    K06279  SHC1; SHC-transforming protein 1
   05226 Gastric cancer
    K06279  SHC1; SHC-transforming protein 1
   05214 Glioma
    K06279  SHC1; SHC-transforming protein 1
   05220 Chronic myeloid leukemia
    K06279  SHC1; SHC-transforming protein 1
   05224 Breast cancer
    K06279  SHC1; SHC-transforming protein 1
  09164 Substance dependence
   05034 Alcoholism
    K06279  SHC1; SHC-transforming protein 1
  09167 Infectious diseases
   05100 Bacterial invasion of epithelial cells
    K06279  SHC1; SHC-transforming protein 1
  09168 Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K06279  SHC1; SHC-transforming protein 1
   01522 Endocrine resistance
    K06279  SHC1; SHC-transforming protein 1
BRITE hierarchy
Genes
HSA: 6464(SHC1)
PTR: 457351(SHC1)
PPS: 100993361(SHC1)
GGO: 101136424(SHC1)
PON: 100173225(SHC1)
NLE: 100606068(SHC1)
MCC: 718982(SHC1)
MCF: 102142777(SHC1)
CSAB: 103223899(SHC1)
RRO: 104663483(SHC1)
RBB: 108526812(SHC1)
CJC: 100390337(SHC1)
SBQ: 101038895(SHC1) 101047748
MMU: 20416(Shc1)
RNO: 85385(Shc1)
CGE: 100758936(Shc1)
NGI: 103751254(Shc1)
HGL: 101717434(Shc1)
CCAN: 109688030(Shc1)
OCU: 100342812(SHC1)
TUP: 102481002(SHC1)
CFA: 490439(SHC1)
AML: 100480856(SHC1)
UMR: 103668383(SHC1)
ORO: 101373821(SHC1)
FCA: 101092911(SHC1)
PTG: 102949026(SHC1)
AJU: 106988382(SHC1)
BTA: 507196(SHC1)
BOM: 102265814(SHC1)
BIU: 109553931(SHC1)
PHD: 102344979(SHC1)
CHX: 102170926(SHC1)
OAS: 101113548(SHC1)
SSC: 100156321(SHC1)
CFR: 102524489(SHC1)
CDK: 105089005(SHC1)
BACU: 103015382(SHC1)
LVE: 103074885(SHC1)
OOR: 101276908(SHC1)
ECB: 100063053(SHC1)
EPZ: 103552865(SHC1)
EAI: 106828516(SHC1)
MYB: 102245916(SHC1)
MYD: 102755241(SHC1)
HAI: 109393422(SHC1)
RSS: 109434683(SHC1)
PALE: 102894443(SHC1)
LAV: 100653766(SHC1)
TMU: 101358105
MDO: 100016090(SHC1)
SHR: 100926921(SHC1)
GGA: 395934(SHC1)
MGP: 100540048(SHC1)
CJO: 107324486(SHC1)
APLA: 101791792(SHC1)
ACYG: 106048510
TGU: 100229782(SHC1)
GFR: 102039503(SHC1)
FAB: 101807411(SHC1)
PHI: 102106714(SHC1)
PMAJ: 107214540(SHC1)
CCW: 104698657(SHC1)
FPG: 101919976(SHC1)
FCH: 102048929(SHC1)
CLV: 102093713(SHC1)
EGZ: 104127244(SHC1)
ASN: 102376721(SHC1)
AMJ: 106737253(SHC1)
PSS: 102457971(SHC1)
CMY: 102941809(SHC1)
CPIC: 101952789(SHC1)
ACS: 100566335(shc1)
PVT: 110081020(SHC1)
PBI: 103049298(SHC1)
GJA: 107117081(SHC1)
XLA: 108700442(shc1.S) 399198(shc1.L)
NPR: 108795195(SHC1) 108795196
DRE: 323818(shc1)
SANH: 107673667(shc1) 107677023
CCAR: 109108120
IPU: 108265869(shc1)
AMEX: 103030808(shc1)
TRU: 101071954(shc1) 105417270(shc4)
LCO: 104918187(shc1)
NCC: 104962177(shc1)
MZE: 101480827(shc1)
OLA: 101154895(shc1)
XMA: 102228847(shc1)
PRET: 103478162(shc1)
NFU: 107379732(shc1)
CSEM: 103388227(shc1)
LCF: 108885949(shc1)
HCQ: 109521038(shc1)
BPEC: 110162980(shc1) 110173049(shc4)
ELS: 105024470(shc1)
SFM: 108925486(shc1)
LCM: 102356771(SHC1)
CIN: 100181792
SPU: 578929
APLC: 110990360
SKO: 102802005
DME: Dmel_CG3715(Shc)
DSI: Dsimw501_GD14181(Dsim_GD14181)
MDE: 101892485
AAG: 5571016
AME: 412172
BIM: 100749343
BTER: 100648173
SOC: 105193309
AEC: 105143333
ACEP: 105625063
PBAR: 105433457
HST: 105188999
CFO: 105252997
LHU: 105677602
PGC: 109856287
NVI: 100118291
TCA: 658971
DPA: 109532895
NVL: 108561427
BMOR: 101739196
PMAC: 106714389
PRAP: 110994846
PXY: 105391294
API: 100570104
DNX: 107173943
ZNE: 110830796
FCD: 110848166
TUT: 107362363
CEL: CELE_F54A5.3(shc-1)
CBR: CBG05128(Cbr-shc-1)
BMY: Bm1_16800
CRG: 105331060
MYI: 110460076
OBI: 106871874
LAK: 106154724
EPA: 110236258
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F
  Title
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
  Journal
J Biol Chem 279:13224-33 (2004)
DOI:10.1074/jbc.M307456200
  Sequence
[hsa:6464]
Reference
PMID:1623525
  Authors
Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG
  Title
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
  Journal
Cell 70:93-104 (1992)
DOI:10.1016/0092-8674(92)90536-L
  Sequence
[hsa:6464]
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